Articles that mention Hiroshi Mashimo -Optical Coherence Tomography News

Hiroshi Mashimo

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1. Mentioned In 38 Articles
2. Tethered capsule en face optical coherence tomography for imaging Barrett’s esophagus in unsedated patients
  
  Explore arxiv.org May 26 2020 Gastroenterology
  
  Objective Detection of Barretts esophagus (BE) at points of care outside the endoscopy suite may improve screening access and reduce esophageal adenocarcinoma mortality. Tethered capsule optical coherence tomography (OCT) can volumetrically image esophageal mucosa and detect BE in unsedated patients. We investigated ultrahigh-speed tethered capsule, swept-source OCT (SS-OCT) in unsedated patients, improved device design, developed procedural techniques, measured how capsule contact and longitudinal pullback non-uniformity affect coverage, and assessed patient ...
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  Mentions: Massachusetts Institute of Technology James G. Fujimoto Thorlabs
3. Application of OCT in the Gastrointestinal Tract
  
  Explore MDPI Open Access Journals Platform Jul 25 2019 Gastroenterology
  
  Optical coherence tomography (OCT) is uniquely poised for advanced imaging in the gastrointestinal (GI) tract as it allows real-time, subsurface and wide-field evaluation at near-microscopic resolution, which may improve the current limitations or even obviate the need of superficial random biopsies in the surveillance of early neoplasias in the near future. OCTs greatest impact so far in the GI tract has been in the study of the tubular esophagus owing ...
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  Mentions: Hiroshi Mashimo
4. Volumetric laser endomicroscopy and its application to Barrett's esophagus: results from a 1,000 patient registry
  
  Explore Journals May 2 2019 Gastroenterology
  
  Volumetric laser endomicroscopy (VLE) uses optical coherence tomography (OCT) for real-time, microscopic cross-sectional imaging. A US-based multi-center registry was constructed to prospectively collect data on patients undergoing upper endoscopy during which a VLE scan was performed. The objective of this registry was to determine usage patterns of VLE in clinical practice and to estimate quantitative and qualitative performance metrics as they are applied to Barrett's esophagus (BE) management. All ...
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  Mentions: Hiroshi Mashimo NinePoint Medical Michael B. Wallace
5. Computer-Aided Analysis of Gland-Like Subsurface Hyposcattering Structures in Barrett’s Esophagus Using Optical Coherence Tomography
  
  Explore MDPI Open Access Journals Platform Nov 28 2018 Gastroenterology
  
  (1) Background: Barretts esophagus (BE) is a complication of chronic gastroesophageal reflux disease and is a precursor to esophageal adenocarcinoma. The clinical implication of subsurface glandular structures of Barretts esophagus is not well understood. Optical coherence tomography (OCT), also known as volumetric laser endomicroscopy (VLE), can assess subsurface glandular structures, which appear as subsurface hyposcattering structures (SHSs). The aim of this study is to develop a computer-aided algorithm and apply ...
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  Mentions: Massachusetts Institute of Technology James G. Fujimoto Harvard University
6. Feature Of The Week 10/08/2018: Clinical Utility of Ultrahigh-Speed Endoscopic Optical Coherence Tomography in Gastroenterology
  
  Explore Optical Coherence Tomography News Oct 7 2018 Gastroenterology
  
  Barretts esophagus (BE) surveillance is limited by biopsy sampling error. Optical coherence tomography (OCT) enables microscopic resolution, high speed, volumetric imaging and is commercially available as volumetric laser endomicroscopy (VLE, NinePoint Medical). Studies investigated cross-sectional OCT dysplasia features, including a diagnostic algorithm (VLE-DA), however, many VLE studies used ex vivo specimens due to challenges in registering biopsy with OCT. We previously demonstrated ultrahigh-speed endoscopic OCT 10x faster than commercial instruments ...
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  Mentions: Massachusetts Institute of Technology James G. Fujimoto Thorlabs
7. Assessment of Barrett’s esophagus and dysplasia with ultrahigh-speed volumetric en face and cross-sectional optical coherence tomography
  
  Explore thieme-connect.de Sep 30 2018 Gastroenterology
  
  Background This study aimed to evaluate the use of ultrahigh-speed volumetric en face and cross-sectional optical coherence tomography (OCT) with micromotor catheters for the in vivo assessment of Barretts esophagus and dysplasia. Methods 74 OCT datasets with correlated biopsy/endoscopic mucosal resection histology (49 nondysplastic Barretts esophagus [NDBE], 25 neoplasia) were obtained from 14 patients with Barretts esophagus and a history of dysplasia and 30 with NDBE. The associations between ...
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  Mentions: Massachusetts Institute of Technology James G. Fujimoto Thorlabs
8. Cycloid scanning for wide field optical coherence tomography endomicroscopy and angiography in vivo
  
  Explore OSA | OSA Publishing Jan 16 2018 Gastroenterology , Probes
  
  Devices that perform wide field-of-view (FOV) precision optical scanning are important for endoscopic assessment and diagnosis of luminal organ disease such as in gastroenterology. Optical scanning for in vivo endoscopic imaging has traditionally relied on one or more proximal mechanical actuators, limiting scan accuracy and imaging speed. There is a need for rapid and precise two-dimensional (2D) microscanning technologies to enable the translation of benchtop scanning microscopies to in vivo ...
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  Mentions: Johns Hopkins University Massachusetts Institute of Technology James G. Fujimoto
9. Optical coherence tomography in gastroenterology: a review and future outlook
  
  Explore SPIE Digital Library Dec 19 2017 Gastroenterology
  
  Optical coherence tomography (OCT) is an imaging technique optically analogous to ultrasound that can generate depth-resolved images with micrometer-scale resolution. Advances in fiber optics and miniaturized actuation technologies allow OCT imaging of the human body and further expand OCT utilization in applications including but not limited to cardiology and gastroenterology. This review article provides an overview of current OCT development and its clinical utility in the gastrointestinal tract, including disease ...
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  Mentions: Columbia University Massachusetts General Hospital Harvard University
10. Ultrahigh-speed endoscopic optical coherence tomography and angiography enables delineation of lateral margins of endoscopic mucosal resection: a case report
  
  Explore SAGE Journals Nov 28 2017 Gastroenterology
  
  Endoscopic mucosal resection (EMR) is a common technique for resecting dysplastic lesions in Barretts esophagus (BE), stomach, and colon, 1 but precise delineation of dysplastic margins before resection and verification of complete removal after resection remain challenging. 2 , 3 Endoscopic optical coherence tomography (OCT) enables three-dimensional visualization of tissue microstructure and is commercially available as Volumetric Laser Endomicroscopy (NinePoint Medical, Bedford, MA, USA). 4 , 5 We recently developed an ultrahigh-speed ...
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  Mentions: Massachusetts Institute of Technology James G. Fujimoto Thorlabs
11. Endoscopic forward-viewing optical coherence tomography and angiography with MHz swept source
  
  Explore OSA | OSA Publishing Aug 9 2017 Gastroenterology , Probes
  
  Endoscopic optical coherence tomography (OCT) instruments are mostly side viewing and rely on at least one proximal scan, thus limiting accuracy of volumetric imaging and en face visualization. Previous forward-viewing OCT devices had limited axial scan speeds. We report a forward-viewing fiber scanning 3D-OCT probe with 900 m field of view and 5 m transverse resolution, imaging at 1 MHz axial scan rate in the human gastrointestinal tract. The probe ...
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  Mentions: Massachusetts Institute of Technology James G. Fujimoto Thorlabs
12. Assessment of the radiofrequency ablation dynamics of esophageal tissue with optical coherence tomography
  
  Explore SPIE | Journal Jul 10 2017 Gastroenterology
  
  Radiofrequency ablation (RFA) is widely used for the eradication of dysplasia and the treatment of early stage esophageal carcinoma in patients with Barretts esophagus (BE). However, there are several factors, such as variation of BE epithelium (EP) thickness among individual patients and varying RFA catheter-tissue contact, which may compromise RFA efficacy. We used a high-speed optical coherence tomography (OCT) system to identify and monitor changes in the esophageal tissue architecture ...
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  Mentions: Massachusetts Institute of Technology James G. Fujimoto Harvard University
13. Endoscopic optical coherence tomography angiography microvascular features associated with dysplasia in Barrett's esophagus: a pilot study (with video)
  
  Explore Elsevier Health Feb 3 2017 Gastroenterology , Oncology
  
  Background and Aims Angiogenesis is associated with neoplastic progression of Barretts esophagus (BE). Volumetric optical coherence tomography angiography (OCTA) visualizes subsurface microvasculature without exogenous contrast agents. We investigated the association of OCTA microvascular features with low-grade dysplasia (LGD) and high-grade dysplasia (HGD). Methods Fifty-two patients undergoing BE surveillance or endoscopic eradication therapies for dysplasia were imaged using volumetric OCTA and corresponding histological diagnoses obtained, to yield 97 data sets (non-dysplastic ...
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  Mentions: Massachusetts Institute of Technology James G. Fujimoto Thorlabs
14. Depth-resolved imaging of colon tumor using optical coherence tomography and fluorescence laminar optical tomography
  
  Explore OSA | OSA Publishing Dec 27 2016 Gastroenterology
  
  Early detection of neoplastic changes remains a critical challenge in clinical cancer diagnosis and treatment. Many cancers arise from epithelial layers such as those of the gastrointestinal (GI) tract. Current standard endoscopic technology is difficult to detect the subsurface lesions. In this research, we investigated the feasibility of a novel multi-modal optical imaging approach including high-resolution optical coherence tomography (OCT) and high-sensitivity fluorescence laminar optical tomography (FLOT) for structural and ...
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  Mentions: University of Maryland University of Rochester Harvard University
15. Volumetric Mapping of Barrett’s Esophagus and Dysplasia With en face Optical Coherence Tomography Tethered Capsule
  
  Explore Nature Publishing Group Nov 9 2016 Gastroenterology
  
  To the Editor: Dysplasia in Barretts Esophagus (BE) is patchy ( 1 ) and sometimes missed by random biopsies. Optical coherence tomography (OCT) can image large areas of the esophagus; however, slow imaging speeds in earlier studies limited visualization to cross-sections. Cross-sectional OCT detected high-grade dysplasia with sensitivity / specificity of ~80 % ( 2 , 3 ). Tethered OCT capsules were demonstrated for cross-sectional imaging in unsedated screening to detect BE ( 4 , 5 ). Our group recently ...
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  Mentions: Massachusetts Institute of Technology James G. Fujimoto Thorlabs
16. Circumferential optical coherence tomography angiography imaging of the swine esophagus using a micromotor balloon catheter
  
  Explore OSA | OSA Publishing Jul 5 2016 Gastroenterology , Probes
  
  We demonstrate a micromotor balloon imaging catheter for ultrahigh speed endoscopic optical coherence tomography (OCT) which provides wide area, circumferential structural and angiographic imaging of the esophagus without contrast agents. Using a 1310 nm MEMS tunable wavelength swept VCSEL light source, the system has a 1.2 MHz A-scan rate and ~8.5 m axial resolution in tissue. The micromotor balloon catheter enables circumferential imaging of the esophagus at 240 ...
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  Mentions: Brigham and Women’s Hospital Massachusetts Institute of Technology James G. Fujimoto
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