1. Guillermo J. Tearney

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    1. Mentioned In 255 Articles

    2. Statistical Properties of Phase-Decorrelation in Phase-Resolved Doppler Optical Coherence Tomography

      Decorrelation noise limits the ability of phase-resolved Doppler optical coherence tomography systems to detect smaller vessels exhibiting slower flow velocities, which limits the utility of the technique in many clinical and biological settings. An understanding of the statistical properties of decorrelation noise can aid in the optimal design of these systems and guide the development of noise mitigating strategies. In this work, the statistical properties of decorrelation noise are derived ...
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    3. OCT-guided laser therapy shows promise

      OCT-guided laser therapy shows promise
      Advances in optical-coherence tomography may lead to a new class of endoscopic, image-guided therapies that target disease with microscopic precision. Nearly 15 years of technical innovation, robust engineering, and cross-disciplinary collaboration have advanced endoscopic optical-coherence tomography1 (OCT) from a promising laboratory tool to clinically deployed instrumentation. The latest OCT technologies are being studied at research hospitals throughout the world for applications such as heart disease and cancer.2 One of ...
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    4. Intravascular optical coherence tomography: Cellular imaging

      Abstract  The vast majority of acute coronary events are attributed to rupture or erosion of high-risk or vulnerable plaques. Novelv imaging techniques are being actively sought that can detect quiescent vulnerable features within coronary plaque and thereby identify populations at risk, monitor plaque progression, and target therapy appropriately. Optical coherence tomography is an intravascular imaging modality capable of detecting and characterizing coronary plaque in vivo. Recently, optical coherence tomography quantification ...
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    5. Distance From the Coronary Ostium as a Predictor of Vulnerable Plaque Morphology; An In-vivo Optical Coherence Tomography Study

      Distance From the Coronary Ostium as a Predictor of Vulnerable Plaque Morphology; An In-vivo Optical Coherence Tomography Study
      Background: Plaque morphology predicts its vulnerability to cause acute coronary events; most of which occur due to disruption of lipid-rich thin-cap fibroatheroma (TCFA). Observational studies show that lesions causing acute events are clustered in the proximal coronary artery segments. Aim: To evaluate whether the location of plaque in the coronary vessel is predictive of vulnerable plaque morphology identified by optical coherence tomography (OCT). Methods: OCT was performed in patients undergoing ...
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    6. Imaging system and related techniques

      BACKGROUND OF THE INVENTION As is known in the art, fiber optic endoscopy is typically conducted by transmitting an image through an array of fibers often referred to as a fiber bundle. While successful for a variety of medical and non-medical applications, utilization of an array of fibers to form the image imposes constraints on the cost, diameter, and flexibility of the imaging device. In an attempt to overcome these ...
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    7. Application of maximum likelihood estimator in nano-scale optical path length measurement using spectral-domain optical coherence phase microscopy

      ...aging systems * (180.3170) Microscopy : Interference microscopy Citation S. M. Motaghian Nezam, C. Joo, G. J. Tearney, and J. F. de Boer, "Application of maximum likelihood estimator in nano-scale optical path leng...
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    8. Comprehensive microscopy of the esophagus in human patients with optical frequency domain imaging

      Comprehensive microscopy of the esophagus in human patients with optical frequency domain imaging
      ...n Shishkov, PhD, Gregory Y. Lauwers, MD, Mari Mino-Kenudson, MD, Brett E. Bouma, PhD, Norman S. Nishioka, MD, Guillermo J. Tearney, MD, PhD Corresponding Author Information Received 25 February 2008; accepted 5 May 2008....
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    9. Apparatus for controlling at least one of at least two sections of at least one fiber

      An apparatus for controlling at least one of at least two sections of at least one fiber can be provided. The apparatus can include an arrangement which may be provided between the first and second sections of a particular continuous fiber of the fibers. A particular one of the first and second sections may be provided in a particular orientation that is perpendicular to an extension of the particular fiber ...
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    10. Comparison of coronary plaque characteristics between diabetic and non-diabetic subjects: An in vivo optical coherence tomography study

      Aims Postmortem series have reported that subjects with diabetes mellitus have coronary plaques with larger necrotic cores and increased macrophage infiltration. Optical coherence tomography (OCT) is a high-resolution imaging modality that allows in vivo characterization of atherosclerotic plaques. Using OCT imaging, we compared in vivo plaque characteristics between diabetic and non-diabetic subjects. Methods Sixty-three patients undergoing cardiac catheterization were enrolled. OCT imaging was performed in culprit coronary arteries. Assessment of ...
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    11. Apparatus And Method For Simultaneous Inspection At Different Depths Based On The Principle Of Frequency Domain Optical Coherence Tomography (Wo 2008/089406)

      Apparatus And Method For Simultaneous Inspection At Different Depths Based On The Principle Of Frequency Domain Optical Coherence Tomography (Wo 2008/089406)
      Exemplary embodiments of an apparatus are provided. For example, the exemplary apparatus can include at least one first arrangement providing at least one first electro- magnetic radiation to a sample, at least one second electro-magnetic radiation to a first reference and at least one third electro-magnetic radiation to a second reference. A frequency of radiation provided by the first arrangement generally varies over time. The exemplary apparatus may also include ...
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    12. In vivo association between positive coronary artery remodelling and coronary plaque characteristics assessed by intravascular optical coherence tomography

      Aims: Positive coronary arterial remodelling has been shown to be associated with unstable coronary syndromes and ex vivo histological characteristics of plaque vulnerability such as a large lipid core and high macrophage content. The aim of this study is to evaluate the in vivo association between coronary artery remodelling and underlying plaque characteristics identified by optical coherence tomography (OCT). OCT is a unique imaging modality capable of characterizing these important ...
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  2. About Guillermo J. Tearney

    Guillermo J. Tearney

    Guillermo Tearney M.D., Ph.D. is Professor of Pathology at Harvard Medical School, an Affiliated Faculty member of the Harvard-MIT Division of Health Sciences and Technology (HST), and the Associate Director of the Wellman Center for Photomedicine at the Massachusetts Genera lHospital. Dr. Tearney received his MD magna cum laude from Harvard Medical School and received his PhD in Electrical Engineering and Computer Science from the Massachusetts Institute of Technology.


    Dr. Tearney’s research interests are focused on the development and clinical validation of non-invasive, high-resolution optical imaging methods for disease diagnosis. Dr. Tearney's lab was the first to perform human imaging in the coronary arteries and gastrointestinal tract in vivo with Optical Coherence Tomography (OCT), which provides cross-sectional images of tissue architectural microstructure at a resolution of 10 μm. He has also conducted many of the seminal studies validating OCT and is considered an expert on OCT image interpretation. Recently, Dr. Tearney's lab has invented a next generation OCT technology, termed μOCT, which has a resolution of 1 μm and is capable of imaging cells and sub cellular structures in the coronary wall. Dr. Tearney has also developed several other technologies, including a confocal endomicroscope capable of imaging the entire esophagus, an ultraminiature three-dimensional endoscope, a highly efficient form of near field scanning optical microscopy (NSOM), and novel fluorescence spectroscopy and multimodality imaging techniques. He has an active program in Raman spectroscopy and has conducted the first intracoronary Raman in vivo. Dr. Tearney is co-editor of The Handbook of Optical Coherence Tomorgraphy and has written over 170 peer-reviewed publications, including papers that have been highlighted on the covers of Science, Nature Medicine, Circulation, Gastroenterology, and Journal of American College of Cardiology.


    Dr. Tearney’s work extends beyond his laboratory at MGH, many of his technologies are being produced commercially and he has founded the International Working Group on Intracoronary OCT Standardization and Validation, a group that is dedicated to establishing standards to ensure the widespread adoption of this imaging technology


    1. We’ve done a lot of benchtop imaging with micro-OCT, but this is the first time we’ve been able to use it in people...It’s unprecedented to see this pathophysiology dynamically in living patients. It will allow us to begin to understand things we never even knew were there.
      In Innovative tool gives researchers new look at the nasal airway in CF patients
    2. Coronary imaging has rapidly evolved over the past decade and has become an important part of the practice of diagnostic and interventional cardiology...I’m looking forward to once again collaborating with Infraredx who pioneered the development of the only FDA-cleared dual-modality NIRS-IVUS device which is playing a vital role in furthering our understanding of the vulnerable plaque and its correlation to future coronary events. Our partnership will focus on ways to harness the collective value of current imaging modalities in order to provide clinicians with more comprehensive information on the coronary vasculature to help guide treatment decisions.
      In Infraredx Announces Research Collaboration with Massachusetts General Hospital to Explore New Generation of Cardiovascular Imaging Devices
    3. With our procedure, instead you swallow a capsule. And that capsule captures these microscopic images while you are in the living person. Without taking the tissue out. Not only that but it gathers the microscopic images of the entire esophagus, not just one little spot. So we get a much better understanding and a much better picture of the detailed structure of the esophagus and we are able to get a much better diagnoses.
      In Cancer detection as easy as popping a pill (video)
    4. The images produced have been some of the best we have seen of the esophagus...We originally were concerned that we might miss a lot of data because of the small size of the capsule; but we were surprised to find that, once the pill has been swallowed, it is firmly ‘grasped’ by the esophagus, allowing complete microscopic imaging of the entire wall. Other methods we have tried can compress the esophageal lining, making it difficult to obtain accurate, three-dimensional pictures. The capsule device provides additional key diagnostic information by making it possible to see the surface structure in greater detail.
      In Pill-sized device rivals endoscopy: Novel imaging system screens for Barrett’s esophagus in minutes
    5. OFDI imaging with laser marking has the potential to improve the diagnostic paradigm for patients suspected of having Barrett's esophagus, one of the most common precursors to esophageal cancer... There is a large and growing unmet need to improve the gastroenterologist's ability to detect, diagnose and make critical treatment decisions for patients with Barrett's esophagus, and this technological advancement may significantly improve this paradigm. Provided these results can be confirmed in an ongoing, larger study, OFDI-based guided biopsy may soon be able to help clinicians make more precise and rapid diagnoses while taking fewer, but more targeted, biopsies allowing patients to receive more tailored management for diseases like Barrett's esophagus.
      In NinePoint Medical Announces New Data Presented on Innovative Optical Frequency Domain Imaging Technology at 19th UEGW Meeting
    6. MicroOCT has the contrast and resolution required to investigate the cellular and subcellular components underlying coronary atherosclerosis, the disease that precipitates heart attack...This high level of performance opens up the future possibility of observing these microscopic features in human patients, which has implications for improving the understanding, diagnosis, and therapeutic monitoring of coronary artery disease.
      In A closer look at atherosclerosis: High-res imaging reveals cellular details of coronary arteries
    7. High quality images provided by optical frequency domain imaging – or OFDI – may one day enable physicians to implement routine, less invasive screening procedures for high-risk patients...The ability to perform accurate diagnoses for conditions like Barrett’s esophagus could also provide significant improvements over random biopsies that are currently the standard of care for patients at risk for developing esophageal cancer.
      In NinePoint Medical Licenses 188 Patents and Patent Applications from Massachusetts General Hospital
    8. These results are comparable to what is seen with drug eluting stents in terms of thickness--we did not see a significant hyperplastic injury response.
      In vProtect(TM) Luminal Shield Stabilizes Vulnerable Plaque
    9. The wealth of information that we can now obtain will undoubtedly improve our ability to understand coronary artery disease and may allow cardiologists to diagnose and treat plaque before it leads to serious problems.
      In America wakes up to 3-D human coronary artery imaging