1. Hiram G. Bezerra

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    1. Mentioned In 88 Articles

    2. Automated Volumetric Intravascular Plaque Classification Using Optical Coherence Tomography

      Explore vvvvw.aaai.org Cardiology
      Automated Volumetric Intravascular Plaque Classification Using Optical Coherence Tomography
      An estimated 17.5 million people died from a cardiovascular disease in 2012, representing 31 percent of all global deaths. Most acute coronary events result from rupture of the protective fibrous cap overlying an atherosclerotic plaque. The task of early identification of plaque types that can potentially rupture is, therefore, of great importance. The state-of-the-art approach to imaging blood vessels is intravascular optical coherence tomography (IVOCT). However, currently, this is ...
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      Mentions: Andrew M. Rollins Case Western Reserve University David L. Wilson

    3. The REMEDEE-OCT Study : An Evaluation of the Bioengineered COMBO Dual-Therapy CD34 Antibody–Covered Sirolimus-Eluting Coronary Stent Compared With a Cobalt-Chromium Everolimus-Eluting Stent in Patients With Acute Coronary Syndromes: Insights From Optical

      Explore ScienceDirect Cardiology
      The REMEDEE-OCT Study : An Evaluation of the Bioengineered COMBO Dual-Therapy CD34 Antibody–Covered Sirolimus-Eluting Coronary Stent Compared With a Cobalt-Chromium Everolimus-Eluting Stent in Patients With Acute Coronary Syndromes: Insights From Optical
      Objectives The aim of the present study was to evaluate vascular healing of the bioengineered COMBO Dual Therapy Stent compared with a cobalt-chromium (CoCr) everolimus-eluting stent (EES) as assessed by optical coherence tomography in patients with acute coronary syndromes. Background CD34+ cells promote endothelial repair after vascular injury. The bioengineered COMBO Dual Therapy Stent combines CD34+ cellcapturing technology with abluminal sirolimus release, but more data from clinical studies evaluating the ...
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      Mentions: Case Western Reserve University Cardiovascular Research Foundation Academic Medical Center at the University of Amsterdam

    5. Difference in Vascular Response between Sirolimus-eluting- and Everolimus-eluting Stents in Ostial Left Circumflex Artery after Unprotected Left Main as Observed by

      Explore Elsevier Health Cardiology
      Difference in Vascular Response between Sirolimus-eluting- and Everolimus-eluting Stents in Ostial Left Circumflex Artery after Unprotected Left Main as Observed by
      Background Kissing-balloon technique (KBT) is commonly performed during percutaneous coronary intervention of distal unprotected left main coronary artery (ULM) aiming at obtaining optimal opening of the side branch (left circumflex artery; LCX) ostium. Nonetheless, detailed evaluation of vascular response to stents in LCX ostium is lacking. We therefore evaluated the vascular response to different drug-eluting stents (DES) in ostial LCX after ULM by means of optical coherence tomography (OCT). Methods ...
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      Mentions: Case Western Reserve University Hiram G. Bezerra Wei Wang

    7. Failure Mechanisms and Neoatherosclerosis Patterns in Very Late Drug-Eluting and Bare-Metal Stent Thrombosis

      Explore Circulation Cardiology
      Failure Mechanisms and Neoatherosclerosis Patterns in Very Late Drug-Eluting and Bare-Metal Stent Thrombosis
      Background There are few clinical studies on the pathophysiological mechanisms of very late stent thrombosis (VLST). We report optical coherence tomography findings in patients with VLST and compare the findings between bare-metal stents (BMS) and drug-eluting stents (DES). Methods and Results We conducted a registry of stent thrombosis at 4 North American centers with optical coherence tomography imaging programs SAFE registry (The Study of Late Stent Failure Evaluated by OCT ...
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      Mentions: University of Pittsburgh Case Western Reserve University University of British Columbia

    8. Dextran or Saline Can Replace Contrast for Intravascular Optical Coherence Tomography in Lower Extremity Arteries

      Explore Journal of Endovascular Therapy Cardiology
      Dextran or Saline Can Replace Contrast for Intravascular Optical Coherence Tomography in Lower Extremity Arteries
      Purpose: To examine the hypothesis that alternative flush media could be used for lower extremity optical coherence tomography (OCT) imaging in long lesions that would normally require excessive use of contrast. Methods: The OPTical Imaging Measurement of Intravascular Solution Efficacy (OPTIMISE) trial was a single-center, prospective study ( ClinicalTrials.gov identifier NCT01743872 ) that enrolled 23 patients (mean age 6811 years; 14 men) undergoing endovascular intervention involving the superficial femoral artery. Four ...
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      Mentions: Case Western Reserve University Hiram G. Bezerra

    9. Three-dimensional registration of intravascular optical coherence tomography and cryo-image volumes for microscopic-resolution validation

      Explore SPIE | Journal Cardiology
      Three-dimensional registration of intravascular optical coherence tomography and cryo-image volumes for microscopic-resolution validation
      Evidence suggests high-resolution, high-contrast, 100 frames / s 100frames/s intravascular optical coherence tomography (IVOCT) can distinguish plaque types, but further validation is needed, especially for automated plaque characterization. We developed experimental and three-dimensional (3-D) registration methods to provide validation of IVOCT pullback volumes using microscopic, color, and fluorescent cryo-image volumes with optional registered cryo-histology. A specialized registration method matched IVOCT pullback images acquired in the catheter reference frame to a ...
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      Mentions: Case Western Reserve University Marco A. Costa Madhusudhana Gargesha

    11. Optical coherence tomography assessment of in-stent restenosis after percutaneous coronary intervention with two-stent technique in unprotected left main

      Explore International Journal of Cardiology Cardiology
      Optical coherence tomography assessment of in-stent restenosis after percutaneous coronary intervention with two-stent technique in unprotected left main
      Background Optical coherence tomography (OCT) has contributed to a better understanding of in-stent restenosis (ISR); however, studies evaluating ISR pattern after two-stent technique in unprotected left main (ULM) are lacking. We aim to evaluate the ISR pattern of proximal LAD and LCX after two-stent technique in ULM. Methods We performed OCT in 26 patients with isolated or combined ISR (identified by angiography as 50%) after two stent implantation in the ...
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      Mentions: National Institutes of Health Hiram G. Bezerra Wei Wang

    12. Processing to determine optical parameters of atherosclerotic disease from phantom and clinical intravascular optical coherence tomography three-dimensional pullbacks

      Explore SPIE | Journal Cardiology
      Processing to determine optical parameters of atherosclerotic disease from phantom and clinical intravascular optical coherence tomography three-dimensional pullbacks
      Analysis of intravascular optical coherence tomography (IVOCT) data has potential for real-time in vivo plaque classification. We developed a processing pipeline on a three-dimensional local region of support for estimation of optical properties of atherosclerotic plaques from coronary artery, IVOCT pullbacks. Using realistic coronary artery disease phantoms, we determined insignificant differences in mean and standard deviation estimates between our pullback analyses and more conventional processing of stationary acquisitions with frame ...
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      Mentions: Andrew M. Rollins Case Western Reserve University Guy Lamouche

    13. Angiographic and Intracoronary Manifestations of Coronary Fibromuscular Dysplasia

      Explore Circulation Cardiology , Oncology
      Angiographic and Intracoronary Manifestations of Coronary Fibromuscular Dysplasia
      Background We previously described a strong association between fibromuscular dysplasia (FMD) and spontaneous coronary artery dissection. Angiographic manifestations of coronary FMD aside from dissection were considered rare. However, we observed several coronary FMD angiographic abnormalities with corresponding optical coherence tomography abnormalities. Methods and Results Baseline demographics and imaging of patients with suspected coronary FMD at Vancouver General Hospital were reviewed. Presence of multifocal (string-of-beads) extracoronary FMD was confirmed by 2 ...
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      Mentions: Hiram G. Bezerra

    14. 3D registration of intravascular optical coherence tomography and cryo-image volumes for microscopic-resolution validation

      Explore Conference Proceedings Cardiology
      3D registration of intravascular optical coherence tomography and cryo-image volumes for microscopic-resolution validation
      High resolution, 100 frames/sec intravascular optical coherence tomography (IVOCT) can distinguish plaque types, but further validation is needed, especially for automated plaque characterization. We developed experimental and 3D registration methods, to provide validation of IVOCT pullback volumes using microscopic, brightfield and fluorescent cryoimage volumes, with optional, exactly registered cryo-histology. The innovation was a method to match an IVOCT pullback images, acquired in the catheter reference frame, to a true ...
      Read Full Article
      Mentions: Case Western Reserve University Marco A. Costa Madhusudhana Gargesha

    15. Classification of calcium in intravascular OCT images for the purpose of intervention planning

      Explore Conference Proceedings Cardiology
      Classification of calcium in intravascular OCT images for the purpose of intervention planning
      The presence of extensive calcification is a primary concern when planning and implementing a vascular percutaneous intervention such as stenting. If the balloon does not expand, the interventionalist must blindly apply high balloon pressure, use an atherectomy device, or abort the procedure. As part of a project to determine the ability of Intravascular Optical Coherence Tomography (IVOCT) to aid intervention planning, we developed a method for automatic classification of calcium ...
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      Mentions: Case Western Reserve University David L. Wilson Hiram G. Bezerra

    16. Coronary optical coherence tomography: A practical overview of current clinical applications

      Explore ScienceDirect Cardiology
      Coronary optical coherence tomography: A practical overview of current clinical applications
      Coronary optical coherence tomography has emerged as the most powerful in-vivo imaging modality to evaluate vessel structure in detail. It is a useful research tool that provides insights into the pathogenesis of coronary artery disease. This technology has an important clinical role that is still being developed. We review the evidence on the wide spectrum of potential clinical applications for coronary optical coherence tomography, which encompass the successive stages in ...
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      Mentions: Case Western Reserve University Marco A. Costa Hiram G. Bezerra
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  4. About Hiram G. Bezerra

    Hiram G. Bezerra, M.D., is with the University Hospitals Case Medical Center-Interventional Cardiovascular Center and Research & Innovation Center.

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