1. Hiroshi Ishikawa

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    1. Mentioned In 99 Articles

    2. In Vivo Sublayer Analysis Of Human Retinal Inner Plexiform Layer Obtained By Visible-Light Optical Coherence Tomography

      Explore bioRxiv.org Ophthalmology
      In Vivo Sublayer Analysis Of Human Retinal Inner Plexiform Layer Obtained By Visible-Light Optical Coherence Tomography
      Purpose: Growing evidence suggests, in glaucoma, the dendritic degeneration of subpopulation of the retinal ganglion cells (RGCs) may precede RGCs soma death. Since different RGCs synapse in different IPL sublayers, visualization of the lamellar structure of the IPL could enable both clinical and fundamental advances in glaucoma understanding and management. In this pilot study, we investigated whether visible-light optical coherence tomography (vis-OCT) could detect the difference in the inner plexiform ...
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      Mentions: Joel S. Schuman Hiroshi Ishikawa Northwestern University

    3. Self-supervised Denoising via Diffeomorphic Template Estimation: Application to Optical Coherence Tomography

      Explore arxiv.org
      Self-supervised Denoising via Diffeomorphic Template Estimation: Application to Optical Coherence Tomography
      Optical Coherence Tomography (OCT) is pervasive in both the research and clinical practice of Ophthalmology. However, OCT images are strongly corrupted by noise, limiting their interpretation. Current OCT denoisers leverage assumptions on noise distributions or generate targets for training deep supervised denoisers via averaging of repeat acquisitions. However, recent self-supervised advances allow the training of deep denoising networks using only repeat acquisitions without clean targets as ground truth, reducing the ...
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      Mentions: Joel S. Schuman Hiroshi Ishikawa NYU Langone Medical Center

    4. Attention-guided 3D-CNN Framework for Glaucoma Detection and Structural-Functional Association using Volumetric Images

      Explore IEEE Xplore Ophthalmology
      Attention-guided 3D-CNN Framework for Glaucoma Detection and Structural-Functional Association using Volumetric Images
      The direct analysis of 3D Optical Coherence Tomography (OCT) volumes enables deep learning models (DL) to learn spatial structural information and discover new bio-markers that are relevant to glaucoma. Downsampling 3D input volumes is the state-of-art solution to accommodate for the limited number of training volumes as well as the available computing resources. However, this limits the network's ability to learn from small retinal structures in OCT volumes. In ...
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      Mentions: Joel S. Schuman Gadi Wollstein Hiroshi Ishikawa

    5. Improved Denoising of Optical Coherence Tomography via Repeated Acquisitions and Unsupervised Deep Learning

      Explore IOVS Journal Ophthalmology
      Improved Denoising of Optical Coherence Tomography via Repeated Acquisitions and Unsupervised Deep Learning
      Purpose : Optical Coherence Tomography (OCT) is widely used, yet its interpretation is confounded by strong speckle noise. Previous denoising methods make strong assumptions on noise characteristics and struggle to retain fine structure. We present a data-driven registration and denoising method which vastly improves image fidelity while requiring only repeated noisy acquisitions of individual subjects. Methods : Noise2Noise is an unsupervised denoising approach for repeatedly acquired noisy images (Lehtinen, ICML , 2018). By ...
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      Mentions: Joel S. Schuman Hiroshi Ishikawa NYU Langone Medical Center

    6. Dueling Deep Q-Network for Unsupervised Inter-frame Eye Movement Correction in Optical Coherence Tomography Volumes

      Explore arxiv.org Ophthalmology
      Dueling Deep Q-Network for Unsupervised Inter-frame Eye Movement Correction in Optical Coherence Tomography Volumes
      In optical coherence tomography (OCT) volumes of retina, the sequential acquisition of the individual slices makes this modality prone to motion artifacts, misalignments between adjacent slices being the most noticeable. Any distortion in OCT volumes can bias structural analysis and influence the outcome of longitudinal studies. On the other hand, presence of speckle noise that is characteristic of this imaging modality, leads to inaccuracies when traditional registration techniques are employed ...
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      Mentions: Joel S. Schuman Gadi Wollstein Hiroshi Ishikawa

    7. ASSESSING THE ABILITY OF PREOPERATIVE QUANTITATIVE SPECTRAL-DOMAIN OPTICAL COHERENCE TOMOGRAPHY CHARACTERISTICS TO PREDICT VISUAL OUTCOME IN IDIOPATHIC MACULAR HOLE SURGERY

      Explore LWW Online Ophthalmology
      ASSESSING THE ABILITY OF PREOPERATIVE QUANTITATIVE SPECTRAL-DOMAIN OPTICAL COHERENCE TOMOGRAPHY CHARACTERISTICS TO PREDICT VISUAL OUTCOME IN IDIOPATHIC MACULAR HOLE SURGERY
      Purpose: To determine which spectral domain optical coherence tomography biomarkers of idiopathic macular hole (MH) correlate with the postoperative best-corrected visual acuity (BCVA) in anatomically closed MH. Methods: Retrospective analysis of spectral domain optical coherence tomography scans of 44 patients presenting with MH followed for a mean of 17 months. Widths of MH aperture, base, and ellipsoid zone disruption were calculated from presenting foveal spectral domain optical coherence tomography B-scans ...
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      Mentions: Joel S. Schuman Gadi Wollstein Hiroshi Ishikawa

    8. Retinal blood flow reduction in normal-tension glaucoma with single-hemifield damage by Doppler optical coherence tomography

      Explore BJO Online Ophthalmology
      Retinal blood flow reduction in normal-tension glaucoma with single-hemifield damage by Doppler optical coherence tomography
      Aims To evaluate the associations between retinal blood flow (RBF) and optical coherence tomography (OCT) structural measurements in normal-tension glaucoma (NTG) eyes with single-hemifield visual field (VF) damage by the Doppler OCT. Methods The Doppler OCT was used to measure temporal artery (TA) RBF and temporal vein (TV) RBF. Retinal nerve fibre layer thickness (RNFLT) was measured by spectral-domain OCT. Results Forty-three consecutive eyes of 43 patients with NTG with ...
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      Mentions: Joel S. Schuman Gadi Wollstein Hiroshi Ishikawa

    9. 3D-CNN for Glaucoma Detection Using Optical Coherence Tomography

      Explore Home - Springer Ophthalmology
      3D-CNN for Glaucoma Detection Using Optical Coherence Tomography
      The large size of raw 3D optical coherence tomography (OCT) volumes poses challenges for deep learning methods as it cannot be accommodated on a single GPU in its original resolution. The direct analysis of these volumes however, provides advantages such as circumventing the need for the segmentation of retinal structures. Previously, a deep learning (DL) approach was proposed for the detection of glaucoma directly from 3D OCT volumes, where the ...
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      Mentions: Joel S. Schuman Gadi Wollstein Hiroshi Ishikawa

    10. Speckle reduction in visible-light optical coherence tomography using scan modulation

      Explore SPIE Digital Library Ophthalmology
      Speckle reduction in visible-light optical coherence tomography using scan modulation
      We present a technique to reduce speckle in visible-light optical coherence tomography (vis-OCT) that preserves fine structural details and is robust against sample motion. Specifically, we locally modulate B-scans orthogonally to their axis of acquisition. Such modulation enables acquisition of uncorrelated speckle patterns from similar anatomical locations, which can be averaged to reduce speckle. To verify the effectiveness of speckle reduction, we performed in-vivo retinal imaging using modulated raster and ...
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      Mentions: Joel S. Schuman Hiroshi Ishikawa Northwestern University

    11. Inference of visual field test performance from OCT volumes using deep learning

      Explore arxiv.org Ophthalmology
      Inference of visual field test performance from OCT volumes using deep learning
      Visual field tests (VFT) are pivotal for glaucoma diagnosis and conducted regularly to monitor disease progression. Here we address the question to what degree aggregate VFT measurements such as Visual Field Index (VFI) and Mean Deviation (MD) can be inferred from Optical Coherence Tomography (OCT) scans of the Optic Nerve Head (ONH) or the macula. Accurate inference of VFT measurements from OCT could reduce examination time and cost. We propose ...
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      Mentions: Joel S. Schuman Gadi Wollstein Hiroshi Ishikawa

    13. Designing visible-light optical coherence tomography towards clinics

      Explore Home
      Designing visible-light optical coherence tomography towards clinics
      Background: The capabilities of visible-light optical coherence tomography (vis-OCT) in noninvasive anatomical and functional retinal imaging have been demonstrated by multiple groups in both rodents and healthy human subjects. Translating laboratory prototypes to an integrated clinical-environment-friendly system is required to explore the full potential of vis-OCT in disease management. Methods: We developed and optimized a portable vis-OCT system for human retinal imaging in clinical settings. We acquired raster- and circular-scan ...
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      Mentions: Joel S. Schuman Gadi Wollstein Hiroshi Ishikawa

    14. Quantitative assessment of outer retinal folds on enface optical coherence tomography after vitrectomy for rhegmatogenous retinal detachment

      Explore Nature Publishing Group Ophthalmology
      Quantitative assessment of outer retinal folds on enface optical coherence tomography after vitrectomy for rhegmatogenous retinal detachment
      We aimed to investigate the possible causes of metamorphopsia for rhegmatogenous retinal detachment (RRD) based on findings of enface optical coherence tomography (OCT). The study was a retrospective, consecutive case series of 33 eyes with macula-off RRD. Metamorphopsia was measured by M-CHARTS and enface OCT images covering a macular area of 66mm square obtained at 1, 3, and 6 months postoperatively. Within the outer retinal slabs of enface OCT, multiple ...
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      Mentions: Hiroshi Ishikawa

    15. Retinal optical coherence tomography image enhancement via deep learning

      Explore OSA | OSA Publishing
      Retinal optical coherence tomography image enhancement via deep learning
      Optical coherence tomography (OCT) images of the retina are a powerful tool for diagnosing and monitoring eye disease. However, they are plagued by speckle noise, which reduces image quality and reliability of assessment. This paper introduces a novel speckle reduction method inspired by the recent successes of deep learning in medical imaging. We present two versions of the network to reflect the needs and preferences of different end-users. Specifically, we ...
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      Mentions: Joel S. Schuman Gadi Wollstein Hiroshi Ishikawa
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  4. About Hiroshi Ishikawa

    Hiroshi Ishikawa

    Hiroshi Ishikawa MD is an Assistant Professor, Department of Ophthalmology and Bioengineering at the UPMC Eye Center, Eye and Ear Institute, Department of Ophthalmology, University of Pittsburgh School of Medicine.

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