1. Harbin Medical University

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    1. Mentioned In 91 Articles

    2. Pre-infarction Angina and Culprit Lesion Morphologies in Patients with a First ST-segment Elevation Acute Myocardial Infarction: Insights from In Vivo Optical Coherence Tomography

      Pre-infarction Angina and Culprit Lesion Morphologies in Patients with a First ST-segment Elevation Acute Myocardial Infarction: Insights from In Vivo Optical Coherence Tomography
      Aims: This study aimed to evaluate the relationship between pre-infarction angina (PIA) and in vivo culprit lesion characteristics as assessed by intravascular optical coherence tomography (OCT) in patients with a first ST-segment elevation myocardial infarction (STEMI). Methods and results: A total of 305 consecutive patients with a first STEMI who underwent OCT imaging of culprit lesions during primary percutaneous coronary intervention (PCI) were prospectively enrolled. OCT findings of the culprit ...
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    3. Study on STEMI Reperfusion Strategy Based on the Characterization of Criminal Lesions Stability

      Study on STEMI Reperfusion Strategy Based on the Characterization of Criminal Lesions Stability
      A randomized controlled study of whether stent implantation in STEMI patients with 70% coronary stenosis was designed. A total of 240 STEMI patients with coronary artery diameter stenosis 70% were randomly assigned to either an OCT-guided group or an angiography-guided group. OCT guidance group: Stent implantation or drug therapy is determined based on the stability of the culprit lesions by the OCT. Angiographic guide group: According to the results of ...
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    4. Impact of vessel curvature on neointimal healing after stent implantation as assessed by optical coherence tomography

      Impact of vessel curvature on neointimal healing after stent implantation as assessed by optical coherence tomography
      Purpose: Previous studies have indicated that stent implantation could alter the vessel geometry, which may impact the neointimal healing process. Curvature is an important parameter for evaluating vessel geometry. The purpose of our study was to investigate the relationship between vessel curvature and neointimal healing after stent implantation. Methods: Fifty-nine patients with acute coronary syndrome (ACS) who underwent stent implantation were enrolled in the study. According to the post-percutaneous coronary ...
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    5. In vivo predictors of plaque erosion in patients with ST-segment elevation myocardial infarction: a clinical, angiographical, and intravascular optical coherence tomography study

      In vivo predictors of plaque erosion in patients with ST-segment elevation myocardial infarction: a clinical, angiographical, and intravascular optical coherence tomography study
      Aims Plaque erosion is a significant substrate of acute coronary thrombosis. This study sought to determine in vivo predictors of plaque erosion in patients with ST-segment elevation myocardial infarction (STEMI). Methods and results A prospective series of 822 STEMI patients underwent pre-intervention optical coherence tomography. Using established diagnostic criteria, 209 had plaque erosion (25.4%) and 564 had plaque rupture (68.6%). Plaque erosion was more frequent in women 50years ...
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    6. Correlation of Serum Uric Acid Levels with Nonculprit Plaque Instability in Patients with Acute Coronary Syndromes: A 3-Vessel Optical Coherence Tomography Study

      Correlation of Serum Uric Acid Levels with Nonculprit Plaque Instability in Patients with Acute Coronary Syndromes: A 3-Vessel Optical Coherence Tomography Study
      Elevated serum uric acid (SUA) level is known to be a prognostic factor in patients with acute coronary syndrome (ACS). However, the correlation between SUA level and coronary plaque instability has not been fully evaluated. The aim of this study was to investigate the association between SUA level and plaque instability of nonculprit lesions in patients with ACS using optical coherence tomography. A total of 150 patients with ACS who ...
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    7. Does spotty calcification attenuate the response of nonculprit plaque to statin therapy?: A serial optical coherence tomography study

      Does spotty calcification attenuate the response of nonculprit plaque to statin therapy?: A serial optical coherence tomography study
      Objectives The aim of this study was to determine if spotty calcification decreases the response of plaque progression to statin therapy. Background Previous studies showed that the presence of spotty calcification is a marker of vulnerable plaque. However, the relationship between spotty calcification and plaque progression is not clear. Methods Ninety-six nonculprit lipid-rich plaques in 69 patients who received serial optical coherence tomography (OCT) imaging were included. Plaques were divided ...
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    8. EROSION Study (Effective Anti-Thrombotic Therapy Without Stenting: Intravascular Optical Coherence Tomography–Based Management in Plaque Erosion)

      EROSION Study (Effective Anti-Thrombotic Therapy Without Stenting: Intravascular Optical Coherence Tomography–Based Management in Plaque Erosion)
      Background The initial EROSION study (Effective Anti-Thrombotic Therapy Without Stenting: Intravascular Optical Coherence TomographyBased Management in Plaque Erosion) demonstrated that patients with acute coronary syndrome caused by plaque erosion might be stabilized with aspirin and ticagrelor without stenting for 1 month. However, a long-term evaluation of outcomes is lacking. The aim of this study was to assess whether the initial benefit of noninterventional therapy for patients with acute coronary syndrome ...
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    9. Culprit plaque characteristics in women vs men with a first ST-segment elevation myocardial infarction: In vivo optical coherence tomography insights

      Culprit plaque characteristics in women vs men with a first ST-segment elevation myocardial infarction: In vivo optical coherence tomography insights
      Background It is unclear whether more severe coronary atherosclerosis is a prerequisite to an initial acute coronary event in women vs men. Hypothesis Women may have more severe coronary atherosclerosis than men in patients with acute coronary event. Methods We used intravascular optical coherence tomography (OCT) to evaluate gender differences in culprit-plaque morphology in patients with a first ST-segment elevation myocardial infarction (STEMI).We retrospectively enrolled 211 consecutive patients who ...
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    10. In Vivo Calcium Detection by Comparing Optical Coherence Tomography, Intravascular Ultrasound, and Angiography

      In Vivo Calcium Detection by Comparing Optical Coherence Tomography, Intravascular Ultrasound, and Angiography
      Objectives The aim of this study was to evaluate optical coherence tomography (OCT) and intravascular ultrasound (IVUS) versus coronary angiography in the assessment of target lesion calcification and its effect on stent expansion. Background IVUS is more sensitive than angiography in the detection of coronary artery calcium, but the relationship among IVUS, OCT, and angiography has not been studied. Methods Overall, 440 lesions (440 patients with stable angina) underwent OCT- ...
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    11. Impact of Cigarette Smoking and Smoking Cessation on Stent Changes as Determined by Optical Coherence Tomography after Sirolimus Stent Implantation

      Impact of Cigarette Smoking and Smoking Cessation on Stent Changes as Determined by Optical Coherence Tomography after Sirolimus Stent Implantation
      There is debate regarding whether smoking results in microstructural changes after stenting. The aim of this study was to evaluate the microstructural changes after stenting in patients with different smoking statuses. We retrospectively identified 220 sirolimus-eluting stents in 179 patients who underwent follow-up optical coherence tomography examination 12 months after sirolimus stenting. Subjects were classified as current smokers (CS, n=31), smoking cessation 1 year (SC1Y, n=36), smoking cessation ...
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    12. Association of Platelet to lymphocyte ratio with non-culprit atherosclerotic plaque vulnerability in patients with acute coronary syndrome: an optical coherence tomography study

      Association of Platelet to lymphocyte ratio with non-culprit atherosclerotic plaque vulnerability in patients with acute coronary syndrome: an optical coherence tomography study
      Background The platelet to lymphocyte ratio (PLR), an indirect inflammatory biomarker, has been recently demonstrated to be associated with severity of coronary artery disease. In the present study, we sought to investigate whether PLR is associated with vulnerable plaque characteristics of non-culprit lesions in patients with acute coronary syndrome (ACS). Methods The patients in our study were divided into two groups (high PLR group and low PLR group). A total ...
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    13. Role of Optical Coherence Tomography in Diagnosis and Treatment of Patients with Acute Coronary Syndrome

      Role of Optical Coherence Tomography in Diagnosis and Treatment of Patients with Acute Coronary Syndrome
      Acute coronary syndrome (ACS) is the main cause of death worldwide and the leading cause of disease burden in high-income countries. ACS refers to a constellation of clinical symptoms that are compatible with acute myocardial ischemia. It describes a spectrum of clinical manifestations that result from a common pathophysiological process. The most common cause of ACS are rupture of an atherosclerotic lesion containing a large necrotic core and a thin ...
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    14. Clinical Significance of Lipid-Rich Plaque Detected by Optical Coherence Tomography : A 4-Year Follow-Up Study

      Clinical Significance of Lipid-Rich Plaque Detected by Optical Coherence Tomography : A 4-Year Follow-Up Study
      Background Lipid-rich plaque (LRP) is thought to be a precursor to cardiac events. However, its clinical significance in coronary arteries has never been systematically investigated. Objectives This study investigated the prevalence and clinical significance of LRP in the nonculprit region of the target vessel in patients undergoing percutaneous coronary intervention (PCI). Methods The study included 1,474 patients from 20 sites across 6 countries undergoing PCI, who had optical coherence ...
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    15. Relation Between Superficial Calcifications and Plaque Rupture: An Optical Coherence Tomography Study

      Relation Between Superficial Calcifications and Plaque Rupture: An Optical Coherence Tomography Study
      Background There are several forms of calcium deposition, which play different roles in the stability of the coronary artery. It remains unknown whether certain calcification morphological characteristics determine rupture of lipid-rich lesions in the same plaque in acute coronary syndrome (ACS). Methods We retrospectively analyzed 550 patients with ACS between May 2008 and October 2014, who had undergone pre-intervention optical coherence tomography (OCT) imaging examination. A total of 78 patients ...
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    16. Impact of statins therapy on morphological changes in lipid-rich plaques stratified by 10-Year framingham risk score: A serial optical coherence tomography study

      Impact of statins therapy on morphological changes in lipid-rich plaques stratified by 10-Year framingham risk score: A serial optical coherence tomography study
      The aim of the study was to investigate the impact of statins therapy on morphological changes of lipid-rich plaques by OCT (optical coherence tomography) in patients with known CHD (coronary heart disease), stratified by FRS. Ninety-seven lipid-rich plaques from sixty-nine patients who received statins therapy and underwent serial OCT images (baseline, 6-month and 12-month) were divided into 2 groups according to the FRS (framingham risk score): low risk group A ...
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  2. About Harbin Medical University

    Harbin Medical University

    Harbin Medical University is a public university located in Harbin, Heilongjiang , China . It was established in 1926 as Harbin Medical College. It was renamed to University in 1958.  Harbin, a beautiful city well-known for its ice and snow  and reputed as “Eastern Paris”. HMU has a  scenic view on the campus dotted with ancient-style buildings, with a total  area of 2.36 million square meters.