1. James G. Fujimoto

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    1. Mentioned In 371 Articles

    2. Endoscopic optical coherence tomography angiography microvascular features associated with dysplasia in Barrett's esophagus: a pilot study (with video)

      Endoscopic optical coherence tomography angiography microvascular features associated with dysplasia in Barrett's esophagus: a pilot study (with video)
      Background and Aims Angiogenesis is associated with neoplastic progression of Barretts esophagus (BE). Volumetric optical coherence tomography angiography (OCTA) visualizes subsurface microvasculature without exogenous contrast agents. We investigated the association of OCTA microvascular features with low-grade dysplasia (LGD) and high-grade dysplasia (HGD). Methods Fifty-two patients undergoing BE surveillance or endoscopic eradication therapies for dysplasia were imaged using volumetric OCTA and corresponding histological diagnoses obtained, to yield 97 data sets (non-dysplastic ...
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    3. Cubic meter volume optical coherence tomography

      Cubic meter volume optical coherence tomography
      Optical coherence tomography (OCT) is a powerful three-dimensional (3D) imaging modality with micrometer-scale axial resolution and up to multi-GigaVoxel/s imaging speed. However, the imaging range of high-speed OCT has been limited. Here, we report 3D OCT over cubic meter volumes using a long coherence length, 1310 nm vertical-cavity surface-emitting laser and silicon photonic integrated circuit dual-quadrature receiver technology combined with enhanced signal processing. We achieved 15 m depth resolution ...
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    4. USC Roski Eye Institute Joins the ARVO Campaign to Promote the Impact of Optical Coherence Tomography, USC Clinician/Scientist one of OCT Inventors

      USC Roski Eye Institute Joins the ARVO Campaign to Promote the Impact of Optical Coherence Tomography, USC Clinician/Scientist one of OCT Inventors
      ...treoretinal surgeon and retinal disease expert, published his creation of OCT along with two MIT researchers, James G. Fujimoto, PhD and Eric Swanson, MS. Then in 2005, Puliafito developed the use of ultra-high speed Fou...
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    5. Optical Coherence Tomography Angiography Characteristics of Iris Melanocytic Tumors

      Optical Coherence Tomography Angiography Characteristics of Iris Melanocytic Tumors
      Purpose To evaluate tumor vasculature with optical coherence tomography angiography (OCTA) in malignant iris melanomas and benign iris lesions. Design Cross-sectional observational clinical study. Participants Patients with iris lesions and healthy volunteers. Methods Eyes were imaged using OCTA systems operating at 1050- and 840-nm wavelengths. Three-dimensional OCTA scans were acquired. Iris melanoma patients treated with radiation therapy were imaged again after I-125 plaque brachytherapy at 6 and 18 months. Main ...
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    6. Volumetric Mapping of Barrett’s Esophagus and Dysplasia With en face Optical Coherence Tomography Tethered Capsule

      Volumetric Mapping of Barrett’s Esophagus and Dysplasia With en face Optical Coherence Tomography Tethered Capsule
      To the Editor: Dysplasia in Barretts Esophagus (BE) is patchy ( 1 ) and sometimes missed by random biopsies. Optical coherence tomography (OCT) can image large areas of the esophagus; however, slow imaging speeds in earlier studies limited visualization to cross-sections. Cross-sectional OCT detected high-grade dysplasia with sensitivity / specificity of ~80 % ( 2 , 3 ). Tethered OCT capsules were demonstrated for cross-sectional imaging in unsedated screening to detect BE ( 4 , 5 ). Our group recently ...
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    7. OCT - catching macular degeneration before vision loss

      OCT - catching macular degeneration before vision loss
      Growing old leads to a growing number of health problems, including those that challenge our ability to see. Age-related macular degeneration (AMD) is a disease that -- until recently -- robbed the elderly of the ability to read, drive and see the faces of their loved ones. Thanks to the invention of OCT, doctors can catch the disease before vision is lost. And with the aid of new drugs, AMD can be ...
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    8. Analysis of Scleral Feeder Vessel in Myopic Choroidal Neovascularization Using Optical Coherence Tomography Angiography

      Analysis of Scleral Feeder Vessel in Myopic Choroidal Neovascularization Using Optical Coherence Tomography Angiography
      To describe the appearance of a scleral-derived feeder vessel in a highly myopic eye with secondary choroidal neovascularization (CNV) as visualized on both en face high-speed swept-source (SS) optical coherence tomography angiography (OCTA) prototype, and a commercially available spectral-domain (SD) OCTA, with the corresponding en face and cross-sectional structural OCT images. In this case report, a 60-year-old white male presented with high myopia and secondary CNV in the right eye ...
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    9. SWEPT-SOURCE OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY REVEALS CHORIOCAPILLARIS ALTERATIONS IN EYES WITH NASCENT GEOGRAPHIC ATROPHY AND DRUSEN-ASSOCIATED GEOGRAPHIC ATROPHY

      SWEPT-SOURCE OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY REVEALS CHORIOCAPILLARIS ALTERATIONS IN EYES WITH NASCENT GEOGRAPHIC ATROPHY AND DRUSEN-ASSOCIATED GEOGRAPHIC ATROPHY
      Purpose: To investigate choriocapillaris (CC) alteration in patients with nascent geographic atrophy (nGA) and/or drusen-associated geographic atrophy (DAGA) using swept-source optical coherence tomography angiography (OCTA). Methods: A 1,050-nm wavelength, 400 kHz A-scan rate swept-source optical coherence tomography prototype was used to perform volumetric swept-source optical coherence tomography angiography over 6 mm x 6 mm fields of view in patients with nGA and/or DAGA. The resulting optical coherence ...
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    10. TOWARD QUANTITATIVE OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY: Visualizing Blood Flow Speeds in Ocular Pathology Using Variable Interscan Time Analysis

      TOWARD QUANTITATIVE OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY: Visualizing Blood Flow Speeds in Ocular Pathology Using Variable Interscan Time Analysis
      Purpose: Currently available optical coherence tomography angiography systems provide information about blood flux but only limited information about blood flow speed. The authors develop a method for mapping the previously proposed variable interscan time analysis (VISTA) algorithm into a color display that encodes relative blood flow speed. Methods: Optical coherence tomography angiography was performed with a 1,050 nm, 400 kHz A-scan rate, swept source optical coherence tomography system using ...
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    11. 1-15 of 371 1 2 3 4 ... 23 24 25 »
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  2. About James G. Fujimoto

    James G. Fujimoto

    James Fujimoto is Elihu Thomson Professor of Electrical Engineering and Computer Science at the Massachusetts Institute of Technology, visiting professor of ophthalmology at Tufts University School of Medicine, and adjunct professor at the Medical University of Vienna. His group and collaborators invented and developed OCT, and he co-founded Advanced Ophthalmic Devices and LightLab Imaging, which developed cardiovascular OCT. He has published over 450 peer-reviewed articles and co-edited 13 books. He is a director of the International Society for Optics and Photonics (SPIE) and general co-chair of the SPIE BIOS symposium, and previously was co-chair of two Conferences on Lasers and Electro Optics and the European Conference on Biomedical Optics, and director of the Optical Society (OSA). He has received the Zeiss Research Award, IEEE Photonics Award, and OSA Ives Medal, and he shared the 2002 Rank Prize in Optoelectronics and 2012 António Champalimaud Vision Prize. He is a member of the National Academy of Engineering, National Academy of Sciences, and American Academy of Arts and Sciences.

  3. Quotes

    1. The development of OCT in the early 1990s greatly benefited from components and methods used in fiber-optical communications...And still, 25 years later, advances in the optical communications industry continue to greatly benefit OCT.
      In Macro-scale OCT heralds new industrial uses for the technique
    2. Our study demonstrates world-record results in cubic meter volume imaging, with at least an order of magnitude larger depth range and volume compared to previous demonstrations of three-dimensional OCT...These results provide a proof-of-principle demonstration for using OCT in this new regime...Long-range OCT is a new range of operation that requires extremely high performance light sources, integrated optical receivers and signal processing.
      In Researchers achieve meter-scale optical coherence tomography for first time
    3. "The development of OCT in the early 1990s greatly benefited from components and methods used in fiber optical communications,. And still, 25 years later, advances in the optical communications industry continue to greatly benefit OCT.
      In Researchers achieve meter-scale optical coherence tomography for first time
    4. The newest swept-source OCT has the advantage that the light source frequency sweep range and repetition rate can be adjusted to tailor the resolution, imaging range, and axial scan repetition rate for the specific imaging application.
      In Swept-source OCT and glaucoma
    5. We are now approaching a point with OCT where ophthalmologists have a view of the retina that is similar to that of pathologists...In the future, functional imaging will make subtle changes in pathology more measurable, and these advances will enhance sensitivity when monitoring disease progression and response to therapy.
      In How hardware, software advances expand OCT capabilities
    6. Hand-held instruments can enable screening a wider population outside the traditional points of care...The hand-held platform allows the diagnosis or screening to be performed in a much wider range of settings...Developing screening methods that are accessible to the larger population could significantly reduce unnecessary vision loss.
      In Early Detection of Blinding Eye Disease Could be as Easy as Scanning a Barcode
    7. Hand-held instruments can enable screening a wider population outside the traditional points of care.
      In Early Detection of Blinding Eye Disease Could be as Easy as Scanning a Barcode
    8. The hand-held platform allows the diagnosis or screening to be performed in a much wider range of settings.
      In Early Detection of Blinding Eye Disease Could be as Easy as Scanning a Barcode
    9. Partnership between academics and industry was critical for the development of OCT and is a powerful approach for translating new scientific discoveries into real world clinical practice...Clinical researchers on our team as well as other clinicians at leading international medical centers worked with the early OCT technology, exploring new clinical applications and blazing a trail that the broader clinical community could follow. This interdisciplinary approach was key to the success of this technology.
      In MIT Researchers Dr. James Fujimoto and Mr. Eric Swanson Awarded the 2012 António Champalimaud Vision Award
    10. OCT has the advantage that it can image 1 or 2 millimeters below the surface with high resolution, noninvasively...Increased imaging speed is important; it allows broader coverage or improved resolution...the concept is not that the technology is trying to diagnose the cancer per se, since excisional biopsies do that well...Instead, it is coupling 3D OCT scanning across the sampling area with standard biopsies.
      In Optical Tomography May Aid 3D Cancer Diagnostics