1. Joseph Carroll

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    1. Mentioned In 48 Articles

    2. Optical Coherence Tomography Artifacts Are Associated With Adaptive Optics Scanning Light Ophthalmoscopy Success in Achromatopsia

      Explore TVST Journal Ophthalmology
      Optical Coherence Tomography Artifacts Are Associated With Adaptive Optics Scanning Light Ophthalmoscopy Success in Achromatopsia
      Purpose : To determine whether artifacts in optical coherence tomography (OCT) images are associated with the success or failure of adaptive optics scanning light ophthalmoscopy (AOSLO) imaging in subjects with achromatopsia (ACHM). Methods : Previously acquired OCT and non-confocal, split-detector AOSLO images from one eye of 66 subjects with genetically confirmed achromatopsia (15 CNGA3 and 51 CNGB3 ) were reviewed along with best-corrected visual acuity (BCVA) and axial length. OCT artifacts in interpolated ...
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      Mentions: University of Wisconsin Joseph Carroll Mark E. Pennesi

    3. Medical College of Wisconsin Receives NIH Grant for Assessing Photoreceptor Structure and Function in Normal and Diseased Retinae

      Explore Optical Coherence Tomography News Ophthalmology , Funding
      Medical College of Wisconsin Receives NIH Grant for Assessing Photoreceptor Structure and Function in Normal and Diseased Retinae
      ... Assessing Photoreceptor Structure and Function in Normal and Diseased Retinae. The principal investigator is Joseph Carroll. Below is a summary of the proposed work.

      Inherited retinal...

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      Mentions: University of Wisconsin National Institutes of Health Joseph Carroll

    4. Imaging of Macrophage-Like Cells in Living Human Retina Using Clinical OCT

      Explore IOVS Journal Ophthalmology
      Imaging of Macrophage-Like Cells in Living Human Retina Using Clinical OCT
      Purpose : To image retinal macrophages at the vitreoretinal interface in the living human retina using a clinical optical coherence tomography (OCT) device. Methods : Eighteen healthy controls and three patients with retinopathies were imaged using a clinical spectral-domain OCT. In controls, 10 sequential scans were collected at three different locations: (1) 9 degrees temporal to the fovea, (2) the macula, and (3) the optic nerve head (ONH). Intervisit repeatability was evaluated ...
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      Mentions: University of Wisconsin New York Eye and Ear Infirmary Richard B. Rosen

    5. Assessing the Use of Incorrectly Scaled Optical Coherence Tomography Angiography Images in Peer-Reviewed Studies

      Explore The JAMA Network Ophthalmology
      Assessing the Use of Incorrectly Scaled Optical Coherence Tomography Angiography Images in Peer-Reviewed Studies
      Importance Individual differences in axial length affect the lateral magnification of in vivo retinal images and as a result can affect the accuracy of quantitative measurements made from these images. As measurements from optical coherence tomography angiography (OCTA) images are becoming increasingly used in the diagnosis and monitoring of a wide range of diseases, evaluating which studies use correctly scaled images is crucial to their interpretation. Objective To perform a ...
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      Mentions: University of Wisconsin Joseph Carroll Fred K. Chen

    6. Assessing Retinal Structure in Patients with Parkinson Disease

      Explore OMICS Group Neurology , Ophthalmology
      Assessing Retinal Structure in Patients with Parkinson Disease
      Objective : The retina is an extension of the central nervous system (CNS), and ocular symptoms can precede manifestations of CNS disorders. Given that several neurodegenerative conditions that affect the brain exhibit ocular symptoms, the retina may be an accessible biomarker to monitor disease progression. Dopamine, the key neurotransmitter related to Parkinsons disease (PD), is contained in amacrine and interplexiform cells, which reside in specific retinal layers. Understanding how loss of ...
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      Mentions: University of Wisconsin Joseph Carroll Pooja Godara

    7. Earliest Evidence of Preclinical Diabetic Retinopathy Revealed using OCT Angiography (OCTA) Perfused Capillary Density

      Explore American Journal of Ophthalmology Ophthalmology
      Earliest Evidence of Preclinical Diabetic Retinopathy Revealed using OCT Angiography (OCTA) Perfused Capillary Density
      Purpose To compare perfused capillary density (PCD) in diabetic patients and healthy controls using optical coherence tomography angiography (OCTA). Methods Forty controls, 36 diabetics without clinical retinopathy (NoDR), 38 with nonproliferative retinopathy (NPDR), and 38 with proliferative retinopathy (PDR) were imaged using SD-OCT. A 3x3 mm full-thickness parafoveal OCTA scan was obtained from each participant. Following manual delineation of the foveal avascular zone (FAZ), FAZ area, perimeter, and acircularity index ...
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      Mentions: University of Wisconsin New York Eye and Ear Infirmary Richard B. Rosen

    8. Variability of Foveal Avascular Zone Metrics Derived From Optical Coherence Tomography Angiography Images

      Explore TVST Journal Ophthalmology
      Variability of Foveal Avascular Zone Metrics Derived From Optical Coherence Tomography Angiography Images
      Purpose : To characterize sources of inter- and intrasubject variability in quantitative foveal avascular zone (FAZ) metrics. Methods : Two 33-mm optical coherence tomography angiography scans (centered on the fovea) were acquired in both eyes of 175 subjects. An image of the superficial plexus was extracted from each scan and segmented twice by a single observer. Four quantitative FAZ morphology metrics (area, axis ratio, acircularity, major horizontal axis angle) were calculated, and ...
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      Mentions: University of Wisconsin Joseph Carroll

    9. Imaging Melanin Distribution in the Zebrafish Retina Using Photothermal Optical Coherence Tomography

      Explore TVST Journal Developmental Biology , Ophthalmology
      Imaging Melanin Distribution in the Zebrafish Retina Using Photothermal Optical Coherence Tomography
      Purpose : To demonstrate and validate that photothermal optical coherence tomography (PT-OCT) can image melanin in the retinal pigment epithelium (RPE) and can observe light-driven melanosome translocation in the zebrafish retina. Methods : A commercial spectral domain OCT system was modified to perform both OCT and PT-OCT. Four adult tyrosinase-mosaic zebrafish with varying levels of melanin expression across their retinas were imaged, and the PT-OCT signal for pigmented and nonpigmented regions were ...
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      Mentions: University of Wisconsin Vanderbilt University Melissa C. Skala

    10. Parafoveal Nonperfusion Analysis in Diabetic Retinopathy Using Optical Coherence Tomography Angiography

      Explore TVST Journal Ophthalmology
      Parafoveal Nonperfusion Analysis in Diabetic Retinopathy Using Optical Coherence Tomography Angiography
      Purpose : To describe a new technique for mapping parafoveal intercapillary areas (PICAs) using optical coherence tomography angiography (OCTA), and demonstrate its utility for quantifying parafoveal nonperfusion in diabetic retinopathy (DR). Methods : Nineteen controls, 15 diabetics with no retinopathy (noDR), 15 with nonproliferative diabetic retinopathy (NPDR), and 15 with proliferative diabetic retinopathy (PDR) were imaged with 10 macular OCTA scans. PICAs were automatically delineated on the averaged superficial OCTA images. Following ...
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      Mentions: New York Eye and Ear Infirmary Richard B. Rosen Joseph Carroll

    11. Axial Scaling Is Independent of Ocular Magnification in OCT Images

      Explore IOVS Journal Ophthalmology
      Axial Scaling Is Independent of Ocular Magnification in OCT Images
      We read with great interest the article by Rck et al., 1 as it is a well-known physical principle of optical coherence tomography (OCT) and its basis, low-coherence interferometry, that magnification of the image of the sample using an objective lens or eyes with varying refractive power applies only in the transverse dimension, 2 not the axial dimension. 3 In this article, the authors collected OCT scans of a subretinal ...
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      Mentions: Joseph Carroll

    12. Photothermal optical coherence tomography of indocyanine green in ex vivo eyes

      Explore OSA | OSA Publishing Ophthalmology
      Photothermal optical coherence tomography of indocyanine green in ex vivo eyes
      Indocyanine green (ICG) is routinely used during surgery to stain the inner limiting membrane (ILM) and provide contrast on white light surgical microscopy. While translation of optical coherence tomography (OCT) for intraoperative imaging during ophthalmic surgery has enhanced visualization, the ILM remains difficult to distinguish from underlying retinal structures and ICG does not provide additional OCT contrast. We present photothermal OCT (PT-OCT) for high-specificity detection of ICG on retinal OCT ...
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      Mentions: University of Wisconsin Vanderbilt University Melissa C. Skala

    13. Repeatability and Reproducibility of In Vivo Cone Density Measurements in the Adult Zebrafish Retina

      Explore Home - Springer Developmental Biology , Ophthalmology
      Repeatability and Reproducibility of In Vivo Cone Density Measurements in the Adult Zebrafish Retina
      Zebrafish ( Danio rerio ) are widely used as an experimental model for a wide range of retinal diseases. Previously, optical coherence tomography (OCT) was introduced for quantitative analysis of the zebrafish cone photoreceptor cell mosaic; however no data exists on the intersession reproducibility or intrasession repeatability of such measurements. We imaged 14 wild-type (WT) fish three times each, with 48 h between each time point. En face images of the UV ...
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      Mentions: University of Wisconsin Joseph Carroll

    14. Medical College of Wisconsin Receives NIH Grant for Assessing Photoreceptor Structure and Function in Normal and Diseased Retinae

      Explore Optical Coherence Tomography News Ophthalmology , Funding
      Medical College of Wisconsin Receives NIH Grant for Assessing Photoreceptor Structure and Function in Normal and Diseased Retinae
      Medical College of Wisconsin Receives a 2017 NIH Grant for $545,415 for Assessing Photoreceptor Structure and Function in Normal and Diseased Retinae. The principal investigator is Josepth Carroll. The program began in 2008 and ends in 2021. Below is a summary of the proposed work. Inherited retinal degenerations affect approximately 1 in 1,500 individuals in the US, and given the extreme genotypic and phenotypic heterogeneity, the prospect of ...
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      Mentions: University of Wisconsin National Institutes of Health Joseph Carroll

    15. Register Now for the International Congress on OCT Angiography, "en face" OCT, and Advances in OCT on December 15th in Rome Italy which Already has over 1,000 Attendees.

      Explore Optical Coherence Tomography News
      Register Now for the International Congress on OCT Angiography, "en face" OCT, and Advances in OCT on December 15th in Rome Italy which Already has over 1,000 Attendees.
      ...rd Spaide, Giovanni Staurenghi, Nadia Waheed. Quan Dong Nguyen, SriniVas Sadda, Yves Cohen, Wolfgang Drexler, Joseph Carroll, and Ursula Schmidt Erfurth. The growing number of attendees (from 450 to 1450 in three years) ...
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      Mentions: Philip J. Rosenfeld David Huang Wolfgang Drexler

    16. INTRAOPERATIVE IMAGING OF RETAINED PERFLUOROCARBON LIQUID USING SPECTRAL DOMAIN OPTICAL COHERENCE TOMOGRAPHY

      Explore LWW Online Ophthalmology
      INTRAOPERATIVE IMAGING OF RETAINED PERFLUOROCARBON LIQUID USING SPECTRAL DOMAIN OPTICAL COHERENCE TOMOGRAPHY
      Purpose: To report images of retained perfluorocarbon liquid (PFCL) on the surface of the retina obtained during an intraoperative use of hand-held spectral domain optical coherence tomography. Methods: A 54-year-old man underwent pars plana vitrectomy with injection of PFCL to repair retinal detachment. Postoperatively, visually significant PFCL droplets were found to be retained in the eye. During the surgical removal of PFCL, a hand-held spectral domain optical coherence tomography was ...
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      Mentions: University of Wisconsin Joseph Carroll
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  4. About Joseph Carroll

    Joseph Carroll

    Joseph Carroll is an Associate Professor at the Medical College of Wisconsin.

  5. Related Topics

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    3. New Technology: Bioptigen SDOCT Boosts Flexibility
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    4. Imaging Foveal Microvasculature: Optical Coherence Tomography Angiography Versus Adaptive Optics Scanning Light Ophthalmoscope Fluorescein Angiography
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  6. Quotes

    1. One of the major hurdles in detecting retinal disease is that by the time it can be perceived by the patient or detected with clinical tools, significant cellular damage has often already occurred.
      In Historic First Images of Rod Photoreceptors in the Living Human Eye
    2. That's what's really exciting about this imaging device: it can really make a difference in a patient's life...The ability to now resolve these cells opens up new possibilities for improving care that researchers have been anticipating for a long time—such as using the information in these retinal images to aid in targeting, delivering, and evaluating therapies.
      In Historic First Images of Rod Photoreceptors in the Living Human Eye
    3. Our user capabilities are primarily for research purposes, and we find it's superb for that.
      In New Technology: Bioptigen SDOCT Boosts Flexibility
    4. There's not a single patient who walks through the door that you couldn't image if you needed to.
      In New Technology: Bioptigen SDOCT Boosts Flexibility
    5. But for other diseases where maybe it's a more subtle disruption of say, the photoreceptor layer, it might be very valuable.
      In New Technology: Bioptigen SDOCT Boosts Flexibility