1. Hiram G. Bezerra

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    1. Mentioned In 95 Articles

    2. New Volumetric Analysis Method for Stent Expansion and its Correlation With Final Fractional Flow Reserve and Clinical Outcome An ILUMIEN I Substudy

      Explore interventions.onlinejacc.org Cardiology
      New Volumetric Analysis Method for Stent Expansion and its Correlation With Final Fractional Flow Reserve and Clinical Outcome An ILUMIEN I Substudy
      Download figure Open in new tab Download powerpoint Abstract Objectives This study sought to compare conventional methodology (CM) with a newly described optical coherence tomography (OCT)-derived volumetric stent expansion analysis in terms of fractional flow reserve (FFR)-derived physiology and device-oriented composite endpoints (DoCE). Background The analysis of coronary stent expansion with intracoronary imaging has used CM that relies on the analysis of selected single cross-sections for several decades ...
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      Mentions: Case Western Reserve University Cardiovascular Research Foundation David Holmes

    3. Optimizing Percutaneous Coronary Intervention in Calcified Lesions Insights From Optical Coherence Tomography of Atherectomy

      Explore Circulation Cardiology
      Optimizing Percutaneous Coronary Intervention in Calcified Lesions Insights From Optical Coherence Tomography of Atherectomy
      Optimal coronary stent implantation is among the few successful strategies in preventing stent failures, notably in-stent restenosis and stent thrombosis. 1 Understanding the intravascular milieu is a prerequisite for optimization of percutaneous coronary intervention (PCI). Calcified lesions limit stent expansion, the most robust predictor of target lesion revascularization, and are thus associated with worst outcomes. 2 Coronary angiography is a poor discriminator of calcium distribution and thickness. Reliance on angiography ...
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      Mentions: Case Western Reserve University Brown University Hiram G. Bezerra

    4. Association of skin autofluorescence with plaque vulnerability evaluated by optical coherence tomography in patients with cardiovascular disease

      Explore atherosclerosis-journal.com Cardiology , Dermatology
      Association of skin autofluorescence with plaque vulnerability evaluated by optical coherence tomography in patients with cardiovascular disease
      Background and aims Accumulation of advanced glycation end products (AGEs) can be measured non-invasively by skin autofluorescence (SAF) whose values are elevated in patients with cardiovascular disease (CVD). Optical coherence tomography (OCT) is an intravascular imaging modality that could allow visualization of plaque composition. We aim to examine the relationship between SAF and plaque composition evaluated by frequency-domain OCT in patients with CVD. Methods We prospectively enrolled 108 patients with ...
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      Mentions: Case Western Reserve University Sun Yat-Sen University Hiram G. Bezerra

    5. Mobilization of progenitor cells and assessment of vessel healing after second generation drug-eluting stenting by optical coherence tomography

      Explore ScienceDirect Cardiology
      Mobilization of progenitor cells and assessment of vessel healing after second generation drug-eluting stenting by optical coherence tomography
      Background Bone marrow-derived progenitor cells likely contribute to both endothelial- and smooth muscle cell-dependent healing responses in stent-injured vessel sites. This study aimed to assess mobilization of progenitor cells and vessel healing after zotarolimus-eluting (ZES) and everolimus-eluting (EES) stents. Methods and results In 63 patients undergoing coronary stent implantation, we measured circulating CD34 + CD133 + CD45low cells and serum levels of biomarkers relevant to stem cell mobilization . In 31 patients of ...
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      Mentions: Case Western Reserve University Marco A. Costa Hiram G. Bezerra

    7. OCT guidance during stent implantation in primary Pci: A randomized multicenter study with nine months of optical coherence tomography follow-up

      Explore International Journal of Cardiology Cardiology
      OCT guidance during stent implantation in primary Pci: A randomized multicenter study with nine months of optical coherence tomography follow-up
      Aims To assess the possible merits of optical coherence tomography (OCT) guidance in primary percutaneous coronary intervention (pPCI). Methods and results 201 patients with ST-elevation myocardial infarction (STEMI) were enrolled in this study. Patients were randomized either to pPCI alone (angio-guided group, n = 96) or to pPCI with OCT guidance (OCT-guided group, n = 105) and also either to biolimus A9 or to everolimus-eluting stent implantation. All patients were scheduled for ...
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      Mentions: Marco A. Costa Hiram G. Bezerra Guilherme F. Attizzani

    8. OCT Made Easy (Textbook)

      Explore CRC Press Online Cardiology , Textbooks
      OCT Made Easy (Textbook)
      This book, written by premier authors in the field of OCT intravascular imaging, covers the best practices for using OCT to provide high resolution cross-sectional viewing for atherosclerotic plaque assessment, stent strut coverage and apposition, assessment in stent restenosis evaluation, and PCI guide and optimization. Fully illustrated thorughout in a handy, cath-lab side handbook supplemented by online movie clips, OCT Made Easy includes case studies, angiography, CT correlations, and simple ...
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      Mentions: Case Western Reserve University Marco A. Costa Hiram G. Bezerra

    9. Automated Volumetric Intravascular Plaque Classification Using Optical Coherence Tomography

      Explore vvvvw.aaai.org Cardiology
      Automated Volumetric Intravascular Plaque Classification Using Optical Coherence Tomography
      An estimated 17.5 million people died from a cardiovascular disease in 2012, representing 31 percent of all global deaths. Most acute coronary events result from rupture of the protective fibrous cap overlying an atherosclerotic plaque. The task of early identification of plaque types that can potentially rupture is, therefore, of great importance. The state-of-the-art approach to imaging blood vessels is intravascular optical coherence tomography (IVOCT). However, currently, this is ...
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      Mentions: Andrew M. Rollins Case Western Reserve University David L. Wilson

    10. The REMEDEE-OCT Study : An Evaluation of the Bioengineered COMBO Dual-Therapy CD34 Antibody–Covered Sirolimus-Eluting Coronary Stent Compared With a Cobalt-Chromium Everolimus-Eluting Stent in Patients With Acute Coronary Syndromes: Insights From Optical

      Explore ScienceDirect Cardiology
      The REMEDEE-OCT Study : An Evaluation of the Bioengineered COMBO Dual-Therapy CD34 Antibody–Covered Sirolimus-Eluting Coronary Stent Compared With a Cobalt-Chromium Everolimus-Eluting Stent in Patients With Acute Coronary Syndromes: Insights From Optical
      Objectives The aim of the present study was to evaluate vascular healing of the bioengineered COMBO Dual Therapy Stent compared with a cobalt-chromium (CoCr) everolimus-eluting stent (EES) as assessed by optical coherence tomography in patients with acute coronary syndromes. Background CD34+ cells promote endothelial repair after vascular injury. The bioengineered COMBO Dual Therapy Stent combines CD34+ cellcapturing technology with abluminal sirolimus release, but more data from clinical studies evaluating the ...
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      Mentions: Case Western Reserve University Cardiovascular Research Foundation Academic Medical Center at the University of Amsterdam

    12. Difference in Vascular Response between Sirolimus-eluting- and Everolimus-eluting Stents in Ostial Left Circumflex Artery after Unprotected Left Main as Observed by

      Explore Elsevier Health Cardiology
      Difference in Vascular Response between Sirolimus-eluting- and Everolimus-eluting Stents in Ostial Left Circumflex Artery after Unprotected Left Main as Observed by
      Background Kissing-balloon technique (KBT) is commonly performed during percutaneous coronary intervention of distal unprotected left main coronary artery (ULM) aiming at obtaining optimal opening of the side branch (left circumflex artery; LCX) ostium. Nonetheless, detailed evaluation of vascular response to stents in LCX ostium is lacking. We therefore evaluated the vascular response to different drug-eluting stents (DES) in ostial LCX after ULM by means of optical coherence tomography (OCT). Methods ...
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      Mentions: Case Western Reserve University Hiram G. Bezerra Wei Wang

    14. Failure Mechanisms and Neoatherosclerosis Patterns in Very Late Drug-Eluting and Bare-Metal Stent Thrombosis

      Explore Circulation Cardiology
      Failure Mechanisms and Neoatherosclerosis Patterns in Very Late Drug-Eluting and Bare-Metal Stent Thrombosis
      Background There are few clinical studies on the pathophysiological mechanisms of very late stent thrombosis (VLST). We report optical coherence tomography findings in patients with VLST and compare the findings between bare-metal stents (BMS) and drug-eluting stents (DES). Methods and Results We conducted a registry of stent thrombosis at 4 North American centers with optical coherence tomography imaging programs SAFE registry (The Study of Late Stent Failure Evaluated by OCT ...
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      Mentions: University of Pittsburgh Case Western Reserve University University of British Columbia

    15. Dextran or Saline Can Replace Contrast for Intravascular Optical Coherence Tomography in Lower Extremity Arteries

      Explore Journal of Endovascular Therapy Cardiology
      Dextran or Saline Can Replace Contrast for Intravascular Optical Coherence Tomography in Lower Extremity Arteries
      Purpose: To examine the hypothesis that alternative flush media could be used for lower extremity optical coherence tomography (OCT) imaging in long lesions that would normally require excessive use of contrast. Methods: The OPTical Imaging Measurement of Intravascular Solution Efficacy (OPTIMISE) trial was a single-center, prospective study ( ClinicalTrials.gov identifier NCT01743872 ) that enrolled 23 patients (mean age 6811 years; 14 men) undergoing endovascular intervention involving the superficial femoral artery. Four ...
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      Mentions: Case Western Reserve University Hiram G. Bezerra

    16. Three-dimensional registration of intravascular optical coherence tomography and cryo-image volumes for microscopic-resolution validation

      Explore SPIE | Journal Cardiology
      Three-dimensional registration of intravascular optical coherence tomography and cryo-image volumes for microscopic-resolution validation
      Evidence suggests high-resolution, high-contrast, 100 frames / s 100frames/s intravascular optical coherence tomography (IVOCT) can distinguish plaque types, but further validation is needed, especially for automated plaque characterization. We developed experimental and three-dimensional (3-D) registration methods to provide validation of IVOCT pullback volumes using microscopic, color, and fluorescent cryo-image volumes with optional registered cryo-histology. A specialized registration method matched IVOCT pullback images acquired in the catheter reference frame to a ...
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      Mentions: Case Western Reserve University Marco A. Costa Madhusudhana Gargesha
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  4. About Hiram G. Bezerra

    Hiram G. Bezerra, M.D., is with the University Hospitals Case Medical Center-Interventional Cardiovascular Center and Research & Innovation Center.

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    4. Intracoronary Optical Coherence Tomography: A Comprehensive Review: Clinical and Research Applications
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