1. James Muller

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    1. Mentioned In 5 Articles

    2. OCT-NIRS Imaging for Detection of Coronary Plaque Structure and Vulnerability

      OCT-NIRS Imaging for Detection of Coronary Plaque Structure and Vulnerability
      A combination optical coherence tomography and near-infrared spectroscopy (OCT-NIRS) coronary imaging system is being developed to improve the care of coronary patients. While stenting has improved, complications continue to occur at the stented site and new events are caused by unrecognized vulnerable plaques. An OCT-NIRS device has potential to improve secondary prevention by optimizing stenting and by identifying vulnerable patients and vulnerable plaques. OCT is already in widespread use world-wide ...
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    3. Hybrid intravascular imaging: recent advances, technical considerations, and current applications in the study of plaque pathophysiology

      Hybrid intravascular imaging: recent advances, technical considerations, and current applications in the study of plaque pathophysiology
      Cumulative evidence from histology-based studies demonstrate that the currently available intravascular imaging techniques have fundamental limitations that do not allow complete and detailed evaluation of plaque morphology and pathobiology, limiting the ability to accurately identify high-risk plaques. To overcome these drawbacks, new efforts are developing for data fusion methodologies and the design of hybrid, dual-probe catheters to enable accurate assessment of plaque characteristics, and reliable identification of high-risk lesions. Today ...
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    4. Retinal pathology in Susac syndrome detected by spectral-domain optical coherence tomography

      Retinal pathology in Susac syndrome detected by spectral-domain optical coherence tomography
      Objective: The aim of this non-interventional study was to characterize retinal layer pathology in Susac syndrome (SuS), a disease with presumably autoimmune-mediated microvessel occlusions in the retina, brain, and inner ear, in comparison to the most important differential diagnosis multiple sclerosis (MS). Methods: Seventeen patients with SuS and 17 age- and sex-matched patients with relapsing-remitting MS (RRMS) and healthy controls (HC) were prospectively investigated by spectral-domain optical coherence tomography (OCT ...
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    5. Infraredx Announces Publication of Prospective Study Demonstrating thatNear-Infrared Spectroscopy May Assist in Predicting the Risk of Future Cardiovascular Events, Including Heart Attack and Stroke

      Infraredx Announces Publication of Prospective Study Demonstrating thatNear-Infrared Spectroscopy May Assist in Predicting the Risk of Future Cardiovascular Events, Including Heart Attack and Stroke
      ...measurement of lipid in the coronary artery wall to determine the risk of future coronary events,” said James Muller, M.D., co-founder and chief medical officer of Infraredx. “The identification of patients w...
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  2. About James Muller

    James E. Muller has served as Chief Medical Officer and Chairman of the Board of Infraredx since 2011. Dr. Muller’s interest in the causation of coronary events began in 1985 with the discovery of the morning increase of heart attacks. This led to a series of studies on the triggers of coronary events that, together with observations by other investigators, led to formulation of the concept of a “vulnerable” coronary plaque. In 1989, with Drs. Tofler and Stone, Dr. Muller published an article in CIRCULATION defining vulnerable plaques as those at high likelihood of rupture. In 1998, he founded Infraredx to develop spectroscopic technology to identify lipid core plaques, which are suspected to be vulnerable plaques. In 2005, he resigned from his position as Professor of Medicine at the Harvard Medical School to serve as CEO of Infraredx during the development of the scientific foundation of the lipid core plaque instrument. He is the author of over 300 manuscripts related to coronary artery disease, the leading cause of death in the developed world.