1. Johns Hopkins University

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    1. Mentioned In 378 Articles

    2. Can Optical Coherence Tomography Be Used to Guide Treatment Decisions in Adult or Pediatric Multiple Sclerosis?

      Can Optical Coherence Tomography Be Used to Guide Treatment Decisions in Adult or Pediatric Multiple Sclerosis?
      Purpose of review With the recognition that neurodegeneration represents the principal substrate of disability in multiple sclerosis (MS), there has been increased strives towards identifying biomarkers for accurately quantifying and tracking neurodegeneration during the disease course. The retina provides an opportune window into the central nervous system (CNS) in MS, with retinal changes in MS reflecting not only local, but also global aspects of neurodegeneration and inflammation operative in the ...
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    3. Ophthalmic laser system integrated with speckle variance optical coherence tomography for real-time temperature monitoring

      Ophthalmic laser system integrated with speckle variance optical coherence tomography for real-time temperature monitoring
      A commercial ophthalmic laser system (R;GEN, Lutronic Corp) was integrated with a swept-source optical coherence tomography (OCT) imaging system for real-time tissue temperature monitoring. M-scan OCT images were acquired during laser-pulse radiation, and speckle variance OCT (svOCT) images were analyzed to deduce temporal signal variations related to tissue temperature change from laser-pulse radiation. A phantom study shows that svOCT magnitude increases abruptly after laser pulse radiation and recovered exponentially ...
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    4. Motion-compensated optical coherence tomography using envelope-based surface detection and Kalman-based prediction

      Motion-compensated optical coherence tomography using envelope-based surface detection and Kalman-based prediction
      We present an optical coherence tomography (OCT) imaging system that effectively compensates unwanted axial motion with micron-scale accuracy. The OCT system is based on a swept-source (SS) engine (1060-nm center wavelength, 100-nm full-width sweeping bandwidth, and 100-kHz repetition rate), with axial and lateral resolutions of about 4.5 and 8.5 microns respectively. The SS-OCT system incorporates a distance sensing method utilizing an envelope-based surface detection algorithm. The algorithm locates ...
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    5. In vivo high resolution human corneal imaging using full-field optical coherence tomography

      In vivo high resolution human corneal imaging using full-field optical coherence tomography
      We present the first full-field optical coherence tomography (FFOCT) device capable of in vivo imaging of the human cornea. We obtained images of the epithelial structures, Bowmans layer, sub-basal nerve plexus (SNP), anterior and posterior stromal keratocytes, stromal nerves, Descemets membrane and endothelial cells with visible nuclei. Images were acquired with a high lateral resolution of 1.7 m and relatively large field-of-view of 1.26 mm x 1.26 ...
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    6. Cycloid scanning for wide field optical coherence tomography endomicroscopy and angiography in vivo

      Cycloid scanning for wide field optical coherence tomography endomicroscopy and angiography in vivo
      Devices that perform wide field-of-view (FOV) precision optical scanning are important for endoscopic assessment and diagnosis of luminal organ disease such as in gastroenterology. Optical scanning for in vivo endoscopic imaging has traditionally relied on one or more proximal mechanical actuators, limiting scan accuracy and imaging speed. There is a need for rapid and precise two-dimensional (2D) microscanning technologies to enable the translation of benchtop scanning microscopies to in vivo ...
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    7. Real-time optical coherence tomography incorporated in the operating microscope during cataract surgery

      Real-time optical coherence tomography incorporated in the operating microscope during cataract surgery
      A 55-year-old male presented with reduced vision due to senile cataract. The patient consented to undergo real-time intraoperative anterior segment-optical coherence tomography (AS-OCT) during phacoemulsification with intraocular lens (IOL) implantation. Images were captured at various points during the surgery. The use of AS-OCT incorporated into the surgical microscope was evaluated as an adjunct to cataract surgery. We were able to successfully evaluate, in real-time, wound architecture, the attachment of Descemet ...
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    8. Correlation of Ultra-Widefield Fluorescein Angiography and OCT Angiography in Sickle Cell Retinopathy

      Correlation of Ultra-Widefield Fluorescein Angiography and OCT Angiography in Sickle Cell Retinopathy
      Purpose To determine whether the degree of peripheral nonperfusion seen on ultra-widefield (UWF) fluorescein angiography (FA) correlates with measures of macular vascular flow as seen on OCT angiography (OCTA) in sickle cell retinopathy. Design Prospective, observational study. Participants Patients with sickle cell disease undergoing an eye examination at an urban, tertiary medical center. Methods All patients underwent dilated fundus examination as well as UWF FA and macular OCTA imaging on ...
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    9. Retinal thickness measured with optical coherence tomography and risk of disability worsening in multiple sclerosis: a cohort study

      Retinal thickness measured with optical coherence tomography and risk of disability worsening in multiple sclerosis: a cohort study
      Background Most patients with multiple sclerosis without previous optic neuritis have thinner retinal layers than healthy controls. We assessed the role of peripapillary retinal nerve fibre layer (pRNFL) thickness and macular volume in eyes with no history of optic neuritis as a biomarker of disability worsening in a cohort of patients with multiple sclerosis who had at least one eye without optic neuritis available. Methods In this multicentre, cohort study ...
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    10. Broadband rotary joint for high-speed ultrahigh-resolution endoscopic OCT imaging at 800  nm

      Broadband rotary joint for high-speed ultrahigh-resolution endoscopic OCT imaging at 800  nm
      We report the development of a broadband rotary joint for high-speed ultrahigh-resolution endoscopic optical coherence tomography (OCT) imaging in the 800 nm spectral range. This rotary joint features a pair of achromatic doublets in order to achieve broadband operation for a 3 dB bandwidth over 150 nm. The measured one-way throughput of the rotary joint is greater than 80%, while the fluctuation of the double-pass coupling efficiency during 360 deg ...
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    11. Spectropathology-corroborated multimodal quantitative imaging biomarkers for neuroretinal degeneration in diabetic retinopathy

      Spectropathology-corroborated multimodal quantitative imaging biomarkers for neuroretinal degeneration in diabetic retinopathy
      Introduction: Image-based early detection for diabetic retinopathy (DR) needs value addition due to lack of well-defined disease-specific quantitative imaging biomarkers (QIBs) for neuroretinal degeneration and spectropathological information at the systemic level. Retinal neurodegeneration is an early event in the pathogenesis of DR. Therefore, development of an integrated assessment method for detecting neuroretinal degeneration using spectropathology and QIBs is necessary for the early diagnosis of DR. Methods: The present work explored ...
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    12. Super-achromatic monolithic microprobe for ultrahigh-resolution endoscopic optical coherence tomography at 800 nm

      Super-achromatic monolithic microprobe for ultrahigh-resolution endoscopic optical coherence tomography at 800 nm
      Endoscopic optical coherence tomography (OCT) has emerged as a valuable tool for advancing our understanding of the histomorphology of various internal luminal organs and studying the pathogenesis of relevant diseases. To date, this technology affords limited resolving power for discerning subtle pathological changes associated with early diseases. In addition, it remains challenging to access small luminal organs or pass through narrow luminal sections without potentially causing trauma to tissue with ...
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    13. Optical Coherence Tomography Findings in Endogenous Fungal Chorioretinitis, Retinitis, and Endophthalmitis

      Optical Coherence Tomography Findings in Endogenous Fungal Chorioretinitis, Retinitis, and Endophthalmitis
      BACKGROUND AND OBJECTIVE: To describe spectral-domain optical coherence tomography (SD-OCT) findings in eyes with endogenous fungal chorioretinitis and endophthalmitis. PATIENTS AND METHODS: Retrospective, observational case series of subjects at Wills Eye Hospital and William Beaumont Hospital were identified by screening OCT billing data and cross-referencing with patient charts. Clinical and imaging data were collected for each patient and reviewed. RESULTS: Twelve eyes of seven consecutive patients were identified, demonstrating two ...
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    14. 1-15 of 378 1 2 3 4 ... 24 25 26 »
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  2. About Johns Hopkins University

    Johns Hopkins University

    John Hopkins University mission is to educate its students and cultivate their capacity for life-long learning, to foster independent and original research, and to bring the benefits of discovery to the world.  Hopkins now uses one overarching name - Johns Hopkins Medicine -to identify its whole medical enterprise. This $4 billion virtual organization unites the physicians and scientists of The Johns Hopkins University School of Medicine with the health professionals and facilities that make up the broad Johns Hopkins Health System.  The Wilmer Eye Institute at Johns Hopkins has long been recognized for bringing together ophthalmologists consistently ranked by their peers as among the finest internationally, with a specially trained and highly experienced team of nurses cited by patients for their knowledge, responsiveness, and sensitivity. Johns Hopkins Multiple Sclerosis Center is one of the largest clinical and research MS centers in the world.