1. Institute of Applied Physics

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    1. Mentioned In 120 Articles

    2. Cross-Polarization Optical Coherence Tomography in Comparative in vivo and ex vivo Studies of the Optical Properties of Normal and Tumorous Brain Tissues

      Cross-Polarization Optical Coherence Tomography in Comparative in vivo and ex vivo Studies of the Optical Properties of Normal and Tumorous Brain Tissues
      The aim of the study was to provide visual and quantitative evaluation of tumorous and normal brain tissue images obtained by cross-polarization optical coherence tomography (CP OCT) in a comparative in vivo and ex vivo study. Materials and Methods. The CP OCT as a non-damaging noninvasive optical method for tissue structure imaging was used in the study. It enables obtaining volumetric images of 2.42.41.25 mm 3 in ...
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    3. Optical coherence tomography in gynecology: a narrative review

      Optical coherence tomography in gynecology: a narrative review
      Modern gynecologic practice requires noninvasive diagnostics techniques capable of detecting morphological and functional alterations in tissues of female reproductive organs. Optical coherence tomography (OCT) is a promising tool for providing imaging of biotissues with high resolution at depths up to 2 mm. Design of the customized probes provides wide opportunities for OCT use in gynecology. This paper contains a retrospective insight into the history of OCT employment in gynecology, an ...
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    4. A data-acquisition and control system for spectral-domain optical coherence tomography with a speed of 91 912 A-scans/s based on a USB 3.0 interface

      A data-acquisition and control system for spectral-domain optical coherence tomography with a speed of 91 912 A-scans/s based on a USB 3.0 interface
      We describe a system of optical spectrum registration at the output of an interferometer with controlled phase shifts for an experimental device intended for visualizing the internal structure of an optically turbid specimen, using the method of spectral domain optical coherence tomography. A device for spectral domain optical coherence tomography based on a common-path optical scheme with a USB 3.0 interface for inputting data into a computer has been ...
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    5. Medium chromatic dispersion calculation and correction in spectral-domain optical coherence tomography

      Medium chromatic dispersion calculation and correction in spectral-domain optical coherence tomography
      A method for determining and correcting distortions in spectral-domain optical coherence tomography images caused by medium dispersion was developed. The method is based on analysis of the phase distribution of the interference signal recorded by an optical coherence tomography device using an iterative approach to find and compensate for the effect of a mediums chromatic dispersion on point-spread function broadening in optical coherence tomography. This enables compensation of the impact ...
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    6. Pixel classification method in optical coherence tomography for tumor segmentation and its complementary usage with OCT microangiography

      Pixel classification method in optical coherence tomography for tumor segmentation and its complementary usage with OCT microangiography
      A novel machine-learning method to distinguish between tumor and normal tissue in optical coherence tomography (OCT) has been developed. Pre-clinical murine ear model implanted with mouse colon carcinoma CT-26 was used. Structural-image-based feature sets were defined for each pixel and machine learning classifiers were trained using ground truth OCT images manually segmented by comparison with histology. The accuracy of the OCT tumour segmentation method was then quantified by comparing with ...
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    7. Silicon nanoparticles as contrast agents in the methods of optical biomedical diagnostics

      Silicon nanoparticles as contrast agents in the methods of optical biomedical diagnostics
      The efficiency of light scattering by nanoparticles formed using the method of picosecond laser ablation of silicon in water and by nanoparticles of mechanically grinded mesoporous silicon is compared. The ensembles of particles of both types possess the scattering coefficients sufficient to use them as contrast agents in optical coherence tomography (OCT), particularly in the range of wavelengths 7001000 nm, where the absorption of both silicon and most biological and ...
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    8. Complementary Study of Collagen State in Bladder Diseases Using Cross-Polarization Optical Coherence Tomography, Nonlinear and Atomic Force Microscopy

      Complementary Study of Collagen State in Bladder Diseases Using Cross-Polarization Optical Coherence Tomography, Nonlinear and Atomic Force Microscopy
      The aim of the study is to demonstrate the potential of cross-polarization optical coherence tomography (CP OCT) as a minimally invasive real-time technique for detection of bladder cancer against a background of severe inflammation. Materials and Methods. For the verification of CP OCT diagnostic data related to the condition of collagen comparison with high-resolution microscopy inspection was performed and correlation of the results was calculated. The CP OCT study was ...
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    9. Multiparameter thermo-mechanical OCT-based characterization of laser-induced cornea reshaping

      Multiparameter thermo-mechanical OCT-based characterization of laser-induced cornea reshaping
      Phase-sensitive optical coherence tomography (OCT) is used for visualizing dynamic and cumulative strains and corneashape changes during laser-produced tissue heating. Such non-destructive (non-ablative) cornea reshaping can be used as a basis of emerging technologies of laser vision correction. In experiments with cartilaginous samples, polyacrilamide phantoms and excised rabbit eyes we demonstrate ability of the developed OCT system to simultaneously characterize transient and cumulated strain distributions, surface displacements, scattering tissue properties ...
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    10. Multimodal optical coherence tomography for in vivo imaging of brain tissue structure and microvascular network at glioblastoma

      Multimodal optical coherence tomography for in vivo imaging of brain tissue structure and microvascular network at glioblastoma
      In the case of infiltrative brain tumors the surgeon faces difficulties in determining their boundaries to achieve total resection. The aim of the investigation was to evaluate the performance of multimodal OCT (MM OCT) for differential diagnostics of normal brain tissue and glioma using an experimental model of glioblastoma. The spectral domain OCT device that was used for the study provides simultaneously two modes: cross-polarization and microangiographic OCT. The comparative ...
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    11. Multimodal Optical Coherence Tomography in Visualization of Brain Tissue Structure at Glioblastoma (Experimental Study)

      Multimodal Optical Coherence Tomography in Visualization of Brain Tissue Structure at Glioblastoma (Experimental Study)
      ...Materials and Methods. The spectral domain MM OCT device developed at the Institute of Applied Physics of the Russian Academy of Sciences (Nizhny Novgorod, Russia) was used for the study. It provides two modes of investi...
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    12. Optical coherence tomography for visualizing transient strains and measuring large deformations in laser-induced tissue reshaping

      Optical coherence tomography for visualizing transient strains and measuring large deformations in laser-induced tissue reshaping
      In the context of the development of emerging laser-assisted thermo-mechanical technologies for non-destructive reshaping of avascular collagenous tissues (cartilages and cornea), we report the first application of phase-sensitive optical coherence tomography (OCT) for visualizing transient strains involving supra-wavelength inter-frame displacements of scatterers. Usually phase-sensitive OCT assumes the visualization of sub-pixel and even sub-wavelength displacements of scatterers and fairly small strains (say, 10 3 ), which conventionally implies the necessity of averaging ...
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    13. Collaborative effects of wavefront shaping and optical clearing agent in optical coherence tomography

      Collaborative effects of wavefront shaping and optical clearing agent in optical coherence tomography
      Developing a deep-tissue imaging tool with good optical resolution is one of the important goals of biophotonics because medical diagnosis usually requires imaging of fine details of whole tissue structures. Optical coherence tomography (OCT) is an extensively developed imaging tool for biological tissues. Based on low-coherence interferometry, OCT provides micrometer scale resolution and enables non-invasive high-speed imaging1 . OCT is widely used in ophthalmology because it can fully access retina, choroid ...
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    14. Vessel-contrast enhancement in label-free optical coherence angiography based on phase and amplitude speckle variability

      Vessel-contrast enhancement in label-free optical coherence angiography based on phase and amplitude speckle variability
      Recently proposed in vivo label-free optical coherence angiography techniques based on phase and amplitude speckle variability often require additional signal pre- and post processing operations to enhance vessel-contrast. We observe here 1) contrast enhancement by optimizing the signal normalization/weighing before processing; 2) algorithm based on Kasai estimator for phase compensation between processed A-scans to reduce masking role of motion artifacts; and 3) image projection through the imaging depth for ...
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  2. About Institute of Applied Physics

    Institute of Applied Physics

    Institute of Applied Physics of the Russian Academy of Sciences (IAP RAS) was created by a Decree of the Soviet Government on July 28, 1976. Annually the IAP RAS performs about 350 scientific projects, funded by federal special programs, academic, industry, international and other programs and projects. Among the most prominent achievements of the Institute of Applied Physics RAS are the invention of gyrotrons and gyroklystrons and their upgrading to a high technical level, the development of effective methods to convert and transport powerful electromagnetic radiation, the elaboration of physical principles for excitation and reception of low-frequency sound fields in the ocean and the creation of hardware for hydroacoustics and long-term acoustical monitoring in the ocean, complexes for research of noise radiation characteristics of moving objects, the development of high-rate growth and precision processing of water-soluble crystals, developmet of optical coherent tomography to image biotissue structures and designing an optical tomograph for medical diagnostics of human internal organs  See IAP RAS OCT link HERE.