1. Jonathan D. Oakley

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    1. Mentioned In 21 Articles

    2. Automated analysis of the optic nerve head via optical coherence tomography measurements, methods and representations

      Automated analysis of the optic nerve head via optical coherence tomography measurements, methods and representations
      The present invention relates to structural analysis of the optic nerve head (ONH). In one approach, a 3D volume of intensity data which includes the optic nerve head is acquired using an optical coherence tomography (OCT) system. The vitreoretinal interface (VRI) and the optic disc margin are identified from the 3D data. The minimum area of a surface from the optic disc margin to the VRI is determined. This minimum ...
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    3. The measurement repeatability using different partition methods of intraretinal tomographic thickness maps in healthy human subjects

      The measurement repeatability using different partition methods of intraretinal tomographic thickness maps in healthy human subjects
      ...ETDRS sectors. Jia Tan,1,2,* Ye Yang,2,3,* Hong Jiang,2,4 Che Liu,2 Zhihong Deng,1,2 Byron L Lam,2 Liang Hu,3 Jonathan Oakley,5 Jianhua Wang2 1Department of Ophthalmology, Xiangya Hospital, Changsha, Hunan, People’s Repu...
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    4. Automated analysis of the optic nerve head: measurements, methods and representations

      Automated analysis of the optic nerve head: measurements, methods and representations
      The present invention relates to structural analysis of the optic nerve head (ONH). In one approach, a 3D volume of intensity data which includes the optic nerve head is acquired using an optical coherence tomography (OCT) system. The vitreoretinal interface (VRI) and the optic disc margin are identified from the 3D data. The minimum area of a surface from the optic disc margin to the VRI is determined. This minimum ...
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    5. Changes in macular layers in the early course of non-arteritic ischaemic optic neuropathy

      Changes in macular layers in the early course of non-arteritic ischaemic optic neuropathy
      Purpose To characterise the changes of the retinal layers in patients with acute anterior ischaemic optic neuropathy (AION), aiming to identify imaging markers for predicting the residual visual function. Methods This was a retrospective review of consecutive patients with unilateral AION from January 2010 to December 2013. We analysed affected eyes at baseline and 1 month later, compared to fellow healthy eyes. Utilising novel image analysis software, we conducted algorithmic ...
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    6. Voxeleron Releases Orion, Advanced OCT Analysis Software

      Voxeleron Releases Orion, Advanced OCT Analysis Software
      Orion is an application that offers fully-automated, rapid and accurate segmentation of seven layers in OCT images of the human retina. Currently for research use only, the award-winning software is platform independent - meaning it processes data from different OCT devices - and is now available following extensive beta testing. We used Orion to process a considerable amount of data and found it to be a very useful research tool. The analysis ...
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    7. Methods to reduce variance in OCT analysis of the macula

      Methods to reduce variance in OCT analysis of the macula
      Methods for analyzing optical coherence tomography (OCT) images of the macula to reduce variance and improve disease diagnosis are presented. One embodiment of the invention is directed towards selecting analysis locations and data segmentation techniques to take advantage of structural homogeneities. Another embodiment is directed towards reducing the variance in a collection of normative data by transforming the individual members of the database to correspond to a Standard Macula. Variations ...
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    8. Phoenix Research Labs Partners with Voxeleron to Advance Technology for Eye Research

      Phoenix Research Labs Partners with Voxeleron to Advance Technology for Eye Research
      ...ysis software can only strengthen their customers’ ability to effectively perform fundamental research,” said Jonathan Oakley, PhD, Co-founder and Principal at Voxeleron. “The Voxeleron algorithms offers an unparalleled...
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    9. Voxeleron Announces Release of a New Standard in OCT Retinal Segmentation for Ophthalmic OCT Vendors

      Voxeleron Announces Release of a New Standard in OCT Retinal Segmentation for Ophthalmic OCT Vendors
      ...is based on Voxeleron’s proprietary denoising methods, applicable to both high and low-resolution OCT scans. Jonathan Oakley, Co-Founder and Principal Scientist, says that their methods facilitate faster and more robust...
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    10. In vivo assessment of retinal neuronal layers in multiple sclerosis with manual and automated optical coherence tomography segmentation techniques

      In vivo assessment of retinal neuronal layers in multiple sclerosis with manual and automated optical coherence tomography segmentation techniques
      Macular optical coherence tomography (OCT) segmentation, enabling quantification of retinal axonal and neuronal subpopulations, may help elucidate the neuroretinal pathobiology of multiple sclerosis (MS). This study aimed to determine the agreement, reproducibility, and visual correlations of retinal layer thicknesses measured by different OCT segmentation techniques, on two spectral-domain OCT devices. Macular scans of 52 MS patients and 30 healthy controls from Spectralis OCT and Cirrus HD-OCT were segmented using fully ...
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    11. Macular Ganglion Cell–Inner Plexiform Layer: Automated Detection and Thickness Reproducibility with Spectral Domain–Optical Coherence Tomography in Glaucoma

      Macular Ganglion Cell–Inner Plexiform Layer: Automated Detection and Thickness Reproducibility with Spectral Domain–Optical Coherence Tomography in Glaucoma
      ...ess Reproducibility with Spectral Domain–Optical Coherence Tomography in Glaucoma 1. Jean-Claude Mwanza^1, 2. Jonathan D. Oakley^2, 3. Donald L. Budenz^1, 4. Robert T. Chang^1,^3, 5. O'Rese J. Knight^1,^4 and 6. William ...
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    12. Optical coherence tomography segmentation reveals ganglion cell layer pathology after optic neuritis

      Optical coherence tomography segmentation reveals ganglion cell layer pathology after optic neuritis
      Post-mortem ganglion cell dropout has been observed in multiple sclerosis; however, longitudinal in vivo assessment of retinal neuronal layers following acute optic neuritis remains largely unexplored. Peripapillary retinal nerve fibre layer thickness, measured by optical coherence tomography, has been proposed as an outcome measure in studies of neuroprotective agents in multiple sclerosis, yet potential swelling during the acute stages of optic neuritis may confound baseline measurements. The objective of this ...
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    13. 1-15 of 21 1 2 »
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  2. About Jonathan D. Oakley

    Jonathan D. Oakley

    Jonathan Oakley has a B.Sc. in Computer Science from the University of York, England, a Masters from the department of Medical Physics at University College, London, and a Ph.D. in medical image processing from the Swiss Federal Institute of Technology.  Since then, he has spent over ten years working on image processing algorithm development for KLA-Tencor, Fujifilm and, most recently, Carl Zeiss Meditec Inc., where he worked exclusively in OCT.  While at Zeiss, he was responsible for motion correction, image registration and various anatomical segmentation algorithms including the Optic Nerve Head as well as retinal layer segmentation algorithms, some of which have generated new scientific findings and consequently new market opportunities for ophthalmic imaging in the neurological domain.  In 2010 he and Daniel Russakoff formed Voxeleron LLC.

  3. Quotes

    1. Orion is our flagship product targeted at reading centers burdened with the laborious task of manual segmentation, CROs running clinical trials lacking relevant imaging-based biomarkers, and clinical researchers overwhelmed by data and hamstrung by the limited image analysis tools available...It is the most advanced OCT analysis software package available today, and our road map is comprehensive, including change analysis in the next release.
      In Orion is in Beta - Voxeleron prepares the release of their advanced OCT analysis software
    2. We’re very excited by the opportunity to work with Phoenix. Clearly they have a strong portfolio of technologies optimized for animal eye research, so the addition of image analysis software can only strengthen their customers’ ability to effectively perform fundamental research.
      In Phoenix Research Labs Partners with Voxeleron to Advance Technology for Eye Research