1. Herbert Stepp

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    1. Mentioned In 19 Articles

    2. Intraoperative assessment of laryngeal pathologies with optical coherence tomography integrated into a surgical microscope

      Intraoperative assessment of laryngeal pathologies with optical coherence tomography integrated into a surgical microscope
      Objective Endoscopic examination followed by tissue biopsy is the gold standard in the evaluation of lesions of the upper aerodigestive tract. However, it can be difficult to distinguish between healthy mucosa, dysplasia, and invasive carcinoma. Optical coherence tomography (OCT) is a non-invasive technique which acquires high-resolution, cross-sectional images of tissue in vivo . Integrated into a surgical microscope, it allows the intraoperative evaluation of lesions simultaneously with microscopic visualization. Study Design ...
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    3. Evaluation of confocal laser endomicroscopy as an aid to differentiate primary flat lesions of the larynx: A prospective clinical study

      Evaluation of confocal laser endomicroscopy as an aid to differentiate primary flat lesions of the larynx: A prospective clinical study
      Background In this trial, the ability of confocal laser endomicroscopy (CLE), a new imaging modality with a cellular resolution, to further differentiate primary flat lesions of the larynx was evaluated. Methods First, an optical coherence tomography was used to filter out normal tissue and carcinoma. All other lesions (30 lesions in 19 patients) were investigated with CLE. The suspected diagnosis was compared to histopathology. Results Optical coherence tomography identified all ...
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      Mentions: Herbert Stepp
    4. Effect of optical clearing agents on optical coherence tomography images of cervical epithelium

      Effect of optical clearing agents on optical coherence tomography images of cervical epithelium
      Optical coherence tomography (OCT) can be used as an adjunct to colposcopy in order to detect precancerous and cancerous cervical lesions. Optical clearing agents (OCAs) temporarily reduce the optical scattering of biological tissues. The purpose of this study was to investigate their influence on OCT imaging. OCT images were taken from unsuspicious and suspicious areas of fresh conization specimens immediately after resection and 5, 10, and 20 min after application ...
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    5. Intraoperative optical coherence tomography imaging to identify parathyroid glands

      Intraoperative optical coherence tomography imaging to identify parathyroid glands
      Objective Optical coherence tomography (OCT) is a non-invasive high-resolution imaging technique that permits characterization of microarchitectural features in real time. Previous ex vivo studies have shown that the technique is capable of distinguishing between parathyroid tissue, thyroid tissue, lymph nodes, and adipose tissue. The purpose of this study was to evaluate the practicality of OCT during open and minimally invasive parathyroid and thyroid surgery. Methods During parathyroid and thyroid surgery ...
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    6. Effect of acetic acid on optical coherence tomography (OCT) images of cervical epithelium

      Effect of acetic acid on optical coherence tomography (OCT) images of cervical epithelium
      Optical coherence tomography (OCT) can be used as an adjunct to colposcopy in the identification of precancerous and cancerous cervical lesions. The purpose of this study was to investigate the effect of acetic acid on OCT imaging. OCT images were taken from unsuspicious and suspicious areas of fresh conization specimens immediately after resection and 3 and 10 min after application of 6 % acetic acid. A corresponding histology was obtained from ...
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    7. Encrustation of urologic double pigtail catheters—an ex vivo optical coherence tomography (OCT) study

      Encrustation of urologic double pigtail catheters—an ex vivo optical coherence tomography (OCT) study
      This study aims to evaluate whether optical coherence tomography (OCT) using both the surface and the endoluminal technique is feasible to investigate the locations and degree of encrustation process in clinically used ureteral stents. After removal from patients, 14 polyurethane JJ stents were investigated. A fresh JJ served as a control. The external surfaces were examined using an endoscopic surface OCT whereas the intraluminal surfaces were investigated by an endoluminal ...
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    8. Validation of an ex vivo human cervical tissue model for optical imaging studies

      Validation of an ex vivo human cervical tissue model for optical imaging studies
      Objective To establish and validate an ex vivo human cervical tissue model for optical coherence tomography (OCT) studies with special emphasis on investigating time dependent structural changes of the epithelium. Methods Four hundred OCT images were taken from 80 unsuspicious and suspicious areas of 18 fresh conisation specimens immediately after resection (0 hour) and 1, 2, 3, and 4 hours, referred to as waiting times in the following, postoperatively and ...
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    9. Diagnostic efficacy of backscattering intensity measurements in optical coherence tomography of cervical intraepithelial dysplasia

      Diagnostic efficacy of backscattering intensity measurements in optical coherence tomography of cervical intraepithelial dysplasia
      Background and Objectives The aim of this study was to determine the diagnostic efficacy of backscattering intensity measurements in optical coherence tomography in identifying different grades of cervical intraepithelial dysplasia. Study Design/Materials and Methods OCT images were taken from 153 unsuspicious and suspicious areas of 30 fresh conisation and hysterectomy specimens, evaluated by two blinded investigators using a six-grade classification (normal, inflammation, CIN1, CIN2, CIN3, squamous carcinoma) and later ...
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    10. Feature Of The Week 6/19/11: Optical Coherence Tomography as a Non-Invasive Imaging Technique for Examination of Cervical Tissue

      Feature Of The Week 6/19/11: Optical Coherence Tomography as a Non-Invasive Imaging Technique for Examination of Cervical Tissue
      Researchers from the Department of Obstetrics and Gynecology at Ludwig Maximilians University Munich published on the important topic of using OCT for examination of cancerous cervical tissue. Below is a summary of their work.Invasive cancer of the uterine cervix (ICC) is the second most frequent cancer in women worldwide accounting for 10% of all cancer-related deaths in women. Every year approximately 510,000 women are newly diagnosed with ICC ...
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    11. Optical coherence tomography for the diagnosis of cervical intraepithelial neoplasia

      Optical coherence tomography for the diagnosis of cervical intraepithelial neoplasia
      Background and Objectives Optical coherence tomography (OCT) permits high-resolution imaging of tissue subsurfaces up to 2 mm in depth. The purpose of this study was to evaluate the accuracy and reproducibility of OCT in the characterization of cervical intraepithelial neoplasia (CIN) and to distinguish between different CIN grades. Study Design/Materials and Methods Colposcopy-guided OCT images were taken from unsuspicious and suspicious areas in women with suspected CIN. Each woman ...
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  2. About Herbert Stepp

    Herbert Stepp

    Herbert Stepp is at the Laser Research Laboratory at Ludwig Maximilians University Munich, Germany.