1. Jennifer K. Barton

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    1. Mentioned In 72 Articles

    2. Evaluation of segmentation algorithms for optical coherence tomography images of ovarian tissue

      Evaluation of segmentation algorithms for optical coherence tomography images of ovarian tissue
      Ovarian cancer has the lowest survival rate among all gynecologic cancers predominantly due to late diagnosis. Early detection of ovarian cancer can increase 5-year survival rates from 40% up to 92%, yet no reliable early detection techniques exist. Optical coherence tomography (OCT) is an emerging technique that provides depth-resolved, high-resolution images of biological tissue in real-time and demonstrates great potential for imaging of ovarian tissue. Mouse models are crucial to ...
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    3. Three-dimensional texture analysis of optical coherence tomography images of ovarian tissue

      Three-dimensional texture analysis of optical coherence tomography images of ovarian tissue
      Ovarian cancer has the lowest survival rate among all gynecologic cancers due to predominantly late diagnosis. Optical Coherence Tomography (OCT) has been applied successfully to experimentally image the ovaries in vivo; however, a robust method for analysis is still required to provide quantitative diagnostic information. Recently, texture analysis has proved to be a useful tool for tissue characterization; unfortunately, existing work in the scope of OCT ovarian imaging is limited ...
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    4. Evaluation of segmentation algorithms for optical coherence tomography images of ovarian tissue

      Evaluation of segmentation algorithms for optical coherence tomography images of ovarian tissue
      Ovarian cancer has the lowest survival rate among all gynecologic cancers due to predominantly late diagnosis. Early detection of ovarian cancer can increase 5-year survival rates from 40% up to 92%, yet no reliable early detection techniques exist. Optical coherence tomography (OCT) is an emerging technique that provides depthresolved, high-resolution images of biological tissue in real time and demonstrates great potential for imaging of ovarian tissue. Mouse models are crucial ...
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    5. University of Arizona Receives NIH Grant for Advanced Salpingoscope for Minimally-Invasive Imaging of the Fallopian Tubes

      University of Arizona Receives NIH Grant for Advanced Salpingoscope for Minimally-Invasive Imaging of the Fallopian Tubes
      ...nced Salpingoscope for Minimally-Invasive Imaging of the Fallopian Tubes.  The principal investigator is Jennifer Barton.  The program began in 2016 and ends in 2020.  Below is a summary of the proposed wo...
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    6. Single lens system for forward-viewing navigation and scanning side-viewing optical coherence tomography

      Single lens system for forward-viewing navigation and scanning side-viewing optical coherence tomography
      The optical design for a dual modality endoscope based on piezo scanning fiber technology is presented including a novel technique to combine forward-viewing navigation and side viewing OCT. Potential applications include navigating body lumens such as the fallopian tube, biliary ducts and cardiovascular system. A custom cover plate provides a rotationally symmetric double reflection of the OCT beam to deviate and focus the OCT beam out the side of the ...
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    7. In vivo endoscopic Doppler optical coherence tomography imaging of the colon

      In vivo endoscopic Doppler optical coherence tomography imaging of the colon
      Background and Objective Colorectal cancer (CRC) remains the second deadliest cancer in the United States. Several screening methods exist; however, detection of small polyps remains a challenge. Optical coherence tomography (OCT) has been demonstrated to be capable of detecting lesions as small as 1mm in the mouse colon, but detection is based on measuring a doubling of the mucosa thickness. The colon microvasculature may be an attractive biomarker of early ...
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    8. Optical coherence tomography imaging of colonic crypts in a mouse model of colorectal cancer

      Optical coherence tomography imaging of colonic crypts in a mouse model of colorectal cancer
      Aberrant crypt foci (ACF) are abnormal epithelial lesions that precede development of colonic polyps. As the earliest morphological change in the development of colorectal cancer, ACF is a highly studied phenomenon. The most common method of imaging ACF is chromoendoscopy using methylene blue as a contrast agent. Narrow- band imaging is a contrast-agent-free modality for imaging the colonic crypts. Optical coherence tomography (OCT) is an attractive alternative to chromoendoscopy and ...
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    9. In vivo endoscopic Doppler optical coherence tomography imaging of mouse colon

      In vivo endoscopic Doppler optical coherence tomography imaging of mouse colon
      Colorectal cancer remains the second deadliest cancer in the United States, despite the high sensitivity and specificity of colonoscopy and sigmoidoscopy. While these standard imaging procedures can accurately detect medium and large polyps, some studies have shown miss rates up to 25% for polyps less than 5 mm in diameter. An imaging modality capable of detecting small lesions could potentially improve patient outcomes. Optical coherence tomography (OCT) has been shown ...
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    10. Imaging colon cancer development in mice: IL-6 deficiency prevents adenoma in azoxymethane-treated Smad3 knockouts

      Imaging colon cancer development in mice: IL-6 deficiency prevents adenoma in azoxymethane-treated Smad3 knockouts
      The development of colorectal cancer in the azoxymethane-induced mouse model can be observed by using a miniaturized optical coherence tomography (OCT) imaging system. This system is uniquely capable of tracking disease development over time, allowing for the monitoring of morphological changes in the distal colon due to tumor development and the presence of lymphoid aggregates. By using genetically engineered mouse models deficient in Interleukin 6 (IL-6) and Smad family member ...
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    11. Expanding Functionality of Commercial Optical Coherence Tomography Systems by Integrating a Custom Endoscope

      Expanding Functionality of Commercial Optical Coherence Tomography Systems by Integrating a Custom Endoscope
      Optical coherence tomography (OCT) is a useful imaging modality for detecting and monitoring diseases of the gastrointestinal tract and other tubular structures. The non-destructiveness of OCT enables time-serial studies in animal models. While turnkey commercial research OCT systems are plenty, researchers often require custom imaging probes. We describe the integration of a custom endoscope with a commercial swept-source OCT system and generalize this description to any imaging probe and OCT ...
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  2. About Jennifer K. Barton

    Jennifer K. Barton

    Jennifer K. Barton is Associate Professor, Director, and Chair of  Biomedical  Engineering at the University of Arizona. She also holds appointments in Electrical and Computer Engineering and Optical Sciences  She is also the Director of Tissue Optics Laboratory at University of Arizona.  The Tissue Optics Laboratory is an interdisciplinary effort located at the University of Arizona in the Keating Biosciences Building of the BIO5 Institute.

  3. Quotes

    1. This gives us a very controlled way of looking at ovarian cancer.
      In UA engineers zero in on early detection of ovarian cancer
    2. Our goal is to identify biomarkers at the earliest possible stage of ovarian cancer to build a viable optical imaging technology that will enable early detection and save lives.
      In UA engineers zero in on early detection of ovarian cancer
    3. OCT can be used for a variety of organs, but ovarian cancer caught my attention because it is such a devastating disease...It is a challenge because the ovaries are inside the body and there is no screening technique that works well and most women don’t have any symptoms until it is very advanced...So if we want to look at them with OCT you would have to get right up against the ovary. That won’t work in the general population, but there is a group of women who have high risk of ovarian cancer doctors often recommend removing them. Now that might not be a difficult decision to make in your 60s but that is a terrible decision to have to make in your 20s. Our idea is that if we could tell with certainty the ovaries were normal then that woman could keep her ovaries and just be screened every couple of years.
      In Jennifer Barton is one women who wears many hats at University of Arizona