1. I. Alex Vitkin

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    1. Mentioned In 74 Articles

    2. Feature Of The Week 2/28/10: Multichannel optical coherence tomography using a high-power telescope-less polygon-based swept laser in dual-amplifier configuration

      Feature Of The Week 2/28/10: Multichannel optical coherence tomography using a high-power telescope-less polygon-based swept laser in dual-amplifier configuration
      ...hnology to expand and improve the applications and capability of this imaging modality. The group, led by Dr. Alex Vitkin and Dr. Victor Yang, has clinical experience in circulation imaging of the gastrointestinal tracts...
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    3. Doppler optical coherence tomography for interventional cardiovascular guidance: in vivo feasibility and forward-viewing probe flow phantom demonstration

      Doppler optical coherence tomography for interventional cardiovascular guidance: in vivo feasibility and forward-viewing probe flow phantom demonstration
      We demonstrate the potential of a forward-looking Doppler optical coherence tomography (OCT) probe for color flow imaging in several commonly seen narrowed artery morphologies. As a proof of concept, we present imaging results of a surgically exposed thrombotic occlusion model that was imaged superficially to demonstrate that Doppler OCT can identify flow within the recanalization channels of a blocked artery. We present Doppler OCT images in which the flow is ...
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    4. High-power wavelength-swept laser in Littman telescope-less polygon filter and dual-amplifier configuration for multichannel optical coherence tomography

      High-power wavelength-swept laser in Littman telescope-less polygon filter and dual-amplifier configuration for multichannel optical coherence tomography
      ...herence tomography Michael K. Leung, Adrian Mariampillai, Beau A. Standish, Kenneth K. Lee, Nigel R. Munce, I. Alex Vitkin, and Victor X. Yang Optics Letters, Vol. 34, Issue 18, pp. 2814-2816 doi:...
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    5. Interstitial Doppler Optical Coherence Tomography as a Local Tumor Necrosis Predictor in Photodynamic Therapy of Prostatic Carcinoma: An In vivo Study

      We have tested the feasibility of real-time localized blood flow measurements, obtained with interstitial (IS) Doppler optical coherence tomography (DOCT), to predict photodynamic therapy (PDT)-induced tumor necrosis deep within solid Dunning rat prostate tumors. IS-DOCT was used to quantify the PDT-induced microvascular shutdown rate in s.c. Dunning prostate tumors (n = 28). Photofrin (12.5 mg/kg) was administered 20 to 24 hours before tumor irradiation, with 635 nm ...
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    6. In vivo real time monitoring of vasoconstriction and vasodilation by a combined diffuse reflectance spectroscopy and Doppler optical coherence tomography approach

      Background and Objectives A combined diffuse reflectance (DR) spectroscopy and doppler optical coherence tomography (DOCT) approach may offer a powerful means for assessment of tissue function, and potentially provide a way for earlier cancer detection through non-invasive local blood supply measurements. The goal of the study was to compare a DR-derived blood-content-related index to a measure of local blood supply flow as furnished by DOCT during manipulations with blood circulation ...
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    7. In vivo Optical Coherence Tomography Imaging of Preinvasive Bronchial Lesions

      Purpose: Optical coherence tomography (OCT) is an optical imaging method that can visualize cellular and extracellular structures at and below tissue surface. The objective of the study was to determine if OCT could characterize preneoplastic changes in the bronchial epithelium identified by autofluorescence bronchoscopy. Experimental Design: A 1.5-mm fiberoptic probe was inserted via a bronchoscope into the airways of 138 volunteer heavy smokers participating in a chemoprevention trial and ...
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    8. Electrostatic forward-viewing scanning probe for Doppler optical coherence tomography using a dissipative polymer catheter

      ...eau A. Standish, Mihaela Pop, Kevan J. Anderson, George Y. Liu, Tim Luk, Brian K. Courtney, Graham A. Wright, I. Alex Vitkin, Victor X. D. Yang. A novel flexible scanning optical probe is constructed with a finely etched...
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    9. Innovations in imaging for chronic total occlusions: a glimpse into the future of angiography’s blind-spot

      Comment "This is a potentially huge area for cardiovascular OCT. Chronic occlusions are extremely difficult to get through as the wire ..." - mebrezin
      Brian K. Courtney1,3, Nigel R. Munce2, Kevan J. Anderson2, Amandeep S. Thind2, General Leung2, Perry E. Radau3, F. Stuart Foster2,3, I. Alex Vitkin2,5, Robert S. Schwartz6, Alexander J. Dick1,3,4, Graham A. Wright2,3 and Bradley H. Strauss1,3,4,* 1 Division of Cardiology, Schulich Heart Program, Sunnybrook Health Sciences Centre, Room A-253, 2075 Bayview Avenue, Toronto, Ontario M4N 3M5, Canada 2 Department of Medical Biophysics ...
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    10. Method and apparatus for high resolution coherent optical imaging

      A method and an apparatus for examining the subsurface microstructure of a sample are provided. Radiation from a plurality of optical radiation sources travels along a first optical path. In the first optical path, a device focuses the optical radiati n from each of the optical sources into a plurality of respective focal points along the first optical path to provide substantially continuous coverage of a selected portion of the ...
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    11. 61-74 of 74 « 1 2 3 4 5
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  2. About I. Alex Vitkin

    I. Alex Vitkin

    Alex Vitkin is an engineering physicist/biomedical engineer by training, with further specialization in medical physics and applications of lasers in medicine. He is currently a professor of Medical Biophysics and Radiation Oncology at the University of Toronto, a senior scientist in the division of BioPhysics and BioImaging at the Ontario Cancer Institute, and a clinical medical physicist at Princess Margaret Hospital (all in Toronto, Ontario, Canada). His research is the field of biophotonics, with particular emphasis on optical coherence tomography, tissue polarimetry, and optical fiber sensors. He has published over 140 papers and book chapters on diagnostic and therapeutic uses of light in biomedicine, holds several patents in the field, and currently runs a large laboratory with several undergraduate/graduate students and post-doctoral/clinical fellows. His laboratory works closely with clinicians and with industry, and he is a consultant for several biophotonics companies. He has been a Guest Editor for the Optics and Photonics News special issue on Biophotonics, for the Journal of Applied Physics special issue on Applied Biophysics, for the Journal of Biomedical Optics special issue on Advanced Coherence Domain Methods, and currently serves as a topical editor of Optics Letters (second 3-year term). He has lectured widely at national and international levels, including delivering special seminars and summer school modules on biophotonics in Mexico, Brazil, Taiwan, New Zealand, Ukraine, Germany, USA, Cyprus, and Russia; he is currently an active participant in the SPIE Visiting Lecturer and OSA Travelling Lecturer programs. Dr. Vitkin is also a board-certified medical physicist through the CanadianCollege of Physicists in Medicine (CCPM), and a Fellow of the Optical Society of America (OSA) and of the Society of Photo-Optical Instrumentation Engineers (SPIE).