1. Jay S. Duker

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    1. Mentioned In 183 Articles

    2. Controlling for Artifacts in Widefield Optical Coherence Tomography Angiography Measurements of Non-Perfusion Area

      Explore Nature Publishing Group Ophthalmology
      Controlling for Artifacts in Widefield Optical Coherence Tomography Angiography Measurements of Non-Perfusion Area
      The recent clinical adoption of optical coherence tomography (OCT) angiography (OCTA) has enabled non-invasive, volumetric visualization of ocular vasculature at micron-scale resolutions. Initially limited to 3mm3mm and 6mm6mm fields-of-view (FOV), commercial OCTA systems now offer 12mm12mm, or larger, imaging fields. While larger FOVs promise a more complete visualization of retinal disease, they also introduce new challenges to the accurate and reliable interpretation of OCTA data. In particular, because of vignetting ...
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      Mentions: Massachusetts Institute of Technology James G. Fujimoto Andre J. Witkin

    3. Impact of Binarization Thresholding and Brightness/Contrast Adjustment Methodology on Optical Coherence Tomography Angiography Image Quantification

      Explore American Journal of Ophthalmology Ophthalmology
      Impact of Binarization Thresholding and Brightness/Contrast Adjustment Methodology on Optical Coherence Tomography Angiography Image Quantification
      Purpose Binarization is a critical technique in OCTA image analysis, but there is no consistency in the method used in published OCTA studies. This study assessed whether differences in OCTA binarization and brightness/contrast adjustments affect quantification metrics. Design Prospective cross-sectional validity study Methods This was a single-center study examining 21 eyes of 11 healthy individuals. All eyes were imaged using the Carl Zeiss PLEX Elite 9000 swept source-OCTA, and ...
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      Mentions: Jay S. Duker Tufts University Nadia K. Waheed

    4. Early hydroxychloroquine retinopathy: optical coherence tomography abnormalities preceding Humphrey visual field defects

      Explore BJO Online Ophthalmology
      Early hydroxychloroquine retinopathy: optical coherence tomography abnormalities preceding Humphrey visual field defects
      Background/Aims Hydroxychloroquine (HCQ) retinopathy may result in severe and irreversible vision loss, emphasising the importance of screening and early detection. The purpose of this study is to report the novel finding of early optical coherence tomography (OCT) abnormalities due to HCQ toxicity that may develop in the setting of normal Humphrey visual field (HVF) testing. Methods Data from patients with chronic HCQ exposure was obtained from seven tertiary care ...
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      Mentions: Case Western Reserve University Jay S. Duker LuEsther T. Mertz Retinal Research Center

    6. QUANTIFICATION OF RETINAL CAPILLARY NONPERFUSION IN DIABETICS USING WIDE-FIELD OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY

      Explore LWW Online Ophthalmology
      QUANTIFICATION OF RETINAL CAPILLARY NONPERFUSION IN DIABETICS USING WIDE-FIELD OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY
      Purpose: To combine advances in high-speed, wide-field optical coherence tomography angiography ( OCTA ) with image processing methods for semiautomatic quantitative analysis of capillary nonperfusion in patients with diabetic retinopathy (DR). Methods: Sixty-eight diabetic patients (73 eyes), either without retinopathy or with different degrees of retinopathy, were prospectively recruited for volumetric swept-source OCTA imaging using 12 mm 12 mm fields centered at the fovea. A custom, semiautomatic software algorithm was used to ...
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      Mentions: Massachusetts Institute of Technology James G. Fujimoto Andre J. Witkin

    8. VISUALIZATION OF CHOROIDAL NEOVASCULARIZATION USING TWO COMMERCIALLY AVAILABLE SPECTRAL DOMAIN OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY DEVICES

      Explore LWW Online Ophthalmology
      VISUALIZATION OF CHOROIDAL NEOVASCULARIZATION USING TWO COMMERCIALLY AVAILABLE SPECTRAL DOMAIN OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY DEVICES
      Purpose: To compare the sensitivity of detection and the measured size of choroidal neovascularization ( CNV ) on two commercially available spectral domain optical coherence tomography angiography ( OCTA ) devices, the Optovue RTVue XR Avanti with AngioVue and the Zeiss Cirrus HD-OCT with AngioPlex. Methods: Patients with CNV lesions were imaged consecutively on both OCTA devices on the same day of their visit. 3 3 mm and 6 6 mm scans centered at ...
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      Mentions: Optovue Andre J. Witkin Jay S. Duker

    9. Microscope-Integrated Intraoperative Ultrahigh-Speed Swept-Source Optical Coherence Tomography for Widefield Retinal and Anterior Segment Imaging

      Explore Healio.com Ophthalmology
      Microscope-Integrated Intraoperative Ultrahigh-Speed Swept-Source Optical Coherence Tomography for Widefield Retinal and Anterior Segment Imaging
      BACKGROUND AND OBJECTIVE: To demonstrate the feasibility of retinal and anterior segment intraoperative widefield imaging using an ultrahigh-speed, swept-source optical coherence tomography (SS-OCT) surgical microscope attachment. PATIENTS AND METHODS: A prototype post-objective SS-OCT using a 1,050-nm wavelength, 400 kHz A-scan rate, vertical cavity surface-emitting laser (VCSEL) light source was integrated to a commercial ophthalmic surgical microscope after the objective. Each widefield OCT data set was acquired in 3 seconds ...
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      Mentions: Massachusetts Institute of Technology James G. Fujimoto Thorlabs

    10. OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY TO DETECT MACULAR CAPILLARY ISCHEMIA IN PATIENTS WITH INNER RETINAL CHANGES AFTER RESOLVED DIABETIC MACULAR EDEMA

      Explore LWW Online Ophthalmology
      OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY TO DETECT MACULAR CAPILLARY ISCHEMIA IN PATIENTS WITH INNER RETINAL CHANGES AFTER RESOLVED DIABETIC MACULAR EDEMA
      To compare foveal vascular anatomy between patients with and without disorganization of retinal inner layers (DRILs) after resolved diabetic macular edema using optical coherence tomography angiography (OCTA). Methods: Twenty-four eyes of 21 age- and sex-matched patients with resolved diabetic macular edema were included in this retrospective, cross-sectional study. All eyes were imaged with enhanced high-definition line or cross-line structural B scans and 3 3-mm OCTA scans. Optical coherence tomography B ...
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      Mentions: Andre J. Witkin Jay S. Duker Tufts University

    11. Polypoidal Choroidal Vasculopathy on Swept-Source Optical Coherence Tomography Angiography with Variable Interscan Time Analysis

      Explore TVST Journal Ophthalmology
      Polypoidal Choroidal Vasculopathy on Swept-Source Optical Coherence Tomography Angiography with Variable Interscan Time Analysis
      Purpose : To use a novel optical coherence tomography angiography (OCTA) algorithm termed variable interscan time analysis (VISTA) to evaluate relative blood flow speeds in polypoidal choroidal vasculopathy (PCV). Methods : Prospective cross-sectional study enrolling patients with confirmed diagnosis of PCV. OCTA of the retina and choroid was obtained with a prototype swept-source OCT system. The acquired OCT volumes were centered on the branching vascular network (BVN) and polyps as determined by ...
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      Mentions: Universidade Federal de São Paulo Massachusetts Institute of Technology James G. Fujimoto

    12. Image Averaging, a Powerful Tool in Optical Coherence Tomography and OCT Angiography

      Explore The JAMA Network Ophthalmology
      Image Averaging, a Powerful Tool in Optical Coherence Tomography and OCT Angiography
      In an elegantly conducted study, Uji et al 1 describe the association of averaging multiple en face images with the quality of the optical coherence tomography angiography (OCTA) images of the choroidal microvasculature. They demonstrate that the resulting vascular images approximate much more closely the structure of the choriocapillaris as visualized histopathologically. This is an interesting and potentially important advance in the ability of OCTA to image the choriocapillaris in ...
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      Mentions: Jay S. Duker Tufts University Nadia K. Waheed

    13. Atlas of Retinal OCT: Optical Coherence Tomography (Textbook)

      Explore elsevier.com Ophthalmology , Textbooks
      Atlas of Retinal OCT: Optical Coherence Tomography (Textbook)
      Optical Coherence Tomography has revolutionized todays eye care. This remarkable non-invasive scanning technology is unparalleled for aiding diagnosis of retinal disease and recording disease progression. Atlas of Retinal OCT: Optical Coherence Tomography provides expert guidance in this rapidly evolving area with high-quality, oversized images that show precise detail and assist with rapid, accurate clinical decision making.
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      Mentions: Jay S. Duker Tufts University Nadia K. Waheed

    14. Diagnosing Choroidal Neovascularization in Asymptomatic Individuals Using Optical Coherence Tomography Angiography

      Explore Healio.com Ophthalmology
      Diagnosing Choroidal Neovascularization in Asymptomatic Individuals Using Optical Coherence Tomography Angiography
      Optical coherence tomography angiography (OCTA) is a noninvasive, rapid imaging technique that generates angiographic images without intravenous dye injections. Cross-sectional studies have described the presence of asymptomatic choroidal neovascularization (CNV) in patients with intermediate age-related macular degeneration (AMD). This case report describes the OCT features on longitudinal follow-up of a patient who started with unilateral asymptomatic CNV and eventually developed symptomatic exudative AMD.
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      Mentions: Jay S. Duker Tufts University Nadia K. Waheed

    15. Visualization of changes in the foveal avascular zone in both observed and treated diabetic macular edema using optical coherence tomography angiography

      Explore journalretinavitreous.biomedcentral.com Ophthalmology
      Visualization of changes in the foveal avascular zone in both observed and treated diabetic macular edema using optical coherence tomography angiography
      Background Central vision loss in diabetic retinopathy is commonly related to diabetic macular edema (DME). The objective of this study was to describe changes between consecutive visits on optical coherence tomography angiography (OCTA) of the foveal avascular zone (FAZ) in eyes with DME. Methods 20 eyes from 14 patients with DME were imaged on 2 successive clinic visits separated by at least 1 month. The mean interval between visits was ...
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      Mentions: Andre J. Witkin Jay S. Duker Tufts University

    16. Analysis Of AGE-RELATED Choroidal Layers Thinning In Healthy Eyes Using SWEPT-SOURCE Optical Coherence Tomography

      Explore LWW Online Ophthalmology
      Analysis Of AGE-RELATED Choroidal Layers Thinning In Healthy Eyes Using SWEPT-SOURCE Optical Coherence Tomography
      Purpose: To study the changes in the choroidal layers thickness with age in a healthy population using swept-source optical coherence tomography. Methods: Retrospective data analysis of a subgroup of eyes from a previous single-center, prospective, cross-sectional, noninterventional study. One hundred and sixty-nine healthy eyes were evaluated using swept-source optical coherence tomography. Inclusion criteria were best-corrected visual acuity between 20/20 and 20/25, spherical equivalent between 3 diopters, and no ...
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      Mentions: Jay S. Duker Tufts University San Carlos University Hospital
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  4. About Jay S. Duker

    Jay S. Duker

    Jay S. Duker is an Ophthalmologist and Director of the New England Eye Center at Tufts University School of Medicine.  Dr. Duker specializes in both medical and surgical diseases of the posterior segment. His primary surgical interests include retinal detachment, proliferative vitreoretinopathy, proliferative diabetic retinopathy, retinopathy of prematurity, and posterior segment trauma. He is also available for consultation in posterior segment uveitis, AIDS-related retinitis, intraocular tumors, and retinal vascular disorders.

  5. Related Topics

    1. Photoreceptor Disruption Secondary to Posterior Vitreous Detachment as Visualized Using High-Speed Ultrahigh-Resolution Optical Coherence Tomography
      173 articles also mentioned Tufts University
    2. Retinal Neovascularization Secondary to Proliferative Diabetic Retinopathy Characterized By Spectral Domain Optical Coherence Tomography
      63 articles also mentioned Nadia K. Waheed
    3. Still evolving, OCT technology has revolutionized diagnostics
      36 articles also mentioned Carl Zeiss Meditec

  6. Quotes

    1. The deeper you go with spectral domain imaging, there is more noise. That doesn't happen with swept source...They are significantly more expensive than spectral domain..."Commercial pressure” is another reason for the lack of uptake, in that, for companies that already successfully manufacture and sell OCT machines, retooling for the new technology could “cannibalize” the existing business.
      In Cost inhibits adoption of SS-OCT
    2. Incorporation of OCT structural imaging onto ICG angiography provides an anatomic frame of reference for late (ICG) leaks and reveals the flow characteristics of specific anatomic features.
      In Combined imaging techniques aid identification of occult retinal disease
    3. I think measuring the hole is very helpful to determine your success rate, and smaller holes close better than bigger holes.
      In OCT useful for measuring macular holes before closure surgery