1. James G. Fujimoto

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    1. Mentioned In 289 Articles

    2. High-Speed Ultrahigh-Resolution OCT of Bruch's Membrane in Membranoproliferative Glomerulonephritis Type 2

      High-Speed Ultrahigh-Resolution OCT of Bruch's Membrane in Membranoproliferative Glomerulonephritis Type 2

      Membranoproliferative glomerulonephritis (MPGN) type 2 is characterized by electron-dense deposits in the glomerular basement membrane and drusen-like deposits in Bruch's membrane. Over time, atrophic changes in the retina and retinal pigment epithelium occur, which can progress to choroidal neovascularization (CNV). This report describes a patient with MPGN type 2 who developed progressive loss of vision secondary to CNV. High-speed ultrahigh-resolution optical coherence tomography (UHR-OCT) showed an irregular Bruch's membrane that measured 10 μm beneath the foveal center. High-speed UHR-OCT can potentially be used to analyze Bruch's membrane in secondary ocular manifestations of diseases such as MPGN type ...

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    3. Ultrahigh speed endoscopic optical coherence tomography for gastroenterology

      Ultrahigh speed endoscopic optical coherence tomography for gastroenterology

      We describe an ultrahigh speed endoscopic swept source optical coherence tomography (OCT) system for clinical gastroenterology using a vertical-cavity surface-emitting laser (VCSEL) and micromotor imaging catheter. The system had a 600 kHz axial scan rate and 8 µm axial resolution in tissue. Imaging was performed with a 3.2 mm diameter imaging catheter at 400 frames per second with a 12 µm spot size. Three-dimensional OCT (3D-OCT) imaging was performed in patients with a cross section of pathologies undergoing upper and lower endoscopy. The use of distally actuated imaging catheters enabled OCT imaging with more flexibility, such as volumetric imaging ...

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    4. Depth-encoded all-fiber swept source polarization sensitive OCT

      Depth-encoded all-fiber swept source polarization sensitive OCT

      Polarization sensitive optical coherence tomography (PS-OCT) is a functional extension of conventional OCT and can assess depth-resolved tissue birefringence in addition to intensity. Most existing PS-OCT systems are relatively complex and their clinical translation remains difficult. We present a simple and robust all-fiber PS-OCT system based on swept source technology and polarization depth-encoding. Polarization multiplexing was achieved using a polarization maintaining fiber. Polarization sensitive signals were detected using fiber based polarization beam splitters and polarization controllers were used to remove the polarization ambiguity. A simplified post-processing algorithm was proposed for speckle noise reduction relaxing the demand for phase stability. We ...

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    5. Clinical Guide to Angio-OCT (Non Invasive, Dyeless OCT Angiography) (Textbook)

      Clinical Guide to Angio-OCT (Non Invasive, Dyeless OCT Angiography)  (Textbook)

      The book discusses the clinical possibilities of Angio-OCT. Most imaging in the book (77 figures in Chapters 5, 7.1 and 10) has been performed with XR-Avanti Optovue SD-OCT device using SSADA algorithm. A few figures in chapters 3, 7.2 and 8 have been performed with a swept source OCT prototype using SSADA algorithm. Another technique is described in chapter 11, using ultrahigh speed, SS-OCT and its applications to optical coherence tomography-angiography (OCTA). Key Features Angio-OCT (Dyeless OCT Angiography) is a new TECHNOLOGY that gives already useful results, that can be applied to day-to-day clinical ophthalmology. Several different OCT ...

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    6. Endothelial Shear Stress and Coronary Plaque Characteristics in Humans: A Combined Frequency-Domain Optical Coherence Tomography and Computational Fluid Dynamics Study

      Endothelial Shear Stress and Coronary Plaque Characteristics in Humans: A Combined Frequency-Domain Optical Coherence Tomography and Computational Fluid Dynamics Study

      Background —Despite the exposure of the entire vasculature to the atherogenic effects of systemic risk factors, atherosclerotic plaques preferentially develop at sites with disturbed flow. This study aimed at exploring in vivo the relationship between local endothelial shear stress (ESS) and coronary plaque characteristics in humans, using computational fluid dynamics and frequency-domain optical coherence tomography (FD-OCT). Methods and Results —Three-dimensional coronary artery reconstruction was performed in 21 patients (24 arteries) presenting with acute coronary syndrome using FD-OCT and coronary angiography. Each coronary artery was divided into sequential 3-mm segments, and analyzed for the assessment of local ESS and plaque characteristics ...

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    7. Computer-Aided Image Analysis Algorithm to Enhance In Vivo Diagnosis of Plaque Erosion by Intravascular Optical Coherence Tomography

      Computer-Aided Image Analysis Algorithm to Enhance In Vivo Diagnosis of Plaque Erosion by Intravascular Optical Coherence Tomography

      Background —Recent reports show that plaque erosion can be diagnosed in vivo using optical coherence tomography (OCT) in patients with acute coronary syndromes (ACS). However, quantitative OCT image criteria for computer-aided diagnosis of plaque erosion have not been established. Methods and Results —A total of 42 patients with ACS caused by plaque erosion were included. Plaque erosion was identified according to the previously established OCT criteria. Both optical properties and morphological features of the focal eroded region as well as erosion-adjacent region were analyzed using a custom designed computer algorithm. Non-eroded fibrous plaques remote from the erosion site within the ...

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    8. Enhanced Vitreous Imaging in Healthy Eyes Using Swept Source Optical Coherence Tomography

      Enhanced Vitreous Imaging in Healthy Eyes Using Swept Source Optical Coherence Tomography

      Purpose To describe enhanced vitreous imaging for visualization of anatomic features and microstructures within the posterior vitreous and vitreoretinal interface in healthy eyes using swept-source optical coherence tomography (SS-OCT). The study hypothesis was that long-wavelength, high-speed, volumetric SS-OCT with software registration motion correction and vitreous window display or high-dynamic-range (HDR) display improves detection sensitivity of posterior vitreous and vitreoretinal features compared to standard OCT logarithmic scale display. Design Observational prospective cross-sectional study. Methods Multiple wide-field three-dimensional SS-OCT scans (500×500A-scans over 12×12 mm 2 ) were obtained using a prototype instrument in 22 eyes of 22 healthy volunteers. A registration ...

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    9. MIT Receives NIH Grant for Optical Biopsy Using Optical Coherence Tomography

      MIT Receives NIH Grant for Optical Biopsy Using Optical Coherence Tomography
      ...4 NIH Grant for $302,576 for Optical Biopsy Using Optical Coherence Tomography. THe principal investigator is James Fujimoto. The program began in 1997 and ends in 2019. Below is a summary of the proposed work. This is ...
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    10. Forward viewing OCT endomicroscopy (Thesis)

      Forward viewing OCT endomicroscopy (Thesis)

      A forward viewing fiber optic-based imaging probe device was designed and constructed for use with ultrahigh speed optical coherence tomography in the human gastrointestinal tract. The light source was a MEMS-VCSEL at 1300 nm wavelength running at 300 kHz sweep rate, giving an effective A-line rate of 600 kHz. Data was acquired with a 1.8 GS/s A/D card optically clocked by a maximum fringe frequency of 1 GHz. The optical beam from the probe was scanned by a freely deflecting optical fiber that was mounted proximally on a piezoelectric tubular actuator, which was electrically driven in two ...

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    11. Choroidal Haller's and Sattler's Layer Thickness Measurement Using 3-Dimensional 1060-nm Optical Coherence Tomography

      Choroidal Haller's and Sattler's Layer Thickness Measurement Using 3-Dimensional 1060-nm Optical Coherence Tomography

      Objectives To examine the feasibility of automatically segmented choroidal vessels in three-dimensional (3D) 1060-nmOCT by testing repeatability in healthy and AMD eyes and by mapping Haller's and Sattler's layer thickness in healthy eyes Methods Fifty-five eyes (from 45 healthy subjects and 10 with non-neovascular age-related macular degeneration (AMD) subjects) were imaged by 3D-1060-nmOCT over a 36°x36° field of view. Haller's and Sattler's layer were automatically segmented, mapped and averaged across the Early Treatment Diabetic Retinopathy Study grid. For ten AMD eyes and ten healthy eyes, imaging was repeated within the same session and on another ...

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    12. 1-15 of 289 1 2 3 4 ... 18 19 20 »
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  2. About James G. Fujimoto

    James G. Fujimoto

    James. G. Fujimoto is a principal investigator in the Research Laboratory of Electronics (RLE) at the Massachusetts Institute of Technology (MIT). He received his S.B., S.M., and Ph.D. in electrical engineering from MIT in 1979, 1981, and 1984 respectively. He joined the MIT faculty in 1985 as Assistant Professor of Electrical Engineering. Since 1994, he has been Professor of Electrical Engineering at MIT and Adjunct Professor of Ophthalmology at Tufts University.

    Professor Fujimoto's area of research involves the development and application of femtosecond laser technology, studies of ultrafast phenomena, and laser medicine and surgery. His research group in RLE and collaborators invented optical coherence tomography and pioneered its development. 

    James G Fujimoto has published over 250 journal articles, is editor or author of 5 books, and holds numerous U.S. patents for his discoveries. He is a fellow of the National Academy of Engineering and the American Association for the Advancement of Science. Among his many honors include the 1999 Discover Magazine Award for Technological Innovation and the 2001 Rank Prize in Optoelectronics.

  3. Quotes

    1. The newest swept-source OCT has the advantage that the light source frequency sweep range and repetition rate can be adjusted to tailor the resolution, imaging range, and axial scan repetition rate for the specific imaging application.
      In Swept-source OCT and glaucoma
    2. We are now approaching a point with OCT where ophthalmologists have a view of the retina that is similar to that of pathologists...In the future, functional imaging will make subtle changes in pathology more measurable, and these advances will enhance sensitivity when monitoring disease progression and response to therapy.
      In How hardware, software advances expand OCT capabilities
    3. Hand-held instruments can enable screening a wider population outside the traditional points of care...The hand-held platform allows the diagnosis or screening to be performed in a much wider range of settings...Developing screening methods that are accessible to the larger population could significantly reduce unnecessary vision loss.
      In Early Detection of Blinding Eye Disease Could be as Easy as Scanning a Barcode
    4. Hand-held instruments can enable screening a wider population outside the traditional points of care.
      In Early Detection of Blinding Eye Disease Could be as Easy as Scanning a Barcode
    5. The hand-held platform allows the diagnosis or screening to be performed in a much wider range of settings.
      In Early Detection of Blinding Eye Disease Could be as Easy as Scanning a Barcode
    6. Partnership between academics and industry was critical for the development of OCT and is a powerful approach for translating new scientific discoveries into real world clinical practice...Clinical researchers on our team as well as other clinicians at leading international medical centers worked with the early OCT technology, exploring new clinical applications and blazing a trail that the broader clinical community could follow. This interdisciplinary approach was key to the success of this technology.
      In MIT Researchers Dr. James Fujimoto and Mr. Eric Swanson Awarded the 2012 António Champalimaud Vision Award
    7. OCT has the advantage that it can image 1 or 2 millimeters below the surface with high resolution, noninvasively...Increased imaging speed is important; it allows broader coverage or improved resolution...the concept is not that the technology is trying to diagnose the cancer per se, since excisional biopsies do that well...Instead, it is coupling 3D OCT scanning across the sampling area with standard biopsies.
      In Optical Tomography May Aid 3D Cancer Diagnostics
    8. Ultrahigh-speed imaging is important because it enables the acquisition of large three-dimensional volumetric data sets with micron-scale resolution.
      In New High-speed 3-D Imaging System Holds Potential for Improved Cancer Screening
    9. Excisional biopsy is one of the gold standards for the diagnosis of cancer, but is a sampling procedure. If the biopsy is taken in a normal region of tissue and misses the cancer, the biopsy result is negative although the patient still has cancer.
      In New High-speed 3-D Imaging System Holds Potential for Improved Cancer Screening
    10. This device development is one of the major technical challenges in endoscopic OCT because probes must be small enough so that they can be introduced into the body, but still be able to scan an optical beam at high speeds...Increasing imaging speeds has also been an important research objective because high-resolution volumetric imaging requires very large amounts of data in order to cover appreciable regions of tissue, so rapid image acquisition rates are a powerful advantage.
      In New High-speed 3-D Imaging System Holds Potential for Improved Cancer Screening