1. Harvard University

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    1. Mentioned In 973 Articles

    2. Improved sensitivity roll-off in dual reference, buffered spectral-domain optical coherence tomography

      Improved sensitivity roll-off in dual reference, buffered spectral-domain optical coherence tomography
      Significance: While spectral-domain optical coherence tomography (SD-OCT) is a preferred form of OCT imaging, sensitivity roll-off limits its applicability for certain biomedical imaging applications. Aim: The aim of this work is to extend the imaging range of conventional SD-OCT systems for imaging large luminal organs such as the gastrointestinal tract. Approach: We present an SD-OCT system operating at a center wavelength of 1300 nm that uses two delayed reference arms ...
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    3. Apparatus, devices and methods for in vivo imaging and diagnosis

      Apparatus, devices and methods for in vivo imaging and diagnosis
      Exemplary method and apparatus for diagnosing or characterizing an inflammation within an anatomical structure can be provided. For example, using at least one source arrangement, it is possible to provide at least one first electro-magnetic radiation to the anatomical structure at least one first wavelength in vivo. With at least one detector arrangement, it is possible to detect at least one second electro-magnetic radiation at least one second wavelength provided ...
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    4. Feasibility and safety of tethered capsule endomicroscopy in patients with Barrett’s esophagus in a multi-center study

      Feasibility and safety of tethered capsule endomicroscopy in patients with Barrett’s esophagus in a multi-center study
      Background Aims Tethered capsule endomicroscopy (TCE) involves swallowing small tethered pill that implements optical coherence tomography (OCT) imaging, procuring high resolution images of the whole esophagus. Here, we demonstrate and evaluate the feasibility and safety of TCE and a portable OCT imaging system in patients with Barretts esophagus (BE) in a multi-center (5-site) clinical study. Methods Untreated patients with BE as per endoscopic biopsy diagnosis were eligible to participate in ...
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    5. Multi-beam OCT imaging based on an integrated, free-space interferometer

      Multi-beam OCT imaging based on an integrated, free-space interferometer
      While it is a common practice to increase the speed of swept-source optical coherence tomography (OCT) systems by using a high-speed source, this approach may not always be optimal. Parallelization in the form of multiple imaging beams is an alternative approach, but scalable and low-loss multi-beam OCT architectures are needed to capitalize on its advantages. In this study, we demonstrate an eight-beam OCT system using an interferometer architecture comprising planar ...
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    6. Retinal applications of swept source optical coherence tomography (OCT) and optical coherence tomography angiography (OCTA)

      Retinal applications of swept source optical coherence tomography (OCT) and optical coherence tomography angiography (OCTA)
      The advent of optical coherence tomography (OCT) revolutionized both clinical assessment and research of vitreoretinal conditions. Since then, extraordinary advances have been made in this imaging technology, including the relatively recent development of swept-source OCT (SS-OCT). SS-OCT enables a fast scan rate and utilizes a tunable swept laser at longer wavelengths than conventional spectral-domain devices. These features enable imaging of larger areas with reduced motion artifact, and a better visualization ...
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    7. Quantitative evaluation of the human vocal fold extracellular matrix using multiphoton microscopy and optical coherence tomography

      Quantitative evaluation of the human vocal fold extracellular matrix using multiphoton microscopy and optical coherence tomography
      Identifying distinct normal extracellular matrix (ECM) features from pathology is of the upmost clinical importance for laryngeal diagnostics and therapy. Despite remarkable histological contributions, our understanding of the vocal fold (VF) physiology remains murky. The emerging field of non-invasive 3D optical imaging may be well-suited to unravel the complexity of the VF microanatomy. This study focused on characterizing the entire VF ECM in length and depth with optical imaging. A ...
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    8. Postdoctoral Research Fellowships (Machine Vision/Image Analysis) at Massachusetts General Hospital

      Postdoctoral Research Fellowships (Machine Vision/Image Analysis) at Massachusetts General Hospital
      ...de at the rank of postdoctoral fellow at Harvard Medical School. MGHs role as a leading teaching affiliate of Harvard Medical School and close ties to Harvard University and MIT provide an outstanding environment for dev...
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    9. Postdoctoral Research Fellowships (In Vivo Microscopy) at Massachusetts General Hospital

      Postdoctoral Research Fellowships (In Vivo Microscopy) at Massachusetts General Hospital
      ...de at the rank of postdoctoral fellow at Harvard Medical School. MGHs role as a leading teaching affiliate of Harvard Medical School and close ties to Harvard University and MIT provide an outstanding environment for dev...
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    10. Postdoctoral Research Fellowships (Optical Coherence Tomography) at Massachusetts General Hospital

      Postdoctoral Research Fellowships (Optical Coherence Tomography) at Massachusetts General Hospital
      ...ard Medical School, commensurate with the applicants experience. MGHs role as a leading teaching affiliate of Harvard Medical School and close ties to Harvard University and MIT provide an outstanding environment for dev...
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    11. Predictors for Rapid Progression of Coronary Calcification: An Optical Coherence Tomography Study

      Predictors for Rapid Progression of Coronary Calcification: An Optical Coherence Tomography Study
      Background The role of coronary calcification in cardiovascular events and plaque stabilization is still being debated, and factors involved in the progression of coronary calcification are not fully understood. This study aimed to identify the predictors for rapid progression of coronary calcification. Methods and Results Patients with serial optical coherence tomography imaging at baseline and at 6 months were selected. Changes in the calcification index and predictors for progression of ...
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    12. Past, present and future role of retinal imaging in neurodegenerative disease

      Retinal imaging technology is rapidly advancing and can provide ever-increasing amounts of information about the structure, function and molecular composition of retinal tissue in humans in vivo . Most importantly, this information can be obtained rapidly, non-invasively and in many cases using Food and Drug Administration-approved devices that are commercially available. Technologies such as optical coherence tomography have dramatically changed our understanding of retinal disease and in many cases have significantly ...
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    13. Detection of neovascularisation in the vitreoretinal interface slab using widefield swept-source optical coherence tomography angiography in diabetic retinopathy

      Detection of neovascularisation in the vitreoretinal interface slab using widefield swept-source optical coherence tomography angiography in diabetic retinopathy
      Aims To compare the efficacy of diabetic retinal neovascularisation (NV) detection using the widefield swept-source optical coherence tomography angiography (WF SS-OCTA) vitreoretinal interface (VRI) Angio slab and SS-OCT VRI Structure slab. Methods A prospective, observational study was performed at Massachusetts Eye and Ear from January 2019 to June 2020. Patients with proliferative diabetic retinopathy (PDR), patients with non-proliferative diabetic retinopathy and patients with diabetes but without diabetic retinopathy were included ...
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    14. Effects of lipid composition on photothermal optical coherence tomography signals

      Effects of lipid composition on photothermal optical coherence tomography signals
      Significance: Photothermal optical coherence tomography (PT-OCT) has the promise to offer structural images coregistered with chemical composition information, which can offer a significant impact in early detection of diseases such as atherosclerosis. Aim: We take the first step in understanding the relation between PT-OCT signals and the endogenous tissue composition by considering the interplay between the opto-thermo-physical properties of tissue as a function of its lipid composition and the ensuing ...
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    15. Optical Coherence Tomography Predictors for a Favorable Vascular Response to Statin Therapy

      Optical Coherence Tomography Predictors for a Favorable Vascular Response to Statin Therapy
      Background Specific plaque phenotypes that predict a favorable response to statin therapy have not been systematically studied. This study aimed to identify optical coherence tomography predictors for a favorable vascular response to statin therapy. Methods and Results Patients who had serial optical coherence tomography imaging at baseline and at 6 months were included. Thin‐cap area (defined as an area with fibrous cap thickness 200 m) was measured using a ...
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    16. 1-15 of 973 1 2 3 4 ... 63 64 65 »
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  2. About Harvard University

    Harvard University

    Harvard University is a private university in Cambridge, Massachusetts, U.S. Founded in 1636 by the colonial Massachusetts legislature Harvard is the oldest institution of higher learning in the United States.  Harvard Medical School  is one of the graduate schools of Harvard University. It is a prestigious American medical school located in the Longwood Medical Area of the Mission Hill neighborhood of Boston, Massachusetts.  Schepens Eye Research Institute fights blindness by developing new technologies, therapies and knowledge to retain and restore vision. Through a continuum of discovery, the Institute works toward a future in which blindness is prevented, alleviated, and, ultimately, cured.