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1. Mentioned In 378 Articles
2. Can Optical Coherence Tomography Be Used to Guide Treatment Decisions in Adult or Pediatric Multiple Sclerosis?
  
  Explore Home - Springer Mar 27 2018 Neurology , Ophthalmology
  
  Purpose of review With the recognition that neurodegeneration represents the principal substrate of disability in multiple sclerosis (MS), there has been increased strives towards identifying biomarkers for accurately quantifying and tracking neurodegeneration during the disease course. The retina provides an opportune window into the central nervous system (CNS) in MS, with retinal changes in MS reflecting not only local, but also global aspects of neurodegeneration and inflammation operative in the ...
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  Mentions: Johns Hopkins University
3. Multimodal Retinal Imaging in Incontinentia Pigmenti Including Optical Coherence Tomography Angiography
  
  Explore The JAMA Network Mar 27 2018 Ophthalmology
  
  ...al pathologies. Design, Setting, and Participants Prospective, cross-sectional study at Wilmer Eye Institute, Johns Hopkins University. Five participants with a clinical diagnosis of IP were included and underwent multim...
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  Mentions: Johns Hopkins University University of Iowa
4. OCT is an alternative to MRI for monitoring MS - Yes
  
  Explore SAGE Journals Mar 24 2018 Neurology , Ophthalmology
  
  For decades, magnetic resonance imaging (MRI) has been the cornerstone of monitoring disease activity in multiple sclerosis (MS) in clinical practice mainly through the use of conventional measures through the primary representation of inflammatory activity...
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  Mentions: Johns Hopkins University
5. Ophthalmic laser system integrated with speckle variance optical coherence tomography for real-time temperature monitoring
  
  Explore SPIE Digital Library Feb 27 2018 Ophthalmology
  
  A commercial ophthalmic laser system (R;GEN, Lutronic Corp) was integrated with a swept-source optical coherence tomography (OCT) imaging system for real-time tissue temperature monitoring. M-scan OCT images were acquired during laser-pulse radiation, and speckle variance OCT (svOCT) images were analyzed to deduce temporal signal variations related to tissue temperature change from laser-pulse radiation. A phantom study shows that svOCT magnitude increases abruptly after laser pulse radiation and recovered exponentially ...
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  Mentions: Johns Hopkins University Jin U. Kang Changho Lee
6. Motion-compensated optical coherence tomography using envelope-based surface detection and Kalman-based prediction
  
  Explore SPIE Digital Library Feb 17 2018
  
  We present an optical coherence tomography (OCT) imaging system that effectively compensates unwanted axial motion with micron-scale accuracy. The OCT system is based on a swept-source (SS) engine (1060-nm center wavelength, 100-nm full-width sweeping bandwidth, and 100-kHz repetition rate), with axial and lateral resolutions of about 4.5 and 8.5 microns respectively. The SS-OCT system incorporates a distance sensing method utilizing an envelope-based surface detection algorithm. The algorithm locates ...
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  Mentions: Johns Hopkins University Jin U. Kang
7. Lights, camera, action! New endomicroscopic probes visualize living animal cell activity
  
  Explore bme.jhu.edu Feb 9 2018 Probes
  
  ...d safer way to diagnose a variety of diseases, says Xingde Li, Ph.D. , professor of biomedical engineering at the Johns Hopkins University School of Medicine. In a paper published Nov. 3 in Light: Science Applications ,...
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  Mentions: Johns Hopkins University Xingde Li
8. In vivo high resolution human corneal imaging using full-field optical coherence tomography
  
  Explore OSA | OSA Publishing Jan 16 2018 Ophthalmology
  
  We present the first full-field optical coherence tomography (FFOCT) device capable of in vivo imaging of the human cornea. We obtained images of the epithelial structures, Bowmans layer, sub-basal nerve plexus (SNP), anterior and posterior stromal keratocytes, stromal nerves, Descemets membrane and endothelial cells with visible nuclei. Images were acquired with a high lateral resolution of 1.7 m and relatively large field-of-view of 1.26 mm x 1.26 ...
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  Mentions: University of Pittsburgh Johns Hopkins University Claude Boccara
9. Cycloid scanning for wide field optical coherence tomography endomicroscopy and angiography in vivo
  
  Explore OSA | OSA Publishing Jan 16 2018 Gastroenterology , Probes
  
  Devices that perform wide field-of-view (FOV) precision optical scanning are important for endoscopic assessment and diagnosis of luminal organ disease such as in gastroenterology. Optical scanning for in vivo endoscopic imaging has traditionally relied on one or more proximal mechanical actuators, limiting scan accuracy and imaging speed. There is a need for rapid and precise two-dimensional (2D) microscanning technologies to enable the translation of benchtop scanning microscopies to in vivo ...
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  Mentions: Johns Hopkins University Massachusetts Institute of Technology James G. Fujimoto
10. Real-time optical coherence tomography incorporated in the operating microscope during cataract surgery
  
  Explore meajo.org Dec 28 2017 Ophthalmology
  
  A 55-year-old male presented with reduced vision due to senile cataract. The patient consented to undergo real-time intraoperative anterior segment-optical coherence tomography (AS-OCT) during phacoemulsification with intraocular lens (IOL) implantation. Images were captured at various points during the surgery. The use of AS-OCT incorporated into the surgical microscope was evaluated as an adjunct to cataract surgery. We were able to successfully evaluate, in real-time, wound architecture, the attachment of Descemet ...
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  Mentions: Johns Hopkins University
11. Correlation of Ultra-Widefield Fluorescein Angiography and OCT Angiography in Sickle Cell Retinopathy
  
  Explore ScienceDirect Dec 18 2017 Ophthalmology
  
  Purpose To determine whether the degree of peripheral nonperfusion seen on ultra-widefield (UWF) fluorescein angiography (FA) correlates with measures of macular vascular flow as seen on OCT angiography (OCTA) in sickle cell retinopathy. Design Prospective, observational study. Participants Patients with sickle cell disease undergoing an eye examination at an urban, tertiary medical center. Methods All patients underwent dilated fundus examination as well as UWF FA and macular OCTA imaging on ...
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  Mentions: Johns Hopkins University University of Iowa
12. Retinal thickness measured with optical coherence tomography and risk of disability worsening in multiple sclerosis: a cohort study
  
  Explore TheLancet.com Dec 12 2017 Neurology , Ophthalmology
  
  Background Most patients with multiple sclerosis without previous optic neuritis have thinner retinal layers than healthy controls. We assessed the role of peripapillary retinal nerve fibre layer (pRNFL) thickness and macular volume in eyes with no history of optic neuritis as a biomarker of disability worsening in a cohort of patients with multiple sclerosis who had at least one eye without optic neuritis available. Methods In this multicentre, cohort study ...
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  Mentions: Peter A. Calabresi Johns Hopkins University Laura J. Balcer
13. Broadband rotary joint for high-speed ultrahigh-resolution endoscopic OCT imaging at 800 nm
  
  Explore OSA | OSA Publishing Dec 8 2017 Gastroenterology , Probes
  
  We report the development of a broadband rotary joint for high-speed ultrahigh-resolution endoscopic optical coherence tomography (OCT) imaging in the 800 nm spectral range. This rotary joint features a pair of achromatic doublets in order to achieve broadband operation for a 3 dB bandwidth over 150 nm. The measured one-way throughput of the rotary joint is greater than 80%, while the fluctuation of the double-pass coupling efficiency during 360 deg ...
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  Mentions: Johns Hopkins University Xingde Li
14. Spectropathology-corroborated multimodal quantitative imaging biomarkers for neuroretinal degeneration in diabetic retinopathy
  
  Explore Medical Journals Publisher Nov 22 2017 Ophthalmology
  
  Introduction: Image-based early detection for diabetic retinopathy (DR) needs value addition due to lack of well-defined disease-specific quantitative imaging biomarkers (QIBs) for neuroretinal degeneration and spectropathological information at the systemic level. Retinal neurodegeneration is an early event in the pathogenesis of DR. Therefore, development of an integrated assessment method for detecting neuroretinal degeneration using spectropathology and QIBs is necessary for the early diagnosis of DR. Methods: The present work explored ...
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  Mentions: Johns Hopkins University Indian Institute of Technology at Delhi Rice University
15. Super-achromatic monolithic microprobe for ultrahigh-resolution endoscopic optical coherence tomography at 800 nm
  
  Explore Nature Publishing Group Nov 21 2017
  
  Endoscopic optical coherence tomography (OCT) has emerged as a valuable tool for advancing our understanding of the histomorphology of various internal luminal organs and studying the pathogenesis of relevant diseases. To date, this technology affords limited resolving power for discerning subtle pathological changes associated with early diseases. In addition, it remains challenging to access small luminal organs or pass through narrow luminal sections without potentially causing trauma to tissue with ...
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  Mentions: Johns Hopkins University Xingde Li
16. Optical Coherence Tomography Findings in Endogenous Fungal Chorioretinitis, Retinitis, and Endophthalmitis
  
  Explore Healio.com Nov 13 2017 Ophthalmology
  
  BACKGROUND AND OBJECTIVE: To describe spectral-domain optical coherence tomography (SD-OCT) findings in eyes with endogenous fungal chorioretinitis and endophthalmitis. PATIENTS AND METHODS: Retrospective, observational case series of subjects at Wills Eye Hospital and William Beaumont Hospital were identified by screening OCT billing data and cross-referencing with patient charts. Clinical and imaging data were collected for each patient and reviewed. RESULTS: Twelve eyes of seven consecutive patients were identified, demonstrating two ...
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  Mentions: Johns Hopkins University James P. Dunn
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