1. Indiana University

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    1. Mentioned In 118 Articles

    2. An improved method for murine laser-induced choroidal neovascularization lesion quantification from optical coherence tomography images

      An improved method for murine laser-induced choroidal neovascularization lesion quantification from optical coherence tomography images
      Laser-induced choroidal neovascularization (L-CNV) in murine models is a standard method for assessing therapies, genetics, and mechanisms relevant to the blinding eye disease neovascular or wet age-related macular degeneration. The ex vivo evaluation of these lesions involves confocal microscopy analysis. In vivo evaluation via optical coherence tomography (OCT) has previously been established and allows longitudinal assessment of lesion development. However, to produce robust data, evaluation of many lesions may be ...
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    3. The effect of axial length to basement-membrane opening to fovea distance on optical coherence tomography

      The effect of axial length to basement-membrane opening to fovea distance on optical coherence tomography
      Background: Optical Coherence Tomography (OCT) lateral scaling is influenced by axial length (AL). There is a need to incorporate a method to correct this measurement bias for accurate lateral OCT measurement. Purpose: To identify the correlation of optic-nerve-to-fovea distance measurement to AL by OCT) as an internal factor for lateral scaling. Methods: Using Heidelberg Spectralis OCT, distance from the basement membrane opening at the optic disc margin to the centre ...
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    4. Reflectance-Based Structural Quantification of the Healthy and Glaucomatous Retinal Nerve ...

      Reflectance-Based Structural Quantification of the Healthy and Glaucomatous Retinal Nerve ...
      Glaucoma is a group of progressive optic neuropathies that can lead to irreversible vision loss if left untreated. Spectral-domain optical coherence tomography (SD-OCT) is an important imaging tool used in the diagnosis and management of glaucoma. It provides thickness measurements of the retinal nerve fiber layer (RNFL), a useful index for monitoring progressive thinning that occurs from damage. However, there exists high between-subject variability in RNFL thickness in people free ...
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    5. Valve-Like Outflow System Behavior With Motion Slowing in Glaucoma Eyes: Findings Using a Minimally Invasive Glaucoma Surgery-MIGS-Like Platform and Optical Coherence Tomography Imaging

      Valve-Like Outflow System Behavior With Motion Slowing in Glaucoma Eyes: Findings Using a Minimally Invasive Glaucoma Surgery-MIGS-Like Platform and Optical Coherence Tomography Imaging
      Purpose: This study aimed to investigate anatomic relationships and biomechanics of pressure-dependent trabecular meshwork and distal valve-like structure deformation in normal and glaucoma eyes using high-resolution optical coherence tomography (HR-OCT). Methods: We controlled Schlemm's canal (SC) pressure during imaging with HR-OCT in segments of three normal (NL) and five glaucomatous (GL) ex vivo eyes. The dissected limbal wedges were studied from 15 locations (5 NL and 10 GL). A ...
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    6. Development of high-speed, integrated high-resolution optical coherence microscopy and dual-channel fluorescence microscopy for the simultaneous co-registration of reflectance and fluorescence signals

      Development of high-speed, integrated high-resolution optical coherence microscopy and dual-channel fluorescence microscopy for the simultaneous co-registration of reflectance and fluorescence signals
      Optical coherence microscopy is an imaging technique capable of generating three-dimensional images of structures in tissue, but with limited functional imaging ability. Fluorescence microscopy offers functional information of cellular activities. The integration of both imaging modalities can enable the evaluation of the impact of structural information on cells activities. To develop an integrated system combining high-resolution optical coherence microscopy (HR-OCM) and dual-channel scanning confocal fluorescence microscopy (DC-SCFM) to enable the ...
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    7. Cross-Polarization Optical Coherence Tomographic Assessment of In situ Simulated Erosive Tooth Wear

      Cross-Polarization Optical Coherence Tomographic Assessment of In situ Simulated Erosive Tooth Wear
      This clinical study tested cross-polarization optical coherence tomography (CP-OCT) monitoring of erosive tooth wear (ETW). Twenty participants completed a 14-day/arm, 3-arm crossover study simulating different ETW severities. Participants received two enamel specimens (per arm) and were randomized to: severe (s-ETW, lemon juice/pH:2.5/4.25%w/v citric acid), moderate (m-ETW, grapefruit juice/pH:3.5/1.03%w/v citric acid), and non-ETW (water). Enamel thickness ...
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    8. Weakly supervised individual ganglion cell segmentation from adaptive optics OCT images for glaucomatous damage assessment

      Weakly supervised individual ganglion cell segmentation from adaptive optics OCT images for glaucomatous damage assessment
      Cell-level quantitative features of retinal ganglion cells (GCs) are potentially important biomarkers for improved diagnosis and treatment monitoring of neurodegenerative diseases such as glaucoma, Parkinsons disease, and Alzheimers disease. Yet, due to limited resolution, individual GCs cannot be visualized by commonly used ophthalmic imaging systems, including optical coherence tomography (OCT), and assessment is limited to gross layer thickness analysis. Adaptive optics OCT (AO-OCT) enables in vivo imaging of individual retinal ...
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    9. Phase II multi-center trial of optical coherence tomography as an adjunct to white light cystoscopy for intravesical real time imaging and staging of bladder cancer

      Phase II multi-center trial of optical coherence tomography as an adjunct to white light cystoscopy for intravesical real time imaging and staging of bladder cancer
      Background: Optical coherence tomography (OCT) is a novel imaging modality that provides microstructural information of different tissue layers using near-infrared light. This prospective, multicenter phase II trial aimed to assess the accuracy of OCT-assisted cystoscopy for bladder tumor staging. Methods: Patients with primary or recurrent bladder tumors (Ta,T1) identified by outpatient cystoscopy were included. The primary objective was to assess the accuracy and positive predictive value of for determining ...
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    10. Detection and analyzing plane of non-cavitated approximal caries by cross-polarized optical coherence tomography (CP-OCT)

      Detection and analyzing plane of non-cavitated approximal caries by cross-polarized optical coherence tomography (CP-OCT)
      Objective: The objective was to assess the detection ability and the effect of analyzing plane of CP-OCT for non-cavitated approximal caries. Methods: Thirty human extracted premolars were selected based on micro-computed tomography [-CT: - CT = 0: sound (n = 12), -CT = 1/2: caries into outer-/inner-half of enamel (n = 6 each), -CT = 3: caries into outer one-third of dentine (n = 6)]. Teeth were mounted in a custommade device to simulate approximal ...
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    11. Multi-reference global registration of individual A-lines in adaptive optics optical coherence tomography retinal images

      Multi-reference global registration of individual A-lines in adaptive optics optical coherence tomography retinal images
      Significance: Adaptive optics optical coherence tomography (AO-OCT) technology enables non-invasive, high-resolution three-dimensional (3D) imaging of the retina and promises earlier detection of ocular disease. However, AO-OCT data are corrupted by eye-movement artifacts that must be removed in post-processing, a process rendered time-consuming by the immense quantity of data. Aim: To efficiently remove eye-movement artifacts at the level of individual A-lines, including those present in any individual reference volume. Approach: We ...
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  2. About Indiana University

    Indiana University

    Indiana University, founded in 1820, is a nine-campus university system in the state of Indiana. The IU system includes the following campuses: Indiana University in Bloomington (flagship campus), Indiana University East in Richmond,Indiana University Kokomo in Kokomo, Indiana University Northwest in Gary,Indiana University South Bend in South Bend, Indiana University Southeast in New Albany.