University of Pittsburgh Receives a 2014 NIH Grant for Novel Glaucoma Diagnostics for Structure and Function
Intra- and Inter-visit Reproducibility of Ganglion Cell – Inner Plexiform Layer Measurements Using Handheld Optical Coherence Tomography in Children with Optic Pathway Gliomas
Purpose To determine the intra- and inter-visit reproducibility of ganglion cell-inner plexiform layer thickness measures using handheld optical coherence tomography (OCT) in sedated children with optic pathway gliomas and/or Neurofibromatosis type 1 (NF1). Design Prospective longitudinal cohort study Methods Children with sporadic optic pathway gliomas and/or NF1 who had ≥ 2 volumes acquired over the macula using handheld OCT during sedation for a clinically indicated MRI were eligible for the intra-visit cohort. Children with repeat handheld OCT imaging within 6 months were eligible for the inter-visit cohort. Total retinal thickness and ganglion cell-inner plexiform layer thickness were measured using ...
Reproducibility of Circumpapillary Retinal Nerve Fiber Layer Measurements Using Handheld Optical Coherence Tomography in Sedated Children
Automated macular pathology diagnosis in three-dimensional (3D) spectral domain optical coherence tomography (SD-OCT) images
Systems and methods of analyzing an optical coherence tomography image of a retina are discussed. A 2-dimensional slice of the image can be aligned to produce an approximately horizontal image of the retina and an edge map based at least in part on the aligned slice. Also, at least one global representation can be determined based on a (multi-scale) spatial division, such as multi-scale spatial pyramid, on the slice and/or edge map. Creating the local features is based on the specified cell structure of the global representation. The local features can be constructed based on local binary pattern (LBP ...
Purpose To determine the reproducibility of automated segmentation of the three-dimensional (3D) lamina cribrosa (LC) microarchitecture scanned in-vivo using optical coherence tomography (OCT). Methods Thirty-nine eyes (8 healthy, 19 glaucoma suspects and 12 glaucoma) from 49 subjects were scanned twice using swept-source (SS−) OCT in a 3.5×3.5×3.64 mm (400×400×896 pixels) volume centered on the optic nerve head, with the focus readjusted after each scan. The LC was automatically segmented and analyzed for microarchitectural parameters, including pore diameter, pore diameter standard deviation (SD), pore aspect ratio, pore area, beam thickness, beam thickness SD, and ...
A Method to Estimate Biomechanics and Mechanical Properties of Optic Nerve Head Tissues From Parameters Measurable Using Optical Coherence Tomography
Tissue properties and biomechanics of the optic nerve head (ONH) are important to the development and progression of glaucoma, but remain mostly unmeasurable in the experiment. We hypothesized that these can be estimated numerically from ocular parameters measurable in-vivo with optical coherence tomography (OCT). Using previously reported parametric models representing human ONHs we simulated acute intraocular pressure (IOP) increases (10 mmHg). Statistical models were fit to predict, from OCT-measurable parameters, 15 outputs of interest including tissue properties, stresses and deformations. The calculations were repeated adding parameters that have recently been proposed as potentially measurable with OCT. We evaluated the sensitivity ...
Repeatability of in vivo 3D lamina cribrosa microarchitecture using adaptive optics spectral domain optical coherence tomography
Purpose To compare three methods of Schlemm's canal (SC) cross-sectional area (CSA) measurement. Methods Ten eyes (10 healthy volunteers) were imaged three times using spectral-domain optical coherence tomography (Cirrus HD-OCT, Zeiss, Dublin, California, USA). Aqueous outflow vascular structures and SC collector channel ostia were used as landmarks to identify a reference location within the limbus. SC CSA was assessed within a 1 mm segment (±15 frames of the reference, 31 frames in all) by three techniques. (1) Using a random number table, SC CSA in five random frames from the set of 31 surrounding the reference were measured and ...
Importance Monitoring young children with optic pathway gliomas (OPGs) for visual deterioration can be difficult owing to age-related noncompliance. Optical coherence tomography (OCT) measures of retinal nerve fiber layer (RNFL) thickness have been proposed as a surrogate marker of vision but this technique is also limited by patient cooperation. Objective To determine whether measures of circumpapillary RNFL thickness, acquired with handheld OCT (HH-OCT) during sedation, can differentiate between young children with and without vision loss from OPGs. Design, Setting, and Participants This cross-sectional analysis of a prospective observational study was conducted at a tertiary-care children’s hospital. Children with an ...
Imaging of the optic nerve and retinal nerve fiber layer: An essential part of glaucoma diagnosis and monitoring
Because glaucomatous damage is irreversible early detection of structural changes in the optic nerve head and retinal nerve fiber layer is imperative for timely diagnosis of glaucoma and monitoring of its progression. Significant improvements in ocular imaging have been made in recent years. Imaging techniques such as optical coherence tomography, scanning laser polarimetry and confocal scanning laser ophthalmoscopy rely on different properties of light to provide objective structural assessment of the optic nerve head, retinal nerve fiber layer and macula. In this review, we discuss the capabilities of these imaging modalities pertinent for diagnosis of glaucoma and detection of progressive ...
In Vivo Lamina Cribrosa Micro-Architecture in Healthy and Glaucomatous Eyes as Assessed by Optical Coherence Tomography
Optical coherence tomography (OCT) is a commonly used imaging modality in the evaluation of glaucomatous damage. The commercially available spectral domain (SD)-OCT offers benefits in glaucoma assessment over the earlier generation of time domain-OCT due to increased axial resolution, faster scanning speeds and has been reported to have improved reproducibility but similar diagnostic accuracy. The capabilities of SD-OCT are rapidly advancing with 3D imaging, reproducible registration, and advanced segmentation algorithms of macular and optic nerve head regions. A review of the evidence to date suggests that retinal nerve fibre layer remains the dominant parameter for glaucoma diagnosis and detection ...
About Joel S. Schuman
Joel S. Schuman, M.D. is a native of Roslyn, NY; he graduated Columbia University (AB, 1980) and Mt. Sinai School of Medicine (MD, 1984). Following internship at New York’s Beth Israel Medical Center (1985), he completed residency training at Medical College of Virginia (1988) and glaucoma fellowship at Massachusetts Eye & Ear Infirmary (clinical 1989, research 1990), where he was a Heed fellow. After just over a year on the Harvard faculty, he moved to New England Medical Center, Tufts University to co-found New England Eye Center in 1991, where he was Residency Director and Glaucoma and Cataract Service Chief. In 1998 he became Professor of Ophthalmology, and Vice Chair in 2001.
Dr. Schuman, is the Eye and Ear Foundation Professor and Chairman of Ophthalmology, the Eye and Ear Institute, University of Pittsburgh School of Medicine and Director of the University of Pittsburgh Medical Center (UPMC) Eye Center. He is also Professor of Bioengineering at the Swanson School of Engineering, University of Pittsburgh, and Professor in the Center for the Neural Basis of Cognition, Carnegie Mellon University and University of Pittsburgh and a member of the McGowan Institute for Regenerative Medicine. Dr. Schuman and his colleagues were the first to identify a molecular marker for human glaucoma, as published in Nature Medicine in 2001. He has been continuously funded by the National Eye Institute as a principal investigator since 1995, is principal investigator of a National Institutes of Health (NIH) grant to study novel glaucoma diagnostics, and is co-investigator of NIH grants for research into novel optical diagnostics and short pulse laser surgery and for advanced imaging in glaucoma. He is an inventor of optical coherence tomography (OCT), used world-wide for ocular diagnostics. Dr. Schuman has published more than 200 peer-reviewed scientific journal articles, has authored or edited 8 books, and has contributed more than 50 book chapters.
Dr. Schuman is a founding member of the ARVO Multidisciplinary Ophthalmic Imaging cross-sectional group, served on the program committee from its founding and chairs the MOI program committee 2007-2008. He is also a founder and chair of ARVO/isie (The International Society for Imaging in the Eye, inaugurated 2002). Dr. Schuman was co-chair of the International Glaucoma Symposium 1998-2007, the world’s largest meeting devoted to glaucoma, which merged with the World Glaucoma Congress in 2007, for which he is Program co-Chair 2007-2011. With the exception of a three year hiatus, he has chaired the Hawaiian Eye meeting glaucoma section since 1993.
I’m delighted by the Champalimaud Foundation’s recognition of our efforts...We continue to work on improving OCT and in the next decade, it could be as portable and easy to use as a standard ophthalmoscope.In Joel S. Schuman, M.D., Part of Team Receiving António Champalimaud Vision Award
That gives the promise to better track progression to detect change over time, and that is really a big advance in terms of changes from time-domain OCT.In OCT devices increasingly finding use outside retinal practice
You can look for characteristic nerve fiber layer abnormalities that are seen in glaucoma and these will show up as arcuate abnormalities — deviations from normal — on the deviation map of the spectral-domain OCT.In OCT devices increasingly finding use outside retinal practice
With imaging we have much younger technology. The progression assessments with these technologies seem to be more sensitive than functional assessment, but they don't necessarily overlap with functional assessment or even with each other.In Better Glaucoma Progression Tracking
I think that in future iterations we will be able to have focal assessment of change, looking at the overall trend as in regression, but also looking at event analysis, analogous to the GPA on visual field.In Better Glaucoma Progression Tracking