1. Harvard University

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    1. Mentioned In 1024 Articles

    2. Optical design, optimization and validation of an extended-depth-of-field optical coherence tomography probe based on mirror-tunneling

      Optical design, optimization and validation of an extended-depth-of-field optical coherence tomography probe based on mirror-tunneling
      We present results from optimizing mirror-tunnel based optical coherence tomography probes, achieving extended depth of field at high resolution. We achieved 6 m spot diameter over 1 mm depth in simulations and validated experimentally.
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    3. Imaging biomarkers for Alzheimer’s disease and glaucoma: Current and future practices

      Imaging biomarkers for Alzheimer’s disease and glaucoma: Current and future practices
      Glaucoma is a leading cause of blindness worldwide. Although intraocular pressure is the main risk factor for glaucoma, several intraocular pressure independent factors have been associated with the risk of developing the disease and its progression. The diagnosis of glaucoma relies on clinical features of the optic nerve, visual field test, and optical coherence tomography. However, the multidisciplinary aspect of the disease suggests that other biomarkers may be useful for ...
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    4. Massachusetts General Hospital Receive NIH Grant for A tethered capsule endoscopic-endomicroscopic (TEEM) approach for improving upper GI tract diagnosis

      Massachusetts General Hospital Receive NIH Grant for A tethered capsule endoscopic-endomicroscopic (TEEM) approach for improving upper GI tract diagnosis
      Massachusetts General Hospital Received a 2022 NIH Grant for $480,931 for A tethered capsule endoscopic-endomicroscopic (TEEM) approach for improving upper GI tract diagnosis. The principal investigator is Guillermo Tearney. Below is a summary of the proposed work. The diagnosis of most upper GI tract conditions is currently accomplished by upper endoscopy with biopsy (EGD). EGD is costly primarily because it requires conscious sedation, necessitating that procedures be conducted by ...
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    5. MEEI Receives NIH Grant for Measuring and Modeling the Cochlear Motions that Drive the Inner and Outer Hair Cells and Produce Otoacoustic Emission

      MEEI Receives NIH Grant for Measuring and Modeling the Cochlear Motions that Drive the Inner and Outer Hair Cells and Produce Otoacoustic Emission
      Massachusetts Eye and Ear Infirmary Received a 2022 NIH Grant for $488,619 for Measuring and Modeling the Cochlear Motions that Drive the Inner and Outer Hair Cells and Produce Otoacoustic Emissions. The principal investigator is Sunil Puria. Below is a summary of the proposed work. Our knowledge of cochlear mechanics is currently undergoing a revolution. While the basilar membrane (BM) has long been considered the principal structure in cochlear ...
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    6. Massachusetts General Hospital Receives NIH Grant for Investigation of Early Detection and Diagnosis of Lung Cancer with Endomicroscopy

      Massachusetts General Hospital Receives NIH Grant for Investigation of Early Detection and Diagnosis of Lung Cancer with Endomicroscopy
      Massachusetts General Hospital Receives a 2022 NIH Grant for $582,146 for Investigation of Early Detection and Diagnosis of Lung Cancer with Endomicroscopy. The principal investigator is Melissa Suter. Below is a summary of the proposed work. Early diagnosis of lung cancer is critical to patient survival. Unfortunately the vast majority of cases are detected once symptoms arise and the cancer has spread offering patients little hope for cure (average ...
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    7. Conversion of Central Subfield Thickness Measurements of Diabetic Macular Edema Across Cirrus and Spectralis Optical Coherence Tomography Instruments

      Conversion of Central Subfield Thickness Measurements of Diabetic Macular Edema Across Cirrus and Spectralis Optical Coherence Tomography Instruments
      Purpose: Develop equations to convert Cirrus central subfield thickness (CST) to Spectralis CST equivalents and vice versa in eyes with diabetic macular edema (DME). Methods: The DRCR Retina Network Protocol O data were split randomly to train (70% sample) and validate (30% sample) conversion equations. Data from an independent study (CADME) also validated the equations. Bland-Altman 95% limits of agreement between predicted and observed values evaluated the equations. Results: Protocol ...
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    8. THE RELATIONSHIP BETWEEN AXIAL RESOLUTION AND SIGNAL-TO-NOISE RATIO IN OPTICAL COHERENCE TOMOGRAPHY

      THE RELATIONSHIP BETWEEN AXIAL RESOLUTION AND SIGNAL-TO-NOISE RATIO IN OPTICAL COHERENCE TOMOGRAPHY
      In optical coherence tomography (OCT), axial resolution and signal-to-noise ratio (SNR) are typically viewed as uncoupled parameters. We show that this is only true for mirror-like surfaces, and that in diffuse scattering samples such as tissue there is an inherent coupling between axial resolution and measurement SNR. We explain the origin of this coupling and demonstrate that it can be used to achieve increased imaging penetration depth at the expense ...
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    9. An inverse method for mechanical characterization of heterogeneous diseased arteries using intravascular imaging

      An inverse method for mechanical characterization of heterogeneous diseased arteries using intravascular imaging
      The increasing prevalence of finite element (FE) simulations in the study of atherosclerosis has spawned numerous inverse FE methods for the mechanical characterization of diseased tissue in vivo. Current approaches are however limited to either homogenized or simplified material representations. This paper presents a novel method to account for tissue heterogeneity and material nonlinearity in the recovery of constitutive behavior using imaging data acquired at differing intravascular pressures by incorporating ...
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    10. Layered Plaque Characteristics and Layer Burden in Acute Coronary Syndromes

      Layered Plaque Characteristics and Layer Burden in Acute Coronary Syndromes
      Recently, layered plaque, an optical coherence tomography equivalent of healed plaque, has been gaining attention. However, detailed layered plaque characteristics including the burden of plaque layer have not been investigated. Patients with acute coronary syndromes who underwent preintervention optical coherence tomography imaging of culprit lesion were included. Layer index, a product of the mean layer arc and layer length, was correlated with the pattern of layer and culprit pathology. In ...
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    11. Advances in Imaging of Subbasal Corneal Nerves With Micro–Optical Coherence Tomography

      Advances in Imaging of Subbasal Corneal Nerves With Micro–Optical Coherence Tomography
      Purpose: To investigate the most peripheral corneal nerve plexus using high-resolution micro-optical coherence tomography (OCT) imaging and to assess OCT's clinical potential as a screening tool for corneal and systemic diseases. Methods: An experimental high-resolution (1.5 1.5 1 m) OCT setup was applied for three-dimensional imaging of the subbasal nerve plexus in nonhuman primates (NHPs) and swine within 3 hours postmortem. Morphologic features of subbasal nerves in ...
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    12. Spectral- and Polarization-Dependent Scattering of Gold Nanobipyramids for Exogenous Contrast in Optical Coherence Tomography

      Spectral- and Polarization-Dependent Scattering of Gold Nanobipyramids for Exogenous Contrast in Optical Coherence Tomography
      Polarization-sensitive optical coherence tomography (PS-OCT) reveals the subsurface microstructure of biological tissue and provides information regarding the polarization state of light backscattered from tissue. Complementing OCT's structural signal with molecular imaging requires strategies to simultaneously detect multiple exogenous contrast agents with high specificity in tissue. Specific detection of molecular probes enables the parallel visualization of physiological, cellular, and molecular processes. Here we demonstrate that, by combining PS-OCT and spectral ...
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    13. 1-15 of 1024 1 2 3 4 ... 67 68 69 »
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  2. About Harvard University

    Harvard University

    Harvard University is a private university in Cambridge, Massachusetts, U.S. Founded in 1636 by the colonial Massachusetts legislature Harvard is the oldest institution of higher learning in the United States.  Harvard Medical School  is one of the graduate schools of Harvard University. It is a prestigious American medical school located in the Longwood Medical Area of the Mission Hill neighborhood of Boston, Massachusetts.  Schepens Eye Research Institute fights blindness by developing new technologies, therapies and knowledge to retain and restore vision. Through a continuum of discovery, the Institute works toward a future in which blindness is prevented, alleviated, and, ultimately, cured.