1. Harvard University

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    1. Mentioned In 520 Articles

    2. Quantitative Fundus Autofluorescence and Optical Coherence Tomography in PRPH2/RDS- and ABCA4-Associated Disease Exhibiting Phenotypic Overlap

      Quantitative Fundus Autofluorescence and Optical Coherence Tomography in PRPH2/RDS- and ABCA4-Associated Disease Exhibiting Phenotypic Overlap
      Purpose. To assess whether quantitative fundus autofluorescence (qAF), a measure of RPE lipofuscin, and spectral-domain optical coherence tomography (SD-OCT) can aid in the differentiation of patients with fundus features that could either be related to ABCA4 mutations or be part of the phenotypic spectrum of pattern dystrophies. Methods. Autofluorescence images (30, 488-nm excitation) from 39 patients (67 eyes) were acquired with a confocal scanning laser ophthalmoscope equipped with an internal ...
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    3. Massachusetts General Hospital Receives NIH Grant for Intracoronary Imaging of Plaque Collagen in Patients.

      Massachusetts General Hospital Receives NIH Grant for Intracoronary Imaging of Plaque Collagen in Patients.
      Massachusetts General Hospital Received a 2015 NIH Grant for $780,355 for Intracoronary Imaging of Plaque Collagen in Patients. The principal investigator is Seemantini Nadkarni. The program began in 2014 and ends in 2018. Below is a summary of the proposed work. The goal of this proposal is to develop and validate an intracoronary imaging device for the assessment of plaque collagen content and architecture in patients. Acute myocardial infarction ...
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    4. Computer-aided analyses of mouse retinal OCT images – an actual application report

      Computer-aided analyses of mouse retinal OCT images – an actual application report
      Purpose There is a need for automated retinal optical coherence tomography (OCT) image analysis tools for quantitative measurements in small animals. Some image processing techniques for retinal layer analysis have been developed, but reports about how useful those techniques are in actual animal studies are rare. This paper presents the use of a retinal layer detection method we developed in an actual mouse study that involves wild type and mutated ...
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    5. Safety and feasibility of volumetric laser endomicroscopy in patients with Barrett’s esophagus (with videos)

      Safety and feasibility of volumetric laser endomicroscopy in patients with Barrett’s esophagus (with videos)
      Background Volumetric laser endomicroscopy (VLE) produces high-resolution, cross-sectional surface, and subsurface images for detecting neoplasia, targeting biopsies, and guiding real-time treatment. Objective To evaluate the safety and feasibility of the Nvision VLE system. Design Prospective, multicenter study. Setting Tertiary-care medical centers. Patients One hundred patients with suspected Barretts esophagus, including 52 patients with prior endotherapy. Interventions The first-generation Nvision VLE Imaging System, a balloon-centered, rotating optical probe provided images of ...
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    6. Feature Of The Week 5/10/2015: Laser Tissue Coagulation and Concurrent Optical Coherence Tomography Through a Double-Clad Fiber Coupler

      Feature Of The Week 5/10/2015: Laser Tissue Coagulation and Concurrent Optical Coherence Tomography Through a Double-Clad Fiber Coupler
      This work is the result of a collaboration between researchers from Professor Caroline Boudouxs team from Polytechnique Montral (Canada) and Professor Brett E. Boumas team at the Wellman Center for Photomedicine (MGH, Boston). The goal is to assess whether OCT-guided biopsy could benefit from the use of double-clad fiber (DCF). DCF allows a single channel fiber-optic probe to be shared: i.e. the core propagating the OCT signal while the ...
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    7. Massachusetts General Hospital Receives NIH Grant for OCTOLOGY: Histology Using Optical Coherence Tomography

      Massachusetts General Hospital Receives NIH Grant for OCTOLOGY: Histology Using Optical Coherence Tomography
      Massachusetts General Hospital Receives a 2015 NIH Grant for $217,500 for OCTOLOGY: Histology Using Optical Coherence Tomography. The principal investigator is Bruce Fischl. The program began in 2015 and ends in 2017. Below is a summary of the proposed work. While histology remains the gold standard for assessing human neuroanatomy, the procedures for sectioning and hand mounting tissue for microscopic imaging are not substantially different than they were 100 ...
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    8. Massachusetts General Hospital Receives NIH Grant for High Resolution Optical Imaging

      Massachusetts General Hospital Receives NIH Grant for High Resolution Optical Imaging
      Massachusetts General Hospital Receives a 2015 NIH Grant for $285,859 for High Resolution Optical Imaging. The principal investigator is David Boas. The program began in 2015 and ends in 2015. Below is a summary of the proposed work. This core will support the theme of functional coupling between glial, endothelial, and neuronal cells by using both in vivo and in vitro novel optical imaging to dissect the mechanisms of ...
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    9. Single input state, single-mode fiber-based polarization-sensitive optical frequency domain imaging by eigenpolarization referencing

      Single input state, single-mode fiber-based polarization-sensitive optical frequency domain imaging by eigenpolarization referencing
      Fiber-based polarization-sensitive optical frequency domain imaging is more challenging than free-space implementations. Using multiple input states, fiber-based systems provide sample birefringence information with the benefit of a flexible sample arm but come at the cost of increased system and acquisition complexity, and either reduce acquisition speed or require increased acquisition bandwidth. Here we show that with the calibration of a single polarization state, fiber-based configurations can approach the conceptual simplicity ...
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    10. Impacts of lesion angle on incidence and distribution of acute vessel wall injuries and strut malapposition after drug-eluting stent implantation assessed by optical coherence tomography

      Impacts of lesion angle on incidence and distribution of acute vessel wall injuries and strut malapposition after drug-eluting stent implantation assessed by optical coherence tomography
      Aims To investigate the impact of lesion angle on the incidence and distribution of acute vessel wall injuries and incomplete stent apposition (ISA) following second-generation drug-eluting stent (DES) implantation using optical coherence tomography (OCT). Several ex vivo studies demonstrated that angled arterial walls are exposed to imbalanced mechanical stress from deployed stents. Methods and results We included 243 lesions treated with a single DES (148 everolimus-eluting stent and 95 zotarolimus-eluting ...
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    11. Common Path Side Viewing Monolithic Ball Lens Probe for Optical Coherence Tomography

      Common Path Side Viewing Monolithic Ball Lens Probe for Optical Coherence Tomography
      Common path probes are highly desirable for optical coherence tomography as they reduce system complexity and cost by eliminating the need of dispersion compensation and polarization controlling optics. In this work, we demonstrate a monolithic ball lens based, common path, side viewing probe that is suitable for Fourier domain optical coherence tomography. The probe design parameters were simulated in Zemax modeling software and the simulated performance parameters were compared with ...
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    12. Multi-functional angiographic OFDI using frequency-multiplexed dual-beam illumination

      Multi-functional angiographic OFDI using frequency-multiplexed dual-beam illumination
      Detection of blood flow inside the tissue sample can be achieved by measuring the local change of complex signal over time in angiographic optical coherence tomography (OCT). In conventional angiographic OCT, the transverse displacement of the imaging beam during the time interval between a pair of OCT signal measurements must be significantly reduced to minimize the noise due to the beam scanning-induced phase decorrelation at the expense of the imaging ...
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  2. About Harvard University

    Harvard University

    Harvard University is a private university in Cambridge, Massachusetts, U.S. Founded in 1636 by the colonial Massachusetts legislature Harvard is the oldest institution of higher learning in the United States.  Harvard Medical School  is one of the graduate schools of Harvard University. It is a prestigious American medical school located in the Longwood Medical Area of the Mission Hill neighborhood of Boston, Massachusetts.  Schepens Eye Research Institute fights blindness by developing new technologies, therapies and knowledge to retain and restore vision. Through a continuum of discovery, the Institute works toward a future in which blindness is prevented, alleviated, and, ultimately, cured.