1. James L. Connolly

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    1. Mentioned In 13 Articles

    2. Integrated Local Binary Pattern Texture Features for Classification of Breast Tissue Imaged by Optical Coherence Microscopy

      Integrated Local Binary Pattern Texture Features for Classification of Breast Tissue Imaged by Optical Coherence Microscopy
      This paper proposes a texture analysis technique that can effectively classify different types of human breast tissue imaged by Optical Coherence Microscopy (OCM). OCM is an emerging imaging modality for rapid tissue screening and has the potential to provide high resolution microscopic images that approach those of histology. OCM images, acquired without tissue staining, however, pose unique challenges to image analysis and pattern classification. We examined multiple types of texture ...
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    3. Swept source optical coherence microscopy using a 1310 nm VCSEL light source

      Swept source optical coherence microscopy using a 1310 nm VCSEL light source
      We demonstrate high speed, swept source optical coherence microscopy (OCM) using a MEMS tunable vertical cavity surface-emitting laser (VCSEL) light source. The light source had a sweep rate of 280 kHz, providing a bidirectional axial scan rate of 560 kHz. The sweep bandwidth was 117 nm centered at 1310 nm, corresponding to an axial resolution of 13.1 m in air, corresponding to 8.1 m (9.6 m spectrally ...
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    4. Integrated Optical Coherence Tomography and Optical Coherence Microscopy Imaging of Ex Vivo Human Renal Tissues

      Integrated Optical Coherence Tomography and Optical Coherence Microscopy Imaging of Ex Vivo Human Renal Tissues
      ...idge, Massachusetts + Financial interest and/or other relationship with Carl Zeiss and Lightlabs Imaging. , * James L. Connolly Affiliations + Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medica...
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    5. MIT Receives NIH Grant for Research on Wavefront Corrected Multimodal Optical Coherence and Two-Photon Microscopy

      MIT Receives NIH Grant for Research on Wavefront Corrected Multimodal Optical Coherence and Two-Photon Microscopy
      ...ciple investigator is Yuankai Tao, and the project is co-sponsored by Prof. James G. Fujimoto (MIT) and Prof. James L. Connolly (Beth Israel Deaconess Medical Center/Harvard Medical School). A brief description of the pr...
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    6. MIT Receives NIH Award for Integrated Optical Coherence Tomography and Microscopy for Molecular-Targeted Imaging

      MIT Receives NIH Award for Integrated Optical Coherence Tomography and Microscopy for Molecular-Targeted Imaging
      ...lecular imaging at Beth Israel Deaconess Medical Center (BIDMC) and the Harvard Medical School (HMS); and Dr. James L. Connolly, a world renowned breast pathologist at BIDMC and HMS. The unique environments provided by M...
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    7. Integrated Optical Coherence Tomography and Microscopy for Ex Vivo Multiscale Evaluation of Human Breast Tissues

      Integrated Optical Coherence Tomography and Microscopy for Ex Vivo Multiscale Evaluation of Human Breast Tissues
      3D tissue imaging methods are expected to improve surgical management of cancer. In this study, we examined the feasibility of two 3D imaging technologies, optical coherence tomography (OCT) and optical coherence microscopy (OCM), to view human breast specimens based on intrinsic optical contrast. Specifically, we imaged 44 ex vivo breast specimens including 34 benign and 10 malignant lesions with an integrated OCT and OCM system developed in our laboratory. The ...
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    8. Cellular resolution ex vivo imaging of gastrointestinal tissues with optical coherence microscopy

      Cellular resolution ex vivo imaging of gastrointestinal tissues with optical coherence microscopy
      Optical coherence microscopy (OCM) combines confocal microscopy and optical coherence tomography (OCT) to improve imaging depth and contrast, enabling cellular imaging in human tissues. We aim to investigate OCM for ex vivo imaging of upper and lower gastrointestinal tract tissues, to establish correlations between OCM imaging and histology, and to provide a baseline for future endoscopic studies. Co-registered OCM and OCT imaging were performed on fresh surgical specimens and endoscopic ...
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    9. Integrated optical coherence tomography and optical coherence microscopy imaging of human pathology

      Integrated optical coherence tomography and optical coherence microscopy imaging of human pathology
      Excisional biopsy is the current gold standard for disease diagnosis; however, it requires a relatively long processing time and it may also suffer from unacceptable false negative rates due to sampling errors. Optical coherence tomography (OCT) is a promising imaging technique that provide real-time, high resolution and three-dimensional (3D) images of tissue morphology. Optical coherence microscopy (OCM) is an extension of OCT, combining both the coherence gating and the confocal ...
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    10. Ex vivo imaging of human thyroid pathology using integrated optical coherence tomography and optical coherence microscopy

      Ex vivo imaging of human thyroid pathology using integrated optical coherence tomography and optical coherence microscopy
      We evaluate the feasibility of optical coherence tomography (OCT) and optical coherence microscopy (OCM) for imaging of benign and malignant thyroid lesions ex vivo using intrinsic optical contrast. 34 thyroid gland specimens are imaged from 17 patients, covering a spectrum of pathology ranging from normal thyroid to benign disease/neoplasms (multinodular colloid goiter, Hashimoto's thyroiditis, and follicular adenoma) and malignant thyroid tumors (papillary carcinoma and medullary carcinoma). Imaging is ...
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    11. Three-dimensional endomicroscopy using optical coherence tomography

      Optical coherence tomography enables micrometre-scale, subsurface imaging of biological tissue by measuring the magnitude and echo time delay of backscattered light. Endoscopic optical coherence tomography imaging inside the body can be performed using fibre-optic probes. To perform three-dimensional optical coherence tomography endomicroscopy with ultrahigh volumetric resolution, however, requires extremely high imaging speeds. Here we report advances in optical coherence tomography technology using a Fourier-domain mode-locked frequency-swept laser as the light ...
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    12. In vivo endomicroscopy using three-dimensional optical coherence tomography and Fourier domain mode locked lasers

      We report an endoscopic optical coherence tomography (OCT) system based on a Fourier Domain Mode Locked (FDML) laser, a novel data acquisition (DAQ) system with optical frequency clocking, and a high-speed spiralscanning fiber probe. The system is capable of acquiring three-dimensional (3D) in vivo ... [Proc. SPIE Int. Soc. Opt. Eng. 6847, 684708 (2008)] published Tue Feb 19, 2008.
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  2. About James L. Connolly

    James L. Connolly

    James L. Connolly is in the Department of Pathology at Beth Israel Deaconess Medical Center.