1. Ji Yi

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    1. Mentioned In 33 Articles

    2. Fiber-based visible and near infrared optical coherence tomography (vnOCT) enables quantitative elastic light scattering spectroscopy in human retina

      Fiber-based visible and near infrared optical coherence tomography (vnOCT) enables quantitative elastic light scattering spectroscopy in human retina
      Elastic light scattering spectroscopy (ELSS) has been proven a powerful method in measuring tissue structures with exquisite nanoscale sensitivity. However, ELSS contrast in the living human retina has been relatively underexplored, primarily due to the lack of imaging tools with a large spectral bandwidth. Here, we report a simple all fiber-based setup to implement dual-channel visible and near infrared (NIR) optical coherence tomography (vnOCT) for human retinal imaging, bridging over ...
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    3. Measurement of Flow‐Mediated Dilation of Mouse Femoral Artery in vivo by Optical Coherence Tomography

      Measurement of Flow‐Mediated Dilation of Mouse Femoral Artery in vivo by Optical Coherence Tomography
      Flow‐mediated vasodilation (FMD) is used for assessment of vascular endothelial function in humans as a predictor of cardiovascular events. It has been challenging to carry it on preclinical murine models due to the diminutive size of the femoral artery. Here, we present a new approach to accurately measure the blood velocity and femoral artery diameters of mice by acquiring Doppler optical coherence tomography (DOCT) and optical coherence tomography angiography ...
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      Mentions: Ji Yi
    4. In vivo broadband visible light optical coherence tomography probe enables inverse spectroscopic analysis

      In vivo broadband visible light optical coherence tomography probe enables inverse spectroscopic analysis
      We report the design and characterization of a 6 mm outer diameter pull-back circumferential scanning visible optical coherence tomography probe. The probes large visible bandwidth (500695 nm) allowed for inverse spectroscopic analysis and an axial resolution of 1.1 m 1.1m in tissue. We verify spectral imaging capabilities by measuring microsphere backscattering spectra and demonstrate in vivo spatial nanoscale characterization of tissue.
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    5. Oblique scanning laser microscopy for simultaneously volumetric structural and molecular imaging using only one raster scan

      Oblique scanning laser microscopy for simultaneously volumetric structural and molecular imaging using only one raster scan
      Multi-modal three dimensional (3D) optical imaging combining both structural sensitivity and molecular specificity is highly desirable in biomedical research. In this paper, we present a method termed oblique scanning laser microscopy (OSLM) to combine optical coherence tomography (OCT), for simultaneously volumetric structural and molecular imaging with cellular resolution in all three dimensions. Conventional 3D laser scanning fluorescence microscopy requires repeated optical sectioning to create z-stacks in depth. Here, the use ...
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    6. Biological tissue analysis by inverse spectroscopic optical coherence tomography

      Biological tissue analysis by inverse spectroscopic optical coherence tomography
      A method and system to measure and image the full optical scattering properties by inverse spectroscopic optical coherence tomography (ISOCT) is disclosed. Tissue is modeled as a medium with continuous refractive index (RI) fluctuation and such a fluctuation is described by the RI correlation functions. By measuring optical quantities of tissue (including the scattering power of the OCT spectrum, the reflection albedo .alpha. defined as the ratio of scattering coefficient ...
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    7. Devices, methods, and systems of functional optical coherence tomography

      Devices, methods, and systems of functional optical coherence tomography
      The present disclosure provides systems and methods for the determining a rate of change of one or more analyte concentrations in a target using non invasive non contact imaging techniques such as OCT. Generally, OCT data is acquired and optical information is extracted from OCT scans to quantitatively determine both a flow rate of fluid in the target and a concentration of one or more analytes. Both calculations can provide ...
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    8. Feature Of The Week 10/16/2016: Real-time Functional Analysis of Inertial Microfluidic Devices via Spectral Domain Optical Coherence Tomography

      Feature Of The Week 10/16/2016: Real-time Functional Analysis of Inertial Microfluidic Devices via Spectral Domain Optical Coherence Tomography
      Inertial microfluidic devices have recently attracted considerable interest due to their unique capability of high-throughput filtration, separation, and sorting of particles and live cells in a continuous flow manner. However, the underlying mechanism is not fully understood yet, which is due to limited options for real-time three-dimensional (3D) tracking and analysis of particles and live cells in microfluidic channels. Although micro-particle image velocimetry using optical confocal microscopy can be used ...
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    9. Real-time Functional Analysis of Inertial Microfluidic Devices via Spectral Domain Optical Coherence Tomography

      Real-time Functional Analysis of Inertial Microfluidic Devices via Spectral Domain Optical Coherence Tomography
      We report the application of spectral-domain optical coherence tomography (SD-OCT) technology that enables real-time functional analysis of sorting microparticles and cells in an inertial microfluidic device. We demonstrated high-speed, high-resolution acquisition of cross-sectional images at a frame rate of 350Hz, with a lateral resolution of 3m and an axial resolution of 1m within the microfluidic channel filled with water. We analyzed the temporal sequence of cross-sectional SD-OCT images to determine ...
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    10. Detection of extracellular matrix modification in cancer models with inverse spectroscopic optical coherence tomography

      Detection of extracellular matrix modification in cancer models with inverse spectroscopic optical coherence tomography
      In cancer biology, there has been a recent effort to understand tumor formation in the context of the tissue microenvironment. In particular, recent progress has explored the mechanisms behind how changes in the cell-extracellular matrix ensemble influence progression of the disease. The extensive use of in vitro tissue culture models in simulant matrix has proven effective at studying such interactions, but modalities for non-invasively quantifying aspects of these systems are ...
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    11. Visible-Light Optical Coherence Tomography Angiography for Monitoring Laser-Induced Choroidal Neovascularization in Mice

      Visible-Light Optical Coherence Tomography Angiography for Monitoring Laser-Induced Choroidal Neovascularization in Mice
      Purpose : This study sought to determine the earliest time-point at which evidence of choroidal neovascularization (CNV) could be detected with visible-light optical coherence tomography angiography (vis-OCTA) in a mouse model of laser-induced CNV. Methods : Visible light-OCTA was used to study laser-induced CNV at different time-points after laser injury to monitor CNV development and measure CNV lesion size. Measurements obtained from vis-OCTA angiograms were compared with histopathologic measurements from isolectin-stained choroidal ...
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    12. Dual-band optical coherence tomography using a single supercontinuum laser source

      Dual-band optical coherence tomography using a single supercontinuum laser source
      We developed a simultaneous visible-light (Vis) and near-infrared (NIR) dual-band optical coherence tomography (OCT) system using a single supercontinuum laser source. The goal was to benchmark our newly developed Vis-OCT against the well-developed NIR-OCT. The Vis-OCT subsystem operated at 91 nm full-width-at-half-maximum (FWHM) bandwidth centered at 566 nm; the NIR-OCT subsystem operated at 93 nm FWHM bandwidth centered at 841 nm. The axial resolutions were 1.8 and 4.4 ...
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    13. Devices, Methods, And Systems Of Functional Optical Coherence Tomography

      Devices, Methods, And Systems Of Functional Optical Coherence Tomography
      The present disclosure provides systems and methods for the determining a rate of change of one or more analyte concentrations in a target using non invasive non contact imaging techniques such as OCT. Generally, OCT data is acquired and optical information is extracted from OCT scans to quantitatively determine both a flow rate of fluid in the target and a concentration of one or more analytes. Both calculations can provide ...
      Read Full Article
    14. Postdoctoral positions open at Boston University School of Medicine

      Postdoctoral positions open at Boston University School of Medicine
      The research is to design, manufacture optical devises, develop novel optical theory and methods for biomedical and clinical applications. The desired experience or interest includes but not limited: light scattering theory, light-tissue interaction, optics design and instrumentation, precision instrumentation, electronics design, programming, fiber optics and endoscopy. Candidate should have PhD degree in physics, optical engineering, biomedical engineering, electronic engineering, mechanical engineering or equivalent training background. Please directly contact PI at ...
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    15. Visible light optical coherence tomography measures retinal oxygen metabolic response to systemic oxygenation

      Visible light optical coherence tomography measures retinal oxygen metabolic response to systemic oxygenation
      The lack of capability to quantify oxygen metabolism noninvasively impedes both fundamental investigation and clinical diagnosis of a wide spectrum of diseases including all the major blinding diseases such as age-related macular degeneration, diabetic retinopathy, and glaucoma. Using visible light optical coherence tomography (vis-OCT), we demonstrated accurate and robust measurement of retinal oxygen metabolic rate (rMRO 2 ) noninvasively in rat eyes. We continuously monitored the regulatory response of oxygen consumption ...
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  2. About Ji Yi

    Ji Yi

    Ji Yi is an assistant professor in Boston University, School of Medicine.  His work focuses on novel optical techniques for early disease detection, and monitoring disease progression and prognosis.  He developed various imaging methods that enable non-invasive detection of nanoscale structural alterations in tissue and the local tissue oxygen metabolism. By applying those techniques, he demonstrated the detection of the earliest form of colorectal and pancreatic cancers, colonization of metastatic breast cancer cells, and retinal diseases. He also studied the nanoscale structural changes in both cellular and extracellular components in field carcinogenesis.  See more at www.yilab.org