1. Henning Morawietz

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    1. Mentioned In 9 Articles

    2. NADPH oxidase 4 protects against development of endothelial dysfunction and atherosclerosis in LDL receptor deficient mice

      NADPH oxidase 4 protects against development of endothelial dysfunction and atherosclerosis in LDL receptor deficient mice
      Aims Endothelial dysfunction is an early step in the development of atherosclerosis. Increased formation of superoxide anions by NADPH oxidase Nox1, 2, and 5 reduces nitric oxide availability and can promote endothelial dysfunction. In contrast, recent evidence supports a vasoprotective role of H 2 O 2 produced by main endothelial isoform Nox4. Therefore, we analysed the impact of genetic deletion of Nox4 on endothelial dysfunction and atherosclerosis in the low-density ...
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    3. Signal power decrease due to fringe washout as an extension of the limited Doppler flow measurement range in spectral domain optical coherence tomography

      Signal power decrease due to fringe washout as an extension of the limited Doppler flow measurement range in spectral domain optical coherence tomography
      ...rus, Clinical Sensoring and Monitoring, Fetscherstrasse 74, Dresden, Saxony 01307, Germany Gregor Mueller and Henning Morawietz Dresden University of Technology, Faculty of Medicine Carl Gustav Carus, Division of Vascula...
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    4. Doppler Fourier Domain Optical Coherence Tomography: A Novel Technique to Analyze Exercise-dependent Changes in Vascular Dynamics of Wild-type and LDL Receptor Knockout Mice in vivo

      ...oluntary running on vascular function of small arteries of wild-type and LDL receptor knockout mice in vivo. Henning Morawietz; Gregor Muller; Julia Walther; Maximliano Cuevas; Claudia Goettsch; Lorenz C Hofbauer; Edmun...
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    5. Blood flow measurement in the in vivo mouse model by the combination of Doppler OCT and the signal power decrease in spectral domain OCT

      Blood flow measurement with spectrometer-based Fourier domain optical coherence tomography (FD OCT) is limited by the motion-induced signal fading and the resulting reduction of flow sensitivity. In this study, a combination of the established Doppler OCT and the numerically simulated signal damping due to obliquely moved scatterers is used to estimate the systolic blood flow velocities in the in vivo mouse model at which the standard Doppler OCT does not ...
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    6. In-vivo Fourier domain optical coherence tomography as a new tool for investigation of vasodynamics in the mouse model

      In-vivo imaging of the vascular system can provide novel insight into the dynamics of vasoconstriction and vasodilation. Fourier domain optical coherence tomography (FD-OCT) is an optical, noncontact imaging technique based on interferometry of short-coherent near-infrared light with axial resolution of less than 10 µm. In this study, we apply FD-OCT as an in-vivo imaging technique to investigate blood vessels in their anatomical context using temporally resolved image stacks. Our chosen ...
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    7. Analysis of Murine Vascular Function In Vivo by Optical Coherence Tomography in Response to High-fat Diet

      In this study, we demonstrate the application of optical coherence tomography (OCT) as a contactless imaging technique to analyze vasodynamics in small blood vessels in vivo. The transluminal OCT imaging of vessels avoids micro traumata in the endothelium and circumvents surgical intervention. It can be performed in the intact perfused vessel and provides a new method to measure vascular function and dynamics in vivo. The resolution of 10 μm and ...
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    8. Analysis of in vitro and in vivo bidirectional flow velocities by phase-resolved doppler fourier-domain OCT

      Fourier-domain Optical Coherence Tomography (FD-OCT) is a non-invasive imaging technique which allows the in vivo examination of subsurface tissue. Besides the structural imaging, FD-OCT is capable to measure blood flow velocities. This method is referred to as phase-resolved Doppler FD-OCT and often used in small retinal vessels (diameters about 100 μm) with low blood flow velocities. In this study, we present a FD-OCT system with a spectrum read-out rate of ...
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    9. Phase-resolved Doppler Fourier Domain Optical Coherence Tomography in the in vivo mouse model

      Blood flow velocities within vasodynamic measurements in the in vivo mouse model were imaged by using phase-resolved Doppler Fourier Domain Optical Coherence Tomography with a spectrum read-out rate of 12 kHz. The high temporal resolution of the system is used to quantify the pulse from real-time cross-sectional images of the murine saphenous artery. The Doppler method was evaluated by imaging a 1% Intralipid emulsion flowing through a glass capillary with ...
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  2. About Henning Morawietz

    Henning Morawietz is with the Department of Vascular Endothelium and Microcirculation, Medical Faculty Carl Gustav Carus, University of Technology Dresden, D-01307 Dresden, Germany.