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    1. Mentioned In 834 Articles

    2. Experimental confirmation of potential swept source optical coherence tomography performance limitations

      Experimental confirmation of potential swept source optical coherence tomography performance limitations
      OCT has demonstrated considerable potential for a wide range of medical applications. Initial work was done in the time domain (TD-OCT) approach, but recent interest has been generated with spectral domain (SD-OCT) approaches. While SD-OCT offers higher data acquisition rates and no movable parts, we recently pointed out th eoretical inferior aspects to its performance relative to TD-OC T. In this paper we focus on specific limitations of swept source ...
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    3. Imaging system and related techniques

      BACKGROUND OF THE INVENTION As is known in the art, fiber optic endoscopy is typically conducted by transmitting an image through an array of fibers often referred to as a fiber bundle. While successful for a variety of medical and non-medical applications, utilization of an array of fibers to form the image imposes constraints on the cost, diameter, and flexibility of the imaging device. In an attempt to overcome these ...
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    4. Evaluation of macular abnormalities in Stargardt’s disease using optical coherence tomography and scanning laser ophthalmoscope microperimetry

      Abstract Background  The purpose of this study is to evaluate the diagnostic value of optical coherence tomography (Stratus OCT) and scanning laser ophthalmoscope (SLO) microperimetry in patients with Stargardt’s disease (STGD), and the correlation between macular morphology and visual function in these patients. Methods  Twenty-two patients with STGD (mean age 44 years, range 11 to 71 years) and 20 age-matched healthy control subjects were included in the study. OCT ...
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    5. Application of maximum likelihood estimator in nano-scale optical path length measurement using spectral-domain optical coherence phase microscopy

      S. M. Motaghian Nezam, C. Joo, G. J. Tearney, J. F. de Boer Spectral-domain optical coherence phase microscopy (SD-OCPM) measures minute phase changes in transparent biological specimens using a common path interferometer and a spectrometer based optical coherence tomography system. The Fourier transform of the acquired interference spectrum in ... [Opt. Express 16, 17186-17195 (2008)]
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    6. Comprehensive microscopy of the esophagus in human patients with optical frequency domain imaging

      Comprehensive microscopy of the esophagus in human patients with optical frequency domain imaging
      Background: Optical coherence tomography (OCT) is a cross-sectional, high-resolution imaging modality that has been shown to accurately differentiate esophageal specialized intestinal metaplasia (SIM) from gastric cardia at the squamocolumnar junction (SCJ) and diagnose high-grade dysplasia and intramucosal carcinoma in patients with SIM. The clinical utility of OCT has been limited, however, by its inability to acquire images over large areas.Objective: The aim of this study was to use recently ...
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    7. Doppler imaging using spectrally-encoded endoscopy

      Doppler imaging using spectrally-encoded endoscopy
      Dvir Yelin, B. E. Bouma, J. J. Rosowsky, G. J. TearneyThe capability to image tissue motion such as blood flow through an endoscope could have many applications in medicine. Spectrally encoded endoscopy (SEE) is a recently introduced technique that utilizes a single optical fiber and miniature diffractive optics to obtain endoscopic images through ... [Opt. Express 16, 14836-14844 (2008)]
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    8. Apparatus for controlling at least one of at least two sections of at least one fiber

      An apparatus for controlling at least one of at least two sections of at least one fiber can be provided. The apparatus can include an arrangement which may be provided between the first and second sections of a particular continuous fiber of the fibers. A particular one of the first and second sections may be provided in a particular orientation that is perpendicular to an extension of the particular fiber ...
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    9. Comparison of coronary plaque characteristics between diabetic and non-diabetic subjects: An in vivo optical coherence tomography study

      Aims Postmortem series have reported that subjects with diabetes mellitus have coronary plaques with larger necrotic cores and increased macrophage infiltration. Optical coherence tomography (OCT) is a high-resolution imaging modality that allows in vivo characterization of atherosclerotic plaques. Using OCT imaging, we compared in vivo plaque characteristics between diabetic and non-diabetic subjects. Methods Sixty-three patients undergoing cardiac catheterization were enrolled. OCT imaging was performed in culprit coronary arteries. Assessment of ...
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    10. Cardiac Optical Coherence Tomography

      Acute coronary syndromes (ACS) are a major cause of morbidity and mortality in the developed world. The risk of future acute coronary events appears to be largely dependent on the presence of morphologically distinct, atherosclerotic plaques,1 rather than the presence of severely stenotic lesions as assessed by angiography.2 Angiography, however, cannot provide details of the vascular wall and identify these so-called "vulnerable plaques". To identify, study and potentially ...
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    11. Macular Holes and Macular Pucker: The Role of Vitreoschsis as Imaged By Optical Coherence Tomography/Scanning Laser Ophthalmoscopy

      Macular Holes and Macular Pucker: The Role of  Vitreoschsis as Imaged By Optical Coherence Tomography/Scanning Laser Ophthalmoscopy
      ...lasmic dense granules. (Courtesy of Joe Craft and Dr Daniel Albert, Cogan Laboratory of Ophthalmic Pathology, Harvard Medical School) ACKNOWLEDGMENTS Funding/Support: None. Financial Disclosures: Dr Rosen and Dr Garcia ...
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  2. About Harvard University

    Harvard University

    Harvard University is a private university in Cambridge, Massachusetts, U.S. Founded in 1636 by the colonial Massachusetts legislature Harvard is the oldest institution of higher learning in the United States.  Harvard Medical School  is one of the graduate schools of Harvard University. It is a prestigious American medical school located in the Longwood Medical Area of the Mission Hill neighborhood of Boston, Massachusetts.  Schepens Eye Research Institute fights blindness by developing new technologies, therapies and knowledge to retain and restore vision. Through a continuum of discovery, the Institute works toward a future in which blindness is prevented, alleviated, and, ultimately, cured.