1. Hao F. Zhang

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    1. Mentioned In 57 Articles

    2. VIS-OCT Opens Eyes to New Approaches

      VIS-OCT Opens Eyes to New Approaches
      First reported in 1991 by Huang and colleagues 1 , OCT has become an important imaging tool for ophthalmology following innovations over the past three decades. OCT noninvasively provides 3D in vivo optical biopsy with microscopic resolution in the eye at a depth range up to the choroid 2 . Besides 3D anatomical imaging, OCT can also provide functional information. The most notable functional extension is OCT angiography (OCTA), which can map ...
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    3. Longitudinal deep-brain imaging in mouse using visible-light optical coherence tomography through chronic microprism cranial window

      Longitudinal deep-brain imaging in mouse using visible-light optical coherence tomography through chronic microprism cranial window
      We longitudinally imaged both the superficial and deep cortical microvascular networks in brains of healthy mice and in a mouse model of stroke in vivo using visible-light optical coherence tomography (vis-OCT). We surgically implanted a microprism in mouse brains sealed by a chronic cranial window. The microprism enabled vis-OCT to image the entire depth of the mouse cortex. Following microprism implantation, we imaged the mice for 28 days and found ...
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    4. Speckle reduction in visible-light optical coherence tomography using scan modulation

      Speckle reduction in visible-light optical coherence tomography using scan modulation
      We present a technique to reduce speckle in visible-light optical coherence tomography (vis-OCT) that preserves fine structural details and is robust against sample motion. Specifically, we locally modulate B-scans orthogonally to their axis of acquisition. Such modulation enables acquisition of uncorrelated speckle patterns from similar anatomical locations, which can be averaged to reduce speckle. To verify the effectiveness of speckle reduction, we performed in-vivo retinal imaging using modulated raster and ...
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    5. Northwestern University Receives NIH Grant for Investigating Nanoscale Neuronal Damages in Early Glaucoma Towards Clinical Optical Detection

      Northwestern University Receives NIH Grant for Investigating Nanoscale Neuronal Damages in Early Glaucoma Towards Clinical Optical Detection
      Northwestern University Receives a 2019 NIH Grant for $535,063 for Investigating Nanoscale Neuronal Damages in Early Glaucoma Towards Clinical Optical Detection. The principal investigator is Hao Zhang. The program began in 2018 and ends in 2022. Below is a summary of the proposed work. Our long-term goal is to develop new functional extensions of optical coherence tomography (vis-OCT) for clinical diagnosis and management of glaucoma. Glaucoma is characterized by ...
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    6. Designing visible-light optical coherence tomography towards clinics

      Designing visible-light optical coherence tomography towards clinics
      Background: The capabilities of visible-light optical coherence tomography (vis-OCT) in noninvasive anatomical and functional retinal imaging have been demonstrated by multiple groups in both rodents and healthy human subjects. Translating laboratory prototypes to an integrated clinical-environment-friendly system is required to explore the full potential of vis-OCT in disease management. Methods: We developed and optimized a portable vis-OCT system for human retinal imaging in clinical settings. We acquired raster- and circular-scan ...
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    7. Product Development Engineer Opening at Opticent Health

      Product Development Engineer Opening at Opticent Health
      Opticent, Inc. (Opticent Health www.opticenthealth.com) , established in 2015, is a fast growing medical device start-up company commercializing visible-light optical coherence tomography (vis-OCT), a novel imaging modality for a variety of applications, including advanced ophthalmic diagnostics. First developed at Northwestern University, Opticent Healths core technologies have been embraced by leading researchers in clinical and pre-clinical ophthalmic investigations, which has fueled rapid commercial development of vis-OCT products. Opticent Health is ...
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    8. Product Development Engineer Opening at Opticent Health

      Product Development Engineer Opening at Opticent Health
      Opticent, Inc. , established in 2015, is a fast growing medical device start-up company commercializing visible-light optical coherence tomography (vis-OCT), a novel imaging modality for a variety of applications, including advanced ophthalmic diagnostics. First developed at Northwestern University, Opticent Healths core technologies have been embraced by leading researchers in clinical ophthalmic research which has fueled rapid commercial development of vis-OCT products. Opticent Health is located in Evanston IL, part of the ...
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    9. Monitoring Acute Stroke in Mouse Model Using Laser Speckle Imaging-Guided Visible-Light Optical Coherence Tomography

      Monitoring Acute Stroke in Mouse Model Using Laser Speckle Imaging-Guided Visible-Light Optical Coherence Tomography
      Objective: Monitoring hemodynamic and vascular changes in the acute stages of mouse stroke models is invaluable in studying ischemic stroke pathophysiology. However, there lacks a tool to simultaneously and dynamically investigate these changes. Methods: We integrated laser speckle imaging (LSI) and visible-light optical coherence tomography (Vis-OCT) to reveal dynamic vascular responses in acute stages in the distal middle cerebral artery occlusion (dMCAO) model in rodents. LSI provides full-field, real-time imaging ...
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    10. Visible-light optical coherence tomography oximetry based on circumpapillary scan and graph-search segmentation

      Visible-light optical coherence tomography oximetry based on circumpapillary scan and graph-search segmentation
      Visible-light optical coherence tomography (vis-OCT) enables retinal oximetry by measuring the oxygen saturation of hemoglobin (sO 2 ) from within individual retinal blood vessels. The sO 2 calculation requires reliable estimation of the true spectrum of backscattered light from the posterior vessel wall. Unfortunately, subject motion and image noise make averaging from multiple A-lines at the same depth position challenging, and lead to inaccurate sO 2 estimation. In this study, we ...
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    11. Visible-light optical coherence tomography: a review

      Visible-light optical coherence tomography: a review
      Visible-light optical coherence tomography (vis-OCT) is an emerging imaging modality, providing new capabilities in both anatomical and functional imaging of biological tissue. It relies on visible light illumination, whereas most commercial and investigational OCTs use near-infrared light. As a result, vis-OCT requires different considerations in engineering design and implementation but brings unique potential benefits to both fundamental research and clinical care of several diseases. Here, we intend to provide a ...
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    12. Spectroscopic Doppler analysis for visible-light optical coherence tomography

      Spectroscopic Doppler analysis for visible-light optical coherence tomography
      Retinal oxygen metabolic rate can be effectively measured by visible-light optical coherence tomography (vis-OCT), which simultaneously quantifies oxygen saturation and blood flow rate in retinal vessels through spectroscopic analysis and Doppler measurement, respectively. Doppler OCT relates phase variation between sequential A-lines to the axial flow velocity of the scattering medium. The detectable phase shift is between and due to its periodicity, which limits the maximum measurable unambiguous velocity without phase ...
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    13. Opticent Receives NIH Grant for Method for Accurate Retinal Oxygen Metabolic Rate Extraction

      Opticent Receives NIH Grant for Method for Accurate Retinal Oxygen Metabolic Rate Extraction
      ...sive monitoring of rMRO2 has the potential to significantly improve the management of proliferative DR. Prof. Hao F. Zhang’s group at Northwestern University demonstrated in 2013 that visible light optical coherence tomo...
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    14. Two Engineering Openings at Startup Company Opticent Health

      Two Engineering Openings at Startup Company Opticent Health
      Opticent, Inc. (Opticent Health www.opticenthealth.com) is a start-up company commercializing an in-house developed patent portfolio related to visible-light optical coherence tomography (OCT) targeting the ophthalmic market. Opticent Healths core technologies were developed at Northwestern University. Since its founding, Opticent Health has experienced rapid market adoption of its OCT instruments and rapid commercial expansion. Opticent Health is located in Evanston IL, part of the greater Chicago metropolitan area. The ...
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    15. Optical coherence tomography angiography of retinal vascular occlusions produced by imaging-guided laser photocoagulation

      Optical coherence tomography angiography of retinal vascular occlusions produced by imaging-guided laser photocoagulation
      Retinal vascular occlusive diseases represent a major form of vision loss worldwide. Rodent models of these diseases have traditionally relied upon a slit-lamp biomicroscope to help visualize the fundus and subsequently aid delivery of high-power laser shots to a target vessel. Here we describe a multimodal imaging system that can produce, image, and monitor retinal vascular occlusions in rodents. The system combines a spectral-domain optical coherence tomography system for cross-sectional ...
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    16. Colposcopic imaging using visible-light optical coherence tomography

      Colposcopic imaging using visible-light optical coherence tomography
      High-resolution colposcopic optical coherence tomography (OCT) provides key anatomical measures, such as thickness and minor traumatic injury of vaginal epithelium, of the female reproductive tract noninvasively. This information can be helpful in both fundamental investigations in animal models and disease screenings in humans. We present a fiber-based visible-light OCT and two probe designs for colposcopic application. One probe conducts circular scanning using a DC motor, and the other probe is ...
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  2. About Hao F. Zhang

    Hao F. Zhang

    Hao F. Zhang is at Northwestern University.