1. John S. Oghalai

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    1. Mentioned In 28 Articles

    2. Miniature, minimally invasive, tunable endoscope for investigation of the middle ear

      Miniature, minimally invasive, tunable endoscope for investigation of the middle ear
      We demonstrate a miniature, tunable, minimally invasive endoscope for diagnosis of the auditory system. The probe is designed to sharply image anatomical details of the middle ear without the need for physically adjusting the position of the distal end of the endoscope. This is achieved through the addition of an electrowetted, tunable, electronically-controlled lens to the optical train. Morphological imaging is enabled by scanning light emanating from an optical coherence ...
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    3. Stanford University Receives a NIH Grant for Optical Coherence Tomography for 3D Measurements of Cochlear Mechanics In Vivo

      Stanford University Receives a  NIH Grant for Optical Coherence Tomography for 3D Measurements of Cochlear Mechanics In Vivo
      Stanford University Receives a 2015 NIH Grant for $448,758 for Optical Coherence Tomography for 3D Measurements of Cochlear Mechanics In Vivo. The principal investigator is John Oghalai. The program began in 2015 and ends in 2020. Below is a summary of the proposed work. The function of the cochlea is to transduce complex sound pressure waves into electrical signals. Organ of Corti vibration is based upon a complex interplay ...
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    4. Feature Of The Week 04/05/15: Noninvasive in vivo Imaging Reveals Differences Between Tectorial Membrane and Basilar Membrane Traveling Waves in the Mouse Cochlea

      Feature Of The Week 04/05/15: Noninvasive in vivo Imaging Reveals Differences Between Tectorial Membrane and Basilar Membrane Traveling Waves in the Mouse Cochlea
      Sound is encoded within the auditory portion of the inner ear, the cochlea, after propagating down its length as a traveling wave. For over half a century, vibratory measurements to study cochlear traveling waves have been made using invasive approaches such as laser Doppler vibrometry. While these studies have provided critical information regarding the non-linear processes within the living cochlea that increase the amplitude of vibration and sharpen frequency tuning ...
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    5. Phase-sensitive optical coherence tomography using an Vernier-tuned distributed Bragg reflector swept laser in the mouse middle ear

      Phase-sensitive optical coherence tomography using an Vernier-tuned distributed Bragg reflector swept laser in the mouse middle ear
      ...e mouse middle ear structures. © 2014 Optical Society of America Jesung Park, Esteban F. Carbajal, Xi Chen, John S. Oghalai, and Brian E. Applegate, "Phase-sensitive optical coherence tomography using an Vernier-tuned ...
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    6. Method And Apparatus For Examining Inner Ear

      Method And Apparatus For Examining Inner Ear
      An apparatus, for examining an inner ear is provided. An endoscope is provided, comprising a wave guide and an end piece comprising an end window to be placed a first distance from an inner ear, wherein the waveguide focuses light to create a focal plane the first distance from the end window. An optical coherence tomography (OCT) system is connected to a second end of the wave guide and comprises ...
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    7. Three Postdoctoral Associate Openings in Biophotonics at Stanford University

      Three Postdoctoral Associate Openings in Biophotonics at Stanford University
      The Stanford Biomedical Optics Group (PI: Audrey K Ellerbee), in collaboration with clinical researchers in the School of Medicine (PI: John Oghalai, MD; PI: Jean Tang, MD), seeks highly motivated postdoctoral candidates with a strong experimental background and solid theoretical preparation in optics, microscopy, medical imaging and image processing. Postdoctoral positions are available related to active research in the following areas: optical coherence tomography, spectroscopy, and point-‐of-‐care devices ...
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    8. Methodology for assessment of structural vibrations by spectral domain optical coherence tomography

      Methodology for assessment of structural vibrations by spectral domain optical coherence tomography
      Clinical diagnosis of cochlear dysfunction typically remains incomplete due to a lack of proper diagnostic methods. Medical imaging modalities can only detect gross changes in the cochlea, and non-invasive in vivo cochlear measurements are scarce. As a result, extensive efforts have been made to adapt optical coherence tomography (OCT) techniques to analyze and study the cochlea. Herein, we detail the methods for measuring vibration using OCT. We used spectral domain ...
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    9. Biophysical Mechanisms Underlying Hearing Loss Associated with a Shortened Tectorial Membrane

      Biophysical Mechanisms Underlying Hearing Loss Associated with a Shortened Tectorial Membrane
      The tectorial membrane (TM) connects to the stereociliary bundles of outer hair cells (OHCs). Herein, we summarize key experimental data and modeling analyses that describe how biophysical alterations to these connections underlie hearing loss. The heterozygous C1509G mutation in alpha tectorin produces partial congenital hearing loss that progresses in humans. We engineered this mutation in mice, and histology revealed that the TM was shortened. DIC imaging of freshly-dissected cochlea as ...
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    10. Quantitative imaging of cochlear soft tissues in wild-type and hearing-impaired transgenic mice by spectral domain optical coherence tomography

      Quantitative imaging of cochlear soft tissues in wild-type and hearing-impaired transgenic mice by spectral domain optical coherence tomography
      ...ing Citation Simon S. Gao, Anping Xia, Tao Yuan, Patrick D. Raphael, Ryan L. Shelton, Brian E. Applegate, and John S. Oghalai, "Quantitative imaging of cochlear soft tissues in wild-type and hearing-impaired transgenic m...
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  2. About John S. Oghalai

    John S. Oghalai

    John S. Oghalai, MD, has been recruited to serve as the new chair of the USC Tina and Rick Caruso Department of Otolaryngology – Head and Neck Surgery, effective Aug. 1.