1. Jiang Zhu

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    1-14 of 14
    1. Mentioned In 14 Articles

    2. Intravascular Optical Coherence Tomography for Characterization of Atherosclerosis with a 1.7 Micron Swept-Source Laser

      Intravascular Optical Coherence Tomography for Characterization of Atherosclerosis with a 1.7 Micron Swept-Source Laser
      The main cause of acute coronary events, such as thrombosis, is the rupture of atherosclerotic plaques. Typical intravascular optical coherence tomography (IVOCT) imaging systems that utilize a 1.3m swept source laser are often used for identifying fibrous cap thickness of plaques, yet cannot provide adequate depth penetration to resolve the size of the lipid pool. Here, we present a novel IVOCT system with a 1.7m center wavelength swept ...
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    3. Miniature probe for mapping mechanical properties of vascular lesions using acoustic radiation force optical coherence elastography

      Miniature probe for mapping mechanical properties of vascular lesions using acoustic radiation force optical coherence elastography
      Cardiovascular diseases are the leading cause of fatalities in the United States. Atherosclerotic plaques are one of the primary complications that can lead to strokes and heart attacks if left untreated. It is essential to diagnose the disease early and distinguish vulnerable plaques from harmless ones. Many methods focus on the structural or molecular properties of plaques. Mechanical properties have been shown to change drastically when abnormalities develop in arterial ...
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    4. Longitudinal shear wave imaging for elasticity mapping using optical coherence elastography

      Longitudinal shear wave imaging for elasticity mapping using optical coherence elastography
      Shear wave measurements for the determination of tissue elastic properties have been used in clinical diagnosis and soft tissue assessment. A shear wave propagates as a transverse wave where vibration is perpendicular to the wave propagation direction. Previous transverse shear wave measurements could detect the shear modulus in the lateral region of the force; however, they could not provide the elastic information in the axial region of the force. In ...
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    5. Coagulation monitoring based on blood elastic measurement using optical coherence tomography

      Coagulation monitoring based on blood elastic measurement using optical coherence tomography
      Blood coagulation monitoring is important to diagnose hematological diseases and cardiovascular diseases and to predict the risk of bleeding and excessive clotting. In this study, we developed a system to dynamically monitor blood coagulation and quantitatively determine the coagulation function by blood elastic measurement. When blood forms a clot from a liquid, ultrasonic force induces a shear wave, which is detected by optical coherence tomography (OCT). The coagulation of porcine ...
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    6. Volumetric vessel reconstruction method for absolute blood flow velocity measurement in Doppler OCT images

      Volumetric vessel reconstruction method for absolute blood flow velocity measurement in Doppler OCT images
      Doppler optical coherence tomography (DOCT) is considered one of the most promising functional imaging modalities for neuro biology research and has demonstrated the ability to quantify cerebral blood flow velocity at a high accuracy. However, the measurement of total absolute blood flow velocity (BFV) of major cerebral arteries is still a difficult problem since it not only relates to the properties of the laser and the scattering particles, but also ...
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    7. 3D mapping of elastic modulus using shear wave optical micro-elastography

      3D mapping of elastic modulus using shear wave optical micro-elastography
      lastography provides a powerful tool for histopathological identification and clinical diagnosis based on information from tissue stiffness. Benefiting from high resolution, three-dimensional (3D), and noninvasive optical coherence tomography (OCT), optical micro-elastography has the ability to determine elastic properties with a resolution of ~10m in a 3D specimen. The shear wave velocity measurement can be used to quantify the elastic modulus. However, in current methods, shear waves are measured near the ...
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    8. Acoustic Radiation Force Optical Coherence Elastography of Corneal Tissue

      Acoustic Radiation Force Optical Coherence Elastography of Corneal Tissue
      We report on a real-time acoustic radiation force optical coherence elastography (ARF-OCE) system to map the relative elasticity of corneal tissue. A modulated ARF is used as excitation to vibrate the cornea, while OCE serves as detection of tissue response. To show feasibility of detecting mechanical contrast using this method, we performed tissue-equivalent agarose phantom studies with inclusions of a different stiffness. We obtained 3-D elastograms of a healthy cornea ...
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    9. Dynamic and quantitative assessment of blood coagulation using optical coherence elastography

      Dynamic and quantitative assessment of blood coagulation using optical coherence elastography
      Reliable clot diagnostic systems are needed for directing treatment in a broad spectrum of cardiovascular diseases and coagulopathy. Here, we report on non-contact measurement of elastic modulus for dynamic and quantitative assessment of whole blood coagulation using acoustic radiation force orthogonal excitation optical coherence elastography (ARFOE-OCE). In this system, acoustic radiation force (ARF) is produced by a remote ultrasonic transducer, and a shear wave induced by ARF excitation is detected ...
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    10. Automatic three-dimensional segmentation combined with in vivo microvascular network imaging of human retina by intensity-based Doppler variance optical coherence tomography

      Automatic three-dimensional segmentation combined with in vivo microvascular network imaging of human retina by intensity-based Doppler variance optical coherence tomography
      Optical coherence tomography (OCT) is a noninvasive method for retinal imaging. In this work, we present an in vivo human retinal microvascular network measurement by an intensity-based Doppler variance (IBDV) based on sweptsource OCT. In addition, an automatic three-dimensional (3-D) segmentation method was used for segmenting intraretinal layers. The microvascular networks were divided into six layers by visualizing of each individual layer with enhanced imaging contrast. This method has potential ...
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    11. Fully distributed absolute blood flow velocity measurement for middle cerebral arteries using Doppler optical coherence tomography

      Fully distributed absolute blood flow velocity measurement for middle cerebral arteries using Doppler optical coherence tomography
      Doppler optical coherence tomography (DOCT) is considered one of the most promising functional imaging modalities for neuro biology research and has demonstrated the ability to quantify cerebral blood flow velocity at a high accuracy. However, the measurement of total absolute blood flow velocity (BFV) of major cerebral arteries is still a difficult problem since it is related to vessel geometry. In this paper, we present a volumetric vessel reconstruction approach ...
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    12. Automatic airway wall segmentation and thickness measurement for long-range optical coherence tomography images

      Automatic airway wall segmentation and thickness measurement for long-range optical coherence tomography images
      We present an automatic segmentation method for the delineation and quantitative thickness measurement of multiple layers in endoscopic airway optical coherence tomography (OCT) images. The boundaries of the mucosa and the sub-mucosa layers are accurately extracted using a graph-theory-based dynamic programming algorithm. The algorithm was tested with sheep airway OCT images. Quantitative thicknesses of the mucosal layers are obtained automatically for smoke inhalation injury experiments.
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    13. In vivo microvascular network imaging of the human retina combined with an automatic three-dimensional segmentation method

      In vivo microvascular network imaging of the human retina combined with an automatic three-dimensional segmentation method
      Microvascular network of the retina plays an important role in diagnosis and monitoring of various retinal diseases. We propose a three-dimensional (3-D) segmentation method with intensity-based Doppler variance (IBDV) based on swept-source optical coherence tomography. The automatic 3-D segmentation method is used to obtain seven surfaces of intraretinal layers. The microvascular network of the retina, which is acquired by the IBDV method, can be divided into six layers. The microvascular ...
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    14. Imaging and characterizing shear wave and shear modulus under orthogonal acoustic radiation force excitation using OCT Doppler variance method

      Imaging and characterizing shear wave and shear modulus under orthogonal acoustic radiation force excitation using OCT Doppler variance method
      We report on a novel acoustic radiation force orthogonal excitation optical coherence elastography (ARFOE-OCE) technique for imaging shear wave and quantifying shear modulus under orthogonal acoustic radiation force (ARF) excitation using the optical coherence tomography (OCT) Doppler variance method. The ARF perpendicular to the OCT beam is produced by a remote ultrasonic transducer. A shear wave induced by ARF excitation propagates parallel to the OCT beam. The OCT Doppler variance ...
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    15. 1-14 of 14
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  2. About Jiang Zhu

    Jiang Zhu

    Jiang Zhu received his Ph.D. degree in Tsinghua University, Beijing, China in 2009. Then as an assistant director of instruments technology department in CapitalBio Corporation, Beijing, he developed the commercial instrument for automatic and high-throughput gene diagnosis. The instrument has been successfully used for genetic hearing-loss mutation detection to prevent pharmacologic ototoxic deafness. He is currently a postdoctoral researcher in university of California, Irvine. He has pioneered in developing optical coherence angiography and optical coherence elastography for clinical practices.