1. Imperial College London

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    1. Mentioned In 99 Articles

    2. Compressed sensing-enabled phase-sensitive swept-source optical coherence tomograph

      Explore OSA | OSA Publishing
      Compressed sensing-enabled phase-sensitive swept-source optical coherence tomograph
      Here we present a novel phase-sensitive swept-source optical coherence tomography (PhS-SS-OCT) system. The simultaneously recorded calibration signal, which is commonly used in SS-OCT to stabilize the phase, is randomly sub-sampled during the acquisition, and it is later reconstructed based on the Compressed Sensing (CS) theory. We first mathematically investigated the method, and verified it through computer simulations. We then conducted a vibrational frequency test and a flow velocity measurement in ...
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      Mentions: Imperial College London Columbia University Christine Hendon

    3. Integrating Handcrafted and Deep Features for Optical Coherence Tomography Based Retinal Disease Classification

      Explore IEEE Xplore
      Integrating Handcrafted and Deep Features for Optical Coherence Tomography Based Retinal Disease Classification
      Deep Neural Networks (DNNs) have been widely applied to automatic analysis of medical images for disease diagnosis, and to help human experts by efficiently processing immense amounts of images. While handcrafted feature has been used for eye disease detection or classification since the 1990s, DNN was recently adopted in this area and showed very promising performance. Since handcrafted and deep feature can extract complementary information, we propose in this paper ...
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      Mentions: Imperial College London Wenzhou Medical College Meixiao Shen

    4. Changes in Coronary Plaque Composition in Patients With Acute Myocardial Infarction Treated With High-Intensity Statin Therapy (IBIS-4): A Serial Optical Coherence Tomography Study

      Explore ScienceDirect Cardiology
      Changes in Coronary Plaque Composition in Patients With Acute Myocardial Infarction Treated With High-Intensity Statin Therapy (IBIS-4): A Serial Optical Coherence Tomography Study
      Objectives This study assessed changes in optical coherence tomography (OCT)-defined plaque composition in patients with ST-elevation myocardial infarction (STEMI) receiving high-intensity statin treatment. Background OCT is a high-resolution modality capable of measuring plaque characteristics including fibrous cap thickness (FCT) and macrophage infiltration. There is limited in vivo evidence regarding the effects of statins on OCT-defined coronary atheroma composition and no evidence in the context of STEMI. Methods In the ...
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      Mentions: Imperial College London Leiden University University of Copenhagen

    5. CLARITY Imaging Study

      Explore Home - ClinicalTrials.gov Ophthalmology , Clinical Trials
      CLARITY Imaging Study
      OCT image quality is necessary to provide accurate diagnostic information to ophthalmologists. The increasing resolution of imaging techniques will require ever more high standards of optical transmission through the cornea and tear film. Given that lubricant drops can improve optical transmission through the cornea, this study will attempt to quantify this. The primary objective is to assess the effect of cross-linked sodium hyaluronate on OCT image quality compared to the ...
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      Mentions: Imperial College London

    10. Feature Of The Week 08/01/2018: OCT Shows Promise in Effecting Outcomes after Coronary Intervention Being Associated with Improved Long-Term Survival

      Explore Optical Coherence Tomography News Cardiology
      Feature Of The Week 08/01/2018: OCT Shows Promise in Effecting Outcomes after Coronary Intervention Being Associated with Improved Long-Term Survival
      Objectives This study aimed to determine the effect on long-term survival of using optical coherence tomography (OCT) during percutaneous coronary intervention (PCI). Background Angiographic guidance for PCI has substantial limitations. The superior spatial resolution of OCT could translate into meaningful clinical benefits, although limited data exist to date about their effect on clinical endpoints. Methods This was a cohort study based on the Pan-London (United Kingdom) PCI registry, which includes ...
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      Mentions: Imperial College London Kings College London Christos V. Bourantas

    11. Angiography Alone Versus Angiography Plus Optical Coherence Tomography to Guide Percutaneous Coronary Intervention: Outcomes From the Pan-London PCI Cohort

      Explore ScienceDirect Cardiology
      Angiography Alone Versus Angiography Plus Optical Coherence Tomography to Guide Percutaneous Coronary Intervention: Outcomes From the Pan-London PCI Cohort
      Objectives This study aimed to determine the effect on long-term survival of using optical coherence tomography (OCT) during percutaneous coronary intervention (PCI). Background Angiographic guidance for PCI has substantial limitations. The superior spatial resolution of OCT could translate into meaningful clinical benefits, although limited data exist to date about their effect on clinical endpoints . Methods This was a cohort study based on the Pan-London (United Kingdom) PCI registry, which includes ...
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      Mentions: Imperial College London Royal Brompton Hospital Christos V. Bourantas

    12. Plaque Burden Influences Accurate Classification of Fibrous Cap Atheroma by In-Vivo Optical Coherence Tomography in a Porcine Model of Advanced Coronary Atherosclerosis

      Explore eurointervention.org Cardiology
      Plaque Burden Influences Accurate Classification of Fibrous Cap Atheroma by In-Vivo Optical Coherence Tomography in a Porcine Model of Advanced Coronary Atherosclerosis
      Aims: In-vivo validation of coronary optical coherence tomography (OCT) against histology and the effects of plaque burden (PB) on plaque classification remain unreported. We investigated this in a porcine model with human-like coronary atherosclerosis. Methods and results: Five female Yucatan D374Y-PCSK9 transgenic hypercholesterolemic mini-pigs were implanted with a coronary shear-modifying stent to induce advanced atherosclerosis. OCT frames (n=201) were obtained 34 weeks after implantation. Coronary arteries were perfusion-fixed, serially ...
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      Mentions: Imperial College London Royal Brompton Hospital Aarhus University

    13. Quality difference of neointima following the implantation of bioresorbable scaffold and metallic stent in patients with ST elevation myocardial infarction: quantitative assessments by light intensity, light attenuation, and backscatter on optical coheren

      Explore eurointervention.org Cardiology
      Quality difference of neointima following the implantation of bioresorbable scaffold and metallic stent in patients with ST elevation myocardial infarction: quantitative assessments by light intensity, light attenuation, and backscatter on optical coheren
      Aims: We aimed to assess possible difference of the neointimal quality after everolimus-eluting bioresorbable scaffold (BVS) implantation in comparison with cobalt chromium everolimus-eluting scaffold (CoCr-EES) by optical frequency domain imaging (OFDI). Methods and results: This study is a post-hoc analysis of TROFI II trial assessing neointimal quality 6-month after the implantation of BVS(N=82) and CoCr-EES(N=87) in STEMI patients. Neointimal light property analysis by OFDI full-automatically computed ...
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      Mentions: Imperial College London Leiden University Academic Medical Center at the University of Amsterdam

    14. The role of intracoronary imaging in acute coronary syndromes: OCT in focus

      Explore Global Cardiology Science and Practice Cardiology
      The role of intracoronary imaging in acute coronary syndromes: OCT in focus
      Optical coherence tomography (OCT) has emerged as a powerful intravascular imaging modality in recent years. The introduction of frequency-domain OCT has simplified the procedure and enabled its safe utilisation in different clinical settings including acute coronary syndromes, where it can determine the mechanism of plaque disruption, thrombus burden, and guide percutaneous coronary intervention. In patients presenting with stent failure (stent thrombosis and instent restenosis), OCT can also be very useful ...
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      Mentions: Imperial College London

    15. Serial Assessment of Tissue Precursors and Progression of Coronary Calcification Analyzed by Fusion of IVUS and OCT

      Explore ScienceDirect Cardiology
      Serial Assessment of Tissue Precursors and Progression of Coronary Calcification Analyzed by Fusion of IVUS and OCT
      Objectives The aim of this study was to assess calcium growth with fused grayscale intravascular ultrasound (IVUS), IVUSvirtual histology, and optical coherence tomography (OCT) from baseline to 5-year follow-up in patients treated with bioresorbable vascular scaffolds. Background IVUS and OCT have individual strengths in assessing plaque composition and volume. Fusion of images obtained using these methods could potentially aid in coronary plaque assessment. Methods Anatomic landmarks and endoluminal radiopaque markers ...
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      Mentions: Imperial College London Leiden University Capital Medical University

    16. In vivo multiphoton microscopy using a handheld scanner with lateral and axial motion compensation

      Explore Wiley Online Library Microscopy , Ophthalmology
      In vivo multiphoton microscopy using a handheld scanner with lateral and axial motion compensation
      This paper reports a handheld multiphoton fluorescence microscope designed for clinical imaging that incorporates axial motion compensation and lateral image stabilization. Spectral domain optical coherence tomography is employed to track the axial position of the skin surface, and lateral motion compensation is realised by imaging the speckle pattern arising from the optical coherence tomography beam illuminating the sample. Our system is able to correct lateral sample velocities of up to ...
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      Mentions: Imperial College London Benjamin E. Sherlock
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  4. About Imperial College London

    Imperial College London

    Imperial College London is consistently rated amongst the world's best universities, Imperial College London is a science-based institution with a reputation for excellence in teaching and research. Imperial's main campus is located in South Kensington in central London. Formerly a constituent college of the University of London, Imperial became independent of the university on 8 July 2007, the 100th anniversary of its founding.

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