1. Hui Wang

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    1. Mentioned In 29 Articles

    2. Polarization sensitive optical coherence tomography using multiple polarization sensitive semiconductor optical amplifiers

      Polarization sensitive optical coherence tomography using multiple polarization sensitive semiconductor optical amplifiers
      This disclosure relates to an OCT apparatus configured to generate to electromagnetic (e.g., optical) signals having two different polarization states. Two or more silicon optical amplifiers (SOAs) can be configured to maintain a respective polarization state in an optical input signal provided from a light source (e.g., a broadband light source). The different polarization states can be combined by an optical combiner (e.g., a polarization maintaining fiber ...
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    3. Spectral calibration for spectral domain optical coherence tomography based on B-scan Doppler shift with tissue images

      Spectral calibration for spectral domain optical coherence tomography based on B-scan Doppler shift with tissue images
      Abstract: We propose a simple method of linearizing spectral interference fringes of spectral domain optical coherence tomography (SD-OCT) based on B-scan Doppler frequency shift (DFS), which can be obtained by offsetting the laser beam from the pivot of a scanning mirror. We show that DFS is proportional to wavenumber. A DFS based calibration curve can be then extracted from either a single mirror image or multiple tissue images. By examining ...
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      Mentions: Hui Wang
    4. Ametropia, retinal anatomy, and OCT abnormality patterns in glaucoma. 2. Impacts of optic nerve head parameters

      Ametropia, retinal anatomy, and OCT abnormality patterns in glaucoma. 2. Impacts of optic nerve head parameters
      Clinicians use retinal nerve fiber layer thickness (RNFLT) measured by optical coherence tomography (OCT) as an adjunct to glaucoma diagnosis. Ametropia is accompanied by changes to the optic nerve head (ONH), which may affect how OCT machines mark RNFLT measurements as abnormal. These changes in abnormality patterns may bias glaucoma diagnosis. Here, we investigate the relationship between OCT abnormality patterns and the following ONH-related and ametropia-associated parameters on 421 eyes ...
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    5. Ametropia, retinal anatomy, and OCT abnormality patterns in glaucoma. 1. Impacts of refractive error and interartery angle

      Ametropia, retinal anatomy, and OCT abnormality patterns in glaucoma. 1. Impacts of refractive error and interartery angle
      Retinal nerve fiber layer thickness (RNFLT) measured by optical coherence tomography (OCT) is widely used in clinical practice to support glaucoma diagnosis. Clinicians frequently interpret peripapillary RNFLT areas marked as abnormal by OCT machines. However, presently, clinical OCT machines do not take individual retinal anatomy variation into account, and according diagnostic biases have been shown particularly for patients with ametropia. The angle between the two major temporal retinal arteries (interartery ...
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    6. Characterizing the optical properties of human brain tissue with high numerical aperture optical coherence tomography

      Characterizing the optical properties of human brain tissue with high numerical aperture optical coherence tomography
      Quantification of tissue optical properties with optical coherence tomography (OCT) has proven to be useful in evaluating structural characteristics and pathological changes. Previous studies primarily used an exponential model to analyze low numerical aperture (NA) OCT measurements and obtain the total attenuation coefficient for biological tissue. In this study, we develop a systematic method that includes the confocal parameter for modeling the depth profiles of high NA OCT, when the ...
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    7. Polarization-sensitive optical coherence tomography of the human brain connectome

      Polarization-sensitive optical coherence tomography of the human brain connectome
      The human brain is composed of approximately 100 billion neurons that communicate through an intricate network of axons and dendrites. 1 The difficulty of tracing these 3D neuronal pathways, however, has been a critical barrier for standard histology (the study of microscopic anatomy) over the past 100 years. Indeed, there is still no technology that can be used to acquire microscopic images in undistorted 3D space for mapping human brain ...
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    8. Impact of temporal resolution on estimating capillary RBC-flux with optical coherence tomography

      Impact of temporal resolution on estimating capillary RBC-flux with optical coherence tomography
      Optical coherence tomography (OCT) has been used to measure capillary red blood cell (RBC) flux. However, one important technical issue is that the accuracy of this method is subject to the temporal resolution (tt) of the repeated RBC-passage B-scans. A ceiling effect arises due to an insufficientttlimiting the maximum RBC-flux that can be measured. In this letter, we first present simulations demonstrating thatt=1.5mst=1.5mspermits measuring RBC-flux up ...
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    9. Quantifying three-dimensional optic axis using polarization-sensitive optical coherence tomography

      Quantifying three-dimensional optic axis using polarization-sensitive optical coherence tomography
      The optic axis of birefringent samples indicates the direction of optical anisotropy, which should be described in three-dimensional (3-D) space. We present a method to quantify the complete 3-D optic axis orientation calculated from in-plane optic axis measurements from a polarization-sensitive optical coherence tomography system. The in-plane axis orientations with different illumination angles allow the calculation of the necessary polar angle. The method then provides the information to produce the ...
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    10. Polarization sensitive optical coherence microscopy for brain imaging

      Polarization sensitive optical coherence microscopy for brain imaging
      Optical coherence tomography (OCT) and optical coherence microscopy (OCM) have demonstrated the ability to investigate cyto- and myelo-architecture in the brain. Polarization-sensitive OCT provides sensitivity to additional contrast mechanisms, specifically the birefringence of myelination and, therefore, is advantageous for investigating white matter fiber tracts. In this Letter, we developed a polarization-sensitive optical coherence microscope (PS-OCM) with a 3.5 m axial and 1.3 m transverse resolution to investigate fiber ...
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    11. Multi-contrast optical coherence tomography for brain imaging and mapping (Thesis)

      Multi-contrast optical coherence tomography for brain imaging and mapping (Thesis)
      Although our knowledge of neuronal function and regional activity has been tremendously enriched in the past decades, coordination of these neurons to form the complex behaviors has yet to be understood. The neuronal pathways (also named connectome) form the structural foundation of the dynamic circuits in the brain. The recent interests in connectome and brainwide database have imposed a pressing need for high-resolution imaging techniques that allows large coverage. This ...
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    12. Cross-validation of serial optical coherence scanning and diffusion tensor imaging: A study on neural fiber maps in human medulla oblongata

      Cross-validation of serial optical coherence scanning and diffusion tensor imaging: A study on neural fiber maps in human medulla oblongata
      We established a strategy to perform cross-validation of serial optical coherence scanner imaging (SOCS) and diffusion tensor imaging (DTI) on a postmortem human medulla. Following DTI, the sample was serially scanned by SOCS, which integrates a vibratome slicer and a multi-contrast optical coherence tomography rig for large-scale three-dimensional imaging at microscopic resolution. The DTI dataset was registered to the SOCS space. An average correlation coefficient of 0.9 was found ...
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    13. In vivo intracardiac OCT imaging through percutaneous access: Towards image guided radio-frequency ablation

      In vivo intracardiac OCT imaging through percutaneous access: Towards image guided radio-frequency ablation
      BACKGROUND Complete catheter-tissue contact and permanent tissue destruction are essential for efficient radio-frequency ablation (RFA) during cardiac arrhythmia treatment. Current methods of monitoring lesion formation are indirect and unreliable. We aim to develop optical coherence tomography (OCT) as an imaging guidance for RFA. OBJECTIVES The purpose of this study is to evaluate the feasibility of using OCT catheter to image endocardia wall in active beating hearts through percutaneous access. This ...
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  2. About Hui Wang

    Hui Wang is a graduate student in The Biophotonics Imaging Laboratories at Case Western University.