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    1. Mentioned In 773 Articles

    2. Improving Access—but Not Outcomes—With Iris Optical Coherence Tomography Angiography

      Improving Access—but Not Outcomes—With Iris Optical Coherence Tomography Angiography
      Throughout the past 2 decades, the exquisite, real-time ocular imaging attainable with optical coherence tomography (OCT) has transformed the practice of ophthalmology. Further increases in processing speed have led to the introduction of OCT angiography (OCT-A). 1 Preliminary work has shown that it is possible to use OCT-A to characterize the vasculature of the iris. 1 The current standard for assessing anterior segment circulation is iris angiography, but this approach ...
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    3. Volumetric non-local-means based speckle reduction for optical coherence tomography

      Volumetric non-local-means based speckle reduction for optical coherence tomography
      We present a novel tomographic non-local-means based despeckling technique, TNode, for optical coherence tomography. TNode is built upon a weighting similarity criterion derived for speckle in a three-dimensional similarity window. We present an implementation using a two-dimensional search window, enabling the despeckling of volumes in the presence of motion artifacts, and an implementation using a three-dimensional window with improved performance in motion-free volumes. We show that our technique provides effective ...
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    4. Ruptures and Thickening : Optical Coherence Tomography as the Arbiter of the Fibrous Cap

      Ruptures and Thickening : Optical Coherence Tomography as the Arbiter of the Fibrous Cap
      Coronary artery disease remains a leading cause of mortality worldwide, primarily through acute events mediated by progression and disruption of thrombosis-provoking atheroma. The necrotic core of advanced atheroma harbors highly prothrombotic material, including components of tissue factor, von Willebrand factor, and plasminogen activator inhibitor1. Exposure of these contents to flowing blood can spur thrombosis and is a critical feature of many acute coronary syndromes (ACS). It is therefore vital that ...
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    5. Wide dynamic range high-speed three-dimensional quantitative OCT angiography with a hybrid-beam scan

      Wide dynamic range high-speed three-dimensional quantitative OCT angiography with a hybrid-beam scan
      We demonstrate a novel hybrid-beam scanning-based quantitative optical coherence tomography angiography (OCTA) that provides high-speed wide dynamic range blood flow speed imaging. The hybrid-beam scanning scheme enables multiple OCTA image acquisitions with a wide range of multiple time intervals simultaneously providing wide dynamic range blood flow speed imaging independent of the blood vessel orientation, which was quantified over a speed range of 0.6 104 mm / s 0.6104mm/s ...
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    6. Apparatus and method for providing diffuse spectroscopy co-registered with optical frequency domain imaging

      Apparatus and method for providing diffuse spectroscopy co-registered with optical frequency domain imaging
      An apparatus can be provided according to certain exemplary embodiments. For example, the apparatus can include a waveguiding first arrangement providing at least one electromagnetic radiation. A configuration can be provided that receives and splits the at least one electromagnetic radiation into a first radiation and a second radiation. The apparatus can further include a waveguiding second arrangement which has a first waveguide and a second waveguide, whereas the first ...
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    7. Needle-based Optical Coherence Tomography to Guide Transbronchial Lymph Node Biopsy

      Needle-based Optical Coherence Tomography to Guide Transbronchial Lymph Node Biopsy
      Background: Transbronchial needle aspiration (TBNA), often used to sample lymph nodes for lung cancer staging , is subject to sampling error even when performed with endobronchial ultrasound. Optical coherence tomography (OCT) is a high-resolution imaging modality that rapidly generates helical cross-sectional images. We aim to determine if needle-based OCT can provide microstructural information in lymph nodes that may be used to guide TBNA, and improve sampling error. Methods: We performed ex ...
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    8. Imaging the Deep Choroidal Vasculature Using Spectral Domain and Swept Source Optical Coherence Tomography Angiography

      Imaging the Deep Choroidal Vasculature Using Spectral Domain and Swept Source Optical Coherence Tomography Angiography
      Purpose: To evaluate the deeper choroidal vasculature in eyes with various ocular disorders using spectral domain (SD) optical coherence tomography angiography (OCTA) and swept source (SS) OCTA. Methods: Patients underwent OCTA imaging with either SD-OCTA (Zeiss Cirrus Angioplex or Optovue AngioVue) or SS-OCTA (Topcon Triton). Retinal pigment epithelium (RPE) integrity, structural visualization of deep choroidal vessels on en face imaging, and OCTA of deep choroidal blood flow signal were analyzed ...
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    9. A Quantum Field Approach for Advancing Optical Coherence Tomography Part I: First Order Correlations, Single Photon Interference, and Quantum Noise

      A Quantum Field Approach for Advancing Optical Coherence Tomography Part I: First Order Correlations, Single Photon Interference, and Quantum Noise
      Optical coherence tomography has become an important imaging technology in cardiology and ophthalmology, with other applications under investigations. Major advances in optical coherence tomography (OCT) imaging are likely to occur through a quantum field approach to the technology. In this paper, which is the first part in a series on the topic, the quantum basis of OCT first order correlations is expressed in terms of full field quantization. Specifically first ...
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    10. Robust wavenumber and dispersion calibration for Fourier-domain optical coherence tomography

      Robust wavenumber and dispersion calibration for Fourier-domain optical coherence tomography
      Many Fourier-domain optical coherence tomography (FD-OCT) systems sample the interference fringes with a non-uniform wavenumber ( k ) interval, introducing a chirp to the signal that depends on the path length difference underlying each fringe. A dispersion imbalance between sample and reference arms also generates a chirp in the fringe signal which, in contrast, is independent of depth. Fringe interpolation to obtain a signal linear in k and compensate dispersion imbalance is ...
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    11. SPECTRAL DOMAIN OPTICAL COHERENCE TOMOGRAPHY FINDINGS AND VISUAL OUTCOME AFTER TREATMENT FOR VITREOMACULAR TRACTION

      SPECTRAL DOMAIN OPTICAL COHERENCE TOMOGRAPHY FINDINGS AND VISUAL OUTCOME AFTER TREATMENT FOR VITREOMACULAR TRACTION
      Purpose: To evaluate the capacity of spectral domain optical coherence tomography macular findings to predict best-corrected visual acuity (BCVA) outcomes after treatment for symptomatic vitreomacular traction. Methods: This consecutive, retrospective study included 24 patients (29 eyes) who experienced vitreomacular traction release with pneumatic vitreolysis (n = 9), intravitreal ocriplasmin (n = 6), or pars plana vitrectomy (n = 14). Preoperative and postoperative spectral domain optical coherence tomography images were used to determine the ...
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    12. Evaluation of choroidal lesions with swept-source optical coherence tomography

      Evaluation of choroidal lesions with swept-source optical coherence tomography
      Aims The aim of our study was to image choroidal lesions with swept-source optical coherence tomography (SS-OCT) and to identify the morphological characteristics associated with optimal visualisation. Methods This was a prospective, cross-sectional study. Patients with choroidal melanocytic lesions 3mm in thickness on B-scan ultrasonography were recruited. All participants underwent SS-OCT. On SS-OCT we evaluated qualitative (eg, lesion outline, detection of scleral-choroidal interface and quality of the image) and quantitative ...
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    13. Optical coherence tomography (OCT) imaging of dynamic airway behavior in an asthma model

      Optical coherence tomography (OCT) imaging of dynamic airway behavior in an asthma model
      To better understand bronchoconstriction in asthma, it is critical to dynamically visualize airway behavior in vivo. However, currently available imaging techniques do not have sufficient temporal and spatial resolution to investigate airway dynamics. We propose to use endobronchial Optical Coherence Tomography (OCT) to provide real-time cross-sectional images of airway dynamics with a high spatial resolution. Our aim was to study the structure and function of spatially distinct airways during tidal ...
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    14. 1-15 of 773 1 2 3 4 ... 50 51 52 »
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  2. About Harvard University

    Harvard University

    Harvard University is a private university in Cambridge, Massachusetts, U.S. Founded in 1636 by the colonial Massachusetts legislature Harvard is the oldest institution of higher learning in the United States.  Harvard Medical School  is one of the graduate schools of Harvard University. It is a prestigious American medical school located in the Longwood Medical Area of the Mission Hill neighborhood of Boston, Massachusetts.  Schepens Eye Research Institute fights blindness by developing new technologies, therapies and knowledge to retain and restore vision. Through a continuum of discovery, the Institute works toward a future in which blindness is prevented, alleviated, and, ultimately, cured.