1. Irina V. Larina

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    1. Mentioned In 56 Articles

    2. Comparison and combination of rotational imaging optical coherence tomography and selective plane illumination microscopy for embryonic study

      Comparison and combination of rotational imaging optical coherence tomography and selective plane illumination microscopy for embryonic study
      Several optical imaging techniques have been applied for high-resolution embryonic imaging using different contrast mechanisms, each with their own benefits and limitations. In this study, we imaged the same E9.5 mouse embryo with rotational imaging optical coherence tomography (RI-OCT) and selective plane illumination microscopy (SPIM). RI-OCT overcomes optical penetration limits of traditional OCT imaging that prohibit full-body imaging of mouse embryos at later stages by imaging the samples from ...
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    3. Speckle variance optical coherence tomography of blood flow in the beating mouse embryonic heart

      Speckle variance optical coherence tomography of blood flow in the beating mouse embryonic heart
      Efficient separation of blood and cardiac wall in the beating embryonic heart is essential and critical for experiment-based computational modelling and analysis of early-stage cardiac biomechanics. Although speckle variance optical coherence tomography (SV-OCT) relying on calculation of intensity variance over consecutively acquired frames is a powerful approach for segmentation of fluid flow from static tissue, application of this method in the beating embryonic heart remains challenging because moving structures generate ...
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    4. A dual-modality optical coherence tomography and selective plane illumination microscopy system for mouse embryonic imaging

      A dual-modality optical coherence tomography and selective plane illumination microscopy system for mouse embryonic imaging
      Both optical coherence tomography (OCT) and selective plane illumination microscopy (SPIM) are frequently used in mouse embryonic research for high-resolution three-dimensional imaging. However, each of these imaging methods provide a unique and independent advantage: SPIM provides morpho-functional information through immunofluorescence and OCT provides a method for whole-embryo 3D imaging. In this study, we have combined rotational imaging OCT and SPIM into a single, dual-modality device to image E9.5 mouse ...
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    5. Live dynamic analysis of the developing cardiovascular system in mice

      Live dynamic analysis of the developing cardiovascular system in mice
      The study of the developing cardiovascular system in mice is important for understanding human cardiogenesis and congenital heart defects. Our research focuses on imaging early development in the mouse embryo to specifically understand cardiovascular development under the regulation of dynamic factors like contractile force and blood flow using optical coherence tomography (OCT). We have previously developed an OCT based approach that combines static embryo culture and advanced image processing with ...
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    6. Dynamic imaging and quantitative analysis of cranial neural tube closure in the mouse embryo using optical coherence tomography

      Dynamic imaging and quantitative analysis of cranial neural tube closure in the mouse embryo using optical coherence tomography
      Neural tube closure is a critical feature of central nervous system morphogenesis during embryonic development. Failure of this process leads to neural tube defects, one of the most common forms of human congenital defects. Although molecular and genetic studies in model organisms have provided insights into the genes and proteins that are required for normal neural tube development, complications associated with live imaging of neural tube closure in mammals limit ...
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    7. Optical Modalities for Embryonic Imaging

      Optical Modalities for Embryonic Imaging
      tudies of disease etiology often rely on the murine (mouse) model, which provides valuable genotypic information. Yet associated phenotypic information from murine embryos is often lacking. Of the various techniques that have been proposed for imaging such embryos, optical modalities may provide the best compromise among speed, penetration depth and resolution. This year, we developed approaches to improve embryonic imaging with optical coherence tomography (OCT), 1 and also provided a ...
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    8. Live four-dimensional optical coherence tomography reveals embryonic cardiac phenotype in mouse mutant

      Live four-dimensional optical coherence tomography reveals embryonic cardiac phenotype in mouse mutant
      Efficient phenotyping of developmental defects in model organisms is critical for understanding the genetic specification of normal development and congenital abnormalities in humans. We previously reported that optical coherence tomography (OCT) combined with live embryo culture is a valuable tool for mouse embryo imaging and four-dimensional (4-D) cardiodynamic analysis; however, its capability for analysis of mouse mutants with cardiac phenotypes has not been previously explored. Here, we report 4-D (three-dimensional ...
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    9. Applicability, usability, and limitations of murine embryonic imaging with optical coherence tomography and optical projection tomography

      Applicability, usability, and limitations of murine embryonic imaging with optical coherence tomography and optical projection tomography
      ...tal alcohol exposure,” Dev. Dyn. 244(4), 607–618 (2015). [CrossRef] [PubMed] C. Wu, N. Sudheendran, M. Singh, I. V. Larina, M. E. Dickinson, and K. V. Larin, “Rotational Imaging OCT for Full-Body Mouse Embryonic Imaging,...
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    10. Four-dimensional live imaging of hemodynamics in mammalian embryonic heart with Doppler optical coherence tomography

      Four-dimensional live imaging of hemodynamics in mammalian embryonic heart with Doppler optical coherence tomography
      Four-dimensional live hemodynamic imaging of the mouse embryonic heart at embryonic day 9.0 using Doppler optical coherence tomography, showing directional blood flows in the sinus venosus, primitive atrium, atrioventricular region and vitelline vein. Hemodynamic analysis of the mouse embryonic heart is essential for understanding the functional aspects of early cardiogenesis and advancing the research in congenital heart defects. However, high-resolution imaging of cardiac hemodynamics in mammalian models remains challenging ...
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    11. Comparison of rotational imaging optical coherence tomography and selective plane illumination microscopy for embryonic study

      Comparison of rotational imaging optical coherence tomography and selective plane illumination microscopy for embryonic study
      The mouse is a common model for studying developmental diseases. Different optical techniques have been developed to investigate mouse embryos, but each has its own set of limitations and restrictions. In this study, we imaged the same E9.5 mouse embryo with rotational imaging Optical Coherence Tomography (RI-OCT) and Selective Plane Illumination Microscopy (SPIM), and compared the two techniques. Results demonstrate that both methods can provide images with micrometer-scale spatial ...
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    12. Live 4D optical coherence tomography for early embryonic mouse cardiac phenotyping

      Live 4D optical coherence tomography for early embryonic mouse cardiac phenotyping
      Studying embryonic mouse development is important for our understanding of normal human embryogenesis and the underlying causes of congenital defects. Our research focuses on imaging early development in the mouse embryo to specifically understand cardiovascular development using optical coherence tomography (OCT). We have previously developed imaging approaches that combine static embryo culture, OCT imaging and advanced image processing to visualize the whole live mouse embryos and obtain 4D (3D+time ...
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    13. Three-dimensional imaging of the developing mouse female reproductive organs with optical coherence tomography

      Three-dimensional imaging of the developing mouse female reproductive organs with optical coherence tomography
      Infertility is a known major health concern and is estimated to impact ~15% of couples in the U.S. The majority of failed pregnancies occur before or during implantation of the fertilized embryo into the uterus. Understanding the mechanisms regulating development by studying mouse reproductive organs could significantly contribute to an improved understanding of normal development of reproductive organs and developmental causes of infertility in humans. Towards this goal, we ...
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    14. Functional optical coherence tomography for high-resolution mapping of cilia beat frequency in the mouse oviduct in vivo

      Functional optical coherence tomography for high-resolution mapping of cilia beat frequency in the mouse oviduct in vivo
      Since mouse is a superior model for genetic analysis of human disorders, reproductive studies in mice have significant implications on further understanding of fertility and infertility in humans. Fertilized oocytes are transported through the reproductive tract by motile cilia lining the lumen of the oviduct as well as by oviduct contractions. While the role of cilia is well recognized, ciliary dynamics in the oviduct is not well understood, largely owing ...
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    15. Rotational imaging optical coherence tomography for full-body mouse embryonic imaging

      Rotational imaging optical coherence tomography for full-body mouse embryonic imaging
      Optical coherence tomography (OCT) has been widely used to study mammalian embryonic development with the advantages of high spatial and temporal resolutions and without the need for any contrast enhancement probes. However, the limited imaging depth of traditional OCT might prohibit visualization of the full embryonic body. To overcome this limitation, we have developed a new methodology to enhance the imaging range of OCT in embryonic day (E) 9.5 ...
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  2. About Irina V. Larina

    Irina V. Larina

    Irina V. Larina is as Assistant Professor in the Department of Molecular Physiology and Biophysics at the at the Baylor College of Medicine.