1. Joseph A. Izatt

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    1. Mentioned In 295 Articles

    2. Macular Optical Coherence Tomography Characteristics at 36 weeks Postmenstrual Age in Infants Examined for Retinopathy of Prematurity

      Macular Optical Coherence Tomography Characteristics at 36 weeks Postmenstrual Age in Infants Examined for Retinopathy of Prematurity
      Objective To report our ability to capture, grade reliably and analyze bedside macular optical coherence tomography (OCT) images from preterm infants and relate OCT findings to biological factors and retinopathy of prematurity (ROP) status at a single time window in the STudy of Eye imaging in Preterm infantS (BabySTEPS). Design Prospective observational study Participants Preterm infants eligible for ROP screening, with parental consent for research and a 361 weeks postmenstrual ...
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    3. Auto-Processed Retinal Vessel Shadow View Images From Bedside Optical Coherence Tomography to Evaluate Plus Disease in Retinopathy of Prematurity

      Auto-Processed Retinal Vessel Shadow View Images From Bedside Optical Coherence Tomography to Evaluate Plus Disease in Retinopathy of Prematurity
      Abstract Purpose : To describe the creation of en face retinal vessel shadow view (RVSV) optical coherence tomography (OCT) images and assess the feasibility of using these for evaluating vascular disease in preterm infants at risk for retinopathy of prematurity (ROP). Methods : In this exploratory study, we selected images from eyes with a range of ROP vascular disease, prospectively acquired from preterm infants using an investigational, noncontact, handheld, bedside swept-source OCT ...
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    4. Lightweight Learning-based Automatic Segmentation of Subretinal Blebs on Microscope-Integrated Optical Coherence Tomography Images

      Lightweight Learning-based Automatic Segmentation of Subretinal Blebs on Microscope-Integrated Optical Coherence Tomography Images
      Purpose Subretinal injections of therapeutics are commonly used to treat ocular diseases. Accurate dosing of therapeutics at target locations is crucial but difficult to achieve using subretinal injections due to leakage, and there is no method available to measure the volume of therapeutics successfully administered to the subretinal location during surgery. Here we introduce the first automatic method for quantifying the volume of subretinal blebs, using porcine eyes injected with ...
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    5. Whole eye optical coherence tomography (OCT) imaging systems and related methods

      Whole eye optical coherence tomography (OCT) imaging systems and related methods
      Whole eye optical coherence tomography (OCT) imaging systems and related methods are disclosed. According to an aspect, an OCT imaging system includes a source having an associated source arm path. Further, the OCT imaging system includes a reference arm coupled to the source arm. Further, the OCT imaging system includes a sample arm having an associated sample arm path and coupled to the source arm. The sample arm includes at ...
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    6. Quantitative topographic curvature maps of the posterior eye utilizing optical coherence tomography

      Quantitative topographic curvature maps of the posterior eye utilizing optical coherence tomography
      Purpose: Deformations of the retina such as staphylomas in myopia or scleral flattening in high intracranial pressure can be challenging to quantify with en face imaging. We describe an OCT based method for the generation of quantitative posterior eye topography maps in normal and pathologic eyes. Methods: Utilizing whole eye OCT we corrected for subjects optical distortions to generate spatially accurate posterior eye OCT volumes and created local curvature ( K ...
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    7. Duke University Receives NIH Grant for Intrasurgical OCT Image-Guided Robot Assist Device for Partial Thickness Corneal Translation

      Duke University Receives NIH Grant for Intrasurgical OCT Image-Guided Robot Assist Device for Partial Thickness Corneal Translation
      ...OCT Image-Guided Robot Assist Device for Partial Thickness Corneal Translation. The principal investigator is Joseph Izatt. Below is a summary of the proposed work.

      This is an applicat...

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    8. Systems and methods for eye tracking for motion corrected ophthalmic optical coherence tomography

      Systems and methods for eye tracking for motion corrected ophthalmic optical coherence tomography
      Systems and methods for eye tracking for motion corrected ophthalmic optical coherence tomography (OCT) are disclosed. According to an aspect, an imaging system includes an eye tracking device configured to determine movement of an eye. The imaging system also includes an OCT apparatus configured to generate OCT images of a retina of the eye. The OCT apparatus includes a scanner operable to be moved for relocating an OCT scan pivot ...
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    9. Spectroscopic optical coherence refraction tomography

      Spectroscopic optical coherence refraction tomography
      In optical coherence tomography (OCT), the axial resolution is often superior to the lateral resolution, which is sacrificed for long imaging depths. To address this anisotropy, we previously developed optical coherence refraction tomography (OCRT), which uses images from multiple angles to computationally reconstruct an image with isotropic resolution, given by the OCT axial resolution. On the other hand, spectroscopic OCT (SOCT), an extension of OCT, trades axial resolution for spectral ...
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    10. Toward Autonomous Robotic Micro-Suturing using Optical Coherence Tomography Calibration and Path Planning

      Toward Autonomous Robotic Micro-Suturing using Optical Coherence Tomography Calibration and Path Planning
      Robotic automation has the potential to assist human surgeons in performing suturing tasks in microsurgery, and in order to do so a robot must be able to guide a needle with sub-millimeter precision through soft tissue. This paper presents a robotic suturing system that uses 3D optical coherence tomography (OCT) system for imaging feedback. Calibration of the robot-OCT and robot-needle transforms, wound detection, keypoint identification, and path planning are all ...
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    11. Optical Coherence Tomography Guided Robotic Needle Insertion for Deep Anterior Lamellar Keratoplasty

      Optical Coherence Tomography Guided Robotic Needle Insertion for Deep Anterior Lamellar Keratoplasty
      Objective: Deep anterior lamellar keratoplasty (DALK) significantly reduces the post-transplantation morbidity in patients eligible for partial-thickness cornea grafts. The popular "big bubble" technique for DALK is so challenging, however, that a significant fraction of corneal pneumodissection attempts fail for surgeons without extensive DALK-specific experience, even with previous-generation cross-sectional optical coherence tomography (OCT) guidance. We seek to develop robotic, volumetric OCT-guided technology capable of facilitating or automating the difficult needle insertion ...
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    12. Optical coherence refraction tomography

      Optical coherence refraction tomography
      Optical coherence tomography (OCT) is a cross-sectional, micrometre-scale imaging modality with widespread clinical application. Typical OCT systems sacrifice lateral resolution to achieve long depths of focus for bulk tissue imaging, and therefore tend to have better axial than lateral resolution. Such anisotropic resolution can obscure fine ultrastructural features. Furthermore, conventional OCT suffers from refraction-induced image distortions. Here, we introduce optical coherence refraction tomography (OCRT), which extends the superior axial resolution ...
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    13. 1-15 of 295 1 2 3 4 ... 18 19 20 »
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  2. About Joseph A. Izatt

    Joseph A. Izatt

    Joseph A. Izatt is a Professor of Biomedical Engineering, Associate Professor of Ophthalmology.  Dr. Izatt holds appointments in both the Department of Biomedical Engineering and the Department of Opthalmology. Izatt is also the Director of the Laboratory for Biophotonics in the Fitzpatrick Center for Photonics and Communications.  Izatt's research interest include biomedical optics, spectroscopy, and imaging; laser-tissue interactions; optical and ultrasonic signal processing; novel methods for high-resolution, and minimally invasive medical imaging and tissue characterization.

  3. Quotes

    1. An historic issue with OCT is that the depth resolution is typically several times better than the lateral resolution...If the layers of imaged tissues happen to be horizontal, then they're well defined in the scan. But to extend the full power of OCT for live imaging of tissues throughout the body, a method for overcoming the tradeoff between lateral resolution and depth of imaging was needed.
      In Machine learning increases resolution of eye imaging technology
    2. The use of metal nanoparticles as contrast agents with photothermal OCT technology could lead to a host of potential clinical applications.
      In Heating Up Microscopy