1. Johns Hopkins University

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    1. Mentioned In 462 Articles

    2. OCT retinal nerve fiber layer thickness differentiates acute optic neuritis from MOG antibody-associated disease and Multiple Sclerosis

      OCT retinal nerve fiber layer thickness differentiates acute optic neuritis from MOG antibody-associated disease and Multiple Sclerosis
      Background: Optic neuritis (ON) is the most common manifestation of myelin oligodendrocyte glycoprotein antibody associated disorder (MOGAD) and multiple sclerosis (MS). Acute ON in MOGAD is thought to be associated with more severe optic disk edema than in other demyelinating diseases, but this has not been quantitatively confirmed. The goal of this study was to determine whether optical coherence tomography (OCT) can distinguish acute ON in MOGAD from MS, and ...
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    3. Role of Multimodality Imaging in the Assessment of Myocardial Infarction With Nonobstructive Coronary Arteries: Beyond Conventional Coronary Angiography

      Role of Multimodality Imaging in the Assessment of Myocardial Infarction With Nonobstructive Coronary Arteries: Beyond Conventional Coronary Angiography
      Myocardial infarction with nonobstructive coronary arteries (MINOCA) is a heterogeneous clinical entity, encompassing multiple different causes, and a cause of substantial morbidity and mortality. Current guidelines suggest a multimodality imaging approach in establishing the underlying cause for MINOCA, which is considered a working diagnosis. Recent studies have suggested that an initial workup consisting of cardiac magnetic resonance and invasive coronary imaging can yield the diagnosis in most patients. Cardiac magnetic ...
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    4. Full-Field Optical Coherence Tomography (FFOCT) for Evaluation of Bronchoscopic Small Biopsy Specimens

      Full-Field Optical Coherence Tomography (FFOCT) for Evaluation of Bronchoscopic Small Biopsy Specimens
      This study sets out to register imaging of small biopsy specimens obtained during bronchoscopy using full-field optical coherence tomography against standard histologic evaluation. Small biopsy specimens obtained through bronchoscopy are commonly employed for the diagnosis and staging of thoracic malignancies. Diagnostic yield is dependent on tissue quality and quantity in specimens obtained through bronchoscopy, and it is thus important to ensure adequate sampling. Rapid on-site cytology (ROSE) is a method ...
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    5. Simultaneous visible light optical coherence tomography and near infrared OCT angiography in retinal pathologies: A case study

      Simultaneous visible light optical coherence tomography and near infrared OCT angiography in retinal pathologies: A case study
      A dual-channel optical coherence tomography system with wavelengths in the visible and near-infrared light ranges can provide both structural and functional information for retinal microvasculature simultaneously. We applied this integrated system in an ongoing clinical study of patients with various retinal pathologies. Here, we present case study results of patients with diabetic retinopathy, central retinal vein occlusion, and sickle cell retinopathy compared to a healthy subject. For the first time ...
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    6. Spectral Domain Optical Coherence Tomography Biomarkers of Retinal Hyperpermeability and Choroidal Inflammation as Predictors of Short-Term Functional and Anatomical Outcomes in Eyes with Diabetic Macular Edema Treated with Intravitreal Bevacizumab

      Spectral Domain Optical Coherence Tomography Biomarkers of Retinal Hyperpermeability and Choroidal Inflammation as Predictors of Short-Term Functional and Anatomical Outcomes in Eyes with Diabetic Macular Edema Treated with Intravitreal Bevacizumab
      Purpose: To assess spectral-domain optical coherence tomography (SD-OCT) biomarkers of short-term outcomes in eyes with diabetic macular edema (DME) treated with intravitreal Bevacizumab (IVB). Methods: In a prospective interventional case series, 66 eyes with DME underwent three monthly IVB injections. Best-corrected visual acuity (BCVA) measurement and SD-OCT were performed at baseline and at 3 months. Multivariate regression analysis was performed to investigate the baseline SD-OCT parameters as predictors of functional ...
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    7. Optical coherence tomography in multiple sclerosis: A 3-year prospective multicenter study

      Optical coherence tomography in multiple sclerosis: A 3-year prospective multicenter study
      Objective: To evaluate changes over 3 years in the thickness of inner retinal layers including the peripapillary retinal nerve fiber layer (pRNFL), and combined macular ganglion cell and inner plexiform layers (mGCIPL), in individuals with relapsing-remitting multiple sclerosis (RRMS) versus healthy controls; to determine whether optical coherence tomography (OCT) is sufficiently sensitive and reproducible to detect small degrees of neuroaxonal loss over time that correlate with changes in brain volume ...
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    8. Optical coherence tomography in multiple sclerosis: A 3-year prospective multicenter study

      Optical coherence tomography in multiple sclerosis: A 3-year prospective multicenter study
      Objective: To evaluate changes over 3 years in the thickness of inner retinal layers including the peripapillary retinal nerve fiber layer (pRNFL), and combined macular ganglion cell and inner plexiform layers (mGCIPL), in individuals with relapsing-remitting multiple sclerosis (RRMS) versus healthy controls; to determine whether optical coherence tomography (OCT) is sufficiently sensitive and reproducible to detect small degrees of neuroaxonal loss over time that correlate with changes in brain volume ...
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    9. Optical Coherence Tomography of Plaque Vulnerability and Rupture: JACC Focus Seminar Part 1/3

      Optical Coherence Tomography of Plaque Vulnerability and Rupture: JACC Focus Seminar Part 1/3
      Plaque rupture is the most common cause of acute coronary syndromes and sudden cardiac death. Characteristics and pathobiology of vulnerable plaques prone to plaque rupture have been studied extensively over 2 decades in humans using optical coherence tomography (OCT), an intravascular imaging technique with micron scale resolution. OCT studies have identified key features of plaque vulnerability and described the in vivo characteristics and spatial distribution of thin cap fibroatheromas as ...
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    10. Johns Hopkins University Receives NIH Grant for Enabling technology for image-guided robot-assisted sub-retinal injections

      Johns Hopkins University Receives NIH Grant for Enabling technology for image-guided robot-assisted sub-retinal injections
      ...in the integration of man, machine and computer for the performance of unprecedented microsurgical maneuvers. Johns Hopkins University Receives a 2021 NIH Grant for $468,446 for Enabling technology for image-guided robot...
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    11. Optical Coherence Tomography Angiography-Derived Flux As a Measure of Physiological Changes in Retinal Capillary Blood Flow

      Optical Coherence Tomography Angiography-Derived Flux As a Measure of Physiological Changes in Retinal Capillary Blood Flow
      Purpose: To compare optical coherence tomography angiography (OCTA)-derived flux with conventional OCTA measures of retinal vascular density in assessment of physiological changes in retinal blood flow. Methods: Healthy subjects were recruited, and 3 3-mm2 fovea-centered scans were acquired using commercially available swept-source OCTA (SS-OCTA) while participants were breathing room air, 100% O2, or 5% CO2. Retinal perfusion was quantified using vessel area density (VAD) and vessel skeleton density (VSD ...
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    12. CNN-based CP-OCT sensor integrated with a subretinal injector for retinal boundary tracking and injection guidance

      CNN-based CP-OCT sensor integrated with a subretinal injector for retinal boundary tracking and injection guidance
      Significance: Subretinal injection is an effective way of delivering transplant genes and cells to treat many degenerative retinal diseases. However, the technique requires high-dexterity and microscale precision of experienced surgeons, who have to overcome the physiological hand tremor and limited visualization of the subretinal space. Aim: To automatically guide the axial motion of microsurgical tools (i.e., a subretinal injector) with microscale precision in real time using a fiber-optic common-path ...
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    13. Stabilizing the phase of swept-source optical coherence tomography by a wrapped Gaussian mixture model

      Stabilizing the phase of swept-source optical coherence tomography by a wrapped Gaussian mixture model
      The phase of an optical coherence tomography (OCT) signal carries critical information about particle micro-displacements. However, swept-source OCT (SSOCT) suffers from phase instability problems due to trigger jitters from the swept source. In this Letter, a wrapped Gaussian mixture model (WGMM) is proposed to stabilize the phase of SSOCT systems. A closed-form iteration solution of the WGMM is derived using the expectation-maximization algorithm. Necessary approximations are made for real-time graphic ...
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    14. Processing-Aware Real-Time Rendering for Optimized Tissue Visualization in Intraoperative 4D OCT

      Processing-Aware Real-Time Rendering for Optimized Tissue Visualization in Intraoperative 4D OCT
      Intraoperative Optical Coherence Tomography (iOCT) has advanced in recent years to provide real-time high resolution volumetric imaging for ophthalmic surgery. It enables real-time 3D feedback during precise surgical maneuvers. Intraoperative 4D OCT generally exhibits lower signal-to-noise ratio compared to diagnostic OCT and visualization is complicated by instrument shadows occluding retinal tissue. Additional constraints of processing data rates upwards of 6GB/s create unique challenges for advanced visualization of 4D OCT ...
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    15. Retinal racemose hemangioma (retinal arteriovenous communication) diagnosed and managed with multimodal imaging

      Retinal racemose hemangioma (retinal arteriovenous communication) diagnosed and managed with multimodal imaging
      Purpose: Retinal racemose hemangioma (RRH) is a rare congenital abnormality of the retinal vasculature with a variety of secondary manifestations that can cause vision loss, including macular edema. This report aims to demonstrate the utility of swept-source optical coherence tomography angiography (SS-OCTA) in further characterizing this abnormality. Methods: Case report with multimodal imaging including SS-OCTA. Results: A 56-year-old woman with blurred vision was diagnosed macular edema secondary to RRH. Localization ...
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    16. Deep Learning in Biomedical Optics

      Deep Learning in Biomedical Optics
      This article reviews deep learning applications in biomedical optics with a particular emphasis on image formation. The review is organized by imaging domains within biomedical optics and includes microscopy, fluorescence lifetime imaging, in vivo microscopy, widefield endoscopy, optical coherence tomography, photoacoustic imaging, diffuse tomography, and functional optical brain imaging. For each of these domains, we summarize how deep learning has been applied and highlight methods by which deep learning can ...
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  2. About Johns Hopkins University

    Johns Hopkins University

    John Hopkins University mission is to educate its students and cultivate their capacity for life-long learning, to foster independent and original research, and to bring the benefits of discovery to the world.  Hopkins now uses one overarching name - Johns Hopkins Medicine -to identify its whole medical enterprise. This $4 billion virtual organization unites the physicians and scientists of The Johns Hopkins University School of Medicine with the health professionals and facilities that make up the broad Johns Hopkins Health System.  The Wilmer Eye Institute at Johns Hopkins has long been recognized for bringing together ophthalmologists consistently ranked by their peers as among the finest internationally, with a specially trained and highly experienced team of nurses cited by patients for their knowledge, responsiveness, and sensitivity. Johns Hopkins Multiple Sclerosis Center is one of the largest clinical and research MS centers in the world.