1. Joseph Carroll

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    1. Mentioned In 36 Articles

    2. Medical College of Wisconsin Receives NIH Grant for Assessing Photoreceptor Structure and Function in Normal and Diseased Retinae

      Medical College of Wisconsin Receives NIH Grant for Assessing Photoreceptor Structure and Function in Normal and Diseased Retinae
      Medical College of Wisconsin Receives a 2017 NIH Grant for $545,415 for Assessing Photoreceptor Structure and Function in Normal and Diseased Retinae. The principal investigator is Josepth Carroll. The program began in 2008 and ends in 2021. Below is a summary of the proposed work. Inherited retinal degenerations affect approximately 1 in 1,500 individuals in the US, and given the extreme genotypic and phenotypic heterogeneity, the prospect of ...
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    3. Register Now for the International Congress on OCT Angiography, "en face" OCT, and Advances in OCT on December 15th in Rome Italy which Already has over 1,000 Attendees.

      Register Now for the International Congress on OCT Angiography, "en face" OCT, and Advances in OCT  on December 15th in Rome Italy which Already has over 1,000 Attendees.
      ...rd Spaide, Giovanni Staurenghi, Nadia Waheed. Quan Dong Nguyen, SriniVas Sadda, Yves Cohen, Wolfgang Drexler, Joseph Carroll, and Ursula Schmidt Erfurth. The growing number of attendees (from 450 to 1450 in three years) ...
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    4. INTRAOPERATIVE IMAGING OF RETAINED PERFLUOROCARBON LIQUID USING SPECTRAL DOMAIN OPTICAL COHERENCE TOMOGRAPHY

      INTRAOPERATIVE IMAGING OF RETAINED PERFLUOROCARBON LIQUID USING SPECTRAL DOMAIN OPTICAL COHERENCE TOMOGRAPHY
      Purpose: To report images of retained perfluorocarbon liquid (PFCL) on the surface of the retina obtained during an intraoperative use of hand-held spectral domain optical coherence tomography. Methods: A 54-year-old man underwent pars plana vitrectomy with injection of PFCL to repair retinal detachment. Postoperatively, visually significant PFCL droplets were found to be retained in the eye. During the surgical removal of PFCL, a hand-held spectral domain optical coherence tomography was ...
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    5. Assessing the Accuracy of Foveal Avascular Zone Measurements Using Optical Coherence Tomography Angiography: Segmentation and Scaling

      Assessing the Accuracy of Foveal Avascular Zone Measurements Using Optical Coherence Tomography Angiography: Segmentation and Scaling
      Purpose : The foveal avascular zone (FAZ) is altered in numerous diseases. We assessed factors (axial length, segmentation method, age, sex) impacting FAZ measurements from optical coherence tomography (OCT) angiography images. Methods : We recruited 116 Caucasian subjects without ocular disease, and acquired two 3 3 mm AngioVue scans per each right eye (232 total scans). In images of the superficial plexus, the FAZ was segmented using the AngioVue semiautomatic nonflow measurement ...
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    6. Quantitative Analysis of Retinal Structure Using Spectral-Domain Optical Coherence Tomography in RPGR-Associated Retinopathy

      Quantitative Analysis of Retinal Structure Using Spectral-Domain Optical Coherence Tomography in RPGR-Associated Retinopathy
      Purpose To quantify retinal structure and progression using spectral-domain optical coherence tomography (SDOCT) in patients with retinitis pigmentosa (RP) associated with retinitis pigmentosa GTPase regulator gene ( RPGR ) mutations. Design Retrospective observational case series. Methods Setting : Moorfields Eye Hospital, London, United Kingdom. Subjects : Both eyes of 32 patients. SDOCT follow-up period of 1 year (3.1 1.4 years). Main Outcome Measures : Ellipsoid zone (EZ) width (EZW) and outer nuclear layer ...
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      Mentions: Joseph Carroll
    7. The Effect of Retinal Melanin on Optical Coherence Tomography Images

      The Effect of Retinal Melanin on Optical Coherence Tomography Images
      Purpose : We assessed the effect of melanin on the appearance of hyperreflective outer retinal bands in optical coherence tomography (OCT) images. Methods : A total of 23 normal subjects and 51 patients with albinism were imaged using the Bioptigen high-resolution spectral-domain OCT. In addition, three wild type, three albino ( slc45a2 b4/b4 ), and eight tyrosinase mosaic zebrafish were imaged with the hand-held Bioptigen Envisu R2200 OCT. To identify pigmented versus nonpigmented ...
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    8. Quantitative Analysis of Retinal Structure using Spectral Domain Optical Coherence Tomography in RPGR-associated Retinopathy

      Quantitative Analysis of Retinal Structure using Spectral Domain Optical Coherence Tomography in RPGR-associated Retinopathy
      Purpose Quantification of retinal structure and progression using spectral-domain optical coherence tomography (SDOCT) in patients with retinitis pigmentosa (RP) associated with retinitis pigmentosa GTPase regulator gene ( RPGR ) mutations Design Retrospective observational case series Methods Setting: Moorfields Eye Hospital, London, United Kingdom. Subjects: Both eyes of 32 patients. SDOCT follow-up period of 1 year (3.11.4 years). Outcome measures: Ellipsoid zone (EZ) width (EZW), outer nuclear layer (ONL) and inner ...
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    9. Visualization of Radial Peripapillary Capillaries Using Optical Coherence Tomography Angiography: The Effect of Image Averaging

      Visualization of Radial Peripapillary Capillaries Using Optical Coherence Tomography Angiography: The Effect of Image Averaging
      Objectives To assess the effect of image registration and averaging on the visualization and quantification of the radial peripapillary capillary (RPC) network on optical coherence tomography angiography (OCTA). Methods Twenty-two healthy controls were imaged with a commercial OCTA system (AngioVue, Optovue, Inc.). Ten 10x10 scans of the optic disc were obtained, and the most superficial layer (50-m slab extending from the inner limiting membrane) was extracted for analysis. Rigid registration ...
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    10. Imaging the adult zebrafish cone mosaic using optical coherence tomography

      Imaging the adult zebrafish cone mosaic using optical coherence tomography
      Zebrafish ( Danio rerio ) provide many advantages as a model organism for studying ocular disease and development, and there is great interest in the ability to non-invasively assess their photoreceptor mosaic. Despite recent applications of scanning light ophthalmoscopy, fundus photography, and gonioscopy to in vivo imaging of the adult zebrafish eye, current techniques either lack accurate scaling information (limiting quantitative analyses) or require euthanizing the fish (precluding longitudinal analyses). Here we ...
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    11. Directional optical coherence tomography systems and methods

      Directional optical coherence tomography systems and methods
      An optical coherence tomography system that includes an optical device having an adjustable optical element configured to displace a pupil entry point of light is provided. Optical coherence tomography methods using the optical coherence tomography system are also provided. The subject optical coherence tomography systems and methods find use in a variety of different applications, including imaging applications.
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    12. Imaging Foveal Microvasculature: Optical Coherence Tomography Angiography Versus Adaptive Optics Scanning Light Ophthalmoscope Fluorescein Angiography

      Imaging Foveal Microvasculature: Optical Coherence Tomography Angiography Versus Adaptive Optics Scanning Light Ophthalmoscope Fluorescein Angiography
      Purpose : To compare the use of optical coherence tomography angiography (OCTA) and adaptive optics scanning light ophthalmoscope fluorescein angiography (AOSLO FA) for characterizing the foveal microvasculature in healthy and vasculopathic eyes. Methods : Four healthy controls and 11 vasculopathic patients (4 diabetic retinopathy, 4 retinal vein occlusion, and 3 sickle cell retinopathy) were imaged with OCTA and AOSLO FA. Foveal perfusion maps were semiautomatically skeletonized for quantitative analysis, which included foveal ...
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    13. ATTENUATION OF THE GANGLION CELL LAYER IN A PREMATURE INFANT REVEALED WITH HANDHELD SPECTRAL DOMAIN OCT

      ATTENUATION OF THE GANGLION CELL LAYER IN A PREMATURE INFANT REVEALED WITH HANDHELD SPECTRAL DOMAIN OCT
      Purpose: To report on subclinical retinal abnormalities shown through handheld spectral domain optical coherence tomography on a premature infant. Methods: Case report. Results: The initial and follow-up exams on a premature infant revealed severely attenuated ganglion cell and nerve fiber layers. There was cystoid macular edema in both eyes at the initial visits, which resolved by the 1-year follow-up. Discussion: Optical coherence tomography can reveal significant retinal abnormalities in premature ...
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      Mentions: Joseph Carroll
    14. En Face Optical Coherence Tomography of Outer Retinal Discontinuity and Fan-Shaped Serous Macular Detachment in Diabetic Macular Edema

      En Face Optical Coherence Tomography of Outer Retinal Discontinuity and Fan-Shaped Serous Macular Detachment in Diabetic Macular Edema
      This case report describes en face optical coherence tomographic imaging of serous macular detachment secondary to retinal microangiopathy in a patient with diabetic retinopathy and macular edema. We report en face optical coherence tomographic (OCT) imaging of serous macular detachment secondary to retinal microangiopathy in a patient with diabetic retinopathy and macular edema. The en face OCT clearly delineated a fan shape of the detachment. Our findings implicate an outer ...
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    15. DIRECTIONAL OPTICAL COHERENCE TOMOGRAPHY PROVIDES ACCURATE OUTER NUCLEAR LAYER AND HENLE FIBER LAYER MEASUREMENTS

      DIRECTIONAL OPTICAL COHERENCE TOMOGRAPHY PROVIDES ACCURATE OUTER NUCLEAR LAYER AND HENLE FIBER LAYER MEASUREMENTS
      PURPOSE: The outer nuclear layer (ONL) contains photoreceptor nuclei, and its thickness is an important biomarker for retinal degenerations. Accurate ONL thickness measurements are obscured in standard optical coherence tomography (OCT) images because of Henle fiber layer (HFL). Improved differentiation of the ONL and HFL boundary is made possible by using directional OCT, a method that purposefully varies the pupil entrance position of the OCT beam. METHODS: Fifty-seven normal eyes ...
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    16. Rapid, Accurate, and Non-Invasive Measurement of Zebrafish Axial Length and Other Eye Dimensions Using SD-OCT Allows Longitudinal Analysis of Myopia and Emmetropization

      Rapid, Accurate, and Non-Invasive Measurement of Zebrafish Axial Length and Other Eye Dimensions Using SD-OCT Allows Longitudinal Analysis of Myopia and Emmetropization
      ...y, Neurobiology and Anatomy, Medical College of Wisconsin, Milwaukee, Wisconsin, United States of America X * Joseph Carroll, Affiliations: Department of Cell Biology, Neurobiology and Anatomy, Medical College of Wiscons...
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  2. About Joseph Carroll

    Joseph Carroll

    Joseph Carroll is an Associate Professor at the Medical College of Wisconsin.

  3. Quotes

    1. One of the major hurdles in detecting retinal disease is that by the time it can be perceived by the patient or detected with clinical tools, significant cellular damage has often already occurred.
      In Historic First Images of Rod Photoreceptors in the Living Human Eye
    2. That's what's really exciting about this imaging device: it can really make a difference in a patient's life...The ability to now resolve these cells opens up new possibilities for improving care that researchers have been anticipating for a long timeā€”such as using the information in these retinal images to aid in targeting, delivering, and evaluating therapies.
      In Historic First Images of Rod Photoreceptors in the Living Human Eye
    3. Our user capabilities are primarily for research purposes, and we find it's superb for that.
      In New Technology: Bioptigen SDOCT Boosts Flexibility
    4. There's not a single patient who walks through the door that you couldn't image if you needed to.
      In New Technology: Bioptigen SDOCT Boosts Flexibility
    5. But for other diseases where maybe it's a more subtle disruption of say, the photoreceptor layer, it might be very valuable.
      In New Technology: Bioptigen SDOCT Boosts Flexibility