1. Jennifer K. Barton

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    1. Mentioned In 73 Articles

    2. Expanding Functionality of Commercial Optical Coherence Tomography Systems by Integrating a Custom Endoscope

      Expanding Functionality of Commercial Optical Coherence Tomography Systems by Integrating a Custom Endoscope
      Optical coherence tomography (OCT) is a useful imaging modality for detecting and monitoring diseases of the gastrointestinal tract and other tubular structures. The non-destructiveness of OCT enables time-serial studies in animal models. While turnkey commercial research OCT systems are plenty, researchers often require custom imaging probes. We describe the integration of a custom endoscope with a commercial swept-source OCT system and generalize this description to any imaging probe and OCT ...
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    3. In vivo molecular imaging of colorectal cancer using quantum dots targeted to vascular endothelial growth factor receptor 2 and optical coherence tomography/laser-induced fluorescence dual-modality imaging

      In vivo molecular imaging of colorectal cancer using quantum dots targeted to vascular endothelial growth factor receptor 2 and optical coherence tomography/laser-induced fluorescence dual-modality imaging
      Optical coherence tomography/laser induced fluorescence (OCT/LIF) dual-modality imaging allows for minimally invasive, nondestructive endoscopic visualization of colorectal cancer in mice. This technology enables simultaneous longitudinal tracking of morphological (OCT) and biochemical (fluorescence) changes as colorectal cancer develops, compared to current methods of colorectal cancer screening in humans that rely on morphological changes alone. We have shown that QDot655 targeted to vascular endothelial growth factor receptor 2 (QD655-VEGFR2) can ...
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    4. Time-serial Assessment of Drug Combination Interventions in a Mouse Model of Colorectal Carcinogenesis Using Optical Coherence Tomography

      Time-serial Assessment of Drug Combination Interventions in a Mouse Model of Colorectal Carcinogenesis Using Optical Coherence Tomography
      Optical coherence tomography (OCT) is a high-resolution, nondestructive imaging modality that enables time-serial assessment of adenoma development in the mouse model of colorectal cancer. In this study, OCT was utilized to evaluate the effectiveness of interventions with the experimental antitumor agent -difluoromethylornithine (DFMO) and a nonsteroidal anti-inflammatory drug sulindac during early [chemoprevention (CP)] and late stages [chemotherapy (CT)] of colon tumorigenesis. Biological endpoints for drug interventions included OCT-generated tumor number ...
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    5. The University of Arizona Receives NIH Grant for Validating a Mouse Model of Ovarian Cancer for Early Detection Through Imaging

      The University of Arizona Receives NIH Grant for Validating a Mouse Model of Ovarian Cancer for Early Detection Through Imaging
      ... Validating a Mouse Model of Ovarian Cancer for Early Detection Through Imaging. The principal invetigator is Jennifer Barton. The program began in 2015 and ends in 2017. Below is a summary of the proposed work.

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    6. Optical design of an optical coherence tomography and multispectral fluorescence imaging endoscope to detect early stage ovarian cancer

      Optical design of an optical coherence tomography and multispectral fluorescence imaging endoscope to detect early stage ovarian cancer
      ...o detect early stage ovarian cancer Tyler Tate ; Molly Keenan ; Elizabeth Swan ; John Black ; Urs Utzinger ; Jennifer Barton; Optical design of an optical coherence tomography and multispectral fluorescence imaging endo...
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    7. In vivo molecular mapping of the tumor microenvironment in an azoxymethane-treated mouse model of colon carcinogenesis

      In vivo molecular mapping of the tumor microenvironment in an azoxymethane-treated mouse model of colon carcinogenesis
      ...ormation 1. Department of Biomedical Engineering, University of Arizona, Tucson, AZ ^* Correspondence to: Jennifer Kehlet Barton, P. O. Box 210066, Tucson, AZ 85721. Email: barton@email.arizona.edu Publication Hist...
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    8. Using Optical Coherence Tomography to Examine Additives in Chinese Song Jun Glaze

      Using Optical Coherence Tomography to Examine Additives in Chinese Song Jun Glaze
      We use optical coherence tomography (OCT) to acquire microstructure images of Chinese Song Jun glaze to reveal the copper and quartz additives used and, in two typical samples, we show that the amount added is considerable. Focusing on these two additives, including the species, amount and granule (particle) size added in the glaze, the objective of the present study is to explore how they functioned in relation to the Jun ...
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    9. Diagnostic potential of multimodal imaging of ovarian tissue using optical coherence tomography and second-harmonic generation microscopy

      Diagnostic potential of multimodal imaging of ovarian tissue using optical coherence tomography and second-harmonic generation microscopy
      Ovarian cancer is particularly deadly because it is usually diagnosed after it has metastasized. We have previously identified features of ovarian cancer using optical coherence tomography (OCT) and second-harmonic generation (SHG) microscopy (targeting collagen). OCT provides an image of the ovarian microstructure, while SHG provides a high-resolution map of collagen fiber bundle arrangement. Here, we investigated the diagnostic potential of dual-modality OCT and SHG imaging. We conducted a fully crossed ...
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    10. In vivo time-serial multi-modality optical imaging in a mouse model of ovarian tumorigenesis

      In vivo time-serial multi-modality optical imaging in a mouse model of ovarian tumorigenesis
      Identification of the early microscopic changes associated with ovarian cancer may lead to development of a diagnostic test for high-risk women. In this study we use optical coherence tomography (OCT) and multiphoton microscopy (MPM) (collecting both two photon excited fluorescence [TPEF] and second harmonic generation [SHG]) to image mouse ovaries in vivo at multiple time points. We demonstrate the feasibility of imaging mouse ovaries in vivo during a long-term survival ...
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    11. University of Arizona Receives NIH Grant for Dual Modality System for Imaging Colon Cancer in Mice

      University of Arizona Receives NIH Grant for Dual Modality System for Imaging Colon Cancer in Mice
      ... grant for $285,247 for Dual Modality System for Imaging Colon Cancer in Mice. The principal investigator was Jennifer Barton. The program began in 2004 and ends in 2014. Below is a summary of the work.

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    12. In vivo three-dimensional optical coherence tomography and multiphoton microscopy in a mouse model of ovarian neoplasia

      In vivo three-dimensional optical coherence tomography and multiphoton microscopy in a mouse model of ovarian neoplasia
      ...muel L. Marion ; Photini Faith Rice ; David L. Bentley ; David Besselsen ; Urs Utzinger ; Patricia B. Hoyer ; Jennifer K. Barton; In vivo three-dimensional optical coherence tomography and multiphoton microscopy in a mou...
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    13. Spiral-scanning, side-viewing optical coherence tomography endoscope for three-dimensional fully sampled in vivo imaging of the mouse colon

      Spiral-scanning, side-viewing optical coherence tomography endoscope for three-dimensional fully sampled in vivo imaging of the mouse colon
      ...tomography endoscope for three-dimensional fully sampled in vivo imaging of the mouse colon Weston A. Welge ; Jennifer K. Barton; Spiral-scanning, side-viewing optical coherence tomography endoscope for three-dimensional...
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    14. University of Arizona receives NIH Grant for Developing a Dual Modality System for Imaging Colon Cancer in Mice

      University of Arizona receives NIH Grant for Developing a Dual Modality System for Imaging Colon Cancer in Mice
      ...Mice. The program is a multi-year program and started in 2004 and ends in 2014. The principle investigator is Jennifer Barton. A brief description of the project is given below. Mouse models of colon cancer are a critic...
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    15. Using optical coherence tomography to characterize thick-glaze structure: Chinese Southern Song Guan glaze case study

      Using optical coherence tomography to characterize thick-glaze structure: Chinese Southern Song Guan glaze case study
      This study explores the structure characteristics of thick glaze, in terms of the case study of Chinese Southern Song Guan (SSG) ware, focusing on the bubble and its media structure, using a novel focus-tracking optical coherence tomography (OCT) system. The OCT images we obtained not only unveil the structural uniqueness of the thick-glaze SSG sample, but also establish a distinguishable structural pattern for aiding authentication. In addition, information revealed in ...
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    16. 16-30 of 73 « 1 2 3 4 5 »
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  2. About Jennifer K. Barton

    Jennifer K. Barton

    Jennifer K. Barton is Associate Professor, Director, and Chair of  Biomedical  Engineering at the University of Arizona. She also holds appointments in Electrical and Computer Engineering and Optical Sciences  She is also the Director of Tissue Optics Laboratory at University of Arizona.  The Tissue Optics Laboratory is an interdisciplinary effort located at the University of Arizona in the Keating Biosciences Building of the BIO5 Institute.

  3. Quotes

    1. This gives us a very controlled way of looking at ovarian cancer.
      In UA engineers zero in on early detection of ovarian cancer
    2. Our goal is to identify biomarkers at the earliest possible stage of ovarian cancer to build a viable optical imaging technology that will enable early detection and save lives.
      In UA engineers zero in on early detection of ovarian cancer
    3. OCT can be used for a variety of organs, but ovarian cancer caught my attention because it is such a devastating disease...It is a challenge because the ovaries are inside the body and there is no screening technique that works well and most women don’t have any symptoms until it is very advanced...So if we want to look at them with OCT you would have to get right up against the ovary. That won’t work in the general population, but there is a group of women who have high risk of ovarian cancer doctors often recommend removing them. Now that might not be a difficult decision to make in your 60s but that is a terrible decision to have to make in your 20s. Our idea is that if we could tell with certainty the ovaries were normal then that woman could keep her ovaries and just be screened every couple of years.
      In Jennifer Barton is one women who wears many hats at University of Arizona