1. Imperial College London

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    1. Mentioned In 118 Articles

    2. Optical Coherence Tomography in Cerebrovascular Disease: Open up New Horizons

      Optical Coherence Tomography in Cerebrovascular Disease: Open up New Horizons
      Optical coherence tomography (OCT), based on the backscattering or reflection of near-infrared light, enables an ultra-high resolution of up to 10 m. The successful application of OCT in coronary artery diseases has sparked increasing interest in its implementation in cerebrovascular diseases. OCT has shown promising potential in the atherosclerotic plaque structure characterization, plaque rupture risk stratification, pre-stenting and post-stenting evaluation, and long-term follow-up in extracranial and intracranial atherosclerotic stenosis (ICAS ...
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    3. Soft-Tissue Material Properties and Mechanogenetics during Cardiovascular Development

      Soft-Tissue Material Properties and Mechanogenetics during Cardiovascular Development
      During embryonic development, changes in the cardiovascular microstructure and material properties are essential for an integrated biomechanical understanding. This knowledge also enables realistic predictive computational tools, specifically targeting the formation of congenital heart defects. Material characterization of cardiovascular embryonic tissue at consequent embryonic stages is critical to understand growth, remodeling, and hemodynamic functions. Two biomechanical loading modes, which are wall shear stress and blood pressure, are associated with distinct molecular ...
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    4. Multimodal brain and retinal imaging of dopaminergic degeneration in Parkinson disease

      Multimodal brain and retinal imaging of dopaminergic degeneration in Parkinson disease
      Parkinson disease (PD) is a progressive disorder characterized by dopaminergic neurodegeneration in the brain. The development of parkinsonism is preceded by a long prodromal phase, and 50% of dopaminergic neurons can be lost from the substantia nigra by the time of the initial diagnosis. Therefore, validation of in vivo imaging biomarkers for early diagnosis and monitoring of disease progression is essential for future therapeutic developments. PET and single-photon emission CT ...
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    5. What are the PROSPECTs and clinical implications of vulnerable plaque?

      What are the PROSPECTs and clinical implications of vulnerable plaque?
      Despite the fact that it has been three decades since James Muller and his colleagues first proposed the concept of vulnerable plaque 1 and 18 years since Naghavi et al. published their consensus document summarizing the concepts behind vulnerable patients and vulnerable plaques, including classifications for clinical and pathological evaluation, 2 , 3 we still have much to learn about the clinical implications of vulnerable plaque ( Graphical Abstract ). Feasibility of vulnerable ...
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    6. Stent type identification with optical coherence tomography: novelty in search of clinical application

      Stent type identification with optical coherence tomography: novelty in search of clinical application
      Over the last three decades, developments in intravascular ultrasound (IVUS) and optical coherence tomography (OCT) have advanced our understanding of coronary disease pathophysiology and improved outcomes of percutaneous coronary intervention (PCI) procedures. Although in daily clinical practice most imaging utilisation relies on a simple, two-dimensional display of cross-sectional coronary images, real-time three-dimensional (3D) visualisation of coronary arteries with OCT offers advantages over and above simple vessel sizing and plaque characterisation ...
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    7. Physiology and Structure of the Small Airways in Patients With Chronic Airflow Obstruction or COVID-19

      Physiology and Structure of the Small Airways in Patients With Chronic Airflow Obstruction or COVID-19
      The purpose of this research project is to study small airways physiological function in patients with chronic obstructive lung disease or COVID-19 and explore the relationship with in-vivo microanatomical small airway structure as measured by OCT. Correlating endobronchial assessment with multiple breath nitrogen washout and impulse oscillometry will allow the characterisation of the relationship between small airway structural findings and these validated investigations. A small volume lung wash, endobronchial brushings ...
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    8. Recent advances in imaging technologies for assessment of retinal diseases

      Recent advances in imaging technologies for assessment of retinal diseases
      Introduction Retinal imaging is a key investigation in ophthalmology. New devices continue to be created to keep up with the demand for better imaging modalities in this field. This review looks to highlight current trends and the future of retinal imaging. Areas covered This review looks at the advances in topographical imaging, photoacoustic microscopy, optical coherence tomography and molecular imaging. There is future scoping Expert opinion Retinal imaging continues to ...
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    9. Utility of Multimodality Intravascular Imaging and the Local Hemodynamic Forces to Predict Atherosclerotic Disease Progression

      Utility of Multimodality Intravascular Imaging and the Local Hemodynamic Forces to Predict Atherosclerotic Disease Progression
      Objectives This study sought to examine the utility of multimodality intravascular imaging and of the endothelial shear stress (ESS) distribution to predict atherosclerotic evolution. Background There is robust evidence that intravascular ultrasound (IVUS)-derived plaque characteristics and ESS distribution can predict, with however limited accuracy, atherosclerotic evolution; nevertheless, it is yet unclear whether multimodality imaging and ESS mapping enable more accurate prediction of coronary plaque progression. Methods A total of ...
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    10. NTU and SERI launch joint laboratory to develop advanced ocular imaging technologies

      NTU and SERI launch joint laboratory to develop advanced ocular imaging technologies
      ...d Graduate colleges. It also has a medical school, the Lee Kong Chian School of Medicine, set up jointly with Imperial College London. NTU is also home to world-class autonomous institutes – the National Institute of Edu...
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    11. The year in cardiology: acute coronary syndromes: The year in cardiology 2019

      The year in cardiology: acute coronary syndromes: The year in cardiology 2019
      The mechanisms and the pathologic substrate of plaque erosion and plaque fissure are different. Indeed, plaques complicated by erosion tend to be matrix-rich, lipid-poor, and usually lack prominent macrophage collections, unlike plaques that rupture, which characteristically have thin fibrous caps, large lipid pools, and abundant foam cells. 9 In a prospective study in 211 patients with STEMI who underwent pre-intervention optical coherence tomography (OCT) examination for the culprit lesion, Tan ...
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    12. Efficacy and Reproducibility of Attenuation-Compensated Optical Coherence Tomography for Assessing External Elastic Membrane Border and Plaque Composition in Native and Stented Segments ― An In Vivo and Histology-Based Study ―

      Efficacy and Reproducibility of Attenuation-Compensated Optical Coherence Tomography for Assessing External Elastic Membrane Border and Plaque Composition in Native and Stented Segments ― An In Vivo and Histology-Based Study ―
      Background: Attenuation-compensated (AC) technique was recently introduced to improve the plaque characterization of optical coherence tomography (OCT). Histological validation demonstrated promising results but the efficacy and reproducibility of this technique for assessing in-vivo tissue composition remains unclear. Methods and Results: OCT images portraying native (n=200) and stented (n=200) segments and 31 histological cross-sections were analyzed. AC-OCT appeared superior to conventional (C)-OCT in detecting the external elastic lamina ...
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    13. Neointimal characteristics comparison between biodegradable-polymer and durable-polymer drug-eluting stents: 3-month follow-up optical coherence tomography light property analysis from the RESTORE registry

      Neointimal characteristics comparison between biodegradable-polymer and durable-polymer drug-eluting stents: 3-month follow-up optical coherence tomography light property analysis from the RESTORE registry
      We aimed to quantitatively assess a possible difference of the neointimal quality between biodegradable polymer- (BP-) and durable polymer drug-eluting stents (DP-DESs). We conducted a single-center all-comer prospective cohort study: the RESTORE registry (UMIN000033009). All patients who received successful OCT examination at planned 3-month follow-up after DES implantation were analyzed. Study population was divided into 2 groups, BP-DES versus DP-DES groups. We evaluated standard OCT variables, coverage percent, and the ...
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    14. Clinical use of intracoronary imaging. Part 2: acute coronary syndromes, ambiguous coronary angiography findings, and guiding interventional decision-making: an expert consensus document of the European Association of Percutaneous Cardiovascular Intervent

      Clinical use of intracoronary imaging. Part 2: acute coronary syndromes, ambiguous coronary angiography findings, and guiding interventional decision-making: an expert consensus document of the European Association of Percutaneous Cardiovascular Intervent
      This consensus document is the second of two reports summarizing the views of an expert panel organized by the European Association of Percutaneous Cardiovascular Interventions (EAPCI) on the clinical use of intracoronary imaging including intravascular ultrasound (IVUS), optical coherence tomography (OCT), and near infrared spectroscopy (NIRS)-IVUS. Beyond guidance of stent selection and optimization of deployment, invasive imaging facilitates angiographic interpretation and may guide treatment in acute coronary syndrome. Intravascular ...
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  2. About Imperial College London

    Imperial College London

    Imperial College London is consistently rated amongst the world's best universities, Imperial College London is a science-based institution with a reputation for excellence in teaching and research. Imperial's main campus is located in South Kensington in central London. Formerly a constituent college of the University of London, Imperial became independent of the university on 8 July 2007, the 100th anniversary of its founding.