1. Hrebesh M. Subhash

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    1. Mentioned In 59 Articles

    2. The how and why of a $10 optical coherence tomography system

      The how and why of a $10 optical coherence tomography system
      Optical Coherence Tomography (OCT) is the fastest growing medical imaging modality with more than $1Bln worth of scans ordered and over $400M worth of equipment shipped in 2010, just nine years after its commercialization. It is at various stages of acceptance and approvals for eye care, coronary care and skin cancer care and is spreading rapidly to other medical specialties. Indeed, it is the leading success of translation of biophotonics ...
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    3. Quantitative assessment of rat corneal thickness and morphology during stem cell therapy by high-speed optical coherence tomography

      Quantitative assessment of rat corneal thickness and morphology during stem cell therapy by high-speed optical coherence tomography
      Optical Coherence Tomography (OCT) is a non-invasive 3 dimensional optical imaging modality that enables high resolution cross sectional imaging in biological tissues and materials. Its high axial and lateral resolution combined with high sensitivity, imaging depth and wide field of view makes it suitable for wide variety of high resolution medical imaging applications at clinically relevant speed. With the advent of swept source lasers, the imaging speed of OCT has ...
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    4. Optimization of modified scanning protocol based correlation mapping optical coherence tomography at 200 kHz VCSEL source for in vivo microcirculation imaging applications

      Optimization of modified scanning protocol based correlation mapping optical coherence tomography at 200 kHz VCSEL source for in vivo microcirculation imaging applications
      Optical Coherence Tomography (OCT) is a non-invasive 3 dimensional optical imaging modality that enables high resolution cross sectional imaging in biological tissues and materials. Unlike other 3 D medical imaging modalities, OCT provides high axial and lateral resolution combined with high sensitivity, imaging depth and wide field of view which makes it suitable for wide variety of medical imaging applications1. Apart from analysing the morphological characteristics of the biological organs ...
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    5. The impact of relative intensity noise on the signal in multiple reference optical coherence tomography

      The impact of relative intensity noise on the signal in multiple reference optical coherence tomography
      Multiple reference optical coherence tomography (MR-OCT) applies a unique low-cost solution to enhance the scanning depth of standard time domain OCT by inserting an partial mirror into the reference arm of the interferometric system. This novel approach achieves multiple reflections for different layers and depths of an sample with minimal effort of engineering and provides an excellent platform for low-cost OCT systems based on well understood production methods for micro-mechanical ...
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    6. Depth-dependent displacement sensitivity analysis and the influence of Doppler angle for quantitative assessment of mechanical properties using phase-sensitive spectral domain optical coherence tomography

      Depth-dependent displacement sensitivity analysis and the influence of Doppler angle for quantitative assessment of mechanical properties using phase-sensitive spectral domain optical coherence tomography
      Optical coherence elastography (OCE) asesses the mechanical properties of samples by applying a mechanical stimulation and detecting the resulting sample displacement using optical coherence tomography (OCT). OCE methods which utilise the phase of the OCT signal offer the potential to detect displacements on the sub-nanometre scale. However, the displacement sensitivity achieveable is directly related to the signal-to-noise ratio and phase stability of the underlying OCT system. Furthermore, the estimation of ...
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    7. Catoptric Objective Based HighSensitive Fourier-Domain Optical Coherence Tomography

      Catoptric Objective Based HighSensitive Fourier-Domain Optical Coherence Tomography
      We introduce a novel catoptric objective based high sensitive Fourier Domain Optical Coherence Tomography (FD-OCT) system for enhanced structural and functional imaging of cochlear microstructures. Unlike the conventional refractive type microscopic objective, catoptric objectives are well-known for their chromatic aberrations free operation and high light gathering efficiency for a broad range of wavelengths. In this study, we present the feasibility of a commercially available catoptric type objective to obtain high-sensitivity ...
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    8. Assessment of curing behavior of light-activated dental composites using intensity correlation based multiple reference optical coherence tomography

      Assessment of curing behavior of light-activated dental composites using intensity correlation based multiple reference optical coherence tomography
      Background and Objectives Monitoring the curing kinetics of light-activated resin is a key area of research. These resins are used in restorative applications and particularly in dental applications. They can undergo volumetric shrinkage due to poor control of the depth dependent curing process, modulated by the intensity and duration of the curing light source. This often results in the formation of marginal gaps, causing pain and damage to the restoration ...
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    9. 3D nondestructive testing system with an affordable multiple reference optical-delay-based optical coherence tomography

      3D nondestructive testing system with an affordable multiple reference optical-delay-based optical coherence tomography
      ...ve., Suite 5B, Mountain View, California 94043, USA *Corresponding author: hrebeshms@gmail.com Roshan Dsouza, Hrebesh M. Subhash, Kai Neuhaus, Josh Hogan, Carol Wilson, and Martin Leahy, "3D nondestructive testing system...
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    10. A NANO-SENSITIVE FOURIER-DOMAIN Optical Coherence Tomography Inspection System

      A NANO-SENSITIVE FOURIER-DOMAIN Optical Coherence Tomography Inspection System
      ntroduction The invention relates to inspection of a variety of objects, including body tissue (also in vivo), cell cultures, materials for material science, and micro and nano electronics components, for example. Most of the fundamental pathological processes in living tissues, including cancer, exhibit changes at the nanoscale level. Recently the diffraction resolution limit has been broken and optical nanoscale microscopy has led to creation of nanoscopic medicine. However, nanoscopy largely ...
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    11. Characterization of light distribution and optimization of detector position for multiple reference optical coherence tomography

      Characterization of light distribution and optimization of detector position for multiple reference optical coherence tomography
      A time-domain optical coherence tomography system with respect to multiple reflections in the reference arm is simulated with Zemax and the optimal detector position is discussed based on the wavefront error. Multiple reference optical coherence tomography (MR-OCT) is a novel optical imaging platform using a single miniature actuator and partial mirror to recirculate light multiple times within the interferometric system. The recirculation corresponds to multiple path delays extending effectively the ...
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    12. Signal simulation and signal processing for multiple reference optical coherence tomography

      Signal simulation and signal processing for multiple reference optical coherence tomography
      The generation of a synthetic MR-OCT signal is presented and compared to a real acquired signal. Multiple reference optical coherence tomography (MR-OCT) is a novel time-domain interferometric system. The MR-OCT principle is adding a partial mirror to extend the axial scan range, which effectively extends the scan depth for imaging. The actuation of the scan mirror required for time-domain OCT, was demonstrated to operate with a low cost miniature voice ...
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    13. Developing cross-correlation as a method for microvessel imaging using clinical intravascular optical coherence tomography systems

      Developing cross-correlation as a method for microvessel imaging using clinical intravascular optical coherence tomography systems
      Current clinical intravascular optical coherence tomography (IV-OCT) imaging systems have limited in-vivo flow imaging capability because of non-uniform catheter rotation and inadequate A-line scan density. Thus any flow-localisation method that seeks to identify sites of variation within the OCT image data-sets, whether that is in amplitude or phase, produces non-representative correlation (or variance) maps. In this study, both mean and the variation within a set of cross-correlation maps, for static ...
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    14. High resolution coherence domain depth-resolved nailfold capillaroscopy based on correlation mapping optical coherence tomography

      High resolution coherence domain depth-resolved nailfold capillaroscopy based on correlation mapping optical coherence tomography
      ...ence domain depth-resolved nailfold capillaroscopy based on correlation mapping optical coherence tomography Hrebesh M. Subhash ; Sean O'Gorman ; Kai Neuhaus ; Martin Leahy; High resolution coherence domain depth-resolv...
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  2. About Hrebesh M. Subhash

    Hrebesh M. Subhash

    Hrebesh Molly Subhash is with the Biophotonics & Imaging Lab in the School of Medicine at the Oregon Health & Science University. Hrebesh is currently a research associate in Biophotonics and Imaging Laboratory (BAIL), School of Medicine, OHSU Hospital at Portland, OR USA. He works with Prof. R. K. Wang, who is the director of BAIL. His current research activity involves the development of novel optical coherence domain imaging techniques for both anatomical and functional imaging.

    He received his Ph.D. degree in Human Sensing and Functional Sensor Engineering in 2008 from Yamagata University, Yonezawa, Japan. He earned his bachelor's degree in Applied Electronics from the University of Kerala in 1998; his master's in Applied Electronics from the University of Bharathiar in 2000; and his M. Phil in Photonics from the International School of Photonics at the Cochin University of Science and Technology in 2004.

    He was a member of Dr. P.K . Gupta's Biomedical Application Section of RRCAT , Indore. I worked with the Optical Imaging Laboratory led by Dr. Divaker Rao and played a key role in developing the first indigenous Optical Coherence Tomography setup in India.