1. Joseph A. Izatt

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    1. Mentioned In 283 Articles

    2. Sr Optical Design Engineer (Bioptigen, Inc.)

      Sr Optical Design Engineer Date posted: December 3, 2007 Location: RTP, NC Job type: Full-time Industry: Biotechnology Description: Description The Senior Optical Design Engineer will be responsible for the design and development of new optical coherence tomography imaging systems and products targeted for research and clinical applications. The engineer will work within and lead product development teams with specific responsibilities assigned for designing optical imaging and spectrographic s
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    3. Three-Dimensional Images and Vessel Rendering Using Optical Coherence Tomography

      Optical coherence tomography (OCT) is an emerging technology in dermatology. Translating the principles of ultrasound to use with light waves, OCT captures in vivo images allowing for 3-dimensional reconstruction and Doppler flow measurements. Compared with confocal microscopy, standard OCT has a greater depth of penetration but lower resolution. This places the technology between traditional ultrasound and confocal microscopy in the trade-off between depth penetration and surface resolution (Figure 1). Optical ...
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    4. Methods, Systems And Computer Program For 3D-Registration Of Three Dimensional Data Sets Obtained By Preferably Optical Coherence Tomography Based On The Alignment Of Projection Images Or Fundus Images, Respectively (Wo 2007/016397)

      Methods of registration of three dimensional data sets obtained from a sample over time are provided. A first three dimensional data set is obtained from the sample at a first time. A first volume intensity projection (VIP) image is created from the first three dimensional data set. One or more first landmarks are identified in the first VIP image. A second three dimensional data set is obtained from the sample ...
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    5. Interferometers for optical coherence tomography and reflectometry

      An interferometer system includes an optical radiation source, an optical circulator connected between the optical radiation source and a sample location for transmitting optical radiation from the optical radiation source to the sample location, an output of the optical circulator connected to direct optical radiation to an optical detector. Various embodiments of such a system are possible. A method of performing OCDR or OCT imaging of a sample which involves ...
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    6. Bioptigen Completes Series A Round Funding Investment Closes at $1.3 Million

      Bioptigen Completes Series A Round Funding Investment Closes at $1.3 Million
      FOR IMMEDIATE RELEASE August 7, 2006 Contact: Winn Maddrey 704.905.2912 BIOPTIGEN COMPLETES SERIES A FUNDING ROUND Investment Closes at $1.3 Million DURHAM, N.C. – Bioptigen, an optical technology company developing proprietary advances in the field of optical coherence tomography (OCT), announces the closing of its Series A round of funding. The round closed at $1.3 million and investors included the Piedmont Angel Network, the Inception Micro-Angel ...
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    7. Method and system for quantitative image correction for optical coherence tomography

      A method of correcting optical coherence tomography (OCT) image data obtained from a layered media sample includes identifying at least one interface from the obtained OCT data and correcting the OCT data for distortion at the at least one interface. The OCT image data can be corrected for extrinsic distortions, such as those caused by scan geometry, as well as, intrinsic distortions, such as those caused by refraction at each ...
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    8. Aspects of basic OCT engine technologies for high speed optical coherence tomography and light source and other improvements in optical coherence tomography

      ...d J. G. Fujimoto, "Optical Coherence Microscopy in Scattering Media," Opt. Lett., vol. 19, pp. 590 592, 1994, J. A. Izatt, M. D. Kulkarni, H.-W. Wang, K. Kobayashi, and M. V. Sivak,"Optical Coherence Tomography and Micro...
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    9. System and method for low coherence broadband quadrature interferometry

      A quadrature broadband interferometry system and method obtains a complete complex interferometric signal instantaneously in both homodyne and heterodyne systems in a simple, compact, and inexpensive setup. This is accomplished by separating interferometric components from non-interferometric components in each of at least two detector signals of an interferometer having a number of N.times.N couplers, scaling the interferometric components, and generating real and imaginary parts of a complex interferometric ...
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    10. Phase-referenced doppler optical coherence tomography

      A phase-referenced Doppler optical coherence tomography (OCT) system includes a low-coherence optical radiation source and a reference source co-propagated to a sample arm and a reference arm. The low-coherence and reference optical radiation reflected from the reference and arms is detected by a pair of detectors, yielding OCT and reference interferometric data output signals. The reference interferometric data output signal can be used to correct the OCT interferometric to yield ...
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    11. Theoretical comparison of the sensitivity of molecular contrast optical coherence tomography techniques

      Theoretical comparison of the sensitivity of molecular contrast optical coherence tomography techniques
      Molecular contrast optical coherence tomography (MCOCT) is an extension of OCT in which contrast resulting from the interaction of light with a contrast agent, leads to the enhanced visualization of a specific morphology or biochemical process in a target specimen. In order to improve the sensitivity and specificity of MCOCT, several spectroscopic techniques have recently been introduced which depend upon coherent detection of scattered light which has been modified by ...
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    12. Frequency-encoded parallel OCT and associated systems and methods

      Frequency-encoded parallel OCT and associated systems and methods
      Rapid scan optical delay techniques are used in parallel implementation of OCT using a detector and signal processing can be carried out using algorithms. Frequency encoded parallel OCT and multi-path, frequency encoded reference delay networks are used. A large number of frequency-correlated depth channels are used to acquire multiple depth scans of a sample. A different frequency shift (Doppler shift) on each different path length, or delay, is used to ...
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  2. About Joseph A. Izatt

    Joseph A. Izatt

    Joseph A. Izatt is a Professor of Biomedical Engineering, Associate Professor of Ophthalmology.  Dr. Izatt holds appointments in both the Department of Biomedical Engineering and the Department of Opthalmology. Izatt is also the Director of the Laboratory for Biophotonics in the Fitzpatrick Center for Photonics and Communications.  Izatt's research interest include biomedical optics, spectroscopy, and imaging; laser-tissue interactions; optical and ultrasonic signal processing; novel methods for high-resolution, and minimally invasive medical imaging and tissue characterization.


    1. An historic issue with OCT is that the depth resolution is typically several times better than the lateral resolution...If the layers of imaged tissues happen to be horizontal, then they're well defined in the scan. But to extend the full power of OCT for live imaging of tissues throughout the body, a method for overcoming the tradeoff between lateral resolution and depth of imaging was needed.
      In Machine learning increases resolution of eye imaging technology
    2. The use of metal nanoparticles as contrast agents with photothermal OCT technology could lead to a host of potential clinical applications.
      In Heating Up Microscopy