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2. Surgical instrument and systems with integrated optical sensor
  
  Explore uspto.gov Aug 14 2018 Patents , Probes
  
  A surgical instrument has a surgical tool that has a proximal end and a distal end, and an optical sensor that has at least a portion attached to the surgical tool. The surgical tool has a portion that is suitable to provide a reference portion of the surgical tool, and the optical sensor has an end fixed relative to the reference portion of the surgical tool such that the reference ...
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  Mentions: Johns Hopkins University Jin U. Kang Peter L. Gehlbach
3. Evaluation of Automated Segmentation Algorithms for Optic Nerve Head Structures in Optical Coherence Tomography Images
  
  Explore IOVS Journal Aug 7 2018 Ophthalmology
  
  Purpose : To compare the identification of optic nerve head (ONH) structures in optical coherence tomography images by observers and automated algorithms. Methods : ONH images in 24 radial scan sets by optical coherence tomography were obtained in 51 eyes of 29 glaucoma patients and suspects. Masked intraobserver and interobserver comparisons were made of marked endpoints of Bruch's membrane opening (BMO) and the anterior lamina cribrosa (LC). BMO and LC positional ...
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  Mentions: Johns Hopkins University
4. Johns Hopkins Research Points to Increasing Role of Artificial Intelligence in Medical Imaging and Diagnostics
  
  Explore Newswise Jun 28 2018 Neurology , Ophthalmology
  
  ...re substantial vision loss has occurred. In 2015, Burlina and APL colleagues teamed up with the Johns Hopkins Wilmer Eye Institute on ways to automate AMD diagnosis. In recent work published in JAMA Ophthalmology they de...
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  Mentions: Johns Hopkins University
5. Leveraging WeChat Social-Media and Messaging Platform to Increase Physical Activity in Chinese Glaucoma Patients
  
  Explore Home - ClinicalTrials.gov Jun 22 2018 Ophthalmology , Clinical Trials
  
  The positive effects of exercise on ocular health are known, but modern lifestyles have made it difficult to incorporate physical activity into the daily lives of the Chinese population. Recent studies suggest that exercise plays an important role in lowering intraocular pressure (IOP) by protecting retinal ganglion cells (RGCs) in glaucoma patients as well as other potential neuroprotective benefits. Increasing the amount of physical activity within the Chinese glaucoma population ...
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  Mentions: Johns Hopkins University Wenzhou Medical College
6. Emerging Applications of Optical Coherence Tomography Angiography (OCTA) in neurological research
  
  Explore Eye and Vision May 22 2018 Neurology , Ophthalmology
  
  Purpose To review the clinical and research value of optical coherence tomography angiography (OCTA) in the field of neurology. Methods Current literature involving OCTA were reviewed through PubMed using the search terms optical coherence tomography angiography, with multiple sclerosis, Alzheimers disease, optic neuropathy, or other closely-related terms. Results OCTA has been applied in research to advance our understanding of the pathobiology of neurological disorders. OCTA-derived blood flow and vessel density ...
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  Mentions: Peter A. Calabresi Johns Hopkins University
7. Evolution of Visual Outcomes in Clinical Trials for Multiple Sclerosis Disease-Modifying Therapies
  
  Explore insights.ovid.com May 15 2018 Neurology , Ophthalmology
  
  rom the Section Editor: In March 2018, the Journal of Neuro-Ophthalmology (JNO) launched its inaugural Disease of the Year section, featuring multiple sclerosis (MS). Beginning from a Bench perspective, Meltzner and colleagues presented an elegant overview of the pathogenic mechanisms believed to underpin central nervous system (CNS) injury in MS. To complement these efforts, Backner and Levin highlighted how the afferent visual pathway, as a putative model of CNS inflammation ...
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  Mentions: Johns Hopkins University Laura J. Balcer FDA
8. Can Optical Coherence Tomography Be Used to Guide Treatment Decisions in Adult or Pediatric Multiple Sclerosis?
  
  Explore Home - Springer Mar 27 2018 Neurology , Ophthalmology
  
  Purpose of review With the recognition that neurodegeneration represents the principal substrate of disability in multiple sclerosis (MS), there has been increased strives towards identifying biomarkers for accurately quantifying and tracking neurodegeneration during the disease course. The retina provides an opportune window into the central nervous system (CNS) in MS, with retinal changes in MS reflecting not only local, but also global aspects of neurodegeneration and inflammation operative in the ...
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  Mentions: Johns Hopkins University
9. Multimodal Retinal Imaging in Incontinentia Pigmenti Including Optical Coherence Tomography Angiography
  
  Explore The JAMA Network Mar 27 2018 Ophthalmology
  
  ...al pathologies. Design, Setting, and Participants Prospective, cross-sectional study at Wilmer Eye Institute, Johns Hopkins University. Five participants with a clinical diagnosis of IP were included and underwent multim...
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  Mentions: Johns Hopkins University University of Iowa
10. OCT is an alternative to MRI for monitoring MS - Yes
  
  Explore SAGE Journals Mar 24 2018 Neurology , Ophthalmology
  
  For decades, magnetic resonance imaging (MRI) has been the cornerstone of monitoring disease activity in multiple sclerosis (MS) in clinical practice mainly through the use of conventional measures through the primary representation of inflammatory activity...
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  Mentions: Johns Hopkins University
11. Ophthalmic laser system integrated with speckle variance optical coherence tomography for real-time temperature monitoring
  
  Explore SPIE Digital Library Feb 27 2018 Ophthalmology
  
  A commercial ophthalmic laser system (R;GEN, Lutronic Corp) was integrated with a swept-source optical coherence tomography (OCT) imaging system for real-time tissue temperature monitoring. M-scan OCT images were acquired during laser-pulse radiation, and speckle variance OCT (svOCT) images were analyzed to deduce temporal signal variations related to tissue temperature change from laser-pulse radiation. A phantom study shows that svOCT magnitude increases abruptly after laser pulse radiation and recovered exponentially ...
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  Mentions: Johns Hopkins University Jin U. Kang Changho Lee
12. Motion-compensated optical coherence tomography using envelope-based surface detection and Kalman-based prediction
  
  Explore SPIE Digital Library Feb 17 2018
  
  We present an optical coherence tomography (OCT) imaging system that effectively compensates unwanted axial motion with micron-scale accuracy. The OCT system is based on a swept-source (SS) engine (1060-nm center wavelength, 100-nm full-width sweeping bandwidth, and 100-kHz repetition rate), with axial and lateral resolutions of about 4.5 and 8.5 microns respectively. The SS-OCT system incorporates a distance sensing method utilizing an envelope-based surface detection algorithm. The algorithm locates ...
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  Mentions: Johns Hopkins University Jin U. Kang
13. Lights, camera, action! New endomicroscopic probes visualize living animal cell activity
  
  Explore bme.jhu.edu Feb 9 2018 Probes
  
  ...d safer way to diagnose a variety of diseases, says Xingde Li, Ph.D. , professor of biomedical engineering at the Johns Hopkins University School of Medicine. In a paper published Nov. 3 in Light: Science Applications ,...
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  Mentions: Johns Hopkins University Xingde Li
14. In vivo high resolution human corneal imaging using full-field optical coherence tomography
  
  Explore OSA | OSA Publishing Jan 16 2018 Ophthalmology
  
  We present the first full-field optical coherence tomography (FFOCT) device capable of in vivo imaging of the human cornea. We obtained images of the epithelial structures, Bowmans layer, sub-basal nerve plexus (SNP), anterior and posterior stromal keratocytes, stromal nerves, Descemets membrane and endothelial cells with visible nuclei. Images were acquired with a high lateral resolution of 1.7 m and relatively large field-of-view of 1.26 mm x 1.26 ...
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  Mentions: University of Pittsburgh Johns Hopkins University Claude Boccara
15. Cycloid scanning for wide field optical coherence tomography endomicroscopy and angiography in vivo
  
  Explore OSA | OSA Publishing Jan 16 2018 Gastroenterology , Probes
  
  Devices that perform wide field-of-view (FOV) precision optical scanning are important for endoscopic assessment and diagnosis of luminal organ disease such as in gastroenterology. Optical scanning for in vivo endoscopic imaging has traditionally relied on one or more proximal mechanical actuators, limiting scan accuracy and imaging speed. There is a need for rapid and precise two-dimensional (2D) microscanning technologies to enable the translation of benchtop scanning microscopies to in vivo ...
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  Mentions: Johns Hopkins University Massachusetts Institute of Technology James G. Fujimoto
16. Real-time optical coherence tomography incorporated in the operating microscope during cataract surgery
  
  Explore meajo.org Dec 28 2017 Ophthalmology
  
  A 55-year-old male presented with reduced vision due to senile cataract. The patient consented to undergo real-time intraoperative anterior segment-optical coherence tomography (AS-OCT) during phacoemulsification with intraocular lens (IOL) implantation. Images were captured at various points during the surgery. The use of AS-OCT incorporated into the surgical microscope was evaluated as an adjunct to cataract surgery. We were able to successfully evaluate, in real-time, wound architecture, the attachment of Descemet ...
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  Mentions: Johns Hopkins University
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