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    1. Mentioned In 83 Articles

    2. Imaging and quantifying ganglion cells and other transparent neurons in the living human retina [Engineering]

      Imaging and quantifying ganglion cells and other transparent neurons in the living human retina [Engineering]
      Ganglion cells (GCs) are fundamental to retinal neural circuitry, processing photoreceptor signals for transmission to the brain via their axons. However, much remains unknown about their role in vision and their vulnerability to disease leading to blindness. A major bottleneck has been our inability to observe GCs and their degeneration in the living human eye. Despite two decades of development of optical technologies to image cells in the living human ...
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    3. OPTICAL PROPERTIES OF PHOTORECEPTOR AND RETINAL PIGMENT EPITHELIUM CELLS INVESTIGATED WITH ADAPTIVE OPTICS OPTICAL COHERENCE TOMOGRAPHY (Thesis)

      OPTICAL PROPERTIES OF PHOTORECEPTOR AND RETINAL PIGMENT EPITHELIUM CELLS INVESTIGATED WITH ADAPTIVE OPTICS OPTICAL COHERENCE TOMOGRAPHY (Thesis)
      Human vision starts when photoreceptors collect and respond to light. Photoreceptors do not function in isolation though, but share close interdependence with neighboring photoreceptors and underlying retinal pigment epithelium (RPE) cells. These cellular interactions are essential for normal function of the photoreceptor-RPE complex, but methods to assess these in the living human eye are limited. One approach that has gained increased promise is highresolution retinal imaging that has undergone tremendous ...
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    4. Tracking dynamics of photoreceptor disc shedding with adaptive optics-optical coherence tomography

      Tracking dynamics of photoreceptor disc shedding with adaptive optics-optical coherence tomography
      Absorption of light by photoreceptors initiates vision, but also leads to accumulation of toxic photo-oxidative compounds in the photoreceptor outer segment (OS). To prevent this buildup, small packets of OS discs are periodically pruned from the distal end of the OS, a process called disc shedding. Unfortunately dysfunction in any part of the shedding event can lead to photoreceptor and RPE dystrophy, and has been implicated in numerous retinal diseases ...
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    5. Evaluation of intraretinal migration of retinal pigment epithelial cells with Jones matrix optical coherence tomography

      Evaluation of intraretinal migration of retinal pigment epithelial cells with Jones matrix optical coherence tomography
      We evaluated intraretinal RPE migration in AMD using multimodal imaging including polarimetric images. Depolarized light images were computed using a PS-SLO. M-DOPU was calculated using multifunctional Jones-matrix OCT. RPE migration was detected in 59 of 155 eyes. Focal similarities could be confirmed among en-face projection images of minimum M-DOPU, depolarized light images, and NIR-AF images.
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    6. Photoreceptor disc shedding in the living human eye

      Photoreceptor disc shedding in the living human eye
      Cone photoreceptors undergo a daily cycle of renewal and shedding of membranous discs in their outer segments (OS), the portion responsible for light capture. These physiological processes are fundamental to maintaining photoreceptor health, and their dysfunction is associated with numerous retinal diseases. While both processes have been extensively studied in animal models and postmortem eyes, little is known about them in the living eye, in particular human. In this study ...
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    7. Optical coherence tomography angiography: an overview of the technology and an assessment of applications for clinical research

      Optical coherence tomography angiography: an overview of the technology and an assessment of applications for clinical research
      In recent years, ophthalmology has experienced significant developments with respect to imaging modalities. Optical coherence tomography angiography is one such technology that seeks to improve diagnostics for retinal diseases. Using standard structural ocular coherence tomography hardware, optical coherence tomography angiography demonstrates the ability to non-invasively visualise the vasculature in the retina and the choroid with high resolution, allowing greater insight into retinal vascular pathologies. In addition, retinal and choroidal vessel ...
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    8. Enamel Thickness Determination by Optical Coherence Tomography: In vitro Validation

      Enamel Thickness Determination by Optical Coherence Tomography: In vitro Validation
      Optical coherence tomography (OCT) has been introduced in dentistry as a nondestructive diagnostic imaging tool that does not utilize ionizing radiation. This study investigated the agreement between polarization-sensitive OCT (PS-OCT), microcomputed tomography (-CT), and histology for enamel thickness measurements. Human enamel samples were prepared and evaluated with -CT and PS-OCT and then sectioned and observed via digital transversal light microscopy. For all methods, a standard transversal section (b-scan) in each ...
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    9. A Review of Adaptive Optics Optical Coherence Tomography: Technical Advances, Scientific Applications, and the Future

      A Review of Adaptive Optics Optical Coherence Tomography: Technical Advances, Scientific Applications, and the Future
      Purpose : Optical coherence tomography (OCT) has enabled virtual biopsy of the living human retina, revolutionizing both basic retina research and clinical practice over the past 25 years. For most of those years, in parallel, adaptive optics (AO) has been used to improve the transverse resolution of ophthalmoscopes to foster in vivo study of the retina at the microscopic level. Here, we review work done over the last 15 years to ...
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    10. Kif14 overexpression accelerates murine retinoblastoma development

      Kif14 overexpression accelerates murine retinoblastoma development
      The mitotic kinesin KIF14 has an essential role in the recruitment of proteins required for the final stages of cytokinesis. Genomic gain and/or overexpression of KIF14 has been documented in retinoblastoma and a number of other cancers, such as breast, lung and ovarian carcinomas, strongly suggesting its role as an oncogene. Despite evidence of oncogenic properties in vitro and in xenografts, Kif14's role in tumor progression has not ...
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  2. About Indiana University

    Indiana University

    Indiana University, founded in 1820, is a nine-campus university system in the state of Indiana. The IU system includes the following campuses: Indiana University in Bloomington (flagship campus), Indiana University East in Richmond,Indiana University Kokomo in Kokomo, Indiana University Northwest in Gary,Indiana University South Bend in South Bend, Indiana University Southeast in New Albany.