1. Ik-Kyung Jang

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    1. Mentioned In 135 Articles

    2. Spatial Heterogeneity of Neoatherosclerosis, and its Relationship with Neovascularization and Adjacent Plaque Characteristics: Optical Coherence Tomography Study

      Spatial Heterogeneity of Neoatherosclerosis, and its Relationship with Neovascularization and Adjacent Plaque Characteristics: Optical Coherence Tomography Study
      ..., Massachusetts General Hospital, Harvard Medical School, Boston, MA + Corresponding Author Information Reprint requests: Ik-Kyung Jang, MD, PhD, Massachusetts General Hospital, Cardiology Division 55 Fruit St....
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    3. Distinct Morphological Features of Ruptured Culprit Plaque for Acute Coronary Events Compared to those with Silent Rupture and Thin-Cap Fibroatheroma: a Combined Optical Coherence Tomography and Intravascular Ultrasound Study

      Distinct Morphological Features of Ruptured Culprit Plaque for Acute Coronary Events Compared to those with Silent Rupture and Thin-Cap Fibroatheroma: a Combined Optical Coherence Tomography and Intravascular Ultrasound Study
      Objectives To identify specific morphological characteristics of ruptured culprit plaques (RCP) responsible for acute events, and compare them with ruptured non-culprit plaques (RNCP) and non-ruptured thin-cap fibroatheroma (TCFA) in patients presenting with acute coronary syndromes (ACS). Background Non-ruptured TCFA and multiple ruptured plaques are detected in the same patients with ACS. It remains unknown whether certain morphological characteristics determine rupture of TCFA and subsequently result in ACS. Methods We analyzed ...
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    4. Comprehensive overview of definitions for optical coherence tomography-based plaque and stent analyses

      Comprehensive overview of definitions for optical coherence tomography-based plaque and stent analyses
      Optical coherence tomography (OCT) is the current state-of-the-art intracoronary imaging modality that allows visualization of detailed morphological characteristics of both atherosclerotic plaque and stent. So far, three expert review documents have been released for standardization of OCT image analysis. In the real world, a variety of definitions are being used by different groups and by different core laboratories to analyze OCT findings because of different clinical/procedural contexts in which ...
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    5. Pancoronary Plaque Vulnerability in Patients with Acute Coronary Syndrome and Ruptured Culprit Plaque: A Three-Vessel Optical Coherence Tomography Study

      Pancoronary Plaque Vulnerability in Patients with Acute Coronary Syndrome and Ruptured Culprit Plaque: A Three-Vessel Optical Coherence Tomography Study
      Background Recent studies described different clinical and underlying plaque characteristics between patients with and without plaque rupture presenting with acute coronary syndrome (ACS). In light of the systemic nature of atherosclerosis, we hypothesized that non-culprit plaques might also express different morphological features in these two groups of patients. Methods Thirty-eight patients with ACS who underwent 3-vessel optical coherence tomography (OCT) imaging were identified from the Massachusetts General Hospital OCT Registry ...
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    6. Feature Of The Week 8/4/13: MGH OCT Registry Reports on In Vivo OCT Studies of Plaque Erosion and Calcified Nodule In Acute Coronary Syndrome

      Feature Of The Week 8/4/13: MGH OCT Registry Reports on In Vivo OCT Studies of Plaque Erosion and Calcified Nodule In Acute Coronary Syndrome
      Pathology studies reported that three most common causes of acute coronary syndrome (ACS) or sudden cardiac death are plaque rupture, plaque erosion and calcified nodules. The morphological and clinical characteristics of the underlying pathology of ACS, especially plaque erosion and calcified nodule, have never been well studied in vivo. Using optical coherence tomography, we found that plaque erosions are the substrate for ACS in 31% of patients and calcified nodules ...
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    7. Effect of Pretreatment With Ticagrelor on Residual Thrombus After PCI in Patients Presenting With ACS in Comparison With Delayed Treatment at the Time of PCI: an OCT Study

      Effect of Pretreatment With Ticagrelor on Residual Thrombus After PCI in Patients Presenting With ACS in Comparison With Delayed Treatment at the Time of PCI: an OCT Study
      ...ponsor: Massachusetts General Hospital Collaborator: AstraZeneca Information provided by (Responsible Party): Ik-Kyung Jang, MD, PhD, Massachusetts General Hospital ClinicalTrials.gov Identifier: NCT01916902 First receiv...
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    8. Correlation Between Degree of Neointimal Hyperplasia and Incidence and Characteristics of Neoatherosclerosis as Assessed by Optical Coherence Tomography

      Correlation Between Degree of Neointimal Hyperplasia and Incidence and Characteristics of Neoatherosclerosis as Assessed by Optical Coherence Tomography
      ...ffiliations + Department of Cardiovascular Medicine, Catholic University of the Sacred Heart, Rome, Italy , * Ik-Kyung Jang, MD, PhD Affiliations + Cardiology Division, Massachusetts General Hospital, Harvard Medical Sch...
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    9. Optical Coherence Tomography – 15 Years in Cardiology –

      Optical Coherence Tomography – 15 Years in Cardiology –
      Since its invention in the late 1990s, intravascular optical coherence tomography (OCT) has been rapidly adopted in clinical research and, more recently, in clinical practice. Given its unprecedented resolution and high image contrast, OCT has been used to visualize plaque characteristics and to evaluate the vascular response to percutaneous coronary intervention. In particular, OCT is becoming the standard modality to evaluate in vivo plaque vulnerability, including the presence of lipid ...
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    10. In Vivo Diagnosis of Plaque Erosion and Calcified Nodule in Patients with Acute Coronary Syndrome by Intravascular Optical Coherence Tomography

      In Vivo Diagnosis of Plaque Erosion and Calcified Nodule in Patients with Acute Coronary Syndrome by Intravascular Optical Coherence Tomography
      Objectives To characterize the morphological features of plaque erosion and calcified nodule in patients with acute coronary syndrome (ACS) by optical coherence tomography (OCT). Background Plaque erosion and calcified nodule have not been systematically investigated in vivo . Methods One hundred and twenty-six patients with ACS who had undergone pre-intervention OCT imaging were included. The culprit lesions were classified as plaque rupture (PR), erosion (OCT-erosion), calcified nodule (OCT-CN), or others using ...
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    11. Comparison of near-infrared spectroscopy and optical coherence tomography for detection of lipid

      Comparison of near-infrared spectroscopy and optical coherence tomography for detection of lipid
      Objectives: To compare intra-coronary near-infrared spectroscopy (NIRS) and optical coherence tomography (OCT) for the detection of lipid, also to identify NIRS signals to differentiate superficial lipid, and to characterize the plaque with yellow block chemograms on NIRS. Background: Intra-coronary NIRS has been developed to detect lipid core plaque (LCP). Methods: We investigated a total of 17 patients who underwent both OCT and NIRS. NIRS analysis included plaque lipid core burden ...
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    12. Comparison of zotarolimus-eluting stent and everolimus-eluting stent for vascular healing response: serial 3-month and 12-month optical coherence tomography study

      Comparison of zotarolimus-eluting stent and everolimus-eluting stent for vascular healing response: serial 3-month and 12-month optical coherence tomography study
      Background: Everolimus-eluting stents (EES) have shown favorable clinical outcomes. However, there have been no studies evaluating early vascular response after EES implantation. We designed a prospective study to compare the neointimal response between zotarolimus-eluting stents (ZES) and EES at 3 and 12 months using serial optical coherence tomography examinations. Methods and results: Sixty patients who underwent 3-month and 12-month follow-up optical coherence tomography (36 EES, 24 ZES) were included. Neointimal ...
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    13. CBORT 2013 OCT Symposium July 29th at Harvard Medical School Cambridge MA, USA

      CBORT 2013 OCT Symposium July 29th at Harvard Medical School Cambridge MA, USA
      OCT2013 the first international symposium hosted by the Center for Biomedical OCT Research and Translation at Harvard Medical School and Massachusetts General Hospital, will focus on the latest and greatest technical capabilities of OCT, provide an overview of the commercially available OCT systems, discuss advancements in numerous clinical application areas, and introduce emerging preclinical optical imaging techniques. The unique emphasis of technology and clinical utility presented in the symposium will ...
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    14. 61-75 of 135 « 1 2 3 4 5 6 7 8 9 »
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  2. About Ik-Kyung Jang

    Ik-Kyung Jang

    Ik-Kyung Jang, MD, PHD, is with the Cardiology Division at Massachusetts General Hospital and Harvard Medical School. 

    Dr. Jang came to Massachusetts General Hospital in 1987 from Leuven University in Belgium, where he has completed his residency in medicine and fellowship in cardiology. He also successfully defended his doctorate thesis at the same university. After his advanced fellowship in cardiology at MGH, he joined the staff and is currently working as a Physician and an interventional cardiologist in the Cardiology Division. He holds currently an academic title of Associate Professor of Medicine at Harvard Medical School.

     

    A recipient of the Partners in Excellence Award for Research in 2000 and for leadership in 2006, his research roster is extensive, and is focused on acute coronary syndromes including acute myocardial infarction. His earlier research focused on pharmacology and physiology of thrombosis and thrombolysis. In 1994 he extended his interests to clinical studies. Since founding the Coronary Clinical Trial Group within the Cardiac Unit in 1995, he has conducted numerous clinical studies. He also led Clinical Research Office of the Cardiology Division between 2003 and 2006. He is currently the Director of the Cardiology Laboratory for Integrative Physiology and Imaging (CLIPI). He has been collaborating with the Cardiac Imaging Group at MGH to develop and evaluate different imaging modalities to visualize cardiac structures, including coronary atheromatous plaques.

     

    For the last eleven years he has pioneered the application of intravascular Optical Coherence Tomography (OCT) to patients to better characterize vulnerable plaque and to understand the mechanisms of plaque rupture. Dr. Jang has been invited to lectures at numerous national and international meetings. His publications number more than 200.

  3. Quotes

    1. The C7-XR Imaging System represents a significant step forward for intracoronary imaging...We were all amazed with the speed and simplicity of the LightLab OCT procedure, and the clinical utility is truly unique. I expect OCT to rapidly become the new intracoronary imaging standard.
      In LightLab Imaging Announces FDA Clearance of C7-XR™ Coronary OCT Products in the United States
    2. In 2009, more than 10,000 OCT cases were performed. This collaborative effort will bring together this wealth of information and help us facilitate scientific advancement in the field of OCT.
      In Massachusetts General Hospital announces creation of international registry for coronary optical coherence tomography
    3. The development of OCT and its rapid adoption for intravascular imaging is enabling the ability of clinicians to capture in vivo what was previously seen only through a pathologist’s microscope...Of course, the long-term goal is to identify plaques and prevent sudden cardiac death and heart attacks
      In Massachusetts General Hospital announces creation of international registry for coronary optical coherence tomography