1. J. Stuart Nelson

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    1. Mentioned In 16 Articles

    2. In vivo, high-resolution, three-dimensional imaging of port wine stain microvasculature in human skin

      In vivo, high-resolution, three-dimensional imaging of port wine stain microvasculature in human skin
      Port-wine stain (PWS) is a congenital, progressive vascular malformation of the dermis. In the past few years, advances in optical coherence tomography (OCT) technology have greatly increased imaging speed. Sophisticated numerical algorithms have improved the sensitivity of Doppler OCT dramatically. These improvements have enabled the noninvasive, high-resolution, three-dimensional functional imaging of PWS skin. In this study, high-resolution, three-dimensional, microvasculature imaging of PWS using Doppler OCT technique is demonstrated. Three-dimensional imaging ...
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    3. Systems, devices, and methods for optically clearing tissue

      Systems, devices, and methods for optically clearing tissue
      Embodiments of the present disclosure provides systems, devices, and methods for non-invasively modifying, maintaining, or controlling local tissue optical properties. Methods and devices of the disclosure may be used for optically clearing tissue, for example, for diagnostic and/or therapeutic purposes. A method of optically clearing a tissue may comprise contacting the tissue with an optical clearing device having a base, an array of pins fixed to one side of ...
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    4. High speed spectral domain functional optical coherence tomography and optical doppler tomography for in vivo blood flow dynamics and tissue structure

      A system for tomographic imaging includes a source of at least partially coherent radiation, a frequency-swept laser source and an interferometer. The radiation in the interferometer is phase modulated at a modulation frequency for elimination of DC and autocorrelation noises as well as the mirror image. The interference fringes of the radiation backscattered from the sample into the interferometer are detected to obtain a spectral signal. The spectral signal of ...
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    5. Phase-resolved optical coherence tomography and optical Doppler tomography for imaging blood flow in human skin with fast scanning speed and high velocity sensitivity.

      We have developed a novel phase-resolved optical coherence tomography (OCT) and optical Doppler tomography (ODT) system that uses phase information derived from a Hilbert transformation to image blood flow in human skin with fast scanning speed and high velocity sensitivity. Using the phase change between sequential scans to construct flow-velocity imaging, this technique decouples spatial resolution and velocity sensitivity in flow images and increases imaging speed by more than 2 ...
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    6. High resolution optical coherence tomography with an improved depth range using an axicon lens

      In optical coherence tomography (OCT), Axial and lateral resolutions are determined by the source coherence length and numerical aperture of the sampling lens, respectively. While axial resolution can be improved using a broadband light source, there is a trade-off between lateral resolution and focusing depth when conventional optical elements are used. The incorporation of an axicon lens into the sample arm of the interferometer overcomes this limitation. Using an axicon ...
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    7. Phase-resolved functional optical coherence tomography: simultaneous imaging of the stokes vectors, structure, blood flow velocity, standard deviation and birefringence in biological samples

      A phase-resolved functional optical coherence tomography system simultaneously obtains the Stokes vectors, structure, blood flow velocity, standard deviation, and birefringence images in human skin. The multifunctional images were obtained by processing the analytical interference fringe signals derived from the two perpendicular polarization detection channels. The blood flow velocity and standard deviation images were obtained by comparing the phase from the pairs of analytical signals in the neighboring A-lines in the ...
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    8. Imaging transverse flow velocity using spectral bandwidth of the doppler frequency shift in phase-resolved optical doppler tomography

      The Doppler bandwidth extracted from the standard deviation of the frequency shift in phase-resolved optical Doppler tomography (ODT) is used to image the velocity component transverse to the probing beam. The effective numerical aperture (NA) of the optical objective determines the slope of the dependence of the standard deviation on velocity. In the case where the angle between the probing beam and flow direction is within .+-.15 degrees to the ...
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    9. Advances in oral cancer detection using optical coherence tomography

      Advances in oral cancer detection using optical coherence tomography
      Optical coherence tomography (OCT) is a new modality capable of cross sectional imaging of biological tissue. Due to its many technical advantages such as high image resolution, fast acquisition time, and noninvasive capabilities, OCT is potentially useful in various medical applications. Because OCT systems can function with a fiber optic probe, they are applicable to almost any anatomic structures accessible either directly, or by endoscopy. OCT has the potential to ...
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    10. OCT Medical Imaging Inc Startup Company Profile

      OCT Medical Imaging Inc Startup Company Profile
      OCT Medical Imaging is working to market devices that record more detailed images than ultrasound. X-rays, CT scans, MRIs, PET scans, ultrasound. Optical coherence tomography (OCT) uses coherence gating to select minimum backscattered photons for image reconstruction. Axial and lateral resolutions are determined by the source coherence length and numerical aperture of the sampling lens, respectively. While axial resolution can be improved using a broadband light source, there is a ...
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    11. Phase-resolved optical coherence tomography and optical doppler tomography for imaging fluid flow in tissue with fast scanning speed and high velocity sensitivity

      ...eft. 22, 64 (1997); and Z. Chen, T. E. Milner, S. Srinivas, X. Wang, A. Malekafzali, M. J. C. van Gemert, and J. S. Nelson, Opt. Lett. 22,1119 (1997).However, previously developed ODT systems were unable to achieve simul...
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    12. Birefringence imaging in biological tissue using polarization sensitive optical coherent tomography

      Employing a low coherence Michelson interferometer, two dimensional images of optical birefringence in turbid samples as a function of depth are measured. Polarization sensitive detection of the signal formed by interference of backscattered light from the sample and a mirror or reference plane in the reference arm which defines a reference optical path length, give the optical phase delay between light propagating along the fast and slow axes of the ...
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    13. Method and apparatus for optical Doppler tomographic imaging of fluid flow velocity in highly scattering media

      Optical Doppler tomography permits imaging of fluid flow velocity in highly scattering media. The tomography system combines Doppler velocimetry with high spatial resolution of partially coherent optical interferometry to measure fluid flow velocity at discrete spatial locations. Noninvasive in vivo imaging of blood flow dynamics and tissue structures with high spatial resolutions of the order of 2 to 10 microns is achieved in biological systems. The backscattered interference signals derived ...
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    14. 1-16 of 16
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  2. About J. Stuart Nelson

    J. Stuart Nelson

    John S. Nelson is director of the Beckman Laser  Institute.  Dr. Nelson has a very active research program that includes studies at both the basic science and applied levels. The principal goal of his research has been to integrate experimental and theoretical descriptions of light propagation in homogeneous and heterogeneous biological tissues to yield a basis for dosimetry of laser-tissue interactions. Although his work on laser dosimetry is shared with workers in a variety of disciplines and pertinent to many clinical applications, he is particularly interested in addressing the problems associated with light propagation and dosimetry in human skin. The objective of this research is to develop non-invasive sensing techniques to determine experimentally the optical and thermal properties of skin. Substantial independent grant support for this research has been obtained by Dr. Nelson from the Department of Energy, Office of Naval Research, Biomedical Research Technology Program, Whitaker Foundation, Dermatology Foundation, and private industry. In addition, to date he has received five awards from the National Institutes of Health totaling $6,000,000. Dr. Nelson has made numerous contributions to the emerging fields of photomedicine and biomedical optics. To date, he has published more than 240 scientific articles and 13 book chapters.