1. Guillermo J. Tearney

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    1. Mentioned In 255 Articles

    2. Postdoctoral Research Fellowships in Optical Coherence Tomography at The Tearney Lab at the Wellman Center for Photomedicine at the Massachusetts General Hospital Boston, MA USA

      Postdoctoral Research Fellowships in Optical Coherence Tomography at The Tearney Lab at the Wellman Center for Photomedicine at the Massachusetts General Hospital Boston, MA USA
      ...cific areas of interest and contact information for three letters of reference. Address correspondence to Dr. Gary Tearney, note the position you are applying for in the subject line, and send by email to Princess Cruz a...
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    3. Postdoctoral Research Fellowship Opening in In Vivo Microscopy at the Wellman Center for Photomedicine at the Massachusetts General Hospital, Boston USA

      Postdoctoral Research Fellowship Opening in In Vivo Microscopy at the Wellman Center for Photomedicine at the Massachusetts General Hospital, Boston USA
      ...cific areas of interest and contact information for three letters of reference. Address correspondence to Dr. Gary Tearney, note the position you are applying for in the subject line, and send by email to Princess Cruz a...
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    4. Pilot Study for OCT Guided In Vivo Laser Capture Microdissection for Assessing the Prognosis of Barrett's Esophagus

      Pilot Study for OCT Guided In Vivo Laser Capture Microdissection for Assessing the Prognosis of Barrett's Esophagus
      The investigators have developed a new technology, termed in-vivo laser capture microdissection (IVLCM), that addresses the limitations of endoscopic biopsy for screening for BE and provides targeted genomic profiling of aberrant tissue for more precise prediction of EAC risk. The device is a tethered capsule endomicroscope (TCE) that implements optical coherence tomography (OCT) to grab 10-mm-resolution, cross-sectional microscopic images of the entire esophagus after the capsule is swallowed. This OCT-based ...
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    5. Beth Israel Deaconess Medical Center Receives NIH Grant for Intravascular Molecular-Structural Imaging of Coronary Stent Pathobiology

      Beth Israel Deaconess Medical Center Receives NIH Grant for Intravascular Molecular-Structural Imaging of Coronary Stent Pathobiology
      ...ors that are leaders in engineering, optical imaging, vascular biology, and coronary stent design — Dr. Gary Tearney (MGH), Dr. Peter Libby (Brigham and Women's Hospital), and Dr. Elazer Edelman (Massachusetts Inst...
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    6. Measuring Barrett’s Epithelial Thickness with Volumetric Laser Endomicroscopy as a Biomarker to Guide Treatment

      Measuring Barrett’s Epithelial Thickness with Volumetric Laser Endomicroscopy as a Biomarker to Guide Treatment
      Background Radiofrequency ablation (RFA) treatment outcomes vary for unknown reasons. One hypothesis is that variations in Barretts epithelial thickness (BET) are associated with reduced RFA efficacy for thicker BET and strictures for thinner BET. Volumetric laser endomicroscopy (VLE) is an imaging modality that acquires high-resolution, depth-resolved images of BE. However, the attenuation of light by tissue and the lack of layering in Barretts tissue challenge BET measurements and the study ...
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    7. MGH Receives NIH Grant for Unique Value of Real-TIme Shear Stress to Enhance Coronary Disease Management.

      MGH Receives NIH Grant for Unique Value of Real-TIme Shear Stress to Enhance Coronary Disease Management.
      ... Unique Value of Real-TIme Shear Stress to Enhance Coronary Disease Management. The principal investigator is Guillermo Tearney. The program began in 2018 and ends in 2020. Below is a summary of the proposed work. Manag...
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    8. Imaging the Human Prostate Gland Using 1-μm-Resolution Optical Coherence Tomography

      Imaging the Human Prostate Gland Using 1-μm-Resolution Optical Coherence Tomography
      Context. The accuracy of needle biopsy for the detection of prostate cancer is limited by well-known sampling errors. Thus, there is an unmet need for a microscopic screening tool that can screen large regions of the prostate comprehensively for cancer. Previous prostate imaging by optical coherence tomography (OCT) have had insufficient resolution for imaging cellular features related to prostate cancer. We have recently developed micro-optical coherence tomography (OCT) that generates ...
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    9. In Vivo and Ex Vivo Microscopy: Moving Toward the Integration of Optical Imaging Technologies Into Pathology Practice

      In Vivo and Ex Vivo Microscopy: Moving Toward the Integration of Optical Imaging Technologies Into Pathology Practice
      The traditional surgical pathology assessment requires tissue to be removed from the patient, then processed, sectioned, stained, and interpreted by a pathologist using a light microscope. Today, an array of alternate optical imaging technologies allow tissue to be viewed at high resolution, in real time, without the need for processing, fixation, freezing, or staining. Optical imaging can be done in living patients without tissue removal, termed in vivo microscopy, or ...
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    10. Postdoctoral Research Fellowships (Optical Coherence Tomography) The Tearney Lab at the Wellman Center for Photomedicine

      Postdoctoral Research Fellowships (Optical Coherence Tomography) The Tearney Lab at the Wellman Center for Photomedicine
      ...cific areas of interest and contact information for three letters of reference. Address correspondence to Dr. Gary Tearney, note the position you are applying for in the subject line, and send by email to Valerie Madden ...
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    11. Intravascular optical coherence tomography

      Intravascular optical coherence tomography
      Intravascular optical coherence tomography (IVOCT) began at MIT in the early 1990s with the recognition that OCT could be used for clinical applications other than ophthalmology. Initial steps made there towards IVOCT feasibility included the acquisition of cadaver arterial images demonstrating the capacity of OCT to visualize depth-resolved architectural detail of plaque 5 and the development of the first mechanical scanning catheter. 6 Early histopathologic correlation studies from cadaver arteries ...
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    12. NinePoint Medical Appoints Eman Namati, Ph.D., to Chief Executive Officer

      NinePoint Medical Appoints Eman Namati, Ph.D., to Chief Executive Officer
      ... a researcher developing optical imaging systems at Massachusetts General Hospital. He worked with Professors Guillermo Tearney, M.D., Ph.D., and Brett Bouma, Ph.D. on the OCT technology that was licensed to NinePoint Me...
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    13. Apparatus and method for providing diffuse spectroscopy co-registered with optical frequency domain imaging

      Apparatus and method for providing diffuse spectroscopy co-registered with optical frequency domain imaging
      An apparatus can be provided according to certain exemplary embodiments. For example, the apparatus can include a waveguiding first arrangement providing at least one electromagnetic radiation. A configuration can be provided that receives and splits the at least one electromagnetic radiation into a first radiation and a second radiation. The apparatus can further include a waveguiding second arrangement which has a first waveguide and a second waveguide, whereas the first ...
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    14. Visualizing cellular markers of sensorineural hearing loss in the murine cochlea using micro-optical coherence tomography

      Visualizing cellular markers of sensorineural hearing loss in the murine cochlea using micro-optical coherence tomography
      Although sensorineural hearing loss (SNHL) affects 600 million people globally and its prevalence is increasing, therapies remain limited. Advances in therapy development for SNHL are slow because we do not possess a method for visualizing the cochleas interior in living humans and relating visualized pathology to a patients hearing ability. To this end, we are investigating the ability of micro-optical coherence tomography (OCT), a low-coherence interferometric imaging technique that requires ...
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    15. 16-30 of 255 « 1 2 3 4 5 ... 15 16 17 »
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  2. About Guillermo J. Tearney

    Guillermo J. Tearney

    Guillermo Tearney M.D., Ph.D. is Professor of Pathology at Harvard Medical School, an Affiliated Faculty member of the Harvard-MIT Division of Health Sciences and Technology (HST), and the Associate Director of the Wellman Center for Photomedicine at the Massachusetts Genera lHospital. Dr. Tearney received his MD magna cum laude from Harvard Medical School and received his PhD in Electrical Engineering and Computer Science from the Massachusetts Institute of Technology.

     

    Dr. Tearney’s research interests are focused on the development and clinical validation of non-invasive, high-resolution optical imaging methods for disease diagnosis. Dr. Tearney's lab was the first to perform human imaging in the coronary arteries and gastrointestinal tract in vivo with Optical Coherence Tomography (OCT), which provides cross-sectional images of tissue architectural microstructure at a resolution of 10 μm. He has also conducted many of the seminal studies validating OCT and is considered an expert on OCT image interpretation. Recently, Dr. Tearney's lab has invented a next generation OCT technology, termed μOCT, which has a resolution of 1 μm and is capable of imaging cells and sub cellular structures in the coronary wall. Dr. Tearney has also developed several other technologies, including a confocal endomicroscope capable of imaging the entire esophagus, an ultraminiature three-dimensional endoscope, a highly efficient form of near field scanning optical microscopy (NSOM), and novel fluorescence spectroscopy and multimodality imaging techniques. He has an active program in Raman spectroscopy and has conducted the first intracoronary Raman in vivo. Dr. Tearney is co-editor of The Handbook of Optical Coherence Tomorgraphy and has written over 170 peer-reviewed publications, including papers that have been highlighted on the covers of Science, Nature Medicine, Circulation, Gastroenterology, and Journal of American College of Cardiology.

     

    Dr. Tearney’s work extends beyond his laboratory at MGH, many of his technologies are being produced commercially and he has founded the International Working Group on Intracoronary OCT Standardization and Validation, a group that is dedicated to establishing standards to ensure the widespread adoption of this imaging technology

  3. Quotes

    1. We’ve done a lot of benchtop imaging with micro-OCT, but this is the first time we’ve been able to use it in people...It’s unprecedented to see this pathophysiology dynamically in living patients. It will allow us to begin to understand things we never even knew were there.
      In Innovative tool gives researchers new look at the nasal airway in CF patients
    2. Coronary imaging has rapidly evolved over the past decade and has become an important part of the practice of diagnostic and interventional cardiology...I’m looking forward to once again collaborating with Infraredx who pioneered the development of the only FDA-cleared dual-modality NIRS-IVUS device which is playing a vital role in furthering our understanding of the vulnerable plaque and its correlation to future coronary events. Our partnership will focus on ways to harness the collective value of current imaging modalities in order to provide clinicians with more comprehensive information on the coronary vasculature to help guide treatment decisions.
      In Infraredx Announces Research Collaboration with Massachusetts General Hospital to Explore New Generation of Cardiovascular Imaging Devices
    3. With our procedure, instead you swallow a capsule. And that capsule captures these microscopic images while you are in the living person. Without taking the tissue out. Not only that but it gathers the microscopic images of the entire esophagus, not just one little spot. So we get a much better understanding and a much better picture of the detailed structure of the esophagus and we are able to get a much better diagnoses.
      In Cancer detection as easy as popping a pill (video)
    4. The images produced have been some of the best we have seen of the esophagus...We originally were concerned that we might miss a lot of data because of the small size of the capsule; but we were surprised to find that, once the pill has been swallowed, it is firmly ‘grasped’ by the esophagus, allowing complete microscopic imaging of the entire wall. Other methods we have tried can compress the esophageal lining, making it difficult to obtain accurate, three-dimensional pictures. The capsule device provides additional key diagnostic information by making it possible to see the surface structure in greater detail.
      In Pill-sized device rivals endoscopy: Novel imaging system screens for Barrett’s esophagus in minutes
    5. OFDI imaging with laser marking has the potential to improve the diagnostic paradigm for patients suspected of having Barrett's esophagus, one of the most common precursors to esophageal cancer... There is a large and growing unmet need to improve the gastroenterologist's ability to detect, diagnose and make critical treatment decisions for patients with Barrett's esophagus, and this technological advancement may significantly improve this paradigm. Provided these results can be confirmed in an ongoing, larger study, OFDI-based guided biopsy may soon be able to help clinicians make more precise and rapid diagnoses while taking fewer, but more targeted, biopsies allowing patients to receive more tailored management for diseases like Barrett's esophagus.
      In NinePoint Medical Announces New Data Presented on Innovative Optical Frequency Domain Imaging Technology at 19th UEGW Meeting
    6. MicroOCT has the contrast and resolution required to investigate the cellular and subcellular components underlying coronary atherosclerosis, the disease that precipitates heart attack...This high level of performance opens up the future possibility of observing these microscopic features in human patients, which has implications for improving the understanding, diagnosis, and therapeutic monitoring of coronary artery disease.
      In A closer look at atherosclerosis: High-res imaging reveals cellular details of coronary arteries
    7. High quality images provided by optical frequency domain imaging – or OFDI – may one day enable physicians to implement routine, less invasive screening procedures for high-risk patients...The ability to perform accurate diagnoses for conditions like Barrett’s esophagus could also provide significant improvements over random biopsies that are currently the standard of care for patients at risk for developing esophageal cancer.
      In NinePoint Medical Licenses 188 Patents and Patent Applications from Massachusetts General Hospital
    8. These results are comparable to what is seen with drug eluting stents in terms of thickness--we did not see a significant hyperplastic injury response.
      In vProtect(TM) Luminal Shield Stabilizes Vulnerable Plaque
    9. The wealth of information that we can now obtain will undoubtedly improve our ability to understand coronary artery disease and may allow cardiologists to diagnose and treat plaque before it leads to serious problems.
      In America wakes up to 3-D human coronary artery imaging