1. John S. Oghalai

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    1. Mentioned In 22 Articles

    2. Osmotic stabilization prevents cochlear synaptopathy after blast trauma

      Osmotic stabilization prevents cochlear synaptopathy after blast trauma
      Traumatic noise causes hearing loss by damaging sensory hair cells and their auditory synapses. There are no treatments. Here, we investigated mice exposed to a blast wave approximating a roadside bomb. In vivo cochlear imaging revealed an increase in the volume of endolymph, the fluid within scala media, termed endolymphatic hydrops. Endolymphatic hydrops, hair cell loss, and cochlear synaptopathy were initiated by trauma to the mechanosensitive hair cell stereocilia and ...
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    3. Endoscopic optical coherence tomography enables morphological and subnanometer vibratory imaging of the porcine cochlea through the round window

      Endoscopic optical coherence tomography enables morphological and subnanometer vibratory imaging of the porcine cochlea through the round window
      A highly phase stable hand-held (HH) endoscopic system has been developed for optical coherence tomography and vibrometry. Designed to transit the ear canal to the middle ear space and peer through the round window (RW), it is capable of imaging the vibratory function of the cochlear soft tissues with subnanometer scale sensitivity. A side-looking, 9 cm long rigid endoscope with a distal diameter of 1.2 mm, was able to ...
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    4. ELHnet: a convolutional neural network for classifying cochlear endolymphatic hydrops imaged with optical coherence tomography

      ELHnet: a convolutional neural network for classifying cochlear endolymphatic hydrops imaged with optical coherence tomography
      Detection of endolymphatic hydrops is important for diagnosing Menieres disease, and can be performed non-invasively using optical coherence tomography (OCT) in animal models as well as potentially in the clinic. Here, we developed ELHnet, a convolutional neural network to classify endolymphatic hydrops in a mouse model using learned features from OCT images of mice cochleae. We trained ELHnet on 2159 training and validation images from 17 mice, using only the ...
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    5. University of Southern California Receives NIH Grant for Optical Coherence Tomography for 3D Measures of Cochlear Mechanics In Vivo.

      University of Southern California Receives NIH Grant for Optical Coherence Tomography for 3D Measures of Cochlear Mechanics In Vivo.
      University of Southern California Receives a 2017 NIH Grant $317,544 for Optical Coherence Tomography for 3D Measures of Cochlear Mechanics In Vivo. The principal investigator is John Oghalai. The program began in 2015 and ends in 2020. Below is a summary of the proposed work. The function of the cochlea is to transduce complex sound pressure waves into electrical signals. Organ of Corti vibration is based upon a complex ...
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    6. Computer-aided detection and quantification of endolymphatic hydrops within the mouse cochlea in vivo using optical coherence tomography

      Computer-aided detection and quantification of endolymphatic hydrops within the mouse cochlea in vivo using optical coherence tomography
      Diseases that cause hearing loss and/or vertigo in humans such as Menieres disease are often studied using animal models. The volume of endolymph within the inner ear varies with these diseases. Here, we used a mouse model of increased endolymph volume, endolymphatic hydrops, to develop a computer-aided objective approach to measure endolymph volume from images collected in vivo using optical coherence tomography. The displacement of Reissners membrane from its ...
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    7. Stanford University Receives NIH Grant for Cochlear Mechanics in the Mouse

      Stanford University Receives NIH Grant for Cochlear Mechanics in the Mouse
      Stanford University Receives a 2017 NIH Grant for $307,982 for Cochlear Mechanics in the Mouse. The principal investigator is John Oghalai. The program began in 2015 and ends in 2020. Below is a summary of the proposed work. Sound pressure produces force across the mammalian cochlear partition, ultimately creating a vibratory traveling wave that propagates longitudinally up the cochlear duct. The key feature distinguishing this process from the non-mammalian ...
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    8. Stanford Receives NIH Grant for Optical Coherence Tomography for 3D Measures of Cochlear Mechanics In Vivo

      Stanford Receives NIH Grant for Optical Coherence Tomography for 3D Measures of Cochlear Mechanics In Vivo
      Stanford University Receives a 2017 NIH Grant for $364,249 for Optical Coherence Tomography for 3D Measures of Cochlear Mechanics In Vivo. The principal investigator is John Oghalai. The program began in 2015 and ends in 2020. Below is a summary of the proposed work. The function of the cochlea is to transduce complex sound pressure waves into electrical signals. Organ of Corti vibration is based upon a complex interplay ...
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    9. High-speed spectral calibration by complex FIR filter in phase-sensitive optical coherence tomography

      High-speed spectral calibration by complex FIR filter in phase-sensitive optical coherence tomography
      Swept-laser sources offer a number of advantages for Phase-sensitive Optical Coherence Tomography (PhOCT). However, inter- and intra-sweep variability leads to calibration errors that adversely affect phase sensitivity. While there are several approaches to overcoming this problem, our preferred method is to simply calibrate every sweep of the laser. This approach offers high accuracy and phase stability at the expense of a substantial processing burden. In this approach, the Hilbert phase ...
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    10. Phase-sensitive optical coherence tomography-based vibrometry using a highly phase-stable akinetic swept laser source

      Phase-sensitive optical coherence tomography-based vibrometry using a highly phase-stable akinetic swept laser source
      Phase-sensitive Optical Coherence Tomography (PhOCT) is an emerging tool for in vivo investigation of the vibratory function of the intact middle and inner ear. PhOCT is able to resolve micron scale tissue morphology in three dimensions as well as measure picometer scale motion at each spatial position. Most PhOCT systems to date have relied upon the phase stability offered by spectrometer detection. On the other hand swept laser source based ...
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    11. Miniature, minimally invasive, tunable endoscope for investigation of the middle ear

      Miniature, minimally invasive, tunable endoscope for investigation of the middle ear
      We demonstrate a miniature, tunable, minimally invasive endoscope for diagnosis of the auditory system. The probe is designed to sharply image anatomical details of the middle ear without the need for physically adjusting the position of the distal end of the endoscope. This is achieved through the addition of an electrowetted, tunable, electronically-controlled lens to the optical train. Morphological imaging is enabled by scanning light emanating from an optical coherence ...
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    12. Stanford University Receives a NIH Grant for Optical Coherence Tomography for 3D Measurements of Cochlear Mechanics In Vivo

      Stanford University Receives a  NIH Grant for Optical Coherence Tomography for 3D Measurements of Cochlear Mechanics In Vivo
      Stanford University Receives a 2015 NIH Grant for $448,758 for Optical Coherence Tomography for 3D Measurements of Cochlear Mechanics In Vivo. The principal investigator is John Oghalai. The program began in 2015 and ends in 2020. Below is a summary of the proposed work. The function of the cochlea is to transduce complex sound pressure waves into electrical signals. Organ of Corti vibration is based upon a complex interplay ...
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    13. Feature Of The Week 04/05/15: Noninvasive in vivo Imaging Reveals Differences Between Tectorial Membrane and Basilar Membrane Traveling Waves in the Mouse Cochlea

      Feature Of The Week 04/05/15: Noninvasive in vivo Imaging Reveals Differences Between Tectorial Membrane and Basilar Membrane Traveling Waves in the Mouse Cochlea
      Sound is encoded within the auditory portion of the inner ear, the cochlea, after propagating down its length as a traveling wave. For over half a century, vibratory measurements to study cochlear traveling waves have been made using invasive approaches such as laser Doppler vibrometry. While these studies have provided critical information regarding the non-linear processes within the living cochlea that increase the amplitude of vibration and sharpen frequency tuning ...
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    14. Phase-sensitive optical coherence tomography using an Vernier-tuned distributed Bragg reflector swept laser in the mouse middle ear

      Phase-sensitive optical coherence tomography using an Vernier-tuned distributed Bragg reflector swept laser in the mouse middle ear
      ...e mouse middle ear structures. © 2014 Optical Society of America Jesung Park, Esteban F. Carbajal, Xi Chen, John S. Oghalai, and Brian E. Applegate, "Phase-sensitive optical coherence tomography using an Vernier-tuned ...
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  2. About John S. Oghalai

    John S. Oghalai

    John S. Oghalai, MD, has been recruited to serve as the new chair of the USC Tina and Rick Caruso Department of Otolaryngology – Head and Neck Surgery, effective Aug. 1.