1. Joseph A. Izatt

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    1. Mentioned In 283 Articles

    2. In vivo spectral domain optical coherence tomography volumetric imaging and spectral Doppler velocimetry of early stage embryonic chicken heart development

      In vivo spectral domain optical coherence tomography volumetric imaging and spectral Doppler velocimetry of early stage embryonic chicken heart development
      Progress towards understanding embryonic heart development has been hampered by the inability to image embryonic heart structure and simultaneously measure blood flow dynamics, in vivo. We have developed a spectral domain optical coherence tomography system for in vivo volumetric imaging of the chicken embryo heart. We have also developed a technique called spectral Doppler velocimetry (SDV) for quantitative measurement of blood flow dynamics. In vivo volumetric images and SDV measurements ...
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    3. New Technique Sees Into Tissue At Greater Depth, Resolution

      New Technique Sees Into Tissue At Greater Depth, Resolution
      DURHAM, N.C. By coupling a kicked-up version of microscopy with miniscule particles of gold, Duke University scientists are now able to peer so deep into living tissue that they can see molecules interacting. If future studies in animal models prove fruitful, the researchers believe that their new approach can have a wide spectrum of clinical applications, from studying the margins of a tumor as it is removed from the ...
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    4. Heating Up Microscopy

      DURHAM, N.C., Sept. 17, 2008 – Bioengineers at Duke University are using nanospheres of gold to create a photothermal optical coherence tomography (OCT) to witness the interaction of living molecules. OCT, which has been called the optical equivalent of an ultrasound, is commonly used in medical clinics where imaging at the highest resolution is key. If successful, the researchers believe that their new approach can have a wide spectrum of ...
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    5. METHODS, SYSTEMS AND COMPUTER PROGRAM PRODUCTS FOR PROCESSING IMAGES GENERATED USING FOURIER DOMAIN OPTICAL COHERENCE TOMOGRAPHY (FDOCT) (WO 2008/088868)

      Methods, systems and computer program products for managing frequency domain optical coherence tomography (FDOCT) image resolution. A spectrum used to acquire an image of a subject is calibrated and default dispersion correction parameters are set. Default dispersion management parameters associated with a region of the image of the subject are also set. The image of the subject is acquires after setting the default dispersion correction parameters and the default dispersion ...
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    6. Detailed Visualization of the Anterior Segment Using Fourier-Domain Optical Coherence Tomography

      Objective To study details of the anterior chamber drainage angle using Fourier-domain optical coherence tomography in healthy subjects and patients with angle abnormalities. Methods A high-speed anterior segment optical coherence tomography prototype was developed using a 1310-nm-wavelength swept light source. Six healthy subjects and 6 patients with glaucoma were imaged in an observational cross-sectional study. Results Schlemm’s canal and the trabecular meshwork were visualized in all of the patients ...
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    7. Glaucoma becomes clear in device developed at Duke

      Glaucoma becomes clear in device developed at Duke
      For eight years Sandra Naylor went to one eye doctor after another, but none could explain why, exactly, her vision was blurry. It wasn't until she was referred to Dr. Sanjay Asrani, a Duke University glaucoma specialist, that Naylor learned she had an unusual form of glaucoma -- one that could cause her suddenly to lose part of her eyesight. Not so long ago, Asrani wouldn't have been able ...
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  2. About Joseph A. Izatt

    Joseph A. Izatt

    Joseph A. Izatt is a Professor of Biomedical Engineering, Associate Professor of Ophthalmology.  Dr. Izatt holds appointments in both the Department of Biomedical Engineering and the Department of Opthalmology. Izatt is also the Director of the Laboratory for Biophotonics in the Fitzpatrick Center for Photonics and Communications.  Izatt's research interest include biomedical optics, spectroscopy, and imaging; laser-tissue interactions; optical and ultrasonic signal processing; novel methods for high-resolution, and minimally invasive medical imaging and tissue characterization.

  3. Quotes

    1. An historic issue with OCT is that the depth resolution is typically several times better than the lateral resolution...If the layers of imaged tissues happen to be horizontal, then they're well defined in the scan. But to extend the full power of OCT for live imaging of tissues throughout the body, a method for overcoming the tradeoff between lateral resolution and depth of imaging was needed.
      In Machine learning increases resolution of eye imaging technology
    2. The use of metal nanoparticles as contrast agents with photothermal OCT technology could lead to a host of potential clinical applications.
      In Heating Up Microscopy