1. Indiana University

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    1. Mentioned In 95 Articles

    2. Quantitative assessment of human donor corneal endothelium with Gabor domain optical coherence microscopy

      Quantitative assessment of human donor corneal endothelium with Gabor domain optical coherence microscopy
      We report on a pathway for Gabor domain optical coherence microscopy (GD-OCM)-based metrology to assess the donors corneal endothelial layers ex vivo . Six corneas from the Lions Eye Bank at Albany and Rochester were imaged with GD-OCM. The raw 3-D images of the curved corneas were flattened using custom software to enhance the 2-D visualization of endothelial cells (ECs); then the ECs within a circle of 500-m-diameter were analyzed ...
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    3. In vitro longitudinal evaluation of enamel wear by cross-polarization optical coherence tomography

      In vitro longitudinal evaluation of enamel wear by cross-polarization optical coherence tomography
      Objectives Enamel thickness determination by Cross-Polarization Optical Coherence Tomography (CP-OCT) is a promising approach for quantitative monitoring of tooth wear progression. This study evaluated the ability of CP-OCT to quantify the thickness of natural enamel before, during and after tooth wear simulation. Materials and Methods Natural, unpolished human dental enamel slabs were submitted to five wear stages (Wear 1: to level the surfaces; Wear 2 to Wear 5: 0.05 ...
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    4. Capabilities of Gabor-domain optical coherence microscopy for the assessment of corneal disease

      Capabilities of Gabor-domain optical coherence microscopy for the assessment of corneal disease
      To identify the microstructural modification of the corneal layers during the course of the disease, optical technologies have been pushing the boundary of innovation to achieve cellular resolution of deep layers of the cornea. Gabor-domain optical coherence microscopy (GD-OCM), an optical coherence tomography-based technique that can achieve an isotropic of 2-m resolution over a volume of 1mm1mm1.2mm, was developed to investigate the microstructural modifications of corneal layers in four ...
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    5. Research Associate / Postdoctoral Fellow in Adaptive Optics and Optical Coherence Tomography at Indiana University

      Research Associate / Postdoctoral Fellow in Adaptive Optics and Optical Coherence Tomography at Indiana University
      ... Bloomington, IN 47405. For more information see this link:  http://www.opt.indiana.edu/dtmiller/Index.aspx Indiana University is an equal employment and affirmative action employer and a provider of ADA services. All ...
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    6. Label‐free volumetric imaging of conjunctival collecting lymphatics ex vivo by optical coherence tomography lymphangiography

      Label‐free volumetric imaging of conjunctival collecting lymphatics ex vivo by optical coherence tomography lymphangiography
      We employ optical coherence tomography (OCT) and optical coherence microscopy (OCM) to study conjunctival lymphatics in porcine eyes ex vivo . This study is a precursor to the development of in vivo imaging of the collecting lymphatics for potentially guiding and monitoring glaucoma filtration surgery. OCT scans at 1300 nm and higher‐resolution OCM scans at 785 nm reveal the lymphatic vessels via their optical transparency. Equivalent signal characteristics are also ...
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    7. Method to investigate temporal dynamics of ganglion and other retinal cells in the living human eye

      Method to investigate temporal dynamics of ganglion and other retinal cells in the living human eye
      The inner retina is critical for visual processing, but much remains unknown about its neural circuitry and vulnerability to disease. A major bottleneck has been our inability to observe the structure and function of the cells composing these retinal layers in the living human eye. Here, we present a noninvasive method to observe both structural and functional information. Adaptive optics optical coherence tomography (AO-OCT) is used to resolve the inner ...
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    8. Measuring polarization changes in the human outer retina with polarization‐sensitive optical coherence tomography

      Measuring polarization changes in the human outer retina with polarization‐sensitive optical coherence tomography
      Morphological changes in the outer retina such as drusen are established biomarkers to diagnose age‐related macular degeneration. However, earlier diagnosis might be possible by taking advantage of more subtle changes that accompany tissues that bear polarization‐altering properties. To test this hypothesis, we developed a method based on polarization‐sensitive optical coherence tomography with which volumetric data sets of the macula were obtained from 10 young (25years) and 10 ...
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    9. Measuring polarization changes in the human outer retina with polarization-sensitive optical coherence tomography

      Measuring polarization changes in the human outer retina with polarization-sensitive optical coherence tomography
      Morphological changes in the outer retina such as drusen are established biomarkers to diagnose age-related macular degeneration. However earlier diagnosis might be possible by taking advantage of more subtle changes that accompany tissues that bear polarization-altering properties. To test this hypothesis, we developed a method based on polarization-sensitive optical coherence tomography with which volumetric data sets of the macula were obtained from 10 young (25 yr) and 10 older (54 ...
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    10. Imaging and quantifying ganglion cells and other transparent neurons in the living human retina [Engineering]

      Imaging and quantifying ganglion cells and other transparent neurons in the living human retina [Engineering]
      Ganglion cells (GCs) are fundamental to retinal neural circuitry, processing photoreceptor signals for transmission to the brain via their axons. However, much remains unknown about their role in vision and their vulnerability to disease leading to blindness. A major bottleneck has been our inability to observe GCs and their degeneration in the living human eye. Despite two decades of development of optical technologies to image cells in the living human ...
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  2. About Indiana University

    Indiana University

    Indiana University, founded in 1820, is a nine-campus university system in the state of Indiana. The IU system includes the following campuses: Indiana University in Bloomington (flagship campus), Indiana University East in Richmond,Indiana University Kokomo in Kokomo, Indiana University Northwest in Gary,Indiana University South Bend in South Bend, Indiana University Southeast in New Albany.