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  3. About Johannes F. de Boer

    Johannes F. de Boer

    Johannes F. de Boer is a professor in the Department of Physics at Vrije Universiteit, Amsterdam The Netherlands.  His research interests: The long-term goal of the research is to develop minimally invasive optical imaging and microscopy technologies for 3-dimensional structural and functional mapping of biological tissues and specimens. A main thrust of my research is in the area of Optical Coherence Tomography (OCT). OCT creates in-vivo cross-sectional images approaching the cellular level in a non-invasive or minimally invasive way. OCT can potentially provide “optical biopsies” for real time in-vivo diagnosis, and since tissue does not need to be excised, allows functional biopsies of living tissue. My group has pioneered Polarization Sensitive OCT (PS-OCT). Over the past years we have played a leading role in the development of Spectral Domain OCT (SD/FD-OCT and OFDI) that is a hundred to a thousand times more sensitive than current state of the art OCT. The increase of light detection efficiency by 2 to 3 orders of magnitude allows In-vivo video rate imaging of biological structures with better signal to noise and enhanced depth resolution. The increase in speed represents a paradigm shift from point sampling to 3-dimensional screening of large tissue volumes. We were the first to demonstrate video rate OCT and ultra-high resolution imaging of the human retina. The superior phase stability of the new technology results in sensitivity enhancements to functional OCT, such as Doppler velocimetry and polarization and phase sensitivity. This allows video rate mapping of functionality such as flow velocity profiles in retinal arteries and characterization of structural properties such as retinal nerve fiber layer birefringence. We are developing comprehensive 3-D retinal mapping of structure, flow velocity and retinal nerve fiber layer birefringence for a better understanding of a variety of diseases in ophthalmology, in particular glaucoma. In addition, the current research projects include human studies in the area of otolaryngology and skin and small animal imaging. A second and rapidly expanding research area is optical coherence phase contrast microscopy. Phase contrast techniques give motion resolution on the order of 1-2 nm, permitting non-contact optical detection of action potentials in nerve tissue. Combined with the depth discrimination of OCT, this provides the ability to isolate phase changes to within the coherence length of the light source, i.e., 2-3 micron. The combination of structural and phase sensitive microscopy with sub-wavelength resolution allows 3-D phase contrast imaging of cell dynamics.

  1. Johannes F. de Boer

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    1. Mentioned In 52 Articles

    2. Analysis of Normal Retinal Nerve Fiber Layer Thickness by Age, Sex, and Race Using Spectral Domain Optical Coherence Tomography

      Explore LWW Online (May 4 2012) Ophthalmology

      Analysis of Normal Retinal Nerve Fiber Layer Thickness by Age, Sex, and Race Using Spectral Domain Optical Coherence Tomography Purpose: To determine the effects of age, sex, and race on the retinal nerve fiber layer (RNFL) in the normal human eye as measured by the spectral domain optical coherence tomography (SD-OCT) Spectralis machine (Heidelberg Engineering). Methods: Peripapillary SD-OCT RNFL thickness measurements were determined in normal subjects seen at a university-based clinic. One randomly selected eye per subject was used for analysis in this cross-sectional study. Multiple regression analysis was ... (Read Full Article)

      Mentions:   Johannes F. de Boer   Harvard University   Heidelberg Spectralis

    3. Extracting structural features of rat sciatic nerve using polarization-sensitive spectral domain optical coherence tomography

      Explore Linking to Scitation Content (May 4 2012) Neurology

      Extracting structural features of rat sciatic nerve using polarization-sensitive spectral domain optical coherence tomography We present spectral domain polarization-sensitive optical coherence tomography (SD PS-OCT) imaging of peripheral nerves. Structural and polarization-sensitive OCT imaging of uninjured rat sciatic nerves was evaluated both qualitatively and quantitatively. OCT and its functional extension, PS-OCT, were used to image sciatic nerve structure with clear delineation of the nerve boundaries to muscle and adipose tissues. A long-known optical effect, bands of Fontana, was also observed. Postprocessing analysis of these images ... (Read Full Article)

      Mentions:   Johannes F. de Boer   B. Hyle Park   Massachusetts General Hospital

    4. The Effect of Glaucoma on the Optical Attenuation Coefficient of the Retinal Nerve Fiber Layer in Spectral Domain Optical Coherence Tomography Images

      Explore iovs.org (Mar 17 2012) Ophthalmology

      The Effect of Glaucoma on the Optical Attenuation Coefficient of the Retinal Nerve Fiber Layer in Spectral Domain Optical Coherence Tomography Images Purpose: To demonstrate the effect of glaucoma on the optical attenuation coefficient of the retinal nerve fiber layer (RNFL) in Spectral Domain Optical Coherence Tomography (SD-OCT) images. Methods: We analyzed images of the peripapillary areas in 10 healthy and 30 glaucomatous eyes (mild, moderate and advanced glaucoma, 10 eyes each), scanned with the Spectralis OCT (Heidelberg Engineering GmbH, Dossenheim, Germany). To calculate the RNFL attenuation coefficient (µatt), determined by the ... (Read Full Article)

      Mentions:   Johannes F. de Boer   Heidelberg Engineering   Heidelberg Spectralis

    5. Diagnostic Capability of Spectral-Domain Optical Coherence Tomography for Glaucoma

      Explore ScienceDirect (Jan 19 2012) Ophthalmology

      Diagnostic Capability of Spectral-Domain Optical Coherence Tomography for Glaucoma ...ity of Spectral-Domain Optical Coherence Tomography for Glaucoma ^^ * Huijuan Wu^a Author Vitae], * Johannes F. de Boer^b, * Teresa C. Chen^a^, Corresponding author contact information ^, E-mail the corresponding author... (Read Full Article)

      Mentions:   Johannes F. de Boer   Heidelberg Engineering   Massachusetts General Hospital

    6. Phase-stabilized optical frequency domain imaging at 1-µm for the measurement of blood flow in the human choroid

      Explore opticsinfobase.org (Oct 5 2011) Ophthalmology

      Phase-stabilized optical frequency domain imaging at 1-µm for the measurement of blood flow in the human choroid ... Boy Braaf, Koenraad A. Vermeer, Victor Arni D.P. Sicam, Elsbeth van Zeeburg, Jan C. van Meurs, and Johannes F. de Boer Optics Express, Vol. 19, Issue 21, pp. 20886-20903 (2011) doi:10.1364/OE.19.020886 » V... (Read Full Article)

      Mentions:   Johannes F. de Boer   VU University Amsterdam   Koen A. Vermeer

    7. Reproducibility of Retinal Nerve Fiber Layer Thickness Measurements Using Spectral Domain Optical Coherence Tomography

      Explore LWW Online (Oct 1 2011) Ophthalmology

      Reproducibility of Retinal Nerve Fiber Layer Thickness Measurements Using Spectral Domain Optical Coherence Tomography Purpose: To evaluate the reproducibility of the peripapillary retinal nerve fiber layer (RNFL) thickness measurements obtained by Spectralis spectral domain optical coherence tomography (OCT) (Heidelberg Engineering, Heidelberg, Germany) in normal and glaucoma participants. Methods: Participants were recruited from a university-based clinic. Peripapillary RNFL thickness measurements were repeated 3 times during the same visit using the follow-up function. One eye of each participant was randomly selected for statistical analysis. Reproducibility was ... (Read Full Article)

      Mentions:   Johannes F. de Boer   Heidelberg Engineering   Heidelberg Spectralis

    8. VU University Amsterdam Receives NIH Grant for High Resolution 3D Optics Coherence Phase Microscopy

      Explore Optical Coherence Tomography News (Sep 6 2011) Microscopy , Funding

      VU University Amsterdam Receives NIH Grant for High Resolution 3D Optics Coherence Phase Microscopy VU University Amsterdam received a $130,451 2011 NIH grant for work on developing a high resolution 3D optics coherence phase microscopy system. The principal investigator is Johannes De Boer. Below is a summary of that work. Three-dimensional imaging of cells and sub cellular structures has enormous potential in studies on cell physiology and medicine, since it enables the observation of cell behavior in a variety of environments. Many three-dimensional ... (Read Full Article)

      Mentions:   Johannes F. de Boer   VU University Amsterdam

    9. Fully-Funded PhD Position on Medical Image Analysis of 3D Ophthalmic OCT Images for Glaucoma and AMD: The Netherlands

      Explore Optical Coherence Tomography News (Sep 3 2011) Ophthalmology , Jobs & Studentships

      Fully-Funded PhD Position on Medical Image Analysis of 3D Ophthalmic OCT Images for Glaucoma and AMD: The Netherlands Rotterdam Ophthalmic Institute, Rotterdam Eye HospitalWebsite:http://eyeresearch-rotterdam.nlLocation:Schiedamse Vest 160d, Rotterdam, The NetherlandsType:PhD StudentshipPosted:September 02, 2011Expires:October 31, 2011Requisition number:2011-037   Science jobs from Rotterdam Ophthalmic Institute, Rotterdam Eye Hospital: job description --> Research project descriptionOptical coherence tomography (OCT) is a non-invasive medical imaging techniques based on interferometry that provides three-dimensional imaging of the retina at a very high resolution. Related techniques, such as Doppler OCT or ... (Read Full Article)

      Mentions:   Johannes F. de Boer   Delft University of Technology   Koen A. Vermeer

    10. Automated segmentation by pixel classification of retinal layers in ophthalmic OCT images

      Explore opticsinfobase.org (May 27 2011) Ophthalmology

      Automated segmentation by pixel classification of retinal layers in ophthalmic OCT images ...ation of retinal layers in ophthalmic OCT images K. A. Vermeer, J. van der Schoot, H. G. Lemij, and J. F. de Boer Biomedical Optics Express, Vol. 2, Issue 6, pp. 1743-1756 (2011) doi:10.1364/BOE.2.001743 » V... (Read Full Article)

      Mentions:   Johannes F. de Boer   Heidelberg Engineering   Carl Zeiss Meditec

    11. Multifunctional imaging of human retina and choroid with 1050-nm spectral domain optical coherence tomography at 92-kHz line scan rate

      Explore SPIE Digital Library (May 19 2011) Ophthalmology

      Multifunctional imaging of human retina and choroid with 1050-nm spectral domain optical coherence tomography at 92-kHz line scan rate ...9). D. M. de Bruin, D. L. Burnes, J. Loewenstein, Y. Chen, S. Chang, T. C. Chen, D. D. Esmaili, and J. F. de Boer, “In vivo three-dimensional imaging of neovascular age-related macular degeneration using optical f... (Read Full Article)

      Mentions:   Johannes F. de Boer   University of Washington   Ruikang K. Wang

    12. System and method for cladding mode detection

      Explore uspto.gov (Apr 26 2011) Patents

      System and method for cladding mode detection According to an exemplary embodiment, systems and methods can be provided for compensating for, reducing and/or eliminating data associated with at least one aberration provided within a sample. For example, using such exemplary systems and methods, it may be possible to transmit at least one first electromagnetic radiation to the sample via an optical fiber. At least one second electromagnetic radiation can be received from the sample, and the ... (Read Full Article)

      Mentions:   Johannes F. de Boer   Massachusetts General Hospital   Harvard University

    13. Polarization-Sensitive Optical Coherence Tomography Imaging of Benign and Malignant Laryngeal Lesions: An In Vivo Study

      Explore oto.sagepub.com (Apr 1 2011) Otolaryngology

      Polarization-Sensitive Optical Coherence Tomography Imaging of Benign and Malignant Laryngeal Lesions: An In Vivo Study Objective. Optical coherence tomography (OCT), an imaging technology that provides cross-sectional subsurface tissue structure images using back-scattered light, is a promising noninvasive imaging modality for in vivo assessment of vocal fold layered microstructure. Polarization-sensitive OCT (PS-OCT) augments conventional OCT by detecting changes in the polarization state of reflected light. This study imaged various benign and malignant laryngeal pathologies in patients undergoing direct laryngoscopy under general anesthesia to determine whether PS-OCT ... (Read Full Article)

      Mentions:   Johannes F. de Boer   Massachusetts General Hospital   Harvard University

    14. Congratulations to Yuankai Tao a Winner of the Santec & OCT News Student Travel Grant

      Explore Optical Coherence Tomography News (Jan 8 2011)

      Congratulations to Yuankai Tao a Winner of the Santec & OCT News Student Travel Grant ... Nassif, B. Cense, B. H. Park, M. C. Pierce, S. H. Yun, B. E. Bouma, G. J. Tearney, T. C. Chen, and J. F. de Boer, Optics Express 12, 10 (2004). 4. M. Wojtkowski, V. J. Srinivasan, T. H. Ko, J. G. Fujimoto, A. Ko... (Read Full Article)

      Mentions:   Brett E. Bouma   Johannes F. de Boer   Joseph A. Izatt

    15. Polarization-sensitive optical frequency domain imaging based on unpolarized light

      Explore opticsinfobase.org (Jan 4 2011) Oncology

      Polarization-sensitive optical frequency domain imaging based on unpolarized light ...unpolarized light Ki Hean Kim, B. Hyle Park, Yupeng Tu, Tayyaba Hasan, Byunghak Lee, Jianan Li, and Johannes F. de Boer Optics Express, Vol. 19, Issue 2, pp. 552-561 (2011) doi:10.1364/OE.19.000552 » V... (Read Full Article)

      Mentions:   Johannes F. de Boer   B. Hyle Park   Massachusetts General Hospital

    16. PhD and Postdoc positions in Biomedical Optics at University Amsterdam

      Explore Nature Publishing Group (Nov 10 2010) Jobs & Studentships

      PhD and Postdoc positions in Biomedical Optics at University Amsterdam The exact sciences have generated medical imaging technologies such as magnetic resonances, xrays or ultrasound. Optical imaging is the next technology that will be broadly used in the hospital. Optical coherence tomography (OCT) is a non-invasive medical imaging technique based on interferometry. Compared to other medical imaging techniques, OCT can reach much higher resolution. In the clinic these high-resolution images can be used for better diagnosis and monitoring of disease ... (Read Full Article)

      Mentions:   Johannes F. de Boer   VU University Amsterdam

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