1. Indiana University

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    1. Mentioned In 99 Articles

    2. Heterogeneous patterns of tissue injury in NARP syndrome

      Heterogeneous patterns of tissue injury in NARP syndrome
      Point mutations at m.8993TC and m.8993TG of the mtDNA ATPase 6 gene cause the neurogenic weakness, ataxia and retinitis pigmentosa (NARP) syndrome, a mitochondrial disorder characterized by retinal, central and peripheral neurodegeneration. We performed detailed neurological, neuropsychological and ophthalmological phenotyping of a mother and four daughters with NARP syndrome from the mtDNA m.8993TC ATPase 6 mutation, including 3-T brain MRI, spectral domain optical coherence tomography (SD-OCT), adaptive ...
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    3. Devices And Methods For Polarization-Sensitive Optical Coherence Tomography With Adaptive Optics (Wo 2010/085618)

      Devices And Methods For Polarization-Sensitive Optical Coherence Tomography With Adaptive Optics (Wo 2010/085618)
      The present disclosure includes disclosure of devices, and methods to resolve microscopic structures. In at least one exemplary embodiment, a visualization apparatus comprises a source arm having a light source operable to emit a light beam, wherein the light beam defines a beam pathway, a reference arm comprising a reflecting surface positioned within the beam pathway, a sample arm comprising a wavefront sensor, an adaptive optics wavefront corrector, and a ...
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    4. The origins of urothelial carcinoma

      The origins of urothelial carcinoma
      Expert Review of Anticancer Therapy , June 2010, Vol. 10, No. 6, PaIt is now widely believed that there are two major pathways for urothelial carcinogenesis. One pathway usually involves mutation of FGF receptor 3 and gives rise to low-grade papillary tumors that frequently recur but seldom invade. By contrast, high-grade urothelial malignancies, including high-grade papillary urothelial carcinoma and urothelial carcinoma in situ (CIS) usually exhibit deletions or mutations of TP53 ...
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    5. Imaging retinal nerve fiber bundles at ultrahigh-speed and ultrahigh-resolution using OCT with adaptive optics

      Imaging retinal nerve fiber bundles at ultrahigh-speed and ultrahigh-resolution using OCT with adaptive optics
      Ultrahigh speed line scan detectors based on CMOS technology have been recently demonstrated in ultrahigh resolution spectral-domain optical coherence tomography (UHR-SD-OCT) for retinal imaging. While successful, fundamental tradeoffs exist been image acquisition time, image sampling density, and sensitivity, all of which impact the extent of motion artifacts, visualization of fine spatial detail, and detection of faint reflections. Here we investigate these tradeoffs for imaging retinal nerve fiber bundles (RNFBs) using ...
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    6. Retinal imaging with polarization-sensitive optical coherence tomography and adaptive optics

      Retinal imaging with polarization-sensitive optical coherence tomography and adaptive optics
      Various layers of the retina are well known to alter the polarization state of light. Such changes in polarization may be a sensitive indicator of tissue structure and function, and as such have gained increased clinical attention. Here we demonstrate a polarization-sensitive optical coherence tomography (PS-OCT) system that incorporates adaptive optics (AO) in the sample arm and a single line scan camera in the detection arm. We quantify the benefit ...
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    7. Cellular imaging of the living human retina

      Cellular imaging of the living human retina
      A device combining optical coherence tomography and adaptive optics can capture micron-scale 3D pictures of the retina. Viewing the retina through the eye's cornea and crystalline lens dates back to the time of Helmholtz, inventor of the ophthalmoscope. Ophthalmoscopes have advanced substantially since then and are now an indispensable non-invasive tool for diagnosis and treatment monitoring. While there are three principal types—conventional ophthalmoscopes, confocal scanning laser ophthalmoscopes (cSLOs ...
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    8. Volumetric retinal imaging with ultrahigh-resolution spectral-domain optical coherence tomography and adaptive optics using two broadband light sources

      Volumetric retinal imaging with ultrahigh-resolution spectral-domain optical coherence tomography and adaptive optics using two broadband light sources
      Ultrabroadband sources, such as multiplexed superluminescent diodes (SLDs) and femtosecond lasers, have been successfully employed in adaptive optics optical coherence tomography (AO-OCT) systems for ultrahigh resolution retinal imaging. The large cost differential of these sources, however, motivates the need for a performance comparison. Here, we compare the performance of a Femtolasers Integral Ti:Sapphire laser and a Superlum BroadLighter T840, using the same AO-OCT system and the same subject. In ...
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  2. About Indiana University

    Indiana University

    Indiana University, founded in 1820, is a nine-campus university system in the state of Indiana. The IU system includes the following campuses: Indiana University in Bloomington (flagship campus), Indiana University East in Richmond,Indiana University Kokomo in Kokomo, Indiana University Northwest in Gary,Indiana University South Bend in South Bend, Indiana University Southeast in New Albany.