1. Jay S. Duker

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    1. Mentioned In 206 Articles

    2. Optical coherence tomography angiography distortion correction in widefield montage images

      Optical coherence tomography angiography distortion correction in widefield montage images
      Background: Optical coherence tomography (OCT) imaging is inherently susceptible to distortion artifacts due to the natural curvature of the eye. This study proposes a novel model for widefield OCT angiography (OCTA) distortion correction and analyzes the effects of this correction on quantification metrics. Methods: Widefield OCTA images were obtained on normal subjects at five fixation spatial positions. Radial and field distortion correction were applied and images stitched together to form ...
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    3. OCT-OCTA segmentation: combining structural and blood flow information to segment Bruch's membrane

      OCT-OCTA segmentation: combining structural and blood flow information to segment Bruch's membrane
      In this paper we present a fully automated graph-based segmentation algorithm that jointly uses optical coherence tomography (OCT) and OCT angiography (OCTA) data to segment Bruch's membrane (BM). This is especially valuable in cases where the spatial correlation between BM, which is usually not visible on OCT scans, and the retinal pigment epithelium (RPE), which is often used as a surrogate for segmenting BM, is distorted by pathology. We ...
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    4. Retinal hemangioblastoma vascular detail elucidated on swept source optical coherence tomography angiography

      Retinal hemangioblastoma vascular detail elucidated on swept source optical coherence tomography angiography
      Purpose To report the distinct vascular pattern of a treatment-nave retinal hemangioblastoma imaged on swept source optical coherence tomography angiography (SS-OCTA). Observations A 33-year-old female with a history of Von Hippel-Lindau disease presented for follow-up of bilateral retinal hemangioblastomas. Ultra-widefield fundus photography of the left eye revealed a small, juxtapapillary lesion. SS-OCTA imaging centered at the lesion identified two distinct vascular foci. Centrally, the lesion was composed of a dense ...
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    5. Swept Source Optical Coherence Tomography Angiography in Small Choroidal Melanomas and Choroidal Nevi

      Swept Source Optical Coherence Tomography Angiography in Small Choroidal Melanomas and Choroidal Nevi
      Purpose: To evaluate the use of swept source optical coherence tomography angiography (SS-OCTA) to detect distinct vascular features in small choroidal melanomas and choroidal nevi. Methods: Patients with a choroidal nevus or a treatment-nave choroidal melanoma were imaged with color fundus photography, ultrasound and SS-OCTA (12x12mm). High-risk features including overlying fluid, orange pigment, shaggy photoreceptors, acoustic hollowness, depth 2mm, and basal diameter 5mm were assessed. OCTA vascular markers included: choroidal ...
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    6. Efficient and high accuracy 3-D OCT angiography motion correction in pathology

      Efficient and high accuracy 3-D OCT angiography motion correction in pathology
      We describe a novel method for non-rigid 3-D motion correction of orthogonally raster-scanned optical coherence tomography angiography volumes. This is the first approach that aligns predominantly axial structural features such as retinal layers as well as transverse angiographic vascular features in a joint optimization. Combined with orthogonal scanning and favorization of kinematically more plausible displacements, subpixel alignment and micrometer-scale distortion correction is achieved in all 3 dimensions. As no specific ...
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    7. A practical guide to optical coherence tomography angiography interpretation

      A practical guide to optical coherence tomography angiography interpretation
      Background Optical coherence tomography angiography (OCTA) can image the retinal vasculature in vivo, without the need for contrast dye. This technology has been commercially available since 2014, however, much of its use has been limited to the research setting. Over time, more clinical practices have adopted OCTA imaging. While countless publications detail OCTAs use for the study of retinal microvasculature, few studies outline OCTAs clinical utility. Body This review provides ...
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    8. Anterior-segment spectral domain optical coherence tomography in epidermolysis bullosa

      Anterior-segment spectral domain optical coherence tomography in epidermolysis bullosa
      Purpose Assess epidermolysis bullosa (EB)-related corneal pathology using anterior segment optical coherence tomography (AS-OCT) and correlate imaging with clinical metrics in EB patients versus age-matched controls. Methods EB patients and controls were recruited during an EB conference (July 2018) and at Tufts Medical Center (JuneAugust 2019). Subjects completed a questionnaire, had best corrected visual acuity (BCVA) tested, and underwent AS-OCT scanning. Stromal and epithelial thickness were measured. Depth, length ...
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    9. Repeatability of binarization thresholding methods for optical coherence tomography angiography image quantification

      Repeatability of binarization thresholding methods for optical coherence tomography angiography image quantification
      Binarization is a critical step in analysis of retinal optical coherence tomography angiography (OCTA) images, but the repeatability of metrics produced from various binarization methods has not been fully assessed. This study set out to examine the repeatability of OCTA quantification metrics produced using different binarization thresholding methods, all of which have been applied in previous studies, across multiple devices and plexuses. Successive 33 mm foveal OCTA images of 13 ...
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    10. Using the Pathophysiology of Dry AMD to Guide Binarization of the Choriocapillaris on OCTA: A Model

      Using the Pathophysiology of Dry AMD to Guide Binarization of the Choriocapillaris on OCTA: A Model
      Especially since the incorporation of swept laser sources, optical coherence tomography angiography (OCTA) has enabled quantification of choriocapillaris perfusion. A critical step in this process is binarization, which makes angiographic images quantifiable in terms of perfusion metrics. It remains challenging to have confidence that choriocapillaris perfusion metrics reflect the reality of pathophysiologic flow, largely because choice of binarization method can result in significantly different perfusion metric outcomes. This commentary discusses ...
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    11. The long-term effects of anti-vascular endothelial growth factor therapy on the optical coherence tomography angiographic appearance of neovascularization in age-related macular degeneration

      The long-term effects of anti-vascular endothelial growth factor therapy on the optical coherence tomography angiographic appearance of neovascularization in age-related macular degeneration
      Background The short-term effects of anti-vascular endothelial growth factor (anti-VEGF) treatment on macular neovascularization (MNV) morphology is well described, but long-term studies on morphologic changes and correlation of such changes to the type of MNV have not been conducted. This study aims to determine if different types of MNVs in neovascular AMD (nAMD) behave differently with anti-VEGF treatment as visualized on optical coherence tomography angiography (OCTA). Methods Treatment-nave nAMD patients ...
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    12. Model-to-Data Approach for Deep Learning in Optical Coherence Tomography Intraretinal Fluid Segmentation

      Model-to-Data Approach for Deep Learning in Optical Coherence Tomography Intraretinal Fluid Segmentation
      Importance Amid an explosion of interest in deep learning in medicine, including within ophthalmology, concerns regarding data privacy, security, and sharing are of increasing importance. A model-to-data approach, in which the model itself is transferred rather than data, can circumvent many of these challenges but has not been previously demonstrated in ophthalmology. Objective To determine whether a model-to-data deep learning approach (ie, validation of the algorithm without any data transfer ...
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    13. Ultrahigh Resolution Spectral Domain Optical Coherence Tomography for the Assessment of Micro-Structural Changes in Central Serous Chorioretinopathy: A Pilot Study.

      Ultrahigh Resolution Spectral Domain Optical Coherence Tomography for the Assessment of Micro-Structural Changes in Central Serous Chorioretinopathy: A Pilot Study.
      Purpose : In central serous chorioretinopathy (CSCR), choroidal hyperpermeability associated with retinal pigment epithelium (RPE) impairment causes a leakage of fluid from the choroid into the subretinal space, with potential damage to the photoreceptors. We hypothesize that ultrahigh-resolution spectral domain optical coherence tomography (UHR SD-OCT) will enable more detailed assessment of structural changes in this condition. Methods : Patients in all stages of CSCR (acute, chronic and post-resolution) were imaged using an ...
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    14. Evaluating the long-term effects of anti-vascular endothelial growth factor therapy on choroidal neovascularization in age-related macular degeneration using optical coherence tomography angiography

      Evaluating the long-term effects of anti-vascular endothelial growth factor therapy on choroidal neovascularization in age-related macular degeneration using optical coherence tomography angiography
      Purpose : Optical coherence tomography angiography (OCTA) allows for precise, non-invasive monitoring of changes to choroidal neovascularization (CNV) structure over time. The short-term effects of anti-vascular endothelial growth factor (anti-VEGF) treatment on CNV morphology is well described, but long-term studies on morphologic changes and correlation of such to the type of CNV have not been conducted. This study aims to determine if different types of CNVs in neovascular AMD (nAMD) behave ...
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    15. Bringing Deep Learning Models to the Data: An Application in Recognizing Intra-Retinal Fluid on Optical Coherence Tomography (OCT) Images

      Bringing Deep Learning Models to the Data: An Application in Recognizing Intra-Retinal Fluid on Optical Coherence Tomography (OCT) Images
      Purpose : Amidst intense interest in deep learning in medicine, concerns regarding data privacy, security, and sharing are of increasing importance. A model-to-data approach, in which the model itself is transferred rather than data, can circumvent many of these challenges, but has not been previously tested in ophthalmology. The objective of our study was to determine whether a model-to-data deep learning approach (i.e. validation of the algorithm without any data ...
      Read Full Article
    16. Analyzing Relative Flow Speeds in Diabetic Retinopathy Using Variable Interscan Time Analysis Optical Coherence Tomography Angiography

      Analyzing Relative Flow Speeds in Diabetic Retinopathy Using Variable Interscan Time Analysis Optical Coherence Tomography Angiography
      Objective Further insight into the flow characteristics of the vascular features associated with diabetic retinopathy (DR) may improve assessment and treatment of disease progression. The variable interscan time analysis (VISTA) algorithm is an extension of optical coherence tomography angiography (OCTA) that detects relative blood flow speeds which can then be depicted on a color-coded map. This study utilized VISTA to analyze relative blood flow speeds in the microvascular changes associated ...
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  2. About Jay S. Duker

    Jay S. Duker

    Jay S. Duker is an Ophthalmologist and Director of the New England Eye Center at Tufts University School of Medicine.  Dr. Duker specializes in both medical and surgical diseases of the posterior segment. His primary surgical interests include retinal detachment, proliferative vitreoretinopathy, proliferative diabetic retinopathy, retinopathy of prematurity, and posterior segment trauma. He is also available for consultation in posterior segment uveitis, AIDS-related retinitis, intraocular tumors, and retinal vascular disorders.

  3. Quotes

    1. The deeper you go with spectral domain imaging, there is more noise. That doesn't happen with swept source...They are significantly more expensive than spectral domain..."Commercial pressure” is another reason for the lack of uptake, in that, for companies that already successfully manufacture and sell OCT machines, retooling for the new technology could “cannibalize” the existing business.
      In Cost inhibits adoption of SS-OCT
    2. Incorporation of OCT structural imaging onto ICG angiography provides an anatomic frame of reference for late (ICG) leaks and reveals the flow characteristics of specific anatomic features.
      In Combined imaging techniques aid identification of occult retinal disease
    3. I think measuring the hole is very helpful to determine your success rate, and smaller holes close better than bigger holes.
      In OCT useful for measuring macular holes before closure surgery