1. James G. Fujimoto

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    1. Mentioned In 345 Articles

    2. Massachusetts Institute of Technology Receives Grant for Optical Biopsy Using Optical Coherence Tomography

      Massachusetts Institute of Technology Receives Grant for Optical Biopsy Using Optical Coherence Tomography
      ...6 NIH Grant for $288,576 for Optical Biopsy Using Optical Coherence Tomography. The principal investigator is James Fujimoto. The program began in 1997 and ends in 2019. Below is a summary of the proposed work. This is ...
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    3. Carmen A. Puliafito, MD, MBA, Former Dean of Keck School of Medicine of the University of Southern California, Joins Ophthotech as Chief of Strategic Development

      Carmen A. Puliafito, MD, MBA, Former Dean of Keck School of Medicine of the University of Southern California, Joins Ophthotech as Chief of Strategic Development
      ...restigious award in optoelectronics. Dr. Puliafito was also awarded the Champalimaud Vision Award (along with James Fujimoto, Eric Swanson, David Huang and Joel Schuman), often called the "Nobel Prize for Vision," a pres...
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    4. Three-dimensional morphological response of lipid-rich coronary plaques to statin therapy: a serial optical coherence tomography study

      Three-dimensional morphological response of lipid-rich coronary plaques to statin therapy: a serial optical coherence tomography study
      Objective: Previous studies have suggested that intensive statin therapy, compared with moderate statin therapy, provided greater reduction of LDL and better protection against major cardiovascular events. However, the exact dose-dependent mechanism of plaque stabilization remains unclear. The aim of this study is to investigate the three-dimensional (3D) response of fibrous caps overlying lipid plaques to statin therapy. Methods: We applied a novel computer algorithm to investigate the fibrous cap 3D ...
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    5. Select Features of Diabetic Retinopathy on Swept-Source Optical Coherence Tomographic Angiography Compared With Fluorescein Angiography and Normal Eyes

      Select Features of Diabetic Retinopathy on Swept-Source Optical Coherence Tomographic Angiography Compared With Fluorescein Angiography and Normal Eyes
      Importance Optical coherence tomographic angiography (OCTA) is a recently developed noninvasive imaging technique that can visualize the retinal and choroidal microvasculature without the injection of exogenous dyes. Objective To evaluate the potential clinical utility of OCTA using a prototype swept-source OCT (SS-OCT) device and compare it with fluorescein angiography (FA) for analysis of the retinal microvasculature in diabetic retinopathy. Design, Setting, and Participants Prospective, observational cross-sectional study conducted at a ...
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    6. Post-doctoral Associate Position in Biophotonics/Biomedical Optical Imaging at Lehigh University

      Post-doctoral Associate Position in Biophotonics/Biomedical Optical Imaging at Lehigh University
      ...development of diffuse optical spectroscopy and imaging techniques. In August 2007, Dr. Zhou joined Professor James G. Fujimoto’s Laser Medicine and Medical Imaging Group at the Massachusetts Institute of Technology (MIT...
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    7. MIT receives a NIH grant for Novel Diagnostics with Optical Coherence Tomography.

      MIT receives a NIH grant for Novel Diagnostics with Optical Coherence Tomography.
      ...NIH grant for $437,893 for Novel Diagnostics with Optical Coherence Tomography. The principal investigator is James Fujimoto. The program began in 1985 and ends in 2020. Below is a summary of the propose work. This prop...
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    8. Fourth international meeting on OCT Angiography, advances in OCT, and “en face” OCT will be held in Rome December 16 and 17 2016.

      Fourth international meeting on OCT Angiography, advances in OCT, and “en face” OCT will be held in Rome December 16 and 17 2016.
      ... Rosenfeld, David Sarraf, Eric Souied, Richard Spaide, Giovanni Staurenghi, Nadia Waheed. President of Honor: James Fujimoto Coordinators: Amani Fawzi, Martine Mauget Faysse, Andre Romano, Marco Rispoli. For more informa...
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    9. Method and apparatus for motion correction and image enhancement for optical coherence tomography

      Method and apparatus for motion correction and image enhancement for optical coherence tomography
      Images of an object, such as OCT scans of a human eye, can include distortions and data gaps due to relative motion of the object and the image acquisition device. Methods and systems for correction of such distortions and data gaps are described herein. Motion-corrected data is arrived at by applying three-dimensional transforms to input three-dimensional data sets that represent at least partially overlapping regions of the imaged object. The ...
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    10. Choroidal neovascularization analyzed on ultra-high speed swept source optical coherence tomography angiography compared to spectral domain optical coherence tomography angiography

      Choroidal neovascularization analyzed on ultra-high speed swept source optical coherence tomography angiography compared to spectral domain optical coherence tomography angiography
      Purpose To compare visualization of choroidal neovascularization (CNV) secondary to age-related macular degeneration (AMD) using an ultra-high speed swept-source (SS)-optical coherence tomography angiography (OCTA) prototype versus a spectral-domain (SD)-OCTA device. Design Comparative analysis of diagnostic instruments. Methods Patients were prospectively recruited to be imaged on SD-OCT and SS-OCT devices on the same day. The SD-OCT device employed is the RTVue Avanti that operates at 840nm wavelength and 70 ...
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    11. Post-doctoral Associate Position in Biophotonics / Biomedical Optical Imaging at Lehigh University

      Post-doctoral Associate Position in Biophotonics / Biomedical Optical Imaging at Lehigh University
      ...opment of diffuse optical spectroscopy and imaging techniques. In August 2007, Dr. Zhou joined Professor James G. Fujimoto’s Laser Medicine and Medical Imaging Group at the Massachusetts Institute of Technolog...
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    12. Quantitative analysis of the side-branch orifice after bifurcation stenting using en-face processing of OCT images: a comparison between Xience V and Resolute Integrity stents

      Quantitative analysis of the side-branch orifice after bifurcation stenting using en-face processing of OCT images: a comparison between Xience V and Resolute Integrity stents
      Objective: Methods for intravascular assessment of the side-branch (SB) orifice after stenting are not readily available. The aim of this study was to assess the utility of an en-face projection processing for optical coherence tomography (OCT) images for SB evaluation. Methods: Measurements of the SB orifice obtained using en-face OCT images were validated using a phantom model. Linear regression modeling was applied to estimated area measurements made on the en-face ...
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    13. Three Dimensional Enhanced Imaging of Vitreoretinal Interface in Diabetic Retinopathy Using Swept Source Optical Coherence Tomography

      Three Dimensional Enhanced Imaging of Vitreoretinal Interface in Diabetic Retinopathy Using Swept Source Optical Coherence Tomography
      Purpose To analyze the vitreoretinal interface in diabetic eyes using three-dimensional wide-field volumes acquired using high-speed, long-wavelength swept-source optical coherence tomography (SS-OCT). Design Prospective cross-sectional study. Methods Fifty-six diabetic patients (88 eyes) and 11 healthy non-diabetic controls (22 eyes) were recruited. Up to eight SS-OCT volumes were acquired for each eye. A registration algorithm removed motion artifacts and merged multiple SS-OCT volumes to improve signal. Vitreous visualization was enhanced using ...
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  2. About James G. Fujimoto

    James G. Fujimoto

    James. G. Fujimoto is a principal investigator in the Research Laboratory of Electronics (RLE) at the Massachusetts Institute of Technology (MIT). He received his S.B., S.M., and Ph.D. in electrical engineering from MIT in 1979, 1981, and 1984 respectively. He joined the MIT faculty in 1985 as Assistant Professor of Electrical Engineering. Since 1994, he has been Professor of Electrical Engineering at MIT and Adjunct Professor of Ophthalmology at Tufts University.

    Professor Fujimoto's area of research involves the development and application of femtosecond laser technology, studies of ultrafast phenomena, and laser medicine and surgery. His research group in RLE and collaborators invented optical coherence tomography and pioneered its development. 

    James G Fujimoto has published over 250 journal articles, is editor or author of 5 books, and holds numerous U.S. patents for his discoveries. He is a fellow of the National Academy of Engineering and the American Association for the Advancement of Science. Among his many honors include the 1999 Discover Magazine Award for Technological Innovation and the 2001 Rank Prize in Optoelectronics.

  3. Quotes

    1. The newest swept-source OCT has the advantage that the light source frequency sweep range and repetition rate can be adjusted to tailor the resolution, imaging range, and axial scan repetition rate for the specific imaging application.
      In Swept-source OCT and glaucoma
    2. We are now approaching a point with OCT where ophthalmologists have a view of the retina that is similar to that of pathologists...In the future, functional imaging will make subtle changes in pathology more measurable, and these advances will enhance sensitivity when monitoring disease progression and response to therapy.
      In How hardware, software advances expand OCT capabilities
    3. Hand-held instruments can enable screening a wider population outside the traditional points of care...The hand-held platform allows the diagnosis or screening to be performed in a much wider range of settings...Developing screening methods that are accessible to the larger population could significantly reduce unnecessary vision loss.
      In Early Detection of Blinding Eye Disease Could be as Easy as Scanning a Barcode
    4. Hand-held instruments can enable screening a wider population outside the traditional points of care.
      In Early Detection of Blinding Eye Disease Could be as Easy as Scanning a Barcode
    5. The hand-held platform allows the diagnosis or screening to be performed in a much wider range of settings.
      In Early Detection of Blinding Eye Disease Could be as Easy as Scanning a Barcode
    6. Partnership between academics and industry was critical for the development of OCT and is a powerful approach for translating new scientific discoveries into real world clinical practice...Clinical researchers on our team as well as other clinicians at leading international medical centers worked with the early OCT technology, exploring new clinical applications and blazing a trail that the broader clinical community could follow. This interdisciplinary approach was key to the success of this technology.
      In MIT Researchers Dr. James Fujimoto and Mr. Eric Swanson Awarded the 2012 António Champalimaud Vision Award
    7. OCT has the advantage that it can image 1 or 2 millimeters below the surface with high resolution, noninvasively...Increased imaging speed is important; it allows broader coverage or improved resolution...the concept is not that the technology is trying to diagnose the cancer per se, since excisional biopsies do that well...Instead, it is coupling 3D OCT scanning across the sampling area with standard biopsies.
      In Optical Tomography May Aid 3D Cancer Diagnostics
    8. Ultrahigh-speed imaging is important because it enables the acquisition of large three-dimensional volumetric data sets with micron-scale resolution.
      In New High-speed 3-D Imaging System Holds Potential for Improved Cancer Screening
    9. Excisional biopsy is one of the gold standards for the diagnosis of cancer, but is a sampling procedure. If the biopsy is taken in a normal region of tissue and misses the cancer, the biopsy result is negative although the patient still has cancer.
      In New High-speed 3-D Imaging System Holds Potential for Improved Cancer Screening
    10. This device development is one of the major technical challenges in endoscopic OCT because probes must be small enough so that they can be introduced into the body, but still be able to scan an optical beam at high speeds...Increasing imaging speeds has also been an important research objective because high-resolution volumetric imaging requires very large amounts of data in order to cover appreciable regions of tissue, so rapid image acquisition rates are a powerful advantage.
      In New High-speed 3-D Imaging System Holds Potential for Improved Cancer Screening