1. Harvey O. Coxson

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    1. Mentioned In 14 Articles

    2. Sex Differences in Airway Remodeling in a Mouse Model of Chronic Obstructive Pulmonary Disease

      Sex Differences in Airway Remodeling in a Mouse Model of Chronic Obstructive Pulmonary Disease
      Rationale: Adjusting for the amount of smoking, women have a 50% increased risk of COPD compared with men. It is not known what the anatomic basis/mechanism(s) of these sex-related differences in COPD might be. Objective: To characterize the impact of female sex hormones on chronic cigarette smoke-induced airway remodeling and emphysema in a mouse model of COPD. Methods: Airway remodeling and emphysema were determined morphometrically in male, female ...
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    3. Bronchial thermoplasty in asthma: 2-year follow-up using optical coherence tomography

      Bronchial thermoplasty in asthma: 2-year follow-up using optical coherence tomography
      Bronchial thermoplasty (BT) is a novel, nonpharmacological procedure for treatment of severe asthma. Recently, the Asthma Intervention Research 2 clinical trial demonstrated asthmatics had fewer hospitalisations following BT, which persisted 5 years after therapy [1]. However, it is well recognised that asthma is a heterogeneous disease with distinct asthma phenotypes and, not surprisingly, not all asthmatics in that trial benefited from BT [2].
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    4. Validation of Airway Wall Measurements by Optical Coherence Tomography in Porcine Airways

      Validation of Airway Wall Measurements by Optical Coherence Tomography in Porcine Airways
      Examining and quantifying changes in airway morphology is critical for studying longitudinal pathogenesis and interventions in diseases such as chronic obstructive pulmonary disease and asthma. Here we present fiber-optic optical coherence tomography (OCT) as a nondestructive technique to precisely and accurately measure the 2-dimensional cross-sectional areas of airway wall substructure divided into the mucosa (WA muc ), submucosa (WA sub ), cartilage (WA cart ), and the airway total wall area (WAt). Porcine ...
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    5. Automated segmentation of porcine airway wall layers using optical coherence tomography: comparison with manual segmentation and histology

      Automated segmentation of porcine airway wall layers using optical coherence tomography: comparison with manual segmentation and histology
      ...nd histology Miranda Kirby ; Anthony M. D. Lee ; Tara Candido ; Calum MacAulay ; Pierre Lane ; Stephen Lam ; Harvey O. Coxson; Automated segmentation of porcine airway wall layers using optical coherence tomography: com...
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    6. Central Airway Compliance in Asthma: Up or Down? Good or Bad?

      Central Airway Compliance in Asthma: Up or Down? Good or Bad?
      In this issue of the Journal, Williamson and coworkers (pp. 612–619) report on the use of anatomical optical coherence tomography(OCT) to measure the luminal area of central intrathoracic airways (generations 0–5) (1). By coupling this dynamic, in vivomeasurement with simultaneously measured transpulmonary pressure, they derived area–pressure relationships of these airwaysand calculated airway compliance (Caw) and specific compliance(sCaw). They then compared these values in control subjects ...
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    7. Phenotyping Airways Disease With Optical Coherence Tomography

      Phenotyping Airways Disease With Optical Coherence Tomography
      Airway diseases are a major concern around the world. However, the pace of new drug and biomarker discovery has lagged behind those of other common disorders such as cardiovascular diseases and diabetes. One major barrier in airways research has been the inability to accurately visualize large and small airway remodeling or dysplastic/neoplastic (either pre or early cancerous) changes using non or minimally invasive instruments. The advent of optical coherence ...
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    8. Quantitative Assessment of the Airway Wall Using Computed Tomography and Optical Coherence Tomography

      Ever since the site and nature of airflow obstruction in chronic obstructive pulmonary disease was described by Hogg, Thurlbeck, and Macklem, investigators have been looking for methods to noninvasively measure the airway wall dimensions. Recent advances in computed tomography technology and new computer algorithms have made it possible to visualize and measure the airway wall and lumen without the need for tissue. However, while there is great hope for computed ...
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    9. New and Current Clinical Imaging Techniques To Study Chronic Obstructive Pulmonary Disease

      Chronic obstructive pulmonary disease (COPD) is a heterogeneous disease, characterized by both small airway and parenchymal abnormalities. There is increasing evidence to suggest that these two morphologic phenotypes, while related, may have different clinical presentations, prognosis and therapeutic responses to medications. With the advent of novel imaging modalities, it is now possible to evaluate these two morphologic phenotypes in large clinical studies using non or minially invasive methods such as ...
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    10. Gender Differences in Airway Wall Measurements with Optical Coherence Tomography (OCT).

      Purpose: To examine the difference in the relationship between airway wall dimensions and lung function in male and female smokers. Methods: 35 male and 18 female subjects from the BC Lung Health Cohort, who underwent OCT imaging and spirometry, were studied. OCT images, acquired at the time of bronchoscopy, were converted to digital images at 0.5s intervals using frame capture software. Airways were measured using ImageJ (NIH) image analysis ...
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    11. Inter- and Intra-Observer Variability in Measurements of Airways Using Optical Coherence Tomography (OCT).

      Purpose: To devise a protocol for the measurement of airways using optical coherence tomography (OCT) with acceptable inter− and intra−observer variability. Methods: 59 subjects from the British Columbia Lung Health Cohort who underwent OCT imaging were studied. OCT images, acquired at the time of bronchoscopy were converted to digital images at 0.5s intervals using frame capture software. Airways were measured using ImageJ (NIH) image analysis software on 5 ...
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    12. Airway Wall Thickness Assessed Using Computed Tomography and Optical Coherence Tomography

      Airway Wall Thickness Assessed Using Computed Tomography and Optical Coherence Tomography
      Rationale: Computed tomography (CT) has been shown to reliably measure the airway wall dimensions of medium to large airways. Optical coherence tomography (OCT) is a promising new micron-scale resolution imaging technique that can image small airways 2 mm in diameter or less. Objectives: To correlate OCT measurements of airway dimensions with measurements assessed using CT scans and lung function. Methods: Forty-four current and former smokers received spirometry, CT scans, and ...
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  2. About Harvey O. Coxson

    Harvey O. Coxson

    Harvey Coxson is an Assistant Professor of Radiology at the University of British Columbia and Vancouver General Hospital as well as a Principal Investigator at the James Hogg iCAPTURE Centre in Cardiovascular and Pulmonary Research at St Paul’s Hospital. Dr Coxson trained with Dr James Hogg at UBC in quantitative pathology and now specializes in quantitative computed tomography of the lung with correlations to quantitative pathology and pulmonary function in smoking related diseases, such as chronic obstructive pulmonary disease