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    1. Mentioned In 705 Articles

    2. Differences in coronary plaque characteristics between patients with and those without peripheral arterial disease

      Differences in coronary plaque characteristics between patients with and those without peripheral arterial disease
      Introduction: Cardiovascular mortality of patients with combined peripheral arterial disease (PAD) and coronary artery disease (CAD) is twice as high as that in those with either disease alone. It is known that patients with PAD undergoing percutaneous coronary intervention have a higher incidence of adverse cardiac events such as myocardial infarction or target vessel revascularization. Objective: In this study, we compared the detailed characteristics of culprit and nonculprit plaques between ...
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    3. Dynamic neointimal pattern after drug-eluting stent implantation defined by optical coherence tomography

      Dynamic neointimal pattern after drug-eluting stent implantation defined by optical coherence tomography
      Objectives: Certain neointimal patterns including neoatherosclerosis (NA) are known to be associated with poor clinical outcome. The prevalence and time course of different neointimal patterns have not been studied systematically. The aim of this study was to investigate the serial changes in neointimal pattern after drug-eluting stent implantation. Patients and methods: A total of 132 patients with 207 drug-eluting stents, who underwent two follow-up optical coherence tomography studies at 6 ...
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    4. Retinal Loop Vessel Captured with Optical Coherence Tomography-Angiography

      Retinal Loop Vessel Captured with Optical Coherence Tomography-Angiography
      A 50-year-old woman with a history of rheumatoid arthritis and macular hydroxychloroquine toxicity presented for a routine eye examination. An incidental loop vessel of the inferior prepapillary arteriole was readily apparent on examination (Fig 1 A ). Three-dimensional optical coherence tomography (OCT; Avanti, Optovue, Fremont, CA) demonstrated the elevation of this vessel into the vitreous (Fig 1 B ). The vessel was also captured on OCT-angiography (Fig 1 C ) with segmentation of ...
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    5. Shear-Induced Diffusion of Red Blood Cells Measured with Dynamic Light Scattering-Optical Coherence Tomography

      Shear-Induced Diffusion of Red Blood Cells Measured with Dynamic Light Scattering-Optical Coherence Tomography
      Quantitative measurements of intravascular microscopic dynamics, such as absolute blood flow velocity, shear stress, and the diffusion coefficient of red blood cells (RBCs), are fundamental to understanding the blood flow behavior within the microcirculation, and for understanding why diffuse correlation spectroscopy (DCS) measurements of blood flow are dominantly sensitive to the diffusive motion of RBCs. Dynamic Light Scattering-Optical Coherence Tomography (DLS-OCT) takes the advantages of using DLS to measure particle ...
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    6. Simultaneous measurements of lymphatic vessel contraction, flow and valve dynamics in multiple lymphangions using optical coherence tomography

      Simultaneous measurements of lymphatic vessel contraction, flow and valve dynamics in multiple lymphangions using optical coherence tomography
      Lymphatic dysfunction is involved in many diseases including lymphedema, hypertension, autoimmune responses, graft rejection, atherosclerosis, microbial infections, cancer and cancer metastasis. Expanding our knowledge of lymphatic system function can lead to a better understanding of these disease processes and improve treatment options. Here, optical coherence tomography (OCT) methods were used to reveal intraluminal valve dynamics in 3D, and measure lymph flow and vessel contraction simultaneously in three neighboring lymphangions of ...
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    7. Murine chronic lymph node window for longitudinal intravital lymph node imaging

      Murine chronic lymph node window for longitudinal intravital lymph node imaging
      Chronic imaging windows in mice have been developed to allow intravital microscopy of many different organs and have proven to be of paramount importance in advancing our knowledge of normal and disease processes. A model system that allows long-term intravital imaging of lymph nodes would facilitate the study of cell behavior in lymph nodes during the generation of immune responses in a variety of disease settings and during the formation ...
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    8. Assessment of the radiofrequency ablation dynamics of esophageal tissue with optical coherence tomography

      Assessment of the radiofrequency ablation dynamics of esophageal tissue with optical coherence tomography
      Radiofrequency ablation (RFA) is widely used for the eradication of dysplasia and the treatment of early stage esophageal carcinoma in patients with Barretts esophagus (BE). However, there are several factors, such as variation of BE epithelium (EP) thickness among individual patients and varying RFA catheter-tissue contact, which may compromise RFA efficacy. We used a high-speed optical coherence tomography (OCT) system to identify and monitor changes in the esophageal tissue architecture ...
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    9. MGH Receives NIH Grant for $1,512,015 for Center for Biomedical OCT Research and Translation.

      MGH Receives NIH Grant for $1,512,015 for Center for Biomedical OCT Research and Translation.
      Massachusetts General Hospital Receives a 2017 NIH Grant for $1,512,015 for Center for Biomedical OCT Research and Translation. The principal investigator is Brett Bouma. The program began in 2011 and ends in 2021. Below is a summary of the proposed work. Overall the Center for Biomedical OCT Research and Translation seeks to push the technological frontier of optical coherence tomography instrumentation and methods in response to challenges in ...
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    10. Assessment of acquired mucociliary clearance defects using micro-optical coherence tomography

      Assessment of acquired mucociliary clearance defects using micro-optical coherence tomography
      Background Dehydration of airway surface liquid (ASL) disrupts normal mucociliary clearance (MCC) in sinonasal epithelium, which may lead to chronic rhinosinusitis (CRS). Abnormal chloride (Cl ) transport is one such mechanism that contributes to this disorder and can be acquired secondary to environmental perturbations, such as hypoxia at the tissue surface. The objective of this study was to assess the technological feasibility of the novel micro-optical coherence tomography (OCT) imaging technique ...
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    11. SYNTAX Score, and Pre- and Post-Stent Optical Coherence Tomography Findings in the Left Anterior Descending Coronary Artery in Patients with Stable Angina Pectoris

      SYNTAX Score, and Pre- and Post-Stent Optical Coherence Tomography Findings in the Left Anterior Descending Coronary Artery in Patients with Stable Angina Pectoris
      SYNTAX score (SS) has been reported to be an independent predictor of future cardiac events including target lesion revascularization (TLR). The aim of this study was to assess the relationship between SS and plaque characteristics and post-stent vascular response using optical coherence tomography (OCT) in coronary artery tree and left anterior descending artery (LAD) in patients with stable angina. A total of 179 lesions among 165 patients, including 100 lesions ...
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    12. 16  MHz wavelength-swept and wavelength-stepped laser architectures based on stretched-pulse active mode locking with a single continuously chirped fiber Bragg grating

      16  MHz wavelength-swept and wavelength-stepped laser architectures based on stretched-pulse active mode locking with a single continuously chirped fiber Bragg grating
      We demonstrate a novel high-speed and broadband laser architecture based on stretched pulse active mode locking that provides a wavelength-swept and wavelength-stepped output. The laser utilizes a single intracavity 8.3 meter chirped fiber Bragg grating to generate positive and negative dispersion, and can be operated with or without an intracavity fixed FabryPerot etalon to generate wavelength-swept and wavelength-stepped (frequency comb) outputs, respectively. Using a four-path delay line at the ...
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    13. Integrating optical coherence tomography with laryngeal videostroboscopy

      Integrating optical coherence tomography with laryngeal videostroboscopy
      During clinical voice assessment, laryngologists and speech-language pathologists rely heavily on laryngeal endoscopy with videostroboscopy to evaluate pathology and dysfunction of the vocal folds. The cost effectiveness, ease of use, and synchronized audio and visual feedback provided by videostroboscopic assessment serve to maintain its predominant clinical role in laryngeal imaging. However, significant drawbacks include only two-dimensional spatial imaging and the lack of subsurface morphological information. A novel endoscope will be ...
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    14. Introduction to the feature issue on the 25 year anniversary of optical coherence tomography

      Introduction to the feature issue on the 25 year anniversary of optical coherence tomography
      This feature issue commemorates the approximately 25 year history of Optical Coherence Tomography (OCT), one of the most successful biophotonic technologies. While OCT has technological origins traceable to ultrafast laser development and fiber optic system test instrumentation of the 1980s, innovations in low coherence interferometry for optical ranging and imaging for biomedical applications in the U.S., Europe and Japan by the early 1990s led to coinage of the now ...
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    15. System, apparatus and method for utilizing optical dispersion for fourier-domain optical coherence tomography

      System, apparatus and method for utilizing optical dispersion for fourier-domain optical coherence tomography
      An apparatus can be provided which can include a laser arrangement which can be configured to provide a laser radiation, and can include an optical cavity. The optical cavity can include a dispersive optical first arrangement which can be configured to receive and disperse at least one first electro-magnetic radiation so as to provide at least one second electro-magnetic radiation. Such cavity can also include an active optical modulator second ...
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    16. Old and New Methods of Glaucoma Diagnosis Using Spectral-Domain Optical Coherence Tomography: Testing Limitations of Older Retinal Nerve Fiber Layer Thickness Measurements and Diagnostic Potential of Newer Retinal Volume Measurements (Thesis)

      Old and New Methods of Glaucoma Diagnosis Using Spectral-Domain Optical Coherence Tomography: Testing Limitations of Older Retinal Nerve Fiber Layer Thickness Measurements and Diagnostic Potential of Newer Retinal Volume Measurements (Thesis)
      Purpose: Optical coherence tomography (OCT) retinal nerve fiber layer (RNFL) thickness measurements are a reproducible and quantitative diagnostic modality widely used for glaucoma evaluations, but a high rate of testing artifacts limits its clinical utility. In Part I of this thesis, we aimed to characterize artifact types and assess artifact rates in two-dimensional (2D) RNFL thickness measurements obtained by the Spectralis OCT machine (Heidelberg Engineering, Heidelberg, Germany), as well as ...
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  2. About Harvard University

    Harvard University

    Harvard University is a private university in Cambridge, Massachusetts, U.S. Founded in 1636 by the colonial Massachusetts legislature Harvard is the oldest institution of higher learning in the United States.  Harvard Medical School  is one of the graduate schools of Harvard University. It is a prestigious American medical school located in the Longwood Medical Area of the Mission Hill neighborhood of Boston, Massachusetts.  Schepens Eye Research Institute fights blindness by developing new technologies, therapies and knowledge to retain and restore vision. Through a continuum of discovery, the Institute works toward a future in which blindness is prevented, alleviated, and, ultimately, cured.