1. Johns Hopkins University

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    1. Mentioned In 349 Articles

    2. Enhanced Diagnostic Capability for Glaucoma of 3-Dimensional Versus 2-Dimensional Neuroretinal Rim Parameters Using Spectral Domain Optical Coherence Tomography

      Enhanced Diagnostic Capability for Glaucoma of 3-Dimensional Versus 2-Dimensional Neuroretinal Rim Parameters Using Spectral Domain Optical Coherence Tomography
      Purpose: To compare the diagnostic capability of 3-dimensional (3D) neuroretinal rim parameters with existing 2-dimensional (2D) neuroretinal and retinal nerve fiber layer (RNFL) thickness rim parameters using spectral domain optical coherence tomography (SD-OCT) volume scans. Materials and Methods: Design: Institutional prospective pilot study. Study population: 65 subjects (35 open-angle glaucoma patients, 30 normal patients). Observation procedures: One eye of each subject was included. SD-OCT was used to obtain 2D RNFL ...
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    3. Optical coherence tomography: A quantitative tool to measure neurodegeneration and facilitate testing of novel treatments for tissue protection in multiple sclerosis

      Optical coherence tomography: A quantitative tool to measure neurodegeneration and facilitate testing of novel treatments for tissue protection in multiple sclerosis
      Optical coherence tomography (OCT) is a relatively new imaging technology that has been introduced as a powerful biomarker in neurological disease, including multiple sclerosis. In this review, OCT as an imaging technique, its reproducibility and validation in multiple sclerosis, application to other neurodegenerative diseases and future technological directions are discussed.
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    4. Feasibility study: protein denaturation and coagulation monitoring with speckle variance optical coherence tomography

      Feasibility study: protein denaturation and coagulation monitoring with speckle variance optical coherence tomography
      We performed the feasibility study using speckle variance optical coherence tomography (SvOCT) to monitor the thermally induced protein denaturation and coagulation process as a function of temperature and depth. SvOCT provided the depth-resolved image of protein denaturation and coagulation with microscale resolution. This study was conducted using egg white. During the heating process, as the temperature increased, increases in the speckle variance signal was observed as the egg white proteins ...
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    5. Artificial Intelligence With Deep Learning Technology Looks Into Diabetic Retinopathy Screening

      Artificial Intelligence With Deep Learning Technology Looks Into Diabetic Retinopathy Screening
      D iabetic retinopathy is a leading cause of vision loss in the United States and globally, particularly among working-aged individuals. Diabetic retinopathy meets all the criteria for screening: first, the condition (diabetic retinopathy) is an important public health care problem; second, the epidemiology and natural history of the condition, including development from asymptomatic latent to severe disease, are adequately understood; third, the screening test (retinal photography) is simple, safe, validated ...
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    6. Optical coherence tomography systems and methods with magnitude and direction tracking of transverse motion

      Optical coherence tomography systems and methods with magnitude and direction tracking of transverse motion
      An optical coherence tomography (OCT) system having magnitude and direction of motion detection has a light source, and a scanning system arranged in an optical path of the light source. The scanning system is configured to scan an illumination beam of light in a spatial pattern around each of a plurality of points of interest of an object under observation for a corresponding plurality of instants of time in which ...
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    7. Optical coherence tomography in an optic tract lesion, Retinal nerve fiber layer changes

      Optical coherence tomography in an optic tract lesion, Retinal nerve fiber layer changes
      A 49-year-old woman, status post temporal lobe resection, reported a hemianopia. Examination revealed a right afferent pupillary defect, horizontal bow-tie atrophy OD (temporal and nasal), and temporal atrophy OS. Optical coherence tomography showed a bow-tie pattern OD and predominant superior and inferior nerve fiber layer loss OS (figure 1; figure e-1 at Neurology.org ). The pattern OD is due to the combination of papillomacular bundle and nasal RNFL loss. The ...
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    8. Dual optical coherence tomography sensor guided, two-motor, horizontal SMART micro-scissors

      Dual optical coherence tomography sensor guided, two-motor, horizontal SMART micro-scissors
      In microsurgery, the physiological hand tremor of the surgeon remains an important factor affecting procedure efficiency, risk of complications, and ultimately, the efficacy of treatment. The micro-scissors are routinely employed to perform precise sharp dissection of delicate tissues. Here, we present a dual optical coherence tomography (OCT) distance sensor guided, two-motor, horizontal smart micromanipulation aided robotic-surgery tool (SMART) micro-scissors. It is intended to improve surgeon performance by retaining all of ...
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    9. Choroidal Findings in Eyes With Birdshot Chorioretinitis Using Enhanced-Depth Optical Coherence Tomography

      Choroidal Findings in Eyes With Birdshot Chorioretinitis Using Enhanced-Depth Optical Coherence Tomography
      Purpose : The purposes of this study were to describe choroidal findings observed using optical coherence tomography with enhanced depth imaging (EDI-OCT) in eyes with birdshot chorioretinitis (BSCR) and to test the hypothesis that these findings are related to participant demographics, clinical characteristics, and treatment. Methods : In a multicenter, cross-sectional study, 172 eyes of 86 individuals with BSCR underwent a standardized clinical evaluation, including defined protocols for EDI-OCT imaging, with macular ...
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    10. Ghost Reduction in CP-SSOCT Having Multiple References Using Fourier-Domain Shift and Sum

      Ghost Reduction in CP-SSOCT Having Multiple References Using Fourier-Domain Shift and Sum
      We propose, test, and validate a novel Fourier-domain-based method for ghost image artifacts reduction in a common-path SSOCT system having multiple adjacent reference planes. Common-path probes with imaging systems containing high-index sapphire ball or other lenses produce multiple fixed references due to Fresnel reflections from the lens surfaces. The multiple reference planes produce multiple and overlapping optical coherence tomography (OCT) images. Since such ghost artifacts are the result of the ...
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    11. Optical clearing for luminal organ imaging with ultrahigh-resolution optical coherence tomography

      Optical clearing for luminal organ imaging with ultrahigh-resolution optical coherence tomography
      The imaging depth of optical coherence tomography (OCT) in highly scattering biological tissues (such as luminal organs) is limited, particularly for OCT operating at shorter wavelength regions (such as around 800nm). For the first time, the optical clearing effect of the mixture of liquid paraffin and glycerol on luminal organs was explored with ultrahigh-resolution spectral domain OCT at 800nm.Ex vivostudies were performed on pig esophagus and bronchus, and guinea ...
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    12. 1-15 of 349 1 2 3 4 ... 22 23 24 »
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  2. About Johns Hopkins University

    Johns Hopkins University

    John Hopkins University mission is to educate its students and cultivate their capacity for life-long learning, to foster independent and original research, and to bring the benefits of discovery to the world.  Hopkins now uses one overarching name - Johns Hopkins Medicine -to identify its whole medical enterprise. This $4 billion virtual organization unites the physicians and scientists of The Johns Hopkins University School of Medicine with the health professionals and facilities that make up the broad Johns Hopkins Health System.  The Wilmer Eye Institute at Johns Hopkins has long been recognized for bringing together ophthalmologists consistently ranked by their peers as among the finest internationally, with a specially trained and highly experienced team of nurses cited by patients for their knowledge, responsiveness, and sensitivity. Johns Hopkins Multiple Sclerosis Center is one of the largest clinical and research MS centers in the world.