1. Irina V. Larina

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    1. Mentioned In 75 Articles

    2. OCT Reveals Biomechanics of a Developing Mouse Heart, Live in 4D

      OCT Reveals Biomechanics of a Developing Mouse Heart, Live in 4D
      Scientists from Stevens Institute of Technology and Baylor College of Medicine used 4D optical coherence tomography (OCT) to study the pumping mechanism underlying the developing mammalian heart. 4D OCT allowed them to investigate the functional relation between blood flow and heart wall dynamics within different regions of the embryonic heart at a level of detail not currently accessible by other methods. 4D OCT could potentially enable scientists to assess cardiac ...
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    3. Live mechanistic assessment of localized cardiac pumping in mammalian tubular embryonic heart

      Live mechanistic assessment of localized cardiac pumping in mammalian tubular embryonic heart
      Significance: Understanding how the valveless embryonic heart pumps blood is essential to elucidate biomechanical cues regulating cardiogenesis, which is important for the advancement of congenital heart defects research. However, methods capable of embryonic cardiac pumping analysis remain limited, and assessing this highly dynamic process in mammalian embryos is challenging. New approaches are critically needed to address this hurdle. Aim: We report an imaging-based approach for functional assessment of localized pumping ...
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    4. Dynamic Imaging of Mouse Embryos and Cardiac Development in Static Culture

      Dynamic Imaging of Mouse Embryos and Cardiac Development in Static Culture
      Dynamic imaging is a powerful approach to assess the function of a developing organ system. The heart is a dynamic organ that undergoes quick morphological and mechanical changes through early embryonic development. Defining the embyonic mouse heart's normal function is important for our own understanding of human heart development and will inform us on treatments and prevention of congenital heart defects (CHD). Traditional methods such as ultrasound or fluorescence-based ...
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    5. Innovative method offers a new way of studying developmental cardiac biomechanics, live in 4-D

      Innovative method offers a new way of studying developmental cardiac biomechanics, live in 4-D
      ...ping dynamics of the mammalian tubular embryonic heart. Shang Wang of the Stevens Institute of Technology and Irina Larina of the Baylor College of Medicine used cutting-edge 4-D optical coherence tomography (OCT) to stu...
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    6. Baylor College of Medicine Receives NIH Grant for In Vivo Analysis of Mammalian Fertilization

      Baylor College of Medicine Receives NIH Grant for In Vivo Analysis of Mammalian Fertilization
      ... a 2020 NIH Grant for $541,789 for In Vivo Analysis of Mammalian Fertilization. The principal investigator is Irina Larina. Below is a summary of the proposed work. Estrous cycle, ovulation, fertilization, and pre-impla...
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    7. Baylor College of Medicine Receives NIH Grant for In Vivo Analysis of Mammalian Fertilization

      Baylor College of Medicine Receives NIH Grant for In Vivo Analysis of Mammalian Fertilization
      ... a 2019 NIH Grant for $657,043 for In Vivo Analysis of Mammalian Fertilization. The principal investigator is Irina Larina. The program began in 2019 and ends in 2022. Below is a summary of the propose work.

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    8. In Vivo Imaging of the Mouse Reproductive Organs, Embryo Transfer, and Oviduct Cilia Dynamics Using Optical Coherence Tomography

      In Vivo Imaging of the Mouse Reproductive Organs, Embryo Transfer, and Oviduct Cilia Dynamics Using Optical Coherence Tomography
      The oviduct (or fallopian tube) serves as the site where a number of major reproductive events occur for the start of a new life in mammals. Understanding the oviduct physiology is essential to uncover hidden mechanisms of the human reproduction and its disorders, yet the current analysis of the oviduct that is largely limited to in vitro imaging is a significant technical hurdle. To overcome this barrier, we have recently ...
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    9. In vivo three-dimensional tracking of sperm behaviors in the mouse oviduct

      In vivo three-dimensional tracking of sperm behaviors in the mouse oviduct
      Mammalian sperm evolutionarily acquired complex mechanisms regulating their behaviors, which are thought to be critical in navigating through the female reproductive tract toward fertilization. However, all current knowledge of this process is largely extrapolated from in vitro and ex vivo studies, because in vivo analysis of sperm in their native fertilization environment has not been possible. Here we report a functional optical coherence tomography approach that allows, for the first ...
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    10. Functional optical coherence tomography for live dynamic analysis of mouse embryonic cardiogenesis

      Functional optical coherence tomography for live dynamic analysis of mouse embryonic cardiogenesis
      Blood flow, heart contraction, and tissue stiffness are important regulators of cardiac morphogenesis and function during embryonic development. Defining how these factors are integrated is critically important to advance prevention, diagnostics, and treatment of congenital heart defects. Mammalian embryonic development is taking place deep within the female body, which makes cardiodynamic imaging and analysis during early developmental stages in humans inaccessible. With thousands of mutant lines available and well-established genetic ...
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  2. About Irina V. Larina

    Irina V. Larina

    Irina V. Larina is as Assistant Professor in the Department of Molecular Physiology and Biophysics at the at the Baylor College of Medicine.

  3. Quotes

    1. One out of every 100 babies in the United States has a congenital heart defect leading to death...Understanding biomechanical regulation of heart development is highly important for better management of congenital heart defects.
      In Understanding congenital heart defects to prevent them