1. Jay S. Duker

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    1. Mentioned In 198 Articles

    2. Using the Pathophysiology of Dry AMD to Guide Binarization of the Choriocapillaris on OCTA: A Model

      Using the Pathophysiology of Dry AMD to Guide Binarization of the Choriocapillaris on OCTA: A Model
      Especially since the incorporation of swept laser sources, optical coherence tomography angiography (OCTA) has enabled quantification of choriocapillaris perfusion. A critical step in this process is binarization, which makes angiographic images quantifiable in terms of perfusion metrics. It remains challenging to have confidence that choriocapillaris perfusion metrics reflect the reality of pathophysiologic flow, largely because choice of binarization method can result in significantly different perfusion metric outcomes. This commentary discusses ...
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    3. The long-term effects of anti-vascular endothelial growth factor therapy on the optical coherence tomography angiographic appearance of neovascularization in age-related macular degeneration

      The long-term effects of anti-vascular endothelial growth factor therapy on the optical coherence tomography angiographic appearance of neovascularization in age-related macular degeneration
      Background The short-term effects of anti-vascular endothelial growth factor (anti-VEGF) treatment on macular neovascularization (MNV) morphology is well described, but long-term studies on morphologic changes and correlation of such changes to the type of MNV have not been conducted. This study aims to determine if different types of MNVs in neovascular AMD (nAMD) behave differently with anti-VEGF treatment as visualized on optical coherence tomography angiography (OCTA). Methods Treatment-nave nAMD patients ...
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    4. Model-to-Data Approach for Deep Learning in Optical Coherence Tomography Intraretinal Fluid Segmentation

      Model-to-Data Approach for Deep Learning in Optical Coherence Tomography Intraretinal Fluid Segmentation
      Importance Amid an explosion of interest in deep learning in medicine, including within ophthalmology, concerns regarding data privacy, security, and sharing are of increasing importance. A model-to-data approach, in which the model itself is transferred rather than data, can circumvent many of these challenges but has not been previously demonstrated in ophthalmology. Objective To determine whether a model-to-data deep learning approach (ie, validation of the algorithm without any data transfer ...
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    5. Ultrahigh Resolution Spectral Domain Optical Coherence Tomography for the Assessment of Micro-Structural Changes in Central Serous Chorioretinopathy: A Pilot Study.

      Ultrahigh Resolution Spectral Domain Optical Coherence Tomography for the Assessment of Micro-Structural Changes in Central Serous Chorioretinopathy: A Pilot Study.
      Purpose : In central serous chorioretinopathy (CSCR), choroidal hyperpermeability associated with retinal pigment epithelium (RPE) impairment causes a leakage of fluid from the choroid into the subretinal space, with potential damage to the photoreceptors. We hypothesize that ultrahigh-resolution spectral domain optical coherence tomography (UHR SD-OCT) will enable more detailed assessment of structural changes in this condition. Methods : Patients in all stages of CSCR (acute, chronic and post-resolution) were imaged using an ...
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    6. Evaluating the long-term effects of anti-vascular endothelial growth factor therapy on choroidal neovascularization in age-related macular degeneration using optical coherence tomography angiography

      Evaluating the long-term effects of anti-vascular endothelial growth factor therapy on choroidal neovascularization in age-related macular degeneration using optical coherence tomography angiography
      Purpose : Optical coherence tomography angiography (OCTA) allows for precise, non-invasive monitoring of changes to choroidal neovascularization (CNV) structure over time. The short-term effects of anti-vascular endothelial growth factor (anti-VEGF) treatment on CNV morphology is well described, but long-term studies on morphologic changes and correlation of such to the type of CNV have not been conducted. This study aims to determine if different types of CNVs in neovascular AMD (nAMD) behave ...
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    7. Bringing Deep Learning Models to the Data: An Application in Recognizing Intra-Retinal Fluid on Optical Coherence Tomography (OCT) Images

      Bringing Deep Learning Models to the Data: An Application in Recognizing Intra-Retinal Fluid on Optical Coherence Tomography (OCT) Images
      Purpose : Amidst intense interest in deep learning in medicine, concerns regarding data privacy, security, and sharing are of increasing importance. A model-to-data approach, in which the model itself is transferred rather than data, can circumvent many of these challenges, but has not been previously tested in ophthalmology. The objective of our study was to determine whether a model-to-data deep learning approach (i.e. validation of the algorithm without any data ...
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    8. Analyzing Relative Flow Speeds in Diabetic Retinopathy Using Variable Interscan Time Analysis Optical Coherence Tomography Angiography

      Analyzing Relative Flow Speeds in Diabetic Retinopathy Using Variable Interscan Time Analysis Optical Coherence Tomography Angiography
      Objective Further insight into the flow characteristics of the vascular features associated with diabetic retinopathy (DR) may improve assessment and treatment of disease progression. The variable interscan time analysis (VISTA) algorithm is an extension of optical coherence tomography angiography (OCTA) that detects relative blood flow speeds which can then be depicted on a color-coded map. This study utilized VISTA to analyze relative blood flow speeds in the microvascular changes associated ...
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    9. Morphological changes in intraretinal microvascular abnormalities after anti-VEGF therapy visualized on optical coherence tomography angiography

      Morphological changes in intraretinal microvascular abnormalities after anti-VEGF therapy visualized on optical coherence tomography angiography
      Background To examine the baseline morphological characteristics and alterations in intraretinal microvascular abnormalities (IRMAs) in response to anti-vascular endothelial growth factor (anti-VEGF) treatment, documented by optical coherence tomography angiography (OCTA) in diabetic eyes. Methods In this retrospective study, IRMAs were evaluated with multimodal imaging (fundus photography, fluorescein angiography, OCTA) in treatment-nave diabetic eyes before and after anti-VEGF treatment for diabetic macular edema (DME) and/or proliferative diabetic retinopathy (PDR) and ...
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    10. Repeatability and reproducibility of vessel density measurements on optical coherence tomography angiography in diabetic retinopathy

      Repeatability and reproducibility of vessel density measurements on optical coherence tomography angiography in diabetic retinopathy
      Purpose Understanding the precision of measurements on and across optical coherence tomography angiography (OCTA) devices is critical for tracking meaningful change in disease. The purpose of this study is to investigate the repeatability and reproducibility of vessel area density and vessel skeleton density measurements from various commercial OCTA devices in diabetic eyes. Methods Patients were imaged three consecutive times each on three different OCTA devices. En face OCTA images of ...
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    11. Topographic analysis of macular choriocapillaris flow deficits in diabetic retinopathy using swept–source optical coherence tomography angiography

      Topographic analysis of macular choriocapillaris flow deficits in diabetic retinopathy using swept–source optical coherence tomography angiography
      Background The purpose of this study was to investigate the association between diabetic retinopathy (DR) severity and macular choriocapillaris (CC) flow deficit percentage (FD %) in different macular regions using swept-source optical coherence tomography angiography (SS-OCTA). Methods Diabetic patients with SS-OCTA images were graded by severity and retrospectively assessed. CC FD % was calculated in four different regions of the OCTA image: inner, middle, outer, and full-field region. The generalized estimating equations ...
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    12. SPATIAL DISTRIBUTION OF CHORIOCAPILLARIS IMPAIRMENT IN EYES WITH CHOROIDAL NEOVASCULARIZATION SECONDARY TO AGE-RELATED MACULAR DEGENERATION: A Quantitative OCT Angiography Study

      SPATIAL DISTRIBUTION OF CHORIOCAPILLARIS IMPAIRMENT IN EYES WITH CHOROIDAL NEOVASCULARIZATION SECONDARY TO AGE-RELATED MACULAR DEGENERATION: A Quantitative OCT Angiography Study
      Purpose: To develop an optical coherence tomography angiography ( OCTA )-based framework for quantitatively analyzing the spatial distribution of choriocapillaris (CC) impairment around choroidal neovascularization ( CNV ) secondary to age-related macular degeneration. Methods: In a retrospective, cross-sectional study, 400-kHz swept-source OCTA images from 7 eyes of 6 patients with CNV secondary to age-related macular degeneration were quantitatively analyzed using custom software. A lesion-centered zonal OCTA analysis techniquewhich portioned the field-of-view into zones ...
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    13. How SD-OCT is enhancing our management of DR

      How SD-OCT is enhancing our management of DR
      Laser therapy was a major breakthrough in diabetic retinopathy treatment, with its efficacy validated by a number of clinical studies in the last three decades of the 20th century. However, it relied on fundus photography and fluorescein angiography to diagnose clinically significant macular edema. Since then, optical coherence tomography has revolutionized the clinical management of diabetic macular edema because of its widespread availability, ease of use, and ability to quantify ...
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    14. A Framework for Multiscale Quantitation of Relationships Between Choriocapillaris Flow Impairment and Geographic Atrophy Growth

      A Framework for Multiscale Quantitation of Relationships Between Choriocapillaris Flow Impairment and Geographic Atrophy Growth
      Purpose To develop a multiscale analysis framework for investigating the relationships between geographic atrophy (GA) growth rate and choriocapillaris (CC) blood flow impairment using optical coherence tomography (OCT) and OCT angiography (OCTA). Design Retrospective case series. Methods We developed an OCT/OCTA analysis framework that quantitatively measures GA growth rates at global and local scales, and CC impairment at global, zonal, and local scales. A geometric GA growth model was ...
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    15. Global Analysis of Macular Choriocapillaris Perfusion in Dry Age-Related Macular Degeneration using Swept-Source Optical Coherence Tomography Angiography

      Global Analysis of Macular Choriocapillaris Perfusion in Dry Age-Related Macular Degeneration using Swept-Source Optical Coherence Tomography Angiography
      Purpose : Swept-source optical coherence tomography angiography (SS-OCTA) was used to investigate if the clinical stage of dry age-related macular degeneration (AMD) was correlated with global and regional macular choriocapillaris (CC) perfusion. Methods : In this retrospective, cross-sectional study, 6 6-mm SS-OCTA images from eyes with early, intermediate, and advanced dry AMD (56 eyes, 41 patients) were analyzed using algorithms described in the literature to assess regional flow deficit percentage (FD%) and ...
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    16. Retinal Nonperfusion Relationship to Arteries or Veins Observed on Widefield Optical Coherence Tomography Angiography in Diabetic Retinopathy

      Retinal Nonperfusion Relationship to Arteries or Veins Observed on Widefield Optical Coherence Tomography Angiography in Diabetic Retinopathy
      Purpose : To evaluate whether retinal capillary nonperfusion is found predominantly adjacent to arteries or veins in eyes with diabetic retinopathy (DR). Methods : Sixty-three eyes from 44 patients with proliferative DR (PDR) or non-PDR (NPDR) were included. Images (12 12-mm) foveal-centered optical coherence tomography (OCT) angiography (OCTA) images were taken using the Zeiss Plex Elite 9000. In 37 eyes, widefield montages with five fixation points were also obtained. A semiautomatic algorithm ...
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    17. 1-15 of 198 1 2 3 4 ... 12 13 14 »
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  2. About Jay S. Duker

    Jay S. Duker

    Jay S. Duker is an Ophthalmologist and Director of the New England Eye Center at Tufts University School of Medicine.  Dr. Duker specializes in both medical and surgical diseases of the posterior segment. His primary surgical interests include retinal detachment, proliferative vitreoretinopathy, proliferative diabetic retinopathy, retinopathy of prematurity, and posterior segment trauma. He is also available for consultation in posterior segment uveitis, AIDS-related retinitis, intraocular tumors, and retinal vascular disorders.

  3. Quotes

    1. The deeper you go with spectral domain imaging, there is more noise. That doesn't happen with swept source...They are significantly more expensive than spectral domain..."Commercial pressure” is another reason for the lack of uptake, in that, for companies that already successfully manufacture and sell OCT machines, retooling for the new technology could “cannibalize” the existing business.
      In Cost inhibits adoption of SS-OCT
    2. Incorporation of OCT structural imaging onto ICG angiography provides an anatomic frame of reference for late (ICG) leaks and reveals the flow characteristics of specific anatomic features.
      In Combined imaging techniques aid identification of occult retinal disease
    3. I think measuring the hole is very helpful to determine your success rate, and smaller holes close better than bigger holes.
      In OCT useful for measuring macular holes before closure surgery