1. Jason R. Maher

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    1. Mentioned In 8 Articles

    2. Full depth measurement of tenofovir transport in rectal mucosa using confocal Raman spectroscopy and optical coherence tomography

      Full depth measurement of tenofovir transport in rectal mucosa using confocal Raman spectroscopy and optical coherence tomography
      The prophylactic activity of antiretroviral drugs applied as microbicides against sexually transmitted HIV is dependent upon their concentrations in infectable host cells. Within mucosal sites of infection (e.g., vaginal and rectal mucosa), those cells exist primarily in the stromal layer of the tissue. Traditional pharmacokinetic studies of these drugs have been challenged by poor temporal and spatial specificity. Newer techniques to measure drug concentrations, involving Raman spectroscopy, have been ...
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    3. Label-free analysis of tenofovir delivery to vaginal tissue using co-registered confocal Raman spectroscopy and optical coherence tomography

      Label-free analysis of tenofovir delivery to vaginal tissue using co-registered confocal Raman spectroscopy and optical coherence tomography
      Vaginally applied microbicide products offer a female-controlled strategy for preventing sexual transmission of HIV. Microbicide transport processes are central to their functioning, and there is a clear need for a better understanding of them. To contribute to that end, we developed an assay to analyze mass transport rates of microbicide molecules within the epithelial and stromal layers of polarized vaginal mucosal tissue during contact with a gel vehicle. The assay ...
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    4. Dual-axis optical coherence tomography for deep tissue imaging

      Dual-axis optical coherence tomography for deep tissue imaging
      We have developed dual-axis optical coherence tomography (DA-OCT) which enables deep tissue imaging by using a novel off-axis illumination/detection configuration. DA-OCT offers a 100-fold speed increase compared with its predecessor, multispectral multiple-scattering low coherence interferometry (ms2/LCI), by using a new beam scanning mechanism based on a microelectro-mechanical system (MEMS) mirror. The data acquisition scheme was altered to take advantage of this scanning speed, producing tomographic images at a ...
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    5. Evaluation of burn severity in vivo in a mouse model using spectroscopic optical coherence tomography

      Evaluation of burn severity in vivo in a mouse model using spectroscopic optical coherence tomography
      Clinical management of burn injuries depends upon an accurate assessment of the depth of the wound. Current diagnostic methods rely primarily on subjective visual inspection, which can produce variable results. In this study, spectroscopic optical coherence tomography was used to objectively evaluate burn injuries in vivo in a mouse model. Significant spectral differences were observed and correlated with the depth of the injury as determined by histopathology. The relevance of ...
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    6. Functional optical coherence tomography: principles and progress

      Functional optical coherence tomography: principles and progress
      In the past decade, several functional extensions of optical coherence tomography (OCT) have emerged, and this review highlights key advances in instrumentation, theoretical analysis, signal processing and clinical application of these extensions. We review five principal extensions: Doppler OCT (DOCT), polarization-sensitive OCT (PS-OCT), optical coherence elastography (OCE), spectroscopic OCT (SOCT), and molecular imaging OCT. The former three have been further developed with studies in both ex vivo and in vivo ...
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    7. Feature Of The Week 11/16/14: In Vivo Analysis of Burns in a Mouse Model using Spectroscopic OCT

      Feature Of The Week 11/16/14: In Vivo Analysis of Burns in a Mouse Model using Spectroscopic OCT
      Evaluation of burn severity is a significant clinical problem with over 2 million burns reported each year in the United States [1]. The magnitude of this clinical need has inspired the development of many technologies to assess burn depth, but none of these have been widely adopted as clinical judgment still relies primarily on visual inspection, with an accuracy of about 70% [2]. A recent study by researchers at Duke ...
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  2. About Jason R. Maher

    Jason R. Maher

    Jason Maher joined the Biomedical Engineering department at Duke University as a postdoctoral associate after receiving his PhD in optics from the University of Rochester in 2013. His research interests are biomedical optical spectroscopy, interferometry, and imaging for monitoring disease and spatiotemporal distributions of drugs in biological tissue.