1. Guillermo L. Monroy

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    1. Mentioned In 21 Articles

    2. Evaluating optical coherence tomography for surgical margin assessment of canine mammary tumors

      Evaluating optical coherence tomography for surgical margin assessment of canine mammary tumors
      Optical coherence tomography (OCT) uses near‐infrared light waves to generate real‐time, high‐resolution images on the microscopic scale similar to low power histopathology. Previous studies have demonstrated the use of OCT for real‐time surgical margin assessment for human breast cancer. The use of OCT for canine mammary tumors (CMT) could allow intra‐operative visualization of residual tumor at surgical margins. The purpose of this study was to ...
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    3. Characterization of New Optical Imaging Biomarkers of Peripheral Nerve Overstimulation

      Characterization of New Optical Imaging Biomarkers of Peripheral Nerve Overstimulation
      An animal study was designed to explore the potentially damaging effects of electrical overstimulation on peripheral nerves using a polarization‐sensitive optical coherence tomography (PS‐OCT) imaging and stimulation platform. Lewis rats (n = 15) were divided into 3 groups with 2 different levels of stimulation applied to the exposed sciatic nerve: Group 1 (sham control): 0.0 mA/0 Hz, Group 2: 3.4 mA/50 Hz, and Group 3 ...
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    4. Assessing the Effect of Middle Ear Effusions on Wideband Acoustic Immittance Using Optical Coherence Tomography

      Assessing the Effect of Middle Ear Effusions on Wideband Acoustic Immittance Using Optical Coherence Tomography
      Objectives: Wideband acoustic immittance (WAI) noninvasively assesses middle ear function by measuring the sound conduction over a range of audible frequencies. Although several studies have shown the potential of WAI for detecting the presence of middle ear effusions (MEEs), determining the effects of MEE type and amount on WAI in vivo has been challenging due to the anatomical location of middle ear cavity. The purpose of this study is to ...
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    5. Method and apparatus for OCT-based viscometry

      Method and apparatus for OCT-based viscometry
      Methods and apparatus for ascertaining a relative viscosity characterizing a fluid sample. The fluid sample is illuminated through a scattering membrane adjacent to the fluid with broadband radiation. Scattering from particles within the fluid sample characterized by a distribution of characteristic dimensions spanning at least two orders of magnitude is detected, generating a detector signal as a function of depth relative to a specified surface of the scattering membrane at ...
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    6. Automated classification platform for the identification of otitis media using optical coherence tomography

      Automated classification platform for the identification of otitis media using optical coherence tomography
      The diagnosis and treatment of otitis media (OM), a common childhood infection, is a significant burden on the healthcare system. Diagnosis relies on observer experience via otoscopy, although for non-specialists or inexperienced users, accurate diagnosis can be difficult. In past studies, optical coherence tomography (OCT) has been used to quantitatively characterize disease states of OM, although with the involvement of experts to interpret and correlate image-based indicators of infection with ...
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    7. Economical and compact briefcase spectral-domain optical coherence tomography system for primary care and point-of-care applications

      Economical and compact briefcase spectral-domain optical coherence tomography system for primary care and point-of-care applications
      Development of low-cost and portable optical coherence tomography (OCT) systems is of global interest in the OCT research community. Such systems enable utility broadly throughout a clinical facility, or in remote areas that often lack clinical infrastructure. We report the development and validation of a low-cost, portable briefcase spectral-domain optical coherence tomography (SD-OCT) system for point-of-care diagnostics in primary care centers and/or in remote settings. The self-contained briefcase OCT ...
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    8. Noninvasive in vivo optical coherence tomography tracking of chronic otitis media in pediatric subjects after surgical intervention

      Noninvasive in vivo optical coherence tomography tracking of chronic otitis media in pediatric subjects after surgical intervention
      In an institutional review board-approved study, 25 pediatric subjects diagnosed with chronic or recurrent otitis media were observed over a period of six months with optical coherence tomography (OCT). Subjects were followed throughout their treatment at the initial patient evaluation and preoperative consultation, surgery (intraoperative imaging), and postoperative follow-up, followed by an additional six months of records-based observation. At each time point, the tympanic membrane (at the light reflex region ...
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    9. Clinical translation of handheld optical coherence tomography: practical considerations and recent advancements

      Clinical translation of handheld optical coherence tomography: practical considerations and recent advancements
      Since the inception of optical coherence tomography (OCT), advancements in imaging system design and handheld probes have allowed for numerous advancements in disease diagnostics and characterization of the structural and optical properties of tissue. OCT system developers continue to reduce form factor and cost, while improving imaging performance (speed, resolution, etc.) and flexibility for applicability in a broad range of fields, and nearly every clinical specialty. An extensive array of ...
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    10. Intraoperative optical coherence tomography for soft tissue sarcoma differentiation and margin identification

      Intraoperative optical coherence tomography for soft tissue sarcoma differentiation and margin identification
      Background and Objective Sarcomas are rare but highly aggressive tumors, and local recurrence after surgical excision can occur in up to 50% cases. Therefore, there is a strong clinical need for accurate tissue differentiation and margin assessment to reduce incomplete resection and local recurrence. The purpose of this study was to investigate the use of optical coherence tomography (OCT) and a novel image texture-based processing algorithm to differentiate sarcoma from ...
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    11. Low-cost hand-held probe for depth-resolved low-coherence interferometry

      Low-cost hand-held probe for depth-resolved low-coherence interferometry
      We report on the development of a low-cost hand-held low-coherence interferometric imaging system based on the principle of linear optical coherence tomography (Linear OCT), a technique which was first proposed in the early 2000s as a simpler alternative to the conventional time-domain and Fourier-domain OCT. A bench-top implementation of the proposed technique is first presented and validated. The axial resolution, SNR, and sensitivity roll-of of the system was estimated to ...
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    12. A Mosaicking Approach for In Vivo Thickness Mapping of the Human Tympanic Membrane Using Low Coherence Interferometry

      A Mosaicking Approach for In Vivo Thickness Mapping of the Human Tympanic Membrane Using Low Coherence Interferometry
      The thickness of the human tympanic membrane (TM) is known to vary considerably across different regions of the TM. Quantitative determination of the thickness distribution and mapping of the TM is of significant importance in hearing research, particularly in mathematical modeling of middle-ear dynamics. Change in TM thickness is also associated with several middle-ear pathologies. Determination of the TM thickness distribution could therefore also enable a more comprehensive diagnosis of ...
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    13. Non-invasive optical assessment of viscosity of middle ear effusions in otitis media

      Non-invasive optical assessment of viscosity of middle ear effusions in otitis media
      In vivo Optical Coherence Tomography (OCT) image of a human tympanic membrane and Middle Ear Effusion (MEE) (top), with a CCD image of the tympanic membrane surface (inset). Below is the corresponding time-lapse M-mode OCT data acquired along the white dotted line over time, which can be analyzed to determine the StokesEinstein diffusion coefficient of the effusion. Eustachian tube dysfunction can cause fluid to collect within the middle ear cavity ...
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    14. Intraoperative optical coherence tomography for assessing human lymph nodes for metastatic cancer

      Intraoperative optical coherence tomography for assessing human lymph nodes for metastatic cancer
      Background Evaluation of lymph node (LN) status is an important factor for detecting metastasis and thereby staging breast cancer. Currently utilized clinical techniques involve the surgical disruption and resection of lymphatic structure, whether nodes or axillary contents, for histological examination. While reasonably effective at detection of macrometastasis , the majority of the resected lymph nodes are histologically negative. Improvements need to be made to better detect micrometastasis , minimize or eliminate lymphatic ...
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  2. About Guillermo L. Monroy

    Guillermo L. Monroy

    Guillermo L. Monroy is currently a Graduate Research Fellow (Ph.D. candidate) in the Biophotonics Imaging Laboratory, working under the guidance of Professor Stephen Boppart. He received his B.S. in Computer Engineering in 2011, and continued for his M.S. in Bioengineering in 2013 from University of Illinois at Urbana-Champaign. His current interests include the integration of advanced biomedical instrumentation and imaging techniques to improve diagnosis and treatment in healthcare.