1. Joseph A. Izatt

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    1. Mentioned In 294 Articles

    2. Optical Coherence Imaging Systems Having A Mechanism For Shifting Focus And Scanning Modality And Related Adapters (Wo 2008/057391)

      Some embodiments of the present invention provide adapters for use in posterior imaging systems. The adapters include lens set configured to adapt the posterior imaging system to operate as an anterior imaging system. Related optical coherence tomography systems and anterior imaging systems are also provided herein.
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    3. Interferometers for optical coherence domain reflectometry

      An interferometer system includes an optical radiation source, an optical circulator connected between the optical radiation source and a sample location for transmitting optical radiation from the optical radiation source to the sample location, an output of the optical circulator connected to direct optical radiation to an optical detector. Various embodiments of such a system are possible. A method of performing OCDR or OCT imaging of a sample which involves ...
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    4. Methods and systems for reducing complex conjugate ambiguity in interferometric data

      A complex conjugate ambiguity can be resolved in an Optical Coherence Tomography (OCT) interferogram. A reference light signal is propagated along a reference path. A sample light signal is impinged on a sample reflector. The reference light signal is frequency shifted with respect to the sample light signal to thereby separate a positive and a negative displacement of a complex conjugate component of the OCT interferogram.
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    5. Extension of spectral domain phase microscopy to three-dimensional nanoscale displacement mapping in cardiomyocytes

      Extension of spectral domain phase microscopy to three-dimensional nanoscale displacement mapping in cardiomyocytes
      Spectral domain phase microscopy (SDPM) is a functional extension of optical coherence tomography (OCT) whose common-path interferometric design enables phase-referenced imaging of dynamic samples. Like OCT, axial resolution in SDPM is determined by the source coherence length, while lateral resolution is limited by diffraction in the microscope optics. Nonetheless, the quantitative phase information SDPM generates is sensitive to sub-Angstrom displacements of scattering structures. Integrative quantitative phase imaging techniques, such as ...
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    6. Fast detection and segmentation of drusen in retinal optical coherence tomography images

      Accurate detection-characterization of drusen is an important imaging biomarker of age-related macular degeneration (AMD) progression. We report on the development of an automatic method for detection and segmentation of drusen in retinal images captured via high speed spectral domain coherence tomo ... [Proc. SPIE Int. Soc. Opt. Eng. 6844, 68440D (2008)] published Mon Feb 11, 2008.
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    7. Correlation Of Pathologic Features In Spectral Domain Optical Coherence Tomography With Conventional Retinal Studies.

      We delineated pathologic features within three-dimensional spectral domain optical coherence tomography volumes and projected marked sites of pathologic features onto clinically useful two-dimensional localization maps to be overlaid on conventional clinical images.Page: 298DOI: 10.1097/IAE.0b013e3181567798Authors: STOPA, MARCIN MD *+; BOWER, BRADLEY A. BSE +++; DAVIES, Emily BS *; IZATT, JOSEPH A. PhD *++; TOTH, CYNTHIA A. MD *++
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    8. Sr Optical Design Engineer (Bioptigen, Inc.)

      Sr Optical Design Engineer Date posted: December 3, 2007 Location: RTP, NC Job type: Full-time Industry: Biotechnology Description: Description The Senior Optical Design Engineer will be responsible for the design and development of new optical coherence tomography imaging systems and products targeted for research and clinical applications. The engineer will work within and lead product development teams with specific responsibilities assigned for designing optical imaging and spectrographic s
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    9. Three-Dimensional Images and Vessel Rendering Using Optical Coherence Tomography

      Optical coherence tomography (OCT) is an emerging technology in dermatology. Translating the principles of ultrasound to use with light waves, OCT captures in vivo images allowing for 3-dimensional reconstruction and Doppler flow measurements. Compared with confocal microscopy, standard OCT has a greater depth of penetration but lower resolution. This places the technology between traditional ultrasound and confocal microscopy in the trade-off between depth penetration and surface resolution (Figure 1). Optical ...
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    10. Methods, Systems And Computer Program For 3D-Registration Of Three Dimensional Data Sets Obtained By Preferably Optical Coherence Tomography Based On The Alignment Of Projection Images Or Fundus Images, Respectively (Wo 2007/016397)

      Methods of registration of three dimensional data sets obtained from a sample over time are provided. A first three dimensional data set is obtained from the sample at a first time. A first volume intensity projection (VIP) image is created from the first three dimensional data set. One or more first landmarks are identified in the first VIP image. A second three dimensional data set is obtained from the sample ...
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  2. About Joseph A. Izatt

    Joseph A. Izatt

    Joseph A. Izatt is a Professor of Biomedical Engineering, Associate Professor of Ophthalmology.  Dr. Izatt holds appointments in both the Department of Biomedical Engineering and the Department of Opthalmology. Izatt is also the Director of the Laboratory for Biophotonics in the Fitzpatrick Center for Photonics and Communications.  Izatt's research interest include biomedical optics, spectroscopy, and imaging; laser-tissue interactions; optical and ultrasonic signal processing; novel methods for high-resolution, and minimally invasive medical imaging and tissue characterization.


    1. An historic issue with OCT is that the depth resolution is typically several times better than the lateral resolution...If the layers of imaged tissues happen to be horizontal, then they're well defined in the scan. But to extend the full power of OCT for live imaging of tissues throughout the body, a method for overcoming the tradeoff between lateral resolution and depth of imaging was needed.
      In Machine learning increases resolution of eye imaging technology
    2. The use of metal nanoparticles as contrast agents with photothermal OCT technology could lead to a host of potential clinical applications.
      In Heating Up Microscopy