1. Joel S. Schuman

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    1. Mentioned In 145 Articles

    2. Advanced Imaging for Glaucoma Study: Design, Baseline Characteristics, and Inter-Site Comparison

      Advanced Imaging for Glaucoma Study: Design, Baseline Characteristics, and Inter-Site Comparison

      Purpose To report the baseline characteristics of the participants in the Advanced Imaging for Glaucoma Study. To compare the participating sites for variations among subjects and the performance of imaging instruments. Design Multi-center longitudinal observational cohort study Methods A total of 788 participants (1,329 eyes) were enrolled from three academic referral centers. There were 145 participants (289 eyes) in the normal group, 394 participants (663 eyes) in the glaucoma suspect/preperimetric glaucoma group, and 249 participants (377 eyes) in the perimetric glaucoma group. Participants underwent a full clinical exam, standard automated perimetry, and imaging with time-domain and Fourier-domain optical ...

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    3. Emerging technologies open new horizons in glaucoma structural evaluation, management

      Emerging technologies open new horizons in glaucoma structural evaluation, management

      Technological evolution, with optical coherence tomography in the forefront, is gradually but radically changing the diagnostic and management approach to glaucoma. Earlier detection of structural changes allows prediction of functional consequences and quantification of progression. “The physiological structure-function relationship is beyond question and the basis for glaucoma management; however, the available technologies to assess either aspect are far from perfect. Current developments suggest that the threshold for detecting damage might be lower in structural imaging than in standard automated perimetry,” Herbert Reitsamer, MD, said. “The impact of structural documentation on therapy decisions has not been so great in the past ...

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    4. In Vivo Three-Dimensional Characterization of the Healthy Human Lamina Cribrosa with Adaptive Optics Spectral-Domain Optical Coherence Tomography

      In Vivo Three-Dimensional Characterization of the Healthy Human Lamina Cribrosa with Adaptive Optics Spectral-Domain Optical Coherence Tomography

      Purpose: To characterize the in vivo 3D lamina cribrosa (LC) microarchitecture of healthy eyes using adaptive optics spectral-domain optical coherence tomography (AO-SDOCT). Methods: One randomly selected eye from each of 18 healthy subjects was scanned with Cirrus HD-OCT and AO-SDOCT centered on the optic nerve head. LC microarchitecture, imaged by the later device, was semi-automatically segmented and quantified for connective tissue volume fraction (CTVF), beam thickness, pore diameter, pore area and pore aspect ratio. The LC was assessed in central and peripheral regions of equal areas, quadrants and with depth. A linear mixed-effects model weighted by the fraction of visible ...

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    5. University of Pittsburgh Receives a 2014 NIH Grant for Novel Glaucoma Diagnostics for Structure and Function

      University of Pittsburgh Receives a 2014 NIH Grant for Novel Glaucoma Diagnostics for Structure and Function
      ...H Grant for $726,299 for Novel Glaucoma Diagnostics for Structure and Function. The principal investigator is Joel Schuman. The program began in 2000 and ends in 2019. Below is a summary of the proposed work.

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    6. Intra- and Inter-visit Reproducibility of Ganglion Cell – Inner Plexiform Layer Measurements Using Handheld Optical Coherence Tomography in Children with Optic Pathway Gliomas

      Intra- and Inter-visit Reproducibility of Ganglion Cell – Inner Plexiform Layer Measurements Using Handheld Optical Coherence Tomography in Children with Optic Pathway Gliomas

      Purpose To determine the intra- and inter-visit reproducibility of ganglion cell-inner plexiform layer thickness measures using handheld optical coherence tomography (OCT) in sedated children with optic pathway gliomas and/or Neurofibromatosis type 1 (NF1). Design Prospective longitudinal cohort study Methods Children with sporadic optic pathway gliomas and/or NF1 who had ≥ 2 volumes acquired over the macula using handheld OCT during sedation for a clinically indicated MRI were eligible for the intra-visit cohort. Children with repeat handheld OCT imaging within 6 months were eligible for the inter-visit cohort. Total retinal thickness and ganglion cell-inner plexiform layer thickness were measured using ...

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    7. Reproducibility of Circumpapillary Retinal Nerve Fiber Layer Measurements Using Handheld Optical Coherence Tomography in Sedated Children

      Reproducibility of Circumpapillary Retinal Nerve Fiber Layer Measurements Using Handheld Optical Coherence Tomography in Sedated Children
      ... Family Neurofibromatosis Institute * Division of Biostatistics and Study Methodology , Joel S. Schuman x Joel S. Schuman Search for articles by this author Affiliations * UPMC Eye Center, Eye and Ear Institute, ...
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    8. Automated macular pathology diagnosis in three-dimensional (3D) spectral domain optical coherence tomography (SD-OCT) images

      Automated macular pathology diagnosis in three-dimensional (3D) spectral domain optical coherence tomography (SD-OCT) images

      Systems and methods of analyzing an optical coherence tomography image of a retina are discussed. A 2-dimensional slice of the image can be aligned to produce an approximately horizontal image of the retina and an edge map based at least in part on the aligned slice. Also, at least one global representation can be determined based on a (multi-scale) spatial division, such as multi-scale spatial pyramid, on the slice and/or edge map. Creating the local features is based on the specified cell structure of the global representation. The local features can be constructed based on local binary pattern (LBP ...

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    9. Reproducibility of In-Vivo OCT Measured Three-Dimensional Human Lamina Cribrosa Microarchitecture

      Reproducibility of In-Vivo OCT Measured Three-Dimensional Human Lamina Cribrosa Microarchitecture

      Purpose To determine the reproducibility of automated segmentation of the three-dimensional (3D) lamina cribrosa (LC) microarchitecture scanned in-vivo using optical coherence tomography (OCT). Methods Thirty-nine eyes (8 healthy, 19 glaucoma suspects and 12 glaucoma) from 49 subjects were scanned twice using swept-source (SS−) OCT in a 3.5×3.5×3.64 mm (400×400×896 pixels) volume centered on the optic nerve head, with the focus readjusted after each scan. The LC was automatically segmented and analyzed for microarchitectural parameters, including pore diameter, pore diameter standard deviation (SD), pore aspect ratio, pore area, beam thickness, beam thickness SD, and ...

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    10. A Method to Estimate Biomechanics and Mechanical Properties of Optic Nerve Head Tissues From Parameters Measurable Using Optical Coherence Tomography

      A Method to Estimate Biomechanics and Mechanical Properties of Optic Nerve Head Tissues From Parameters Measurable Using Optical Coherence Tomography

      Tissue properties and biomechanics of the optic nerve head (ONH) are important to the development and progression of glaucoma, but remain mostly unmeasurable in the experiment. We hypothesized that these can be estimated numerically from ocular parameters measurable in-vivo with optical coherence tomography (OCT). Using previously reported parametric models representing human ONHs we simulated acute intraocular pressure (IOP) increases (10 mmHg). Statistical models were fit to predict, from OCT-measurable parameters, 15 outputs of interest including tissue properties, stresses and deformations. The calculations were repeated adding parameters that have recently been proposed as potentially measurable with OCT. We evaluated the sensitivity ...

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    11. Repeatability of in vivo 3D lamina cribrosa microarchitecture using adaptive optics spectral domain optical coherence tomography

      Repeatability of in vivo 3D lamina cribrosa microarchitecture using adaptive optics spectral domain optical coherence tomography
      ...ck,^1,^2 Larry Kagemann,^1,^2 Ian A. Sigal,^1,^2 R. Daniel Ferguson,^3 Ankit Patel,^3 Daniel X. Hammer,^4 and Joel S. Schuman^1,^2 ^1UPMC Eye Center, Eye and Ear Institute, Ophthalmology and Visual Science Research Cen...
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    12. Characterisation of Schlemm's canal cross-sectional area

      Characterisation of Schlemm's canal cross-sectional area

      Purpose To compare three methods of Schlemm's canal (SC) cross-sectional area (CSA) measurement. Methods Ten eyes (10 healthy volunteers) were imaged three times using spectral-domain optical coherence tomography (Cirrus HD-OCT, Zeiss, Dublin, California, USA). Aqueous outflow vascular structures and SC collector channel ostia were used as landmarks to identify a reference location within the limbus. SC CSA was assessed within a 1 mm segment (±15 frames of the reference, 31 frames in all) by three techniques. (1) Using a random number table, SC CSA in five random frames from the set of 31 surrounding the reference were measured and ...

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    13. Handheld Optical Coherence Tomography During Sedation in Young Children With Optic Pathway Gliomas

      Handheld Optical Coherence Tomography During Sedation in Young Children With Optic Pathway Gliomas

      Importance Monitoring young children with optic pathway gliomas (OPGs) for visual deterioration can be difficult owing to age-related noncompliance. Optical coherence tomography (OCT) measures of retinal nerve fiber layer (RNFL) thickness have been proposed as a surrogate marker of vision but this technique is also limited by patient cooperation. Objective To determine whether measures of circumpapillary RNFL thickness, acquired with handheld OCT (HH-OCT) during sedation, can differentiate between young children with and without vision loss from OPGs. Design, Setting, and Participants This cross-sectional analysis of a prospective observational study was conducted at a tertiary-care children’s hospital. Children with an ...

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  2. About Joel S. Schuman

    Joel S. Schuman

    Joel S. Schuman, M.D. is a native of Roslyn, NY; he graduated Columbia University (AB, 1980) and Mt. Sinai School of Medicine (MD, 1984). Following internship at New York’s Beth Israel Medical Center (1985), he completed residency training at Medical College of Virginia (1988) and glaucoma fellowship at Massachusetts Eye & Ear Infirmary (clinical 1989, research 1990), where he was a Heed fellow. After just over a year on the Harvard faculty, he moved to New England Medical Center, Tufts University to co-found New England Eye Center in 1991, where he was Residency Director and Glaucoma and Cataract Service Chief. In 1998 he became Professor of Ophthalmology, and Vice Chair in 2001.
    Dr. Schuman, is the Eye and Ear Foundation Professor and Chairman of Ophthalmology, the Eye and Ear Institute, University of Pittsburgh School of Medicine and Director of the University of Pittsburgh Medical Center (UPMC) Eye Center. He is also Professor of Bioengineering at the Swanson School of Engineering, University of Pittsburgh, and Professor in the Center for the Neural Basis of Cognition, Carnegie Mellon University and University of Pittsburgh and a member of the McGowan Institute for Regenerative Medicine. Dr. Schuman and his colleagues were the first to identify a molecular marker for human glaucoma, as published in Nature Medicine in 2001. He has been continuously funded by the National Eye Institute as a principal investigator since 1995, is principal investigator of a National Institutes of Health (NIH) grant to study novel glaucoma diagnostics, and is co-investigator of NIH grants for research into novel optical diagnostics and short pulse laser surgery and for advanced imaging in glaucoma. He is an inventor of optical coherence tomography (OCT), used world-wide for ocular diagnostics. Dr. Schuman has published more than 200 peer-reviewed scientific journal articles, has authored or edited 8 books, and has contributed more than 50 book chapters.

    Dr. Schuman is a founding member of the ARVO Multidisciplinary Ophthalmic Imaging cross-sectional group, served on the program committee from its founding and chairs the MOI program committee 2007-2008. He is also a founder and chair of ARVO/isie (The International Society for Imaging in the Eye, inaugurated 2002). Dr. Schuman was co-chair of the International Glaucoma Symposium 1998-2007, the world’s largest meeting devoted to glaucoma, which merged with the World Glaucoma Congress in 2007, for which he is Program co-Chair 2007-2011. With the exception of a three year hiatus, he has chaired the Hawaiian Eye meeting glaucoma section since 1993.

     

  3. Quotes

    1. OCT will be able to detect glaucomatous abnormalities prior to our current functional measurement technology being able to detect them, and the earlier in the disease that you can detect damage or progression, the more likely it is you are able to prevent further progression with less intensive intervention.
      In Emerging technologies open new horizons in glaucoma structural evaluation, management
    2. I’m delighted by the Champalimaud Foundation’s recognition of our efforts...We continue to work on improving OCT and in the next decade, it could be as portable and easy to use as a standard ophthalmoscope.
      In Joel S. Schuman, M.D., Part of Team Receiving António Champalimaud Vision Award
    3. That gives the promise to better track progression to detect change over time, and that is really a big advance in terms of changes from time-domain OCT.
      In OCT devices increasingly finding use outside retinal practice
    4. You can look for characteristic nerve fiber layer abnormalities that are seen in glaucoma and these will show up as arcuate abnormalities — deviations from normal — on the deviation map of the spectral-domain OCT.
      In OCT devices increasingly finding use outside retinal practice
    5. With imaging we have much younger technology. The progression assessments with these technologies seem to be more sensitive than functional assessment, but they don't necessarily overlap with functional assessment or even with each other.
      In Better Glaucoma Progression Tracking
    6. I think that in future iterations we will be able to have focal assessment of change, looking at the overall trend as in regression, but also looking at event analysis, analogous to the GPA on visual field.
      In Better Glaucoma Progression Tracking