1. Joel S. Schuman

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    1. Mentioned In 138 Articles

    2. Reproducibility of In-Vivo OCT Measured Three-Dimensional Human Lamina Cribrosa Microarchitecture

      Reproducibility of In-Vivo OCT Measured Three-Dimensional Human Lamina Cribrosa Microarchitecture

      Purpose To determine the reproducibility of automated segmentation of the three-dimensional (3D) lamina cribrosa (LC) microarchitecture scanned in-vivo using optical coherence tomography (OCT). Methods Thirty-nine eyes (8 healthy, 19 glaucoma suspects and 12 glaucoma) from 49 subjects were scanned twice using swept-source (SS−) OCT in a 3.5×3.5×3.64 mm (400×400×896 pixels) volume centered on the optic nerve head, with the focus readjusted after each scan. The LC was automatically segmented and analyzed for microarchitectural parameters, including pore diameter, pore diameter standard deviation (SD), pore aspect ratio, pore area, beam thickness, beam thickness SD, and ...

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    3. A Method to Estimate Biomechanics and Mechanical Properties of Optic Nerve Head Tissues From Parameters Measurable Using Optical Coherence Tomography

      A Method to Estimate Biomechanics and Mechanical Properties of Optic Nerve Head Tissues From Parameters Measurable Using Optical Coherence Tomography

      Tissue properties and biomechanics of the optic nerve head (ONH) are important to the development and progression of glaucoma, but remain mostly unmeasurable in the experiment. We hypothesized that these can be estimated numerically from ocular parameters measurable in-vivo with optical coherence tomography (OCT). Using previously reported parametric models representing human ONHs we simulated acute intraocular pressure (IOP) increases (10 mmHg). Statistical models were fit to predict, from OCT-measurable parameters, 15 outputs of interest including tissue properties, stresses and deformations. The calculations were repeated adding parameters that have recently been proposed as potentially measurable with OCT. We evaluated the sensitivity ...

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    4. Repeatability of in vivo 3D lamina cribrosa microarchitecture using adaptive optics spectral domain optical coherence tomography

      Repeatability of in vivo 3D lamina cribrosa microarchitecture using adaptive optics spectral domain optical coherence tomography
      ...ck,^1,^2 Larry Kagemann,^1,^2 Ian A. Sigal,^1,^2 R. Daniel Ferguson,^3 Ankit Patel,^3 Daniel X. Hammer,^4 and Joel S. Schuman^1,^2 ^1UPMC Eye Center, Eye and Ear Institute, Ophthalmology and Visual Science Research Cen...
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    5. Characterisation of Schlemm's canal cross-sectional area

      Characterisation of Schlemm's canal cross-sectional area

      Purpose To compare three methods of Schlemm's canal (SC) cross-sectional area (CSA) measurement. Methods Ten eyes (10 healthy volunteers) were imaged three times using spectral-domain optical coherence tomography (Cirrus HD-OCT, Zeiss, Dublin, California, USA). Aqueous outflow vascular structures and SC collector channel ostia were used as landmarks to identify a reference location within the limbus. SC CSA was assessed within a 1 mm segment (±15 frames of the reference, 31 frames in all) by three techniques. (1) Using a random number table, SC CSA in five random frames from the set of 31 surrounding the reference were measured and ...

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    6. Handheld Optical Coherence Tomography During Sedation in Young Children With Optic Pathway Gliomas

      Handheld Optical Coherence Tomography During Sedation in Young Children With Optic Pathway Gliomas

      Importance Monitoring young children with optic pathway gliomas (OPGs) for visual deterioration can be difficult owing to age-related noncompliance. Optical coherence tomography (OCT) measures of retinal nerve fiber layer (RNFL) thickness have been proposed as a surrogate marker of vision but this technique is also limited by patient cooperation. Objective To determine whether measures of circumpapillary RNFL thickness, acquired with handheld OCT (HH-OCT) during sedation, can differentiate between young children with and without vision loss from OPGs. Design, Setting, and Participants This cross-sectional analysis of a prospective observational study was conducted at a tertiary-care children’s hospital. Children with an ...

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    7. Imaging of the optic nerve and retinal nerve fiber layer: An essential part of glaucoma diagnosis and monitoring

      Imaging of the optic nerve and retinal nerve fiber layer: An essential part of glaucoma diagnosis and monitoring

      Because glaucomatous damage is irreversible early detection of structural changes in the optic nerve head and retinal nerve fiber layer is imperative for timely diagnosis of glaucoma and monitoring of its progression. Significant improvements in ocular imaging have been made in recent years. Imaging techniques such as optical coherence tomography, scanning laser polarimetry and confocal scanning laser ophthalmoscopy rely on different properties of light to provide objective structural assessment of the optic nerve head, retinal nerve fiber layer and macula. In this review, we discuss the capabilities of these imaging modalities pertinent for diagnosis of glaucoma and detection of progressive ...

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    8. In Vivo Lamina Cribrosa Micro-Architecture in Healthy and Glaucomatous Eyes as Assessed by Optical Coherence Tomography

      In Vivo Lamina Cribrosa Micro-Architecture in Healthy and Glaucomatous Eyes as Assessed by Optical Coherence Tomography
      ...n J. Liu^4, 11. Martin Kraus^4,^5, 12. Chen D. Lu^4, 13. Joachim Hornegger^5, 14. James G. Fujimoto^4 and 15. Joel S. Schuman^1,^2 1. ^1Department of Ophthalmology, UPMC Eye Center, Eye and Ear Institute, Ophthalmo...
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    9. OCT for glaucoma diagnosis, screening and detection of glaucoma progression

      OCT for glaucoma diagnosis, screening and detection of glaucoma progression

      Optical coherence tomography (OCT) is a commonly used imaging modality in the evaluation of glaucomatous damage. The commercially available spectral domain (SD)-OCT offers benefits in glaucoma assessment over the earlier generation of time domain-OCT due to increased axial resolution, faster scanning speeds and has been reported to have improved reproducibility but similar diagnostic accuracy. The capabilities of SD-OCT are rapidly advancing with 3D imaging, reproducible registration, and advanced segmentation algorithms of macular and optic nerve head regions. A review of the evidence to date suggests that retinal nerve fibre layer remains the dominant parameter for glaucoma diagnosis and detection ...

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    10. In-Vivo Lamina Cribrosa Microarchitecture in Healthy and Glaucomatous Eyes as Assessed by Optical Coherence Tomography

      In-Vivo Lamina Cribrosa Microarchitecture in Healthy and Glaucomatous Eyes as Assessed by Optical Coherence Tomography

      Purpose: Lamina cribrosa (LC) is a leading location of glaucomatous damage. The purpose of this study is to compare LC 3-dimensional microarchitecture between healthy and glaucomatous eyes in-vivo using optical coherence tomography (OCT). Methods: Sixty-eight eyes (19 healthy and 49 glaucomatous) from 47 subjects were scanned in a 3.5x3.5x3.64mm volume (400x400x896 pixels) at the optic nerve head using swept-source OCT. The LC microarchitecture parameters were measured on the visible LC by an automated segmentation algorithm. The LC parameters were compared to diagnosis and visual field mean deviation (MD) using a linear mixed effects model accounting for age ...

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    11. Automated lamina cribrosa microstructural segmentation in optical coherence tomography scans of healthy and glaucomatous eyes

      Automated lamina cribrosa microstructural segmentation in optical coherence tomography scans of healthy and glaucomatous eyes
      ...owski,^5 Jonathan J. Liu,^5 Martin F. Kraus,^5,^6 Chen D. Lu,^5 Joachim Hornegger,^6 James G. Fujimoto,^5 and Joel S. Schuman^1,^2 ^1UPMC Eye Center, Eye and Ear Institute, Ophthalmology and Visual Science Research Cen...
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    12. Signal Normalization Reduces Systematic Measurement Differences Between Spectral Domain Optical Coherence Tomography Devices

      Signal Normalization Reduces Systematic Measurement Differences Between Spectral Domain Optical Coherence Tomography Devices

      Purpose: To test the effect of a novel signal normalization method for reducing systematic optical coherence tomography (OCT) measurement differences among multiple spectral-domain (SD-) OCT devices. Methods: One hundred and nine eyes from 59 subjects were scanned with two SD-OCT devices (Cirrus and RTVue) at the same visit. OCT image data were normalized to match their signal characteristics between the devices. To compensate signal strength differences, a custom high dynamic range (HDR) processing was also applied only to images with substantially lower signal strength. Global mean peripapillary RNFL thicknesses were then measured automatically from all images using custom segmentation software ...

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    13. University of Pittsburgh Receives NIH Grant for Novel Glaucoma Diagnostics for Structure and Function

      University of Pittsburgh Receives NIH Grant for Novel Glaucoma Diagnostics for Structure and Function
      ...H Grant for $702,923 for Novel Glaucoma Diagnostics for Structure and Function. The principal Investigator is Joel Schuman. The program began in 2000 and ends in 2014. Below is a summary of the proposed work.

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  2. About Joel S. Schuman

    Joel S. Schuman

    Joel S. Schuman, M.D. is a native of Roslyn, NY; he graduated Columbia University (AB, 1980) and Mt. Sinai School of Medicine (MD, 1984). Following internship at New York’s Beth Israel Medical Center (1985), he completed residency training at Medical College of Virginia (1988) and glaucoma fellowship at Massachusetts Eye & Ear Infirmary (clinical 1989, research 1990), where he was a Heed fellow. After just over a year on the Harvard faculty, he moved to New England Medical Center, Tufts University to co-found New England Eye Center in 1991, where he was Residency Director and Glaucoma and Cataract Service Chief. In 1998 he became Professor of Ophthalmology, and Vice Chair in 2001.
    Dr. Schuman, is the Eye and Ear Foundation Professor and Chairman of Ophthalmology, the Eye and Ear Institute, University of Pittsburgh School of Medicine and Director of the University of Pittsburgh Medical Center (UPMC) Eye Center. He is also Professor of Bioengineering at the Swanson School of Engineering, University of Pittsburgh, and Professor in the Center for the Neural Basis of Cognition, Carnegie Mellon University and University of Pittsburgh and a member of the McGowan Institute for Regenerative Medicine. Dr. Schuman and his colleagues were the first to identify a molecular marker for human glaucoma, as published in Nature Medicine in 2001. He has been continuously funded by the National Eye Institute as a principal investigator since 1995, is principal investigator of a National Institutes of Health (NIH) grant to study novel glaucoma diagnostics, and is co-investigator of NIH grants for research into novel optical diagnostics and short pulse laser surgery and for advanced imaging in glaucoma. He is an inventor of optical coherence tomography (OCT), used world-wide for ocular diagnostics. Dr. Schuman has published more than 200 peer-reviewed scientific journal articles, has authored or edited 8 books, and has contributed more than 50 book chapters.

    Dr. Schuman is a founding member of the ARVO Multidisciplinary Ophthalmic Imaging cross-sectional group, served on the program committee from its founding and chairs the MOI program committee 2007-2008. He is also a founder and chair of ARVO/isie (The International Society for Imaging in the Eye, inaugurated 2002). Dr. Schuman was co-chair of the International Glaucoma Symposium 1998-2007, the world’s largest meeting devoted to glaucoma, which merged with the World Glaucoma Congress in 2007, for which he is Program co-Chair 2007-2011. With the exception of a three year hiatus, he has chaired the Hawaiian Eye meeting glaucoma section since 1993.

     

  3. Quotes

    1. I’m delighted by the Champalimaud Foundation’s recognition of our efforts...We continue to work on improving OCT and in the next decade, it could be as portable and easy to use as a standard ophthalmoscope.
      In Joel S. Schuman, M.D., Part of Team Receiving António Champalimaud Vision Award
    2. That gives the promise to better track progression to detect change over time, and that is really a big advance in terms of changes from time-domain OCT.
      In OCT devices increasingly finding use outside retinal practice
    3. You can look for characteristic nerve fiber layer abnormalities that are seen in glaucoma and these will show up as arcuate abnormalities — deviations from normal — on the deviation map of the spectral-domain OCT.
      In OCT devices increasingly finding use outside retinal practice
    4. With imaging we have much younger technology. The progression assessments with these technologies seem to be more sensitive than functional assessment, but they don't necessarily overlap with functional assessment or even with each other.
      In Better Glaucoma Progression Tracking
    5. I think that in future iterations we will be able to have focal assessment of change, looking at the overall trend as in regression, but also looking at event analysis, analogous to the GPA on visual field.
      In Better Glaucoma Progression Tracking