1. Hang Lee

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    1. Mentioned In 56 Articles

    2. Characteristics of non-culprit plaques in acute coronary syndrome patients with layered culprit plaque

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      Characteristics of non-culprit plaques in acute coronary syndrome patients with layered culprit plaque
      Aims Layered plaques represent signs of previous plaque destabilization. A recent study showed that acute coronary syndrome (ACS) patients with layered culprit plaque have more vulnerability at the culprit lesion and systemic inflammation. We aimed to compare the characteristics of non-culprit plaques between patients with or without layered plaque at the culprit lesion. We also evaluated the characteristics of layered non-culprit plaques, irrespective of culprit plaque phenotype. Methods and results ...
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      Mentions: Massachusetts General Hospital Ik-Kyung Jang Harvard University

    3. Healed Culprit Plaques in Patients With Acute Coronary Syndrome

      Explore onlinejacc.org Cardiology
      Healed Culprit Plaques in Patients With Acute Coronary Syndrome
      ackground Healed plaques, morphologically characterized by a layered phenotype, are frequently found in subjects with sudden cardiac death. However, in vivo data are lacking. Objectives The purpose of this study was to determine the prevalence, morphological characteristics, and clinical significance of healed culprit plaques in patients with acute coronary syndromes (ACS) using optical coherence tomography (OCT). Methods A total of 376 ACS patients (252 ST-segment elevation myocardial infarction [MI] and ...
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      Mentions: Massachusetts Institute of Technology James G. Fujimoto Mount Sinai School of Medicine

    4. Differences in coronary plaque morphology between East Asian and Western White patients: an optical coherence tomography study

      Explore LWW Online Cardiology
      Differences in coronary plaque morphology between East Asian and Western White patients: an optical coherence tomography study
      Aims Prevalence of coronary artery disease as well as cardiac mortality varies between Asian and White patients. However, the link between race and plaque characteristics in patients with coronary artery disease remains largely unexplored. Thus, we aimed to investigate the detailed culprit plaque characteristics between East Asian and White patients using optical coherence tomography . Patients and methods A total of 101 East Asians were matched to 101 White patients. Matching ...
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      Mentions: Massachusetts General Hospital Ik-Kyung Jang Harvard University

    6. Nonculprit Plaque Characteristics in Patients With Acute Coronary Syndrome Caused by Plaque Erosion vs Plaque Rupture A 3-Vessel Optical Coherence Tomography Study

      Explore The JAMA Network Cardiology
      Nonculprit Plaque Characteristics in Patients With Acute Coronary Syndrome Caused by Plaque Erosion vs Plaque Rupture A 3-Vessel Optical Coherence Tomography Study
      Importance Patients with culprit plaque rupture are known to have pancoronary plaque vulnerability. However, the characteristics of nonculprit plaques in patients with acute coronary syndromes caused by plaque erosion are unknown. Objective To investigate the nonculprit plaque phenotype in patients with acute coronary syndrome according to culprit plaque pathology (erosion vs rupture) by 3-vessel optical coherence tomography imaging. Design, Setting, and Participants In this observational cohort study, between August 2010 ...
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      Mentions: Brigham and Women’s Hospital Massachusetts General Hospital Ik-Kyung Jang

    7. EROSION Study (Effective Anti-Thrombotic Therapy Without Stenting: Intravascular Optical Coherence Tomography–Based Management in Plaque Erosion)

      Explore Circulation Cardiology
      EROSION Study (Effective Anti-Thrombotic Therapy Without Stenting: Intravascular Optical Coherence Tomography–Based Management in Plaque Erosion)
      Background The initial EROSION study (Effective Anti-Thrombotic Therapy Without Stenting: Intravascular Optical Coherence TomographyBased Management in Plaque Erosion) demonstrated that patients with acute coronary syndrome caused by plaque erosion might be stabilized with aspirin and ticagrelor without stenting for 1 month. However, a long-term evaluation of outcomes is lacking. The aim of this study was to assess whether the initial benefit of noninterventional therapy for patients with acute coronary syndrome ...
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      Mentions: Massachusetts General Hospital Ik-Kyung Jang Shaosong Zhang

    8. Clinical Predictors for Lack of Favorable Vascular Response to Statin Therapy in Patients With Coronary Artery Disease: A Serial Optical Coherence Tomography Study

      Explore jaha.ahajournals.org
      Clinical Predictors for Lack of Favorable Vascular Response to Statin Therapy in Patients With Coronary Artery Disease: A Serial Optical Coherence Tomography Study
      Background Previous studies have demonstrated that statin therapy improves cardiac outcomes, probably by stabilizing thin‐cap fibroatheroma in patients with coronary artery disease. However, major adverse cardiac events still occur in some patients, despite statin therapy. The aim of this study is to identify clinical predictors for the lack of a favorable vascular response to statin therapy in patients with coronary artery disease. Methods and Results A total of 140 ...
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      Mentions: Massachusetts Institute of Technology James G. Fujimoto Massachusetts General Hospital

    9. Low Endothelial Shear Stress Predicts Evolution to High-Risk Coronary Plaque Phenotype in the Future A Serial Optical Coherence Tomography and Computational Fluid Dynamics Stud

      Explore Circulation Cardiology
      Low Endothelial Shear Stress Predicts Evolution to High-Risk Coronary Plaque Phenotype in the Future A Serial Optical Coherence Tomography and Computational Fluid Dynamics Stud
      Background Low endothelial shear stress (ESS) is associated with plaque progression and vulnerability. To date, changes in plaque phenotype over time in relation to ESS have not been studied in humans. The aim of this study was to investigate whether local ESS can predict subsequent changes to plaque phenotype using optical coherence tomography. Methods and Results A total of 25 coronary arteries from 20 patients who underwent baseline and 6-month ...
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      Mentions: Massachusetts General Hospital Ik-Kyung Jang Harvard University

    10. Differences in coronary plaque characteristics between patients with and those without peripheral arterial disease

      Explore LWW Online Cardiology
      Differences in coronary plaque characteristics between patients with and those without peripheral arterial disease
      Introduction: Cardiovascular mortality of patients with combined peripheral arterial disease (PAD) and coronary artery disease (CAD) is twice as high as that in those with either disease alone. It is known that patients with PAD undergoing percutaneous coronary intervention have a higher incidence of adverse cardiac events such as myocardial infarction or target vessel revascularization. Objective: In this study, we compared the detailed characteristics of culprit and nonculprit plaques between ...
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      Mentions: Massachusetts General Hospital Ik-Kyung Jang Harvard University

    11. Dynamic neointimal pattern after drug-eluting stent implantation defined by optical coherence tomography

      Explore LWW Online Cardiology
      Dynamic neointimal pattern after drug-eluting stent implantation defined by optical coherence tomography
      Objectives: Certain neointimal patterns including neoatherosclerosis (NA) are known to be associated with poor clinical outcome. The prevalence and time course of different neointimal patterns have not been studied systematically. The aim of this study was to investigate the serial changes in neointimal pattern after drug-eluting stent implantation. Patients and methods: A total of 132 patients with 207 drug-eluting stents, who underwent two follow-up optical coherence tomography studies at 6 ...
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      Mentions: Massachusetts Institute of Technology Massachusetts General Hospital Ik-Kyung Jang

    12. SYNTAX Score, and Pre- and Post-Stent Optical Coherence Tomography Findings in the Left Anterior Descending Coronary Artery in Patients with Stable Angina Pectoris

      Explore ScienceDirect Cardiology
      SYNTAX Score, and Pre- and Post-Stent Optical Coherence Tomography Findings in the Left Anterior Descending Coronary Artery in Patients with Stable Angina Pectoris
      SYNTAX score (SS) has been reported to be an independent predictor of future cardiac events including target lesion revascularization (TLR). The aim of this study was to assess the relationship between SS and plaque characteristics and post-stent vascular response using optical coherence tomography (OCT) in coronary artery tree and left anterior descending artery (LAD) in patients with stable angina. A total of 179 lesions among 165 patients, including 100 lesions ...
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      Mentions: University of Queensland Massachusetts General Hospital Ik-Kyung Jang

    13. Clinical Significance of Lipid-Rich Plaque Detected by Optical Coherence Tomography : A 4-Year Follow-Up Study

      Explore ScienceDirect Cardiology
      Clinical Significance of Lipid-Rich Plaque Detected by Optical Coherence Tomography : A 4-Year Follow-Up Study
      Background Lipid-rich plaque (LRP) is thought to be a precursor to cardiac events. However, its clinical significance in coronary arteries has never been systematically investigated. Objectives This study investigated the prevalence and clinical significance of LRP in the nonculprit region of the target vessel in patients undergoing percutaneous coronary intervention (PCI). Methods The study included 1,474 patients from 20 sites across 6 countries undergoing PCI, who had optical coherence ...
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      Mentions: University of Pittsburgh Massachusetts Institute of Technology James G. Fujimoto

    14. Management and Outcome of Patients With Acute Coronary Syndrome Caused by Plaque Rupture Versus Plaque Erosion: An Intravascular Optical Coherence Tomography Study

      Explore jaha.ahajournals.org Cardiology
      Management and Outcome of Patients With Acute Coronary Syndrome Caused by Plaque Rupture Versus Plaque Erosion: An Intravascular Optical Coherence Tomography Study
      Background Plaque rupture and erosion are the 2 most common mechanisms for acute coronary syndromes. However, the outcome of these 2 distinct pathologies in patients with acute coronary syndromes has never been studied. Methods and Results We retrospectively studied 141 patients with acute coronary syndromes who underwent optical coherence tomography ( OCT ) imaging of the culprit lesion prior to stenting from the Massachusetts General Hospital OCT Registry. Management (stent versus no ...
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      Mentions: Massachusetts General Hospital Ik-Kyung Jang Shaosong Zhang

    15. Is age an important factor for vascular response to statin therapy? A serial optical coherence tomography and intravascular ultrasound study

      Explore LWW Online
      Is age an important factor for vascular response to statin therapy? A serial optical coherence tomography and intravascular ultrasound study
      Objective: Age-related structural and functional changes in vessel wall may affect the time course of vascular response to statin therapy. In this study, we sought to compare the response of lipid-rich plaque to statin therapy in elderly versus younger patients using optical coherence tomography and intravascular ultrasound. Patients and methods: Sixty-nine patients who underwent serial optical coherence tomography and intravascular ultrasound at the time point of baseline, 6, and 12 ...
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      Mentions: Massachusetts General Hospital Ik-Kyung Jang Shaosong Zhang

    16. Prevalence and Predictors of Multiple Coronary Plaque Ruptures In Vivo 3-Vessel Optical Coherence Tomography Imaging Study

      Explore atvb.ahajournals.org Cardiology
      Prevalence and Predictors of Multiple Coronary Plaque Ruptures In Vivo 3-Vessel Optical Coherence Tomography Imaging Study
      Objective Plaque rupture may be the local expression of a widespread coronary instability. This study aimed to investigate: (1) the prevalence and characteristics of nonculprit plaque rupture; (2) the pancoronary atherosclerotic phenotype in patients with and without nonculprit plaque rupture; and (3) the prevalence and predictors of multiple plaque ruptures. Approach and Results Six hundred and seventy-five nonculprit plaques from 261 patients (34 acute myocardial infarction, 73 unstable angina pectoris ...
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      Mentions: Massachusetts General Hospital Ik-Kyung Jang Harvard University
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  4. About Hang Lee

    Hang Lee

    Hang Lee is with the Biostatistics Center at Massachusetts General Hospital, Harvard Medical School. Dr. Lee is the study statistician of the OCT Registry. He is the lead statistician of the Harvard Catalyst Biostatistics Program at Mass General and the Mass General Clinical Research Program Biostatistics Consulting Laboratory, and he serves as the primary statistician of the Gynecologic Oncology Program at Dana-Farber Harvard Cancer Center. He is also the lead statistician of the NHLBI-funded ROMICAT trial (Rule Out Myocardial Ischemia/Infarction Using Computer Assisted tomography - A Randomized, Controlled, Multicenter Diagnostic Trial). Dr. Lee is Assistant Professor of Medicine at Harvard Medical School and has over 10 years of experience in a wide range of Mass General and Harvard-based collaborative clinical trials and epidemiologic investigations. His statistical expertise is in the longitudinal data, statistical genetics, clinical trials design and complex data analysis, and he has authored and co-authored over 120 clinical study articles.

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    2. Nonculprit Plaques in Patients With Acute Coronary Syndromes Have More Vulnerable Features Compared With Those With Non–Acute Coronary Syndromes: A 3-Vessel Optical Coherence Tomography Study
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