1. Jay S. Duker

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    1. Mentioned In 186 Articles

    2. A Framework for Multiscale Quantitation of Relationships Between Choriocapillaris Flow Impairment and Geographic Atrophy Growth

      Explore American Journal of Ophthalmology Ophthalmology
      A Framework for Multiscale Quantitation of Relationships Between Choriocapillaris Flow Impairment and Geographic Atrophy Growth
      Purpose To develop a multiscale analysis framework for investigating the relationships between geographic atrophy (GA) growth rate and choriocapillaris (CC) blood flow impairment using optical coherence tomography (OCT) and OCT angiography (OCTA). Design Retrospective case series. Methods We developed an OCT/OCTA analysis framework that quantitatively measures GA growth rates at global and local scales, and CC impairment at global, zonal, and local scales. A geometric GA growth model was ...
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      Mentions: Massachusetts Institute of Technology James G. Fujimoto Jay S. Duker

    3. Global Analysis of Macular Choriocapillaris Perfusion in Dry Age-Related Macular Degeneration using Swept-Source Optical Coherence Tomography Angiography

      Explore IOVS Journal Ophthalmology
      Global Analysis of Macular Choriocapillaris Perfusion in Dry Age-Related Macular Degeneration using Swept-Source Optical Coherence Tomography Angiography
      Purpose : Swept-source optical coherence tomography angiography (SS-OCTA) was used to investigate if the clinical stage of dry age-related macular degeneration (AMD) was correlated with global and regional macular choriocapillaris (CC) perfusion. Methods : In this retrospective, cross-sectional study, 6 6-mm SS-OCTA images from eyes with early, intermediate, and advanced dry AMD (56 eyes, 41 patients) were analyzed using algorithms described in the literature to assess regional flow deficit percentage (FD%) and ...
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      Mentions: Massachusetts Institute of Technology James G. Fujimoto Andre J. Witkin

    4. Retinal Nonperfusion Relationship to Arteries or Veins Observed on Widefield Optical Coherence Tomography Angiography in Diabetic Retinopathy

      Explore IOVS Journal Ophthalmology
      Retinal Nonperfusion Relationship to Arteries or Veins Observed on Widefield Optical Coherence Tomography Angiography in Diabetic Retinopathy
      Purpose : To evaluate whether retinal capillary nonperfusion is found predominantly adjacent to arteries or veins in eyes with diabetic retinopathy (DR). Methods : Sixty-three eyes from 44 patients with proliferative DR (PDR) or non-PDR (NPDR) were included. Images (12 12-mm) foveal-centered optical coherence tomography (OCT) angiography (OCTA) images were taken using the Zeiss Plex Elite 9000. In 37 eyes, widefield montages with five fixation points were also obtained. A semiautomatic algorithm ...
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      Mentions: Massachusetts Institute of Technology James G. Fujimoto Andre J. Witkin

    5. DISTINGUISHING INTRARETINAL MICROVASCULAR ABNORMALITIES FROM RETINAL NEOVASCULARIZATION USING OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY

      Explore LWW Online Ophthalmology
      DISTINGUISHING INTRARETINAL MICROVASCULAR ABNORMALITIES FROM RETINAL NEOVASCULARIZATION USING OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY
      Purpose: With the increasing prevalence of diabetes, fast, noninvasive identification of proliferative diabetic retinopathy ( PDR ) becomes essential. This study evaluated the utility of optical coherence tomography angiography ( OCTA ) to characterize intraretinal microvascular abnormalities ( IRMA ) and retinal neovascularization (NV). Methods: Patients with severe non- PDR or PDR were imaged with fluorescein angiography and widefield swept-source OCTA (Zeiss Plex Elite 9000; Carl Zeiss Meditec, Dublin, CA). Regions suspicious for IRMA or retinal ...
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      Mentions: Jay S. Duker Carl Zeiss Meditec Tufts University

    6. Controlling for Artifacts in Widefield Optical Coherence Tomography Angiography Measurements of Non-Perfusion Area

      Explore Nature Publishing Group Ophthalmology
      Controlling for Artifacts in Widefield Optical Coherence Tomography Angiography Measurements of Non-Perfusion Area
      The recent clinical adoption of optical coherence tomography (OCT) angiography (OCTA) has enabled non-invasive, volumetric visualization of ocular vasculature at micron-scale resolutions. Initially limited to 3mm3mm and 6mm6mm fields-of-view (FOV), commercial OCTA systems now offer 12mm12mm, or larger, imaging fields. While larger FOVs promise a more complete visualization of retinal disease, they also introduce new challenges to the accurate and reliable interpretation of OCTA data. In particular, because of vignetting ...
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      Mentions: Massachusetts Institute of Technology James G. Fujimoto Andre J. Witkin

    7. Impact of Binarization Thresholding and Brightness/Contrast Adjustment Methodology on Optical Coherence Tomography Angiography Image Quantification

      Explore American Journal of Ophthalmology Ophthalmology
      Impact of Binarization Thresholding and Brightness/Contrast Adjustment Methodology on Optical Coherence Tomography Angiography Image Quantification
      Purpose Binarization is a critical technique in OCTA image analysis, but there is no consistency in the method used in published OCTA studies. This study assessed whether differences in OCTA binarization and brightness/contrast adjustments affect quantification metrics. Design Prospective cross-sectional validity study Methods This was a single-center study examining 21 eyes of 11 healthy individuals. All eyes were imaged using the Carl Zeiss PLEX Elite 9000 swept source-OCTA, and ...
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      Mentions: Jay S. Duker Tufts University Nadia K. Waheed

    8. Early hydroxychloroquine retinopathy: optical coherence tomography abnormalities preceding Humphrey visual field defects

      Explore BJO Online Ophthalmology
      Early hydroxychloroquine retinopathy: optical coherence tomography abnormalities preceding Humphrey visual field defects
      Background/Aims Hydroxychloroquine (HCQ) retinopathy may result in severe and irreversible vision loss, emphasising the importance of screening and early detection. The purpose of this study is to report the novel finding of early optical coherence tomography (OCT) abnormalities due to HCQ toxicity that may develop in the setting of normal Humphrey visual field (HVF) testing. Methods Data from patients with chronic HCQ exposure was obtained from seven tertiary care ...
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      Mentions: Case Western Reserve University Jay S. Duker LuEsther T. Mertz Retinal Research Center

    10. QUANTIFICATION OF RETINAL CAPILLARY NONPERFUSION IN DIABETICS USING WIDE-FIELD OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY

      Explore LWW Online Ophthalmology
      QUANTIFICATION OF RETINAL CAPILLARY NONPERFUSION IN DIABETICS USING WIDE-FIELD OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY
      Purpose: To combine advances in high-speed, wide-field optical coherence tomography angiography ( OCTA ) with image processing methods for semiautomatic quantitative analysis of capillary nonperfusion in patients with diabetic retinopathy (DR). Methods: Sixty-eight diabetic patients (73 eyes), either without retinopathy or with different degrees of retinopathy, were prospectively recruited for volumetric swept-source OCTA imaging using 12 mm 12 mm fields centered at the fovea. A custom, semiautomatic software algorithm was used to ...
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      Mentions: Massachusetts Institute of Technology James G. Fujimoto Andre J. Witkin

    12. VISUALIZATION OF CHOROIDAL NEOVASCULARIZATION USING TWO COMMERCIALLY AVAILABLE SPECTRAL DOMAIN OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY DEVICES

      Explore LWW Online Ophthalmology
      VISUALIZATION OF CHOROIDAL NEOVASCULARIZATION USING TWO COMMERCIALLY AVAILABLE SPECTRAL DOMAIN OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY DEVICES
      Purpose: To compare the sensitivity of detection and the measured size of choroidal neovascularization ( CNV ) on two commercially available spectral domain optical coherence tomography angiography ( OCTA ) devices, the Optovue RTVue XR Avanti with AngioVue and the Zeiss Cirrus HD-OCT with AngioPlex. Methods: Patients with CNV lesions were imaged consecutively on both OCTA devices on the same day of their visit. 3 3 mm and 6 6 mm scans centered at ...
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      Mentions: Optovue Andre J. Witkin Jay S. Duker

    13. Microscope-Integrated Intraoperative Ultrahigh-Speed Swept-Source Optical Coherence Tomography for Widefield Retinal and Anterior Segment Imaging

      Explore Healio.com Ophthalmology
      Microscope-Integrated Intraoperative Ultrahigh-Speed Swept-Source Optical Coherence Tomography for Widefield Retinal and Anterior Segment Imaging
      BACKGROUND AND OBJECTIVE: To demonstrate the feasibility of retinal and anterior segment intraoperative widefield imaging using an ultrahigh-speed, swept-source optical coherence tomography (SS-OCT) surgical microscope attachment. PATIENTS AND METHODS: A prototype post-objective SS-OCT using a 1,050-nm wavelength, 400 kHz A-scan rate, vertical cavity surface-emitting laser (VCSEL) light source was integrated to a commercial ophthalmic surgical microscope after the objective. Each widefield OCT data set was acquired in 3 seconds ...
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      Mentions: Massachusetts Institute of Technology James G. Fujimoto Thorlabs

    14. OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY TO DETECT MACULAR CAPILLARY ISCHEMIA IN PATIENTS WITH INNER RETINAL CHANGES AFTER RESOLVED DIABETIC MACULAR EDEMA

      Explore LWW Online Ophthalmology
      OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY TO DETECT MACULAR CAPILLARY ISCHEMIA IN PATIENTS WITH INNER RETINAL CHANGES AFTER RESOLVED DIABETIC MACULAR EDEMA
      To compare foveal vascular anatomy between patients with and without disorganization of retinal inner layers (DRILs) after resolved diabetic macular edema using optical coherence tomography angiography (OCTA). Methods: Twenty-four eyes of 21 age- and sex-matched patients with resolved diabetic macular edema were included in this retrospective, cross-sectional study. All eyes were imaged with enhanced high-definition line or cross-line structural B scans and 3 3-mm OCTA scans. Optical coherence tomography B ...
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      Mentions: Andre J. Witkin Jay S. Duker Tufts University

    15. Polypoidal Choroidal Vasculopathy on Swept-Source Optical Coherence Tomography Angiography with Variable Interscan Time Analysis

      Explore TVST Journal Ophthalmology
      Polypoidal Choroidal Vasculopathy on Swept-Source Optical Coherence Tomography Angiography with Variable Interscan Time Analysis
      Purpose : To use a novel optical coherence tomography angiography (OCTA) algorithm termed variable interscan time analysis (VISTA) to evaluate relative blood flow speeds in polypoidal choroidal vasculopathy (PCV). Methods : Prospective cross-sectional study enrolling patients with confirmed diagnosis of PCV. OCTA of the retina and choroid was obtained with a prototype swept-source OCT system. The acquired OCT volumes were centered on the branching vascular network (BVN) and polyps as determined by ...
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      Mentions: Universidade Federal de São Paulo Massachusetts Institute of Technology James G. Fujimoto

    16. Image Averaging, a Powerful Tool in Optical Coherence Tomography and OCT Angiography

      Explore The JAMA Network Ophthalmology
      Image Averaging, a Powerful Tool in Optical Coherence Tomography and OCT Angiography
      In an elegantly conducted study, Uji et al 1 describe the association of averaging multiple en face images with the quality of the optical coherence tomography angiography (OCTA) images of the choroidal microvasculature. They demonstrate that the resulting vascular images approximate much more closely the structure of the choriocapillaris as visualized histopathologically. This is an interesting and potentially important advance in the ability of OCTA to image the choriocapillaris in ...
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      Mentions: Jay S. Duker Tufts University Nadia K. Waheed
    17. 1-15 of 186 1 2 3 4 ... 11 12 13 »
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  4. About Jay S. Duker

    Jay S. Duker

    Jay S. Duker is an Ophthalmologist and Director of the New England Eye Center at Tufts University School of Medicine.  Dr. Duker specializes in both medical and surgical diseases of the posterior segment. His primary surgical interests include retinal detachment, proliferative vitreoretinopathy, proliferative diabetic retinopathy, retinopathy of prematurity, and posterior segment trauma. He is also available for consultation in posterior segment uveitis, AIDS-related retinitis, intraocular tumors, and retinal vascular disorders.

  5. Related Topics

    1. Photoreceptor Disruption Secondary to Posterior Vitreous Detachment as Visualized Using High-Speed Ultrahigh-Resolution Optical Coherence Tomography
      176 articles also mentioned Tufts University
    2. Retinal Neovascularization Secondary to Proliferative Diabetic Retinopathy Characterized By Spectral Domain Optical Coherence Tomography
      66 articles also mentioned Nadia K. Waheed
    3. Still evolving, OCT technology has revolutionized diagnostics
      36 articles also mentioned Carl Zeiss Meditec

  6. Quotes

    1. The deeper you go with spectral domain imaging, there is more noise. That doesn't happen with swept source...They are significantly more expensive than spectral domain..."Commercial pressure” is another reason for the lack of uptake, in that, for companies that already successfully manufacture and sell OCT machines, retooling for the new technology could “cannibalize” the existing business.
      In Cost inhibits adoption of SS-OCT
    2. Incorporation of OCT structural imaging onto ICG angiography provides an anatomic frame of reference for late (ICG) leaks and reveals the flow characteristics of specific anatomic features.
      In Combined imaging techniques aid identification of occult retinal disease
    3. I think measuring the hole is very helpful to determine your success rate, and smaller holes close better than bigger holes.
      In OCT useful for measuring macular holes before closure surgery