1. Jianhua Wang

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    1. Mentioned In 75 Articles

    2. Quantitative analysis of conjunctival microvasculature imaged using optical coherence tomography angiography

      Quantitative analysis of conjunctival microvasculature imaged using optical coherence tomography angiography
      Background The goal was to quantitatively analyze the bulbar conjunctival microvascular density using optical coherence tomography angiography (OCTA) and compare it to the vessel density using functional slit-lamp biomicroscopy (FSLB). Methods Temporal bulbar conjunctiva of 20 eyes (10 healthy subjects) was imaged using both OCTA and FSLB. Image processing was performed including equalization, de-noising, thresholding, and skeletonization. The vessel density was measured by fractal analysis (box counting, Dbox) and pixel ...
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    3. Altered Macular Microvasculature in Mild Cognitive Impairment and Alzheimer Disease

      Altered Macular Microvasculature in Mild Cognitive Impairment and Alzheimer Disease
      Background: The goal of the present study was to analyze the macular microvacular network in mild cognitive impirment (MCI) and Alzheimer disease (AD). Methods: Twelve patients with AD and 19 patients with MCI were recruited together with 21 cognitively normal controls with a similar range of ages. Optical coherence tomography angiography was used to image the retinal microvascular network at the macular region, including retinal vascular network (RVN), superficial vascular ...
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    4. Long scan depth optical coherence tomography on imaging accommodation: impact of enhanced axial resolution, signal-to-noise ratio and speed

      Long scan depth optical coherence tomography on imaging accommodation: impact of enhanced axial resolution, signal-to-noise ratio and speed
      Background Spectral domain optical coherence tomography (SD-OCT) was a useful tool to study accommodation in human eye, but the maximum image depth is limited due to the decreased signal-to-noise ratio (SNR). In this study, improving optical resolutions, speeds and the SNR were achieved by custom built SD-OCT, and the evaluation of the impact of the improvement during accommodation was investigated. Methods Three systems with different spectrometer designs, including two Charge ...
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    5. Altered birefringence of peripapillary retinal nerve fiber layer in multiple sclerosis measured by polarization sensitive optical coherence tomography

      Altered birefringence of peripapillary retinal nerve fiber layer in multiple sclerosis measured by polarization sensitive optical coherence tomography
      Background The retina has been used to study the pathophysiology of multiple sclerosis (MS). Peripapillary retinal nerve fiber layer (pRNFL) thinning has been suggested as an ocular biomarker of neurodegeneration in MS. The goal of this project was to determine the birefringence of the pRNFL by measuring the fiber birefringence using polarization sensitive optical coherence tomography (PS-OCT). Methods Sixty-six MS patients without history of optic neuritis (age: 39.911.0 ...
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    6. Optical coherence tomography for ocular surface and corneal diseases: a review

      Optical coherence tomography for ocular surface and corneal diseases: a review
      The advent of optical coherence tomography (OCT) imaging has changed the way ophthalmologists image the ocular surface and anterior segment of the eye. Its ability to obtain dynamic, high and ultra-high resolution, cross-sectional images of the ocular surface and anterior segment in a noninvasive and rapid manner allows for ease of use. In this review, we focus on the use of anterior segment OCT, which provides an optical biopsy or ...
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    7. Axial elongation measured by long scan depth optical coherence tomography during pilocarpine-induced accommodation in intraocular lens-implanted eyes

      Axial elongation measured by long scan depth optical coherence tomography during pilocarpine-induced accommodation in intraocular lens-implanted eyes
      We used an ultra-long scan depth optical coherence tomography (UL-OCT) system to investigate changes in axial biometry of pseudophakic eyes during pilocarpine- induced accommodation. The right eyes from 25 healthy subjects (age range 49 to 84 years) with an intraocular lens (IOL) were imaged twice in the non-accommodative and the accommodative states. A custom-built UL-OCT instrument imaged the whole eye. Then accommodation was induced by two drops of 0.5 ...
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    8. Characterization of Soft Contact Lens Fitting Using Ultra-Long Scan Depth Optical Coherence Tomography

      Characterization of Soft Contact Lens Fitting Using Ultra-Long Scan Depth Optical Coherence Tomography
      Objectives . To evaluate the centration and movement of soft contact lenses and to verify the repeatability of two repeated measurements of the lens centration and movement using ultra-long scan depth optical coherence tomography (UL-OCT). Methods . A 1-day Acuvue Define lens was tested on both eyes of 10 subjects (5 males and 5 females; mean age, 31.6 years). The centration and blink-induced movement of the contact lens were measured using ...
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    9. Role of high resolution optical coherence tomography in diagnosing ocular surface squamous neoplasia with coexisting ocular surface diseases

      Role of high resolution optical coherence tomography in diagnosing ocular surface squamous neoplasia with coexisting ocular surface diseases
      Purpose Coexistence of an ocular surface disease can mask the typical features of ocular surface squamous neoplasia (OSSN). The purpose of this study was to evaluate high resolution optical coherence tomography (HR-OCT) as an adjunct in the detection and differentiation of OSSN within coexisting ocular surface pathologies. Methods Retrospective study of 16 patients with ocular surface disease and lesions suspicious for OSSN that were evaluated with HR-OCT. HR-OCT images of ...
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    10. The measurement repeatability using different partition methods of intraretinal tomographic thickness maps in healthy human subjects

      The measurement repeatability using different partition methods of intraretinal tomographic thickness maps in healthy human subjects
      Purpose: To determine the repeatability and profiles with different partition methods in intraretinal thickness layers in healthy human subjects, using optical coherence tomography (OCT). Methods: A custom-built ultrahigh-resolution OCT was used to acquire three-dimensional volume of the macula in 20 healthy subjects. The dataset was acquired twice using the macular cube 512128 protocol in an area of 66 mm 2 centered on the fovea. Commercially available segmentation software (Orion) was ...
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    11. In vivo quantification of cochlin in glaucomatous DBA/2J mice using optical coherence tomography

      In vivo quantification of cochlin in glaucomatous DBA/2J mice using optical coherence tomography
      The expression of cochlin in the trabecular meshwork (TM) precedes the clinical glaucoma symptoms in DBA/2J mice. The ability to quantify cochlin in the local tissue (TM) offers potential diagnostic and prognostic values. We present two (spectroscopic and magnetomotive) optical coherence tomography (OCT) approaches for in vivo cochlin quantification in a periodic manner. The cochlin-antibody OCT signal remains stable for up to 24hours as seen at 3.5hours after ...
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    12. Ultra high resolution optical coherence tomography in Boston type I keratoprosthesis

      Ultra high resolution optical coherence tomography in Boston type I keratoprosthesis
      PURPOSE: To evaluate the anterior keratoprosthesis-cornea interface in eyes with Boston type I keratoprosthesis (Kpro). METHODS: In a prospective non-interventional study, patients with Boston type I Kpro underwent ultra-high resolution optical coherence tomography (UHR-OCT) evaluation. The images were used to measure and describe characteristics of the anterior keratoprosthesis-cornea interface, epithelial interaction at the keratoprosthesis edge and the keratoprosthesis-cornea interface gap. RESULTS: Ten patients including 4 male and 6 female subjects ...
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    13. Automatic Biometry of the Anterior Segment During Accommodation Imaged by Optical Coherence Tomography

      Automatic Biometry of the Anterior Segment During Accommodation Imaged by Optical Coherence Tomography
      Objective: To test accuracy and repeatability of a software algorithm that performs automatic biometry of the anterior segment of the human eye imaged with long scan depth optical coherence tomography (OCT). Methods: The ocular anterior segment imaging was performed with custom-built long scan depth OCT. An automatic software algorithm including boundary segmentation, image registration, and optical correction was developed for fast and reliable biometric measurements based on the OCT images ...
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    14. Vertical and Horizontal Corneal Epithelial Thickness Profile Using Ultra-High Resolution and Long Scan Depth Optical Coherence Tomography

      Vertical and Horizontal Corneal Epithelial Thickness Profile Using Ultra-High Resolution and Long Scan Depth Optical Coherence Tomography
      Purpose To determine the vertical and horizontal thickness profiles of the corneal epithelium in vivo using ultra-long scan depth and ultra-high resolution spectral domain optical coherence tomography (SD-OCT). Methods A SD-OCT was developed with an axial resolution of ~3.3 m in tissue and an extended scan depth. Forty-two eyes of 21 subjects were imaged twice. The entire horizontal and vertical corneal epithelial thickness profiles were evaluated. The coefficient of ...
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    15. Agreement of Corneal Epithelial Profiles Produced by Automated Segmentation of SD-OCT Images Having Different Optical Resolutions

      Agreement of Corneal Epithelial Profiles Produced by Automated Segmentation of SD-OCT Images Having Different Optical Resolutions
      Objective: Using a custom-developed segmentation algorithm, agreement of corneal epithelial thickness profile measurements between two spectral domain optical coherence tomography (SD-OCT) systems was assessed. Methods: Eighteen left eyes (18 subjects; mean+/-standard deviation; age, 23.2+/-0.9 years) were imaged twice on nonconsecutive days by a custom-built ultra-high resolution OCT (UHR-OCT) system and a commercial RTVue OCT system. A segmentation algorithm based on axial gradient information and a shortest ...
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  2. About Jianhua Wang

    Jianhua Wang

    Jianhua (Jay) Wang is at the Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami, Miami, Florida.