1. Joseph A. Izatt

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    1. Mentioned In 283 Articles

    2. Detecting preperimetric glaucoma with current diagnostic tools

      Detecting preperimetric glaucoma with current diagnostic tools
      It’s a no-brainer: the earlier glaucoma can be detected the better the chance a patient’s vision has of being saved. Often, before visual field defects are picked up by standard perimetry, the optic disc and the retinal nerve fiber layer undergo structural changes in a glaucoma patient. The ability to detect these changes in preperimetric glaucoma has recently been reported made possible by the advancement of optic nerve ...
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    3. Detailed Visualization of the Anterior Segment Using Fourier-Domain Optical Coherence Tomography

      Objective  To study details of the anterior chamber drainage angle using Fourier-domain optical coherence tomography in healthy subjects and patients with angle abnormalities. Methods  A high-speed anterior segment optical coherence tomography prototype was developed using a 1310-nm-wavelength swept light source. Six healthy subjects and 6 patients with glaucoma were imaged in an observational cross-sectional study. Results  Schlemm’s canal and the trabecular meshwork were visualized in all of the patients ...
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    4. Development of Fourier Domain Optical Coherence Tomography for Applications in Developmental Biology (Thesis)

      Development of Fourier Domain Optical Coherence Tomography for Applications in Developmental Biology (Thesis)
      Developmental biology is a field in which explorations are made to answer how an organism transforms from a single cell to a complex system made up of trillions of highly organized and highly specified cells. This field, however, is not just for discovery, it is crucial for unlocking factors that lead to diseases, defects, or malformations. The one key ingredient that contributes to the success of studies in developmental biology ...
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    5. Optical Coherence Imaging Systems Having A Mechanism For Shifting Focus And Scanning Modality And Related Adapters (Wo 2008/057391)

      Some embodiments of the present invention provide adapters for use in posterior imaging systems. The adapters include lens set configured to adapt the posterior imaging system to operate as an anterior imaging system. Related optical coherence tomography systems and anterior imaging systems are also provided herein.
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    6. Interferometers for optical coherence domain reflectometry

      An interferometer system includes an optical radiation source, an optical circulator connected between the optical radiation source and a sample location for transmitting optical radiation from the optical radiation source to the sample location, an output of the optical circulator connected to direct optical radiation to an optical detector. Various embodiments of such a system are possible. A method of performing OCDR or OCT imaging of a sample which involves ...
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    7. Methods and systems for reducing complex conjugate ambiguity in interferometric data

      A complex conjugate ambiguity can be resolved in an Optical Coherence Tomography (OCT) interferogram. A reference light signal is propagated along a reference path. A sample light signal is impinged on a sample reflector. The reference light signal is frequency shifted with respect to the sample light signal to thereby separate a positive and a negative displacement of a complex conjugate component of the OCT interferogram.
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    8. Extension of spectral domain phase microscopy to three-dimensional nanoscale displacement mapping in cardiomyocytes

      Extension of spectral domain phase microscopy to three-dimensional nanoscale displacement mapping in cardiomyocytes
      Spectral domain phase microscopy (SDPM) is a functional extension of optical coherence tomography (OCT) whose common-path interferometric design enables phase-referenced imaging of dynamic samples. Like OCT, axial resolution in SDPM is determined by the source coherence length, while lateral resolution is limited by diffraction in the microscope optics. Nonetheless, the quantitative phase information SDPM generates is sensitive to sub-Angstrom displacements of scattering structures. Integrative quantitative phase imaging techniques, such as ...
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    9. Fast detection and segmentation of drusen in retinal optical coherence tomography images

      Accurate detection-characterization of drusen is an important imaging biomarker of age-related macular degeneration (AMD) progression. We report on the development of an automatic method for detection and segmentation of drusen in retinal images captured via high speed spectral domain coherence tomo ... [Proc. SPIE Int. Soc. Opt. Eng. 6844, 68440D (2008)] published Mon Feb 11, 2008.
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    10. Correlation Of Pathologic Features In Spectral Domain Optical Coherence Tomography With Conventional Retinal Studies.

      We delineated pathologic features within three-dimensional spectral domain optical coherence tomography volumes and projected marked sites of pathologic features onto clinically useful two-dimensional localization maps to be overlaid on conventional clinical images.Page: 298DOI: 10.1097/IAE.0b013e3181567798Authors: STOPA, MARCIN MD *+; BOWER, BRADLEY A. BSE +++; DAVIES, Emily BS *; IZATT, JOSEPH A. PhD *++; TOTH, CYNTHIA A. MD *++
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  2. About Joseph A. Izatt

    Joseph A. Izatt

    Joseph A. Izatt is a Professor of Biomedical Engineering, Associate Professor of Ophthalmology.  Dr. Izatt holds appointments in both the Department of Biomedical Engineering and the Department of Opthalmology. Izatt is also the Director of the Laboratory for Biophotonics in the Fitzpatrick Center for Photonics and Communications.  Izatt's research interest include biomedical optics, spectroscopy, and imaging; laser-tissue interactions; optical and ultrasonic signal processing; novel methods for high-resolution, and minimally invasive medical imaging and tissue characterization.


    1. An historic issue with OCT is that the depth resolution is typically several times better than the lateral resolution...If the layers of imaged tissues happen to be horizontal, then they're well defined in the scan. But to extend the full power of OCT for live imaging of tissues throughout the body, a method for overcoming the tradeoff between lateral resolution and depth of imaging was needed.
      In Machine learning increases resolution of eye imaging technology
    2. The use of metal nanoparticles as contrast agents with photothermal OCT technology could lead to a host of potential clinical applications.
      In Heating Up Microscopy