1. Jodhbir S. Mehta

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    1. Mentioned In 30 Articles

    2. Optical coherence tomography angiography for the anterior segment

      Optical coherence tomography angiography for the anterior segment
      Optical coherence tomography angiography (OCTA) is a rapid and non-invasive technique for imaging vasculature in the eye. As OCTA can produce high-resolution cross-sectional images and allow depth-resolved analysis for accurate localization of pathology of interest, it has become a promising method for anterior segment imaging. Furthermore, OCTA offers a more patient-friendly alternative to the conventional invasive dye-based fluorescent angiography. However, conventional OCTA systems are typically designed and optimized for the ...
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    3. Vessel density and En-face segmentation of optical coherence tomography angiography to analyse corneal vascularisation in an animal model

      Vessel density and En-face segmentation of optical coherence tomography angiography to analyse corneal vascularisation in an animal model
      Background Optical coherence tomography angiography (OCTA) is a novel non-invasive angiography technology that has recently been extensively studied for its utility in anterior segment imaging. In this study, we compared a split-spectrum amplitude decorrelation angiography (SSADA) OCTA and an optical micro-angiography (OMAG SD) OCTA system to current angiographic technique, indocyanine green angiography (ICGA), to assess corneal vascularisation in an animal model. Methods We imaged 16 rabbits, (one eye per animal ...
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    4. Intraoperative Optical Coherence Tomography–Guided Femtosecond Laser–Assisted Deep Anterior Lamellar Keratoplasty

      Intraoperative Optical Coherence Tomography–Guided Femtosecond Laser–Assisted Deep Anterior Lamellar Keratoplasty
      Purpose: To describe the feasibility and outcomes of intraoperative optical coherence tomography (OCT)guided, femtosecond laser assisted deep anterior lamellar keratoplasty in which the lamellar and tunnel cuts were completed by laser. Methods: The Ziemer Z8 system was used to scan the corneas intraoperatively and guide the stromal lamellar and tunnel cuts created by the laser. Thirty porcine eyes and 3 human cadaver globes were used to evaluate the accuracy ...
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    5. Quantification of the Posterior Cornea Using Swept Source Optical Coherence Tomography

      Quantification of the Posterior Cornea Using Swept Source Optical Coherence Tomography
      Purpose : We define optical coherence tomography (OCT) measurement parameters of the corneal endothelium/Descemet's membrane (DM) complex and peripheral transition zone (TZ) and describe these measurements in an ethnically Chinese population. Methods : OCT images of the anterior segment and iridocorneal angle were obtained from 129 healthy Chinese subjects (129 eyes), aged 40 to 81 years. The scleral spur (SS) and Schwalbe's line (SL) were identified in each image ...
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    6. Comparison of Optical Coherence Tomography Angiography to Indocyanine Green Angiography and Slit Lamp Photography for Corneal Vascularization in an Animal Model

      Comparison of Optical Coherence Tomography Angiography to Indocyanine Green Angiography and Slit Lamp Photography for Corneal Vascularization in an Animal Model
      Corneal neovascularization (CoNV) could be treated by novel anti-angiogenic therapies, though reliable and objective imaging tools to evaluate corneal vasculature and treatment efficacy is still lacking. Optical coherence tomography angiography (OCTA) currently designed as a retinal vascular imaging system has been recently adapted for anterior-segment and showed good potential for successful imaging of CoNV. However, further development requires an animal model where parameters can be studied more carefully with histological ...
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    7. Novel application of In Vivo Micro-Optical Coherence Tomography to assess Cornea scarring in an Animal Model

      Novel application of In Vivo Micro-Optical Coherence Tomography to assess Cornea scarring in an Animal Model
      This pilot study uses a micro-optical coherence tomography (micro-OCT) system with ~1m axial resolution specifically to image the cornea and corneal scars in vivo . We used an established murine corneal scar model by irregular phototherapeutic keratectomy in ten C57BL/6 mice, with serial imaging using the micro-OCT and compared to anterior segment (AS-OCT) (RTvue, Optovue, Fremont, CA) before and after scar induction. Main outcome was agreement between the AS-OCT and ...
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    8. Intraoperative Optical Coherence Tomography Vault Measurement in Posterior Chamber Phakic Intraocular Lens Implantation

      Intraoperative Optical Coherence Tomography Vault Measurement in Posterior Chamber Phakic Intraocular Lens Implantation
      PURPOSE: To describe the use of intraoperative optical coherence tomography (OCT) vault measurement in 5 cases of posterior chamber phakic intraocular lens (IOL) implantation. METHODS: This case series included 5 eyes in 3 consecutive patients undergoing phakic IOL implantation. RTVue OCT (Optovue, Inc., Fremont, CA) was used to obtain intraoperative vault measurements after pupil constriction. Visante OCT (Carl Zeiss Meditec, Jena, Germany) was used to obtain postoperative vault measurements. RESULTS ...
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    9. Needle Depth and Big-Bubble Success in Deep Anterior Lamellar Keratoplasty: An Ex Vivo Microscope-Integrated OCT Study

      Needle Depth and Big-Bubble Success in Deep Anterior Lamellar Keratoplasty: An Ex Vivo Microscope-Integrated OCT Study
      Purpose: To examine big-bubble (BB) formation success rates in deep anterior lamellar keratoplasty (DALK) at various corneal depths using real-time guidance from swept-source, microscope-integrated optical coherence tomography (SS-MIOCT). Methods: The DALK procedure was performed ex vivo with 34 human donor corneoscleral buttons on pressurized artificial anterior chambers using the BB technique employed by Anwar and Teichmann. We inserted a needle under controlled ex vivo conditions to corneal depths ranging from ...
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    10. Applications of Anterior Segment Optical Coherence Tomography in Cornea and Ocular Surface Diseases

      Applications of Anterior Segment Optical Coherence Tomography in Cornea and Ocular Surface Diseases
      Optical coherence tomography (OCT) is a noncontact technology that produces high-resolution cross-sectional images of ocular tissues. Anterior segment OCT (AS-OCT) enables the precise visualization of anterior segment structure; thus, it can be used in various corneal and ocular surface disorders. In this review, the authors will discuss the application of AS-OCT for diagnosis and management of various corneal and ocular surface disorders. Use of AS-OCT for anterior segment surgery and ...
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    11. Enhancement of Corneal Visibility in Optical Coherence Tomography Images with Corneal Opacification

      Enhancement of Corneal Visibility in Optical Coherence Tomography Images with Corneal Opacification
      Purpose : To establish and to rank the performance of a corneal adaptive compensation (CAC) algorithm in enhancing corneal images with scars acquired from three commercially available anterior segment optical coherence tomography (ASOCT) devices. Methods : Horizontal B-scans of the cornea were acquired from 10 patients using three ASOCT devices (Spectralis, RTVue, and Cirrus). We compared ASOCT image quality (with and without CAC) by computing the intralayer contrast (a measure of shadow ...
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    12. Evaluation of a Micro-Optical Coherence Tomography for the Corneal Endothelium in an Animal Model

      Evaluation of a Micro-Optical Coherence Tomography for the Corneal Endothelium in an Animal Model
      Recent developments in optical coherence tomography (OCT) systems for the cornea have limited resolution or acquisition speed. In this study we aim to evaluate the use of a micro-OCT (OCT ~1m axial resolution) compared to existing imaging modalities using animal models of corneal endothelial disease. We used established cryoinjury and bullous keratopathy models in Sprague Dawley rats comparing ex vivo OCT imaging in normal and diseased eyes to (1) histology ...
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    13. Corneal graft evaluation based on optical coherence tomography image

      Corneal graft evaluation based on optical coherence tomography image
      An OCT image of an eye which has been subject to a DSAEK corneal transplant, in which a Descement's membrane in the cornea has been replaced by a graft, is processed to identify the outline of the graft. The process includes the steps of: computationally extracting the boundary of the cornea including the graft; computationally detecting the corners of the graft; computationally extracting points on the boundary between the ...
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    14. Intraobserver repeatability and interobserver reproducibility of corneal measurements in normal eyes using an optical coherence tomography–Placido disk device

      Intraobserver repeatability and interobserver reproducibility of corneal measurements in normal eyes using an optical coherence tomography–Placido disk device
      ... , FRCS(Ed) , Hla Myint Htoon x Hla Myint Htoon Search for articles by this author , PhD , Jodhbir S. Mehta x Jodhbir S. Mehta Search for articles by this author Correspondence * Corresponding author: Jodhbir S. Meht...
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    15. Use of Anterior Segment Optical Coherence Tomography to Predict Corneal Graft Rejection in Small Animal Models

      Use of Anterior Segment Optical Coherence Tomography to Predict Corneal Graft Rejection in Small Animal Models
      Purpose: To correlate the degree of anterior chamber (AC) inflammation and corneal thickness evaluated by anterior segment optical coherence tomography (ASOCT) with corneal graft rejection status and to explore the value of ASOCT in assisting the diagnosis or prediction of graft rejection using a rat penetrating keratoplasty (PK) model. Methods: A total of 40 PKs were performed using Fisher rats (allogeneic groups) and Lewis rats (syngeneic group) as donors and ...
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    16. Intraoperative Anterior Segment Optical Coherence Tomography: A Novel Assessment Tool during Deep Anterior Lamellar Keratoplasty

      Intraoperative Anterior Segment Optical Coherence Tomography: A Novel Assessment Tool during Deep Anterior Lamellar Keratoplasty
      Purpose To describe the use of high-resolution anterior segment optical coherence tomography (AS-OCT) during deep anterior lamellar keratoplasty (DALK). Design Prospective case series. Methods We performed at the Singapore National Eye Centre sequential intraoperative AS-OCT scans using iVue 100-2 (Optovue, Fremont, CA) during different DALK techniques. Results In case 1 (corneal scarring) the OCT images helped guiding manual dissection, showed the depth of the needle track before air injection, and ...
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  2. About Jodhbir S. Mehta

    Jodhbir S. Mehta

    Jodhbir S. Mehta is with the  Tissue Engineering and Stem Cell Group, Singapore Eye Research Institute, the Singapore National Eye Centre, Singapore, and the  Department of Clinical Sciences, Duke-NUS Graduate Medical School, Singapore.