1. Institute of Applied Physics

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    1. Mentioned In 168 Articles

    2. Attenuation coefficient for layer-by-layer assessment of the intestinal wall in acute ischemia according to optical coherence tomography

      Attenuation coefficient for layer-by-layer assessment of the intestinal wall in acute ischemia according to optical coherence tomography
      Small laboratory animals (rats) are suitable objects for modelling acute mesenteric ischemia (AMI) and monitoring changes in the structural tissue and intramural blood flow using optical coherence tomography (OCT) and OCT angiography methods. Combined with evaluation of blood circulation the prevalence of a necrotic tissue is a key factor in assessing intestine viability during surgery and determining the resection margins. While the assessment of the blood vessels network is commonly ...
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    3. Research and Development of the Method for Automating the Diagnostic Analysis of Human Fundus Images Produced by Optical Coherent Tomography Angiography

      Research and Development of the Method for Automating the Diagnostic Analysis of Human Fundus Images Produced by Optical Coherent Tomography Angiography
      Introduction: Severe viral keratitis with hypopyon and retrocorneal plaques is easily misdiagnosed as it mimics fungal or bacterial keratitis and is more likely to undergo emergency therapeutic penetrating keratoplasty (TPK) in the presence of active infection, resulting in poor outcomes. This case series offers some important insights for the management strategy of severe viral keratitis. Methods: This retrospective case series involved five patients with unilateral severe infectious keratitis with hypopyon ...
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    4. Optical clearing and testing of lung tissue using inhalation aerosols: prospects for monitoring the action of viral infections

      Optical clearing and testing of lung tissue using inhalation aerosols: prospects for monitoring the action of viral infections
      Optical clearing of the lung tissue aims to make it more transparent to light by minimizing light scattering, thus allowing reconstruction of the three-dimensional structure of the tissue with a much better resolution. This is of great importance for monitoring of viral infection impact on the alveolar structure of the tissue and oxygen transport. Optical clearing agents (OCAs) can provide not only lesser light scattering of tissue components but also ...
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    5. Multiplexed spatially-focused localization of light in adipose biological tissues

      Multiplexed spatially-focused localization of light in adipose biological tissues
      Last decades the effects of localization and focusing of light in turbid randomly inhomogeneous tissue-like scattering medium have been attracting a particular attention. Weak localization of light in disordered and weakly ordered biological tissue, polarization memory effect, correlations in transmission matrices, focusing light by wavefronts shaping have been widely exploited. Here, we represent an experimentally observed and theoretically confirmed new type of spatial localization of light within biological tissues. General ...
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    6. Brain white matter morphological structure correlation with its optical properties estimated from optical coherence tomography (OCT) data

      Brain white matter morphological structure correlation with its optical properties estimated from optical coherence tomography (OCT) data
      A pilot post-mortem study identifies a strong correlation between the attenuation coefficient estimated from the OCT data and some morphological features of the sample, namely the number of nuclei in the field of view of the histological image and the fiber structural parameter introduced in the study to quantify the difference in the myelinated fibers arrangements. The morphological features were identified from the histopathological images of the sample taken from ...
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    7. OCT-Guided Surgery for Gliomas: Current Concept and Future Perspectives

      OCT-Guided Surgery for Gliomas: Current Concept and Future Perspectives
      Optical coherence tomography (OCT) has been recently suggested as a promising method to obtain in vivo and real-time high-resolution images of tissue structure in brain tumor surgery. This review focuses on the basics of OCT imaging, types of OCT images and currently suggested OCT scanner devices and the results of their application in neurosurgery. OCT can assist in achieving intraoperative precision identification of tumor infiltration within surrounding brain parenchyma by ...
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    8. Single-cell all-optical coherence elastography with optical tweezers

      Single-cell all-optical coherence elastography with optical tweezers
      The elastic properties of cells are important for many of their functions, however the development of label free noninvasive cellular elastography method is a challenging topic. We present a novel single-cell all-optical coherence elastography method that combines optical tweezers producing mechanical excitation on the cell membrane or organelle and phase-sensitive optical coherence microscopy measuring sample response and determining its mechanical properties. The method allows living cells imaging with a lateral ...
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    9. An Improved Analytical Model of a Spectrometer for Optical Coherence Tomography

      An Improved Analytical Model of a Spectrometer for Optical Coherence Tomography
      We present an improved analytical model of a spectrometer for optical coherence tomography (OCT), which more accurately describes the OCT in-depth sensitivity fall-off. The model considers the intrinsic spectral resolution of the dispersive element and the influence of additional components (inequidistance-correcting prism). The model is validated by experimental data obtained both from other studies and our own experiments. The influence of the frequency response of the CCD electrical circuit and ...
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    10. Simulating scan formation in multimodal optical coherence tomography: angular-spectrum formulation based on ballistic scattering of arbitrary-form beams

      Simulating scan formation in multimodal optical coherence tomography: angular-spectrum formulation based on ballistic scattering of arbitrary-form beams
      We present a computationally highly efficient full-wave spectral model of OCT-scan formation with the following features: allowance of arbitrary phase-amplitude profile of illuminating beams; absence of paraxial approximation; utilization of broadly used approximation of ballistic scattering by discrete scatterers without limitations on their density/location and scattering strength. The model can easily incorporate the wave decay, dispersion, measurement noises with given signal-to-noise ratios and arbitrary inter-scan displacements of scatterers. We ...
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    11. Optical coherence tomography, intravascular ultrasound or angiography guidance for distal left main coronary stenting. The ROCK cohort II study

      Optical coherence tomography, intravascular ultrasound or angiography guidance for distal left main coronary stenting. The ROCK cohort II study
      Objectives: to test the safety and efficacy of intravascular imaging and specifically optical coherence tomography (OCT) as a diagnostic tool for left main angioplasty and analyze the mid-term outcome accordingly. Background: Clinical data and international guidelines recommend the use of intravascular imaging ultrasound (IVUS) to guide left main (LM) angioplasty. Despite early experience using OCT in this setting is encouraging, the evidence supporting its use is still limited. Methods: ROCK ...
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    12. Lymph vessels visualization from Optical Coherence Tomography data using depth-resolved attenuation coefficient calculation

      Lymph vessels visualization from Optical Coherence Tomography data using depth-resolved attenuation coefficient calculation
      Multimodal Optical Coherent Tomography grows popularity with researchers and clinicians over the past decade. One of the modalities is lymphangiography, which allows visualization of the lymphatic vessel networks within OCT imaging volume. In the present study, it is shown that lymphatic vessel visualization obtained from the depth-resolved attenuation coefficient distributions, corrected for the noise, shows improved contrast and detail in comparison with previously proposed approaches. We also argue that the ...
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    13. Recognition of individual scatterers against the noise background in the optical coherence tomography image

      Recognition of individual scatterers against the noise background in the optical coherence tomography image
      The problem of recognising single sparsely located scatterers against the noise background in the image obtained by the method of optical coherence tomography (OCT) is considered. An identification method based on the use of specific scanning features upon OCT image registration and on the statistical analysis of image fragments is proposed. The efficiency of the method is demonstrated experimentally in the diagnosis of otitis media with effusion. The approach can ...
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    14. Prospects of Intraoperative Multimodal OCT Application in Patients with Acute Mesenteric Ischemia

      Prospects of Intraoperative Multimodal OCT Application in Patients with Acute Mesenteric Ischemia
      Introduction: Despite the introduction of increasingly multifaceted diagnostic techniques and the general advances in emergency abdominal and vascular surgery, the outcome of treatment of patients with acute impaired intestinal circulation remains unsatisfactory. The non-invasive and high-resolution technique of optical coherence tomography (OCT) can be used intraoperatively to assess intestine viability and associated conditions that frequently emerge under conditions of impaired blood circulation. This study aims to demonstrate the effectiveness of ...
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    15. Capability of physically reasonable OCT-based differentiation between intact brain tissues, human brain gliomas of different WHO grades, and glioma model 101.8 from rats

      Capability of physically reasonable OCT-based differentiation between intact brain tissues, human brain gliomas of different WHO grades, and glioma model 101.8 from rats
      Optical coherence tomography (OCT) of the ex vivo rat and human brain tissue samples is performed. The set of samples comprises intact white and gray matter, as well as human brain gliomas of the World Health Organization (WHO) Grades I-IV and glioma model 101.8 from rats. Analysis of OCT signals is aimed at comparing the physically reasonable properties of tissues, and determining the attenuation coefficient, parameter related to effective ...
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    16. Slow axis displacement correction for stripe artefact removal in optical coherence angiography

      Slow axis displacement correction for stripe artefact removal in optical coherence angiography
      The method for displacement correction along the slow axis of optical coherence tomography (OCT) data volumes is presented. The method is based on the recursive replacement of the next displaced OCT measurements by the weighted summation of itself and the previous OCT measurement in the slow axis dimension already corrected for the displacement. The values of the appropriate weight multipliers were defined from the local correlation of the two measurements ...
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  2. About Institute of Applied Physics

    Institute of Applied Physics

    Institute of Applied Physics of the Russian Academy of Sciences (IAP RAS) was created by a Decree of the Soviet Government on July 28, 1976. Annually the IAP RAS performs about 350 scientific projects, funded by federal special programs, academic, industry, international and other programs and projects. Among the most prominent achievements of the Institute of Applied Physics RAS are the invention of gyrotrons and gyroklystrons and their upgrading to a high technical level, the development of effective methods to convert and transport powerful electromagnetic radiation, the elaboration of physical principles for excitation and reception of low-frequency sound fields in the ocean and the creation of hardware for hydroacoustics and long-term acoustical monitoring in the ocean, complexes for research of noise radiation characteristics of moving objects, the development of high-rate growth and precision processing of water-soluble crystals, developmet of optical coherent tomography to image biotissue structures and designing an optical tomograph for medical diagnostics of human internal organs  See IAP RAS OCT link HERE.