1. Jonathan P. Williamson

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    1. Mentioned In 12 Articles

    2. Phenotyping Airways Disease With Optical Coherence Tomography

      Phenotyping Airways Disease With Optical Coherence Tomography
      Airway diseases are a major concern around the world. However, the pace of new drug and biomarker discovery has lagged behind those of other common disorders such as cardiovascular diseases and diabetes. One major barrier in airways research has been the inability to accurately visualize large and small airway remodeling or dysplastic/neoplastic (either pre or early cancerous) changes using non or minimally invasive instruments. The advent of optical coherence ...
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    3. Elastic Properties of the Central Airways in Obstructive Lung Diseases Measured Using Anatomical Optical Coherence Tomography

      Elastic Properties of the Central Airways in Obstructive Lung Diseases Measured Using Anatomical Optical Coherence Tomography
      Rationale: Our understanding of how airway remodeling affects regional airway elastic properties is limited due to technical difficulties in quantitatively measuring dynamic, in vivo airway dimensions. Such knowledge could help elucidate mechanisms of excessive airway narrowing. Objectives: To utilize anatomical optical coherence tomography (aOCT) to compare central airway elastic properties in control subjects and those with obstructive lung diseases. Methods: Following bronchodilation, airway lumen area (Ai) was measured using aOCT ...
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    4. Airway Narrowing Assessed by Anatomical Optical Coherence Tomography In Vitro: Dynamic Airway Wall Morphology and Function

      Airway Narrowing Assessed by Anatomical Optical Coherence Tomography In Vitro: Dynamic Airway Wall Morphology and Function
      Regulation of airway caliber by lung volume or bronchoconstrictor stimulation is dependent on physiological, structural and mechanical events within the airway wall, including airway smooth muscle (ASM) contraction, deformation of the mucosa and cartilage, and tensioning of elastic matrices linking wall components. Despite close association between events in the airway wall and the resulting airway caliber these have typically been studied separately: the former primarily using histological approaches, the latter ...
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    5. Quantifying tracheobronchial tree dimensions: methods, limitations and emerging techniques

      ...trical, Electronic & Computer Engineering, University of Western Australia, Perth, Australia. CORRESPONDENCE: J. P. Williamson, Dept of Pulmonary Physiology, Sir Charles Gairdner Hospital, Nedlands, Perth 6009, ...
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    6. Measuring airway dimensions during bronchoscopy using anatomical optical coherence tomography

      Airway dimensions are difficult to quantify bronchoscopically because of optical distortion and a limited ability to gauge depth. Anatomical optical coherence tomography (aOCT), a novel imaging technique, may overcome these limitations. This study evaluated the accuracy of aOCT against existing techniques in phantom, excised pig and in vivo human airways. Three comparative studies were performed: (i) micrometer-derived area measurements in ten plastic tubes were compared to aOCT-derived area; (ii) aOCT-derived ...
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    7. A Method Of Providing Quantitative Information About The Lower Airways Of A Lung (Wo 2009/059368)

      A Method Of Providing Quantitative Information About The Lower Airways Of A Lung (Wo 2009/059368)
      The present disclosure provides a method of providing quantitative information about a property of the lower airways of a lung using optical coherence tomography. The method comprises inserting a probe head of an anatomical optical coherence tomography device into the lower airways. Further, the method comprises directing light to, and receiving reflected light from, an internal wall portion of the lower airways. The light is suitable for optical coherence tomography ...
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    8. Feature Of The Week 3/1/09: Optical Coherence Tomography to Improve Diagnostic and Therapeutic Bronchoscopy

      Feature Of The Week 3/1/09: Optical Coherence Tomography to Improve Diagnostic and Therapeutic Bronchoscopy
      ...versity of Western Australia and Sir Charles Gairdner Hospital have been very active. A recent publication by Jonathan P. Williamson et al presents new work on anatomical optical coherence tomography to accurately measur...
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    9. Respiratory gating of endoscopic OCT images of the upper airway

      Robert A. McLaughlin, Julian J. Armstrong, Sven Becker et al. Anatomical optical coherence tomography (aOCT) is an endoscopic imaging modality that can be used to quantify size and shape of the upper airway. We report the application of respiratory gating to aOCT images. Our results show that respiratory gating can reduce motion artefact in upper airway images ... [Proc. SPIE 7004, 70045V (2008)] published Fri May 16, 2008.
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  2. About Jonathan P. Williamson

    Jonathan P. Williamson

    Dr Jonathan Williamson MBBS graduated from the University of New South Wales in 1999 and completed his advanced training in Respiratory and Sleep Medicine at The Royal North Shore Hospital and St Vincents Hospital in Sydney, Australia.  He commenced his PhD in 2007 at the University of Western Australia and Sir Charles Gairdner Hospital in Perth, Australia.  This body of work focuses on the bronchoscopic applications of anatomical optical coherence tomography (aOCT) and will assess validation of the technique in the human lower airway, the role of aOCT in managing tracheobronchial stenoses and investigation into the regional airway stiffness characteristics in asthma, emphysema and bronchiectasis.