1. Harvard University

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    1. Mentioned In 807 Articles

    2. High-speed imaging of human retina in vivo with swept-source optical coherence tomography

      We present the first demonstration of human retinal imaging in vivo using optical frequency domain imaging (OFDI) in the 800-nm range. With 460-μW incident power on the eye, the sensitivity is 91 dB at maximum and >85 dB over 2-mm depth range. The axial resolution is 13 μm in air. We acquired images of retina at 43,200 depth profiles per second and a continuous acquisition speed of 84 frames ...
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    3. Systems and methods for imaging a sample

      A system and method for imaging a sample are provided. In particular, a first combination of light and a second combination of light are received, in which a first cross correlation function is associated with the first combination and a second cross correlation function is associated with the second combination. Each of the first and the second combinations includes a first portion of light which is received from a reference ...
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    4. Comprehensive volumetric optical microscopy in vivo

      Comprehensive volumetric optical microscopy in vivo
      Comprehensive volumetric microscopy of epithelial, mucosal and endothelial tissues in living human patients would have a profound impact in medicine by enabling diagnostic imaging at the cellular level over large surface areas. Considering the vast area of these tissues with respect to the desired sampling interval, achieving this goal requires rapid sampling. Although noninvasive diagnostic technologies are preferred, many applications could be served by minimally invasive instruments capable of accessing ...
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    5. Optical frequency domain imaging of human retina and choroid (Thesis)

      Optical frequency domain imaging of human retina and choroid (Thesis)
      Optical coherence tomography (OCT) has emerged as a practical noninvasive technology for imaging the microstructure of the human eye in vivo. Using optical interferometry to spatially-resolve backreflections from within tissue, this high-resolution technique provides cross-sectional images of the anterior and posterior eye segments that had previously only been possible with histology. Current commercially-available OCT systems suffer limitations in speed and sensitivity, preventing them from effective screening of the retina and ...
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    6. High-resolution imaging of progressive articular cartilage degeneration

      High-resolution imaging of progressive articular cartilage degeneration
      The objective of this study was to develop and verify a new technique for monitoring the progression of osteoarthritis (OA) by combining a rat model with the imaging modality optical coherence tomography (OCT). Time-sequential, in vivo, OCT imaging was performed on the left femoral condyles of 12 Wistar rats following sodium-iodoacetic acid-induced OA progression. The right femoral condyles (untreated) were also imaged and served as controls. Imaging was performed on ...
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    7. Optical Coherence Tomography to Identify Intramucosal Carcinoma and High-Grade Dysplasia in Barrett’s Esophagus

      Optical Coherence Tomography to Identify Intramucosal Carcinoma and High-Grade Dysplasia in Barrett’s Esophagus
      ...l School, Boston , * Norman S. Nishioka Affiliations + Gastrointestinal Unit, Massachusetts General Hospital, Harvard Medical School, Boston + Wellman Center for Photomedicine, Massachusetts General Hospital, Harvard Med...
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    8. Elastography of coronary vessels using optical coherence tomography (Thesis)

      Elastography of coronary vessels using optical coherence tomography (Thesis)
      Atherosclerosis is an inflammatory disease characterized by an accumulation of lipid and fibrous tissue in the arterial wall. Postmortem studies have characterized rupture-prone atherosclerotic plaques by the presence of a large lipid=rich core covered by a thin fibrous cap. Studies employing finite element analysis (FEA) based on ex vivo plaque geometry have found that most plaques rupture at sites of high circumferential stress, thus diagnosis of plaque vulnerability may ...
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    9. Handbook of Optical Coherence Tomography (Book)

      Handbook of Optical Coherence Tomography (Book)
      This contemporary reference presents a comprehensive review of the most recent applications of optical coherence tomography (OCT) in biology, medicine, engineering, and applied physics-summarizing technological advances that led to the availability of viable imaging tools and modern methods of OCT for optical biopsy, surgical guidance, and quality control of advanced composites in situ.
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  2. About Harvard University

    Harvard University

    Harvard University is a private university in Cambridge, Massachusetts, U.S. Founded in 1636 by the colonial Massachusetts legislature Harvard is the oldest institution of higher learning in the United States.  Harvard Medical School  is one of the graduate schools of Harvard University. It is a prestigious American medical school located in the Longwood Medical Area of the Mission Hill neighborhood of Boston, Massachusetts.  Schepens Eye Research Institute fights blindness by developing new technologies, therapies and knowledge to retain and restore vision. Through a continuum of discovery, the Institute works toward a future in which blindness is prevented, alleviated, and, ultimately, cured.