1. Jiawen Li

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    1. Mentioned In 16 Articles

    2. Miniaturized single-fiber-based needle probe for combined imaging and sensing in deep tissue

      Miniaturized single-fiber-based needle probe for combined imaging and sensing in deep tissue
      The ability to visualize structure while simultaneously measuring chemical or physical properties of a biological tissue has the potential to improve our understanding of complex biological processes. We report the first miniaturized single-fiber-based imaging + sensing imaging+sensing probe capable of simultaneous optical coherence tomography (OCT) imaging and temperature sensing. An OCT lens is fabricated at the distal end of a double-clad fiber, including a thin layer of rare-earth-doped tellurite glass ...
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    3. Flexible needle with integrated optical coherence tomography probe for imaging during transbronchial tissue aspiration

      Flexible needle with integrated optical coherence tomography probe for imaging during transbronchial tissue aspiration
      Transbronchial needle aspiration (TBNA) of small lesions or lymph nodes in the lung may result in nondiagnostic tissue samples. We demonstrate the integration of an optical coherence tomography (OCT) probe into a 19-gauge flexible needle for lung tissue aspiration. This probe allows simultaneous visualization and aspiration of the tissue. By eliminating the need for insertion and withdrawal of a separate imaging probe, this integrated design minimizes the risk of dislodging ...
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    4. Integrated intravascular ultrasound and optical coherence tomography technology: a promising tool to identify vulnerable plaques

      Integrated intravascular ultrasound and optical coherence tomography technology: a promising tool to identify vulnerable plaques
      Heart attack is mainly caused by the rupture of a vulnerable plaque. IVUS-OCT is a novel medical imaging modality that provides opportunities for accurate assessment of vulnerable plaquesin vivoin patients. IVUS provides deep penetration to image the whole necrotic core while OCT enables accurate measurement of the fibrous cap of a plaque owing to its high resolution. In this paper, the authors describe the fundamentals, the technical designs and the ...
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    5. Ultrafast optical-ultrasonic system and miniaturized catheter for imaging and characterizing atherosclerotic plaques in vivo

      Ultrafast optical-ultrasonic system and miniaturized catheter for imaging and characterizing atherosclerotic plaques in vivo
      Atherosclerotic coronary artery disease (CAD) is the number one cause of death worldwide. The majority of CAD-induced deaths are due to the rupture of vulnerable plaques. Accurate assessment of plaques is crucial to optimize treatment and prevent death in patients with CAD. Current diagnostic techniques are often limited by either spatial resolution or penetration depth. Several studies have proved that the combined use of optical and ultrasonic imaging techniques increase ...
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    6. Trimodality imaging system and intravascular endoscopic probe: combined optical coherence tomography, fluorescence imaging and ultrasound imaging

      Trimodality imaging system and intravascular endoscopic probe: combined optical coherence tomography, fluorescence imaging and ultrasound imaging
      ... contrast simultaneously. © 2014 Optical Society of America Shanshan Liang, Teng Ma, Joseph Jing, Xiang Li, Jiawen Li, K. Kirk Shung, Qifa Zhou, Jun Zhang, and Zhongping Chen, "Trimodality imaging system and intravascu...
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    7. Integrated IVUS-OCT for Real-Time Imaging of Coronary Atherosclerosis

      Integrated IVUS-OCT for Real-Time Imaging of Coronary Atherosclerosis
      Accurate assessment of atherosclerotic plaque characteristics and the subsequent tailoring of optimal therapy holds great promise for preventing acute coronary syndromes (ACS) and life-threatening sequelae 1 . Combined use of optical coherence tomography (OCT) and intravascular ultrasound (IVUS) was proposed as a potential method for accurate assessment of plaque characteristics and vulnerability ( 2 , ). However, significant challenges remain in trying to adapt an integrated OCT-IVUS system for clinical applications. We report here ...
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    8. Feature Of The Week 11/24/13 : Miniature OCT/IVUS probe for automatically co-registered three-dimensional intracoronary imaging with real-time display

      Feature Of The Week 11/24/13 : Miniature OCT/IVUS probe for automatically co-registered three-dimensional intracoronary imaging with real-time display
      ...linical application of this technique in the near future.For more information see recent Article. Courtesy of Jiawen Li and Zhongping Chen from University of California at Irvine.  This work was a collaboration between D...
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    9. Miniature optical coherence tomography-ultrasound probe for automatically coregistered three-dimensional intracoronary imaging with real-time display

      Miniature optical coherence tomography-ultrasound probe for automatically coregistered three-dimensional intracoronary imaging with real-time display
      ...ry segments, were obtained using this probe and our upgraded system. Histology validation is also presented. Jiawen Li ; Teng Ma ; Joseph Jing ; Jun Zhang ; Pranav M. Patel, et al. "Miniature optical coherence tomograp...
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    10. Integrated intravascular optical coherence tomography (OCT) - ultrasound (US) catheter for characterization of atherosclerotic plaques in vivo

      Integrated intravascular optical coherence tomography (OCT) - ultrasound (US) catheter for characterization of atherosclerotic plaques in vivo
      A miniature integrated intravascular optical coherence tomography (OCT) - ultrasound (US) catheter for real-time imaging of atherosclerotic plaques has been developed, providing high resolution and deep tissue penetration at the same time. This catheter, with an outer diameter of 1.18mm, is suitable for imaging in human coronary arteries. The first in vivo 3D imaging of atherosclerotic microstructure in a rabbit abdominal aorta obtained by an integrated OCT-US catheter is presented ...
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    11. Intravascular atherosclerotic imaging with combined fluorescence and optical coherence tomography probe based on a double-clad fiber combiner

      Intravascular atherosclerotic imaging with combined fluorescence and optical coherence tomography probe based on a double-clad fiber combiner
      We developed a multimodality fluorescence and optical coherence tomography probe based on a double-clad fiber (DCF) combiner. The probe is composed of a DCF combiner, grin lens, and micromotor in the distal end. An integrated swept-source optical coherence tomography and fluorescence intensity imaging system was developed based on the combined probe for the early diagnoses of atherosclerosis. This system is capable of real-time data acquisition and processing as well as ...
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    12. Advances in a fully integrated intravascular OCT-ultrasound system for cardiovascular imaging

      Advances in a fully integrated intravascular OCT-ultrasound system for cardiovascular imaging
      Intracoronary optical coherence tomography (OCT) and intravascular ultrasound (IVUS) are two popular techniques for the detection and determination of atherosclerosis. IVUS allows visualization of plaques while also providing a large penetration depth to determine plaque volume. Intracoronary OCT provides the ability to capture microscopic features associated with high risk plaque. Traditionally to utilize the benefits of both modalities, separate probes and systems had to be used one at a time ...
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    13. Novel combined miniature optical coherence tomography ultrasound probe for in vivo intravascular imaging

      Novel combined miniature optical coherence tomography ultrasound probe for in vivo intravascular imaging
      We have developed a miniature integrated optical coherence tomography (OCT) ultrasound (US) probing system for intravascular imaging applications. In the OCT probe, the light coming out of a single mode fiber is focused by a gradient-index lens and then reflected by a right-angle prism from the side of the probe into the sample. It was combined with a 35 MHz PMN-PT side-viewing ultrasound transducer to obtain the ultrasound image as ...
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    14. 1-16 of 16
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  2. About Jiawen Li

    Jiawen Li

    Jiawen Li received her BS degree in Optical Engineering from Zhejiang University in 2010, and her PhD degree in Biomedical Engineering from University of California Irvine in 2015. She is currently a Research Fellow at University of Western Australia. She has pioneered in developing and applying the integrated IVUS-OCT technology for clinical practices. During her PhD journey, she published 11 papers in high-impact journals and gave more than 16 talks at prestigious international conferences. In 2015, she won the best poster award at Optics in Cardiology conference. Her research interests include optical coherence tomography, needle probe, multimodality imaging, intravascular imaging, and ultra-thin endoscopes.