1. Guillermo J. Tearney

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    1. Mentioned In 219 Articles

    2. Estimation and compensation of dispersion for high-resolution optical coherence tomography system

      Estimation and compensation of dispersion for high-resolution optical coherence tomography system
      Balanced reference-sample arm dispersion is critical in optical coherence tomography systems in order to attain images with the highest axial resolution. Here, an experimental method for the estimation and correction of dispersion in an optical coherence tomography system is presented. The system dispersion was computed from two optical coherence tomography images of the reference mirror that were symmetrically placed around the zero delay point. The method was tested using a ...
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    3. Postdoctoral Research Fellowships in In Vivo Microscopy at the Wellman Center for Photomedicine, Massachusetts General Hospital Boston, MA USA

      Postdoctoral Research Fellowships in In Vivo Microscopy at the Wellman Center for Photomedicine, Massachusetts General Hospital Boston, MA USA
      ...ific areas of interest and contact information for three letters of reference.. Address correspondence to Dr. Gary Tearney, note the position you are applying for in the subject line, and send by email to Princess Cruz a...
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    4. Postdoctoral Research Fellowships in Optical Coherence Tomography at the Wellman Center for Photomedicine Massachusetts General Hospital Boston, MA USA

      Postdoctoral Research Fellowships  in Optical Coherence Tomography at the Wellman Center for Photomedicine Massachusetts General Hospital Boston, MA USA
      ...ific areas of interest and contact information for three letters of reference.. Address correspondence to Dr. Gary Tearney, note the position you are applying for in the subject line, and send by email to Princess Cruz a...
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    5. In-line optical fiber metallic mirror reflector for monolithic common path optical coherence tomography probes

      In-line optical fiber metallic mirror reflector for monolithic common path optical coherence tomography probes
      Background and Objectives Endoscopic optical coherence tomography probes suffer from various artifacts due to dispersion imbalance and polarization mismatch between reference and sample arm light. Such artifacts can be minimized using a common path approach. In this work, we demonstrate a miniaturized common path probe for optical coherence tomography using an inline fiber mirror. Materials and Methods A common path optical fiber probe suitable for performing high-resolution endoscopic optical coherence ...
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    6. Apparatus, systems, methods and computer-accessible medium for spectral analysis of optical coherence tomography images

      Apparatus, systems, methods and computer-accessible medium for spectral analysis of optical coherence tomography images
      According to an exemplary embodiment of the present disclosure, apparatus and method can be provided for generating information for at least one structure. For example, using at least one first arrangement, it is possible to receive at least one first radiation from the at least one structure and at least one second radiation from a reference, and interfere the first and second radiations to generate at least one third radiation ...
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    7. Postdoctoral Research Fellowship in Optical Coherence Tomography at Massachusetts General Hospital

      Postdoctoral Research Fellowship in Optical Coherence Tomography at Massachusetts General Hospital
      Employer Description The Wellman Center is driven by a focus on solving medical problems. We have assembled a multi-disciplinary faculty with expertise in the biological, physical and clinical sciences. By cultivating inter-disciplinary collaboration, we strive to span the research spectrum from basic biological studies through the development and testing of novel diagnostic and treatment technologies to their integration into mainstream clinical practice. Job Description A Postdoctoral research fellowship in the ...
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    8. Extended depth of focus for coherence-based cellular imaging

      Extended depth of focus for coherence-based cellular imaging
      Improving lateral resolution for cross-sectional optical coherence tomography (OCT) imaging is difficult due to the rapid divergence of light once it is focused to a small spot. To overcome this obstacle, we introduce a fiber optics system that generates a coaxially focused multimode (CAFM) beam for depth of focus (DOF) extension. We fabricated a CAFM beam OCT probe and show that the DOF is more than fivefold that of a ...
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    9. Assessment of acquired mucociliary clearance defects using micro-optical coherence tomography

      Assessment of acquired mucociliary clearance defects using micro-optical coherence tomography
      Background Dehydration of airway surface liquid (ASL) disrupts normal mucociliary clearance (MCC) in sinonasal epithelium, which may lead to chronic rhinosinusitis (CRS). Abnormal chloride (Cl ) transport is one such mechanism that contributes to this disorder and can be acquired secondary to environmental perturbations, such as hypoxia at the tissue surface. The objective of this study was to assess the technological feasibility of the novel micro-optical coherence tomography (OCT) imaging technique ...
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    10. Methods and systems for performing angle-resolved Fourier-domain optical coherence tomography

      Methods and systems for performing angle-resolved Fourier-domain optical coherence tomography
      Arrangements, apparatus and methods are provided according to exemplary embodiments of the present invention. In particular, at least one first electro-magnetic radiation may be received and at least one second electro-magnetic radiation within a solid angle may be forwarded to a sample. The second electro-magnetic radiation may be associated with the first electro-magnetic radiation. A plurality of third electro-magnetic radiations can be received from the sample which is associated with ...
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    11. Imaging system, method and distal attachment for multidirectional field of view endoscopy

      Imaging system, method and distal attachment for multidirectional field of view endoscopy
      An exemplary apparatus for imaging at least one anatomical structure can be provided. For example, the apparatus can include an endoscopic first arrangement, a radiation source second arrangement which provides at least one electro-magnetic radiation, and a third arrangement attached to at least one portion of the endoscopic arrangement. The third arrangement can contain an optical arrangement which, upon impact by the at least one electro-magnetic radiation and based thereon ...
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    12. Endoscopic biopsy apparatus, system and method

      Endoscopic biopsy apparatus, system and method
      Exemplary embodiments of apparatus, method and system for determining a position on or in a biological tissue can be provided. For example, using such exemplary embodiment, it is possible to control the focus of an optical imaging probe. In another exemplary embodiment, it is possible to implement a marking apparatus together with or into an optical imaging probe. According to one exemplary embodiment, it is possible (using one or more ...
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    13. Illuminating dynamic neutrophil trans-epithelial migration with micro-optical coherence tomography

      Illuminating dynamic neutrophil trans-epithelial migration with micro-optical coherence tomography
      A model of neutrophil migration across epithelia is desirable to interrogate the underlying mechanisms of neutrophilic breach of mucosal barriers. A co-culture system consisting of a polarized mucosal epithelium and human neutrophils can provide a versatile model of trans-epithelial migration in vitro , but observations are typically limited to quantification of migrated neutrophils by myeloperoxidase correlation, a destructive assay that precludes direct longitudinal study. Our laboratory has recently developed a new ...
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    14. Assessment of ciliary phenotype in primary ciliary dyskinesia by micro-optical coherence tomography

      Assessment of ciliary phenotype in primary ciliary dyskinesia by micro-optical coherence tomography
      Ciliary motion defects cause defective mucociliary transport (MCT) in primary ciliary dyskinesia (PCD). Current diagnostic tests do not assess how MCT is affected by perturbation of ciliary motion. In this study, we sought to use micro-optical coherence tomography (OCT) to delineate the mechanistic basis of cilia motion defects of PCD genes by functional categorization of cilia motion. Tracheae from three PCD mouse models were analyzed using OCT to characterize ciliary ...
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    15. Postdoctoral Research Fellowships in Optical Coherence Tomography at Massachusetts General Hosptial

      Postdoctoral Research Fellowships in Optical Coherence Tomography at Massachusetts General Hosptial
      ...cific areas of interest and contact information for three letters of reference. Address correspondence to Dr. Gary Tearney, note the position you are applying for in the subject line, and send by email to Valerie Madden ...
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    16. Flexible, high-resolution micro-optical coherence tomography endobronchial probe toward in vivo imaging of cilia

      Flexible, high-resolution micro-optical coherence tomography endobronchial probe toward in vivo imaging of cilia
      We report the design and fabrication of a flexible, longitudinally scanning high-resolution micro-optical coherence tomography (OCT) endobronchial probe, optimized for micro-anatomical imaging in airways. The 2.4 mm diameter and flexibility of the probe allows it to be inserted into the instrument channel of a standard bronchoscope, enabling real-time video guidance of probe placement. To generate a depth-of-focus enhancing annular beam, we utilized a new fabrication method, whereby a hollow ...
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  2. About Guillermo J. Tearney

    Guillermo J. Tearney

    Guillermo Tearney M.D., Ph.D. is Professor of Pathology at Harvard Medical School, an Affiliated Faculty member of the Harvard-MIT Division of Health Sciences and Technology (HST), and the Associate Director of the Wellman Center for Photomedicine at the Massachusetts Genera lHospital. Dr. Tearney received his MD magna cum laude from Harvard Medical School and received his PhD in Electrical Engineering and Computer Science from the Massachusetts Institute of Technology.

     

    Dr. Tearney’s research interests are focused on the development and clinical validation of non-invasive, high-resolution optical imaging methods for disease diagnosis. Dr. Tearney's lab was the first to perform human imaging in the coronary arteries and gastrointestinal tract in vivo with Optical Coherence Tomography (OCT), which provides cross-sectional images of tissue architectural microstructure at a resolution of 10 μm. He has also conducted many of the seminal studies validating OCT and is considered an expert on OCT image interpretation. Recently, Dr. Tearney's lab has invented a next generation OCT technology, termed μOCT, which has a resolution of 1 μm and is capable of imaging cells and sub cellular structures in the coronary wall. Dr. Tearney has also developed several other technologies, including a confocal endomicroscope capable of imaging the entire esophagus, an ultraminiature three-dimensional endoscope, a highly efficient form of near field scanning optical microscopy (NSOM), and novel fluorescence spectroscopy and multimodality imaging techniques. He has an active program in Raman spectroscopy and has conducted the first intracoronary Raman in vivo. Dr. Tearney is co-editor of The Handbook of Optical Coherence Tomorgraphy and has written over 170 peer-reviewed publications, including papers that have been highlighted on the covers of Science, Nature Medicine, Circulation, Gastroenterology, and Journal of American College of Cardiology.

     

    Dr. Tearney’s work extends beyond his laboratory at MGH, many of his technologies are being produced commercially and he has founded the International Working Group on Intracoronary OCT Standardization and Validation, a group that is dedicated to establishing standards to ensure the widespread adoption of this imaging technology

  3. Quotes

    1. Coronary imaging has rapidly evolved over the past decade and has become an important part of the practice of diagnostic and interventional cardiology...I’m looking forward to once again collaborating with Infraredx who pioneered the development of the only FDA-cleared dual-modality NIRS-IVUS device which is playing a vital role in furthering our understanding of the vulnerable plaque and its correlation to future coronary events. Our partnership will focus on ways to harness the collective value of current imaging modalities in order to provide clinicians with more comprehensive information on the coronary vasculature to help guide treatment decisions.
      In Infraredx Announces Research Collaboration with Massachusetts General Hospital to Explore New Generation of Cardiovascular Imaging Devices
    2. With our procedure, instead you swallow a capsule. And that capsule captures these microscopic images while you are in the living person. Without taking the tissue out. Not only that but it gathers the microscopic images of the entire esophagus, not just one little spot. So we get a much better understanding and a much better picture of the detailed structure of the esophagus and we are able to get a much better diagnoses.
      In Cancer detection as easy as popping a pill (video)
    3. The images produced have been some of the best we have seen of the esophagus...We originally were concerned that we might miss a lot of data because of the small size of the capsule; but we were surprised to find that, once the pill has been swallowed, it is firmly ‘grasped’ by the esophagus, allowing complete microscopic imaging of the entire wall. Other methods we have tried can compress the esophageal lining, making it difficult to obtain accurate, three-dimensional pictures. The capsule device provides additional key diagnostic information by making it possible to see the surface structure in greater detail.
      In Pill-sized device rivals endoscopy: Novel imaging system screens for Barrett’s esophagus in minutes
    4. OFDI imaging with laser marking has the potential to improve the diagnostic paradigm for patients suspected of having Barrett's esophagus, one of the most common precursors to esophageal cancer... There is a large and growing unmet need to improve the gastroenterologist's ability to detect, diagnose and make critical treatment decisions for patients with Barrett's esophagus, and this technological advancement may significantly improve this paradigm. Provided these results can be confirmed in an ongoing, larger study, OFDI-based guided biopsy may soon be able to help clinicians make more precise and rapid diagnoses while taking fewer, but more targeted, biopsies allowing patients to receive more tailored management for diseases like Barrett's esophagus.
      In NinePoint Medical Announces New Data Presented on Innovative Optical Frequency Domain Imaging Technology at 19th UEGW Meeting
    5. MicroOCT has the contrast and resolution required to investigate the cellular and subcellular components underlying coronary atherosclerosis, the disease that precipitates heart attack...This high level of performance opens up the future possibility of observing these microscopic features in human patients, which has implications for improving the understanding, diagnosis, and therapeutic monitoring of coronary artery disease.
      In A closer look at atherosclerosis: High-res imaging reveals cellular details of coronary arteries
    6. High quality images provided by optical frequency domain imaging – or OFDI – may one day enable physicians to implement routine, less invasive screening procedures for high-risk patients...The ability to perform accurate diagnoses for conditions like Barrett’s esophagus could also provide significant improvements over random biopsies that are currently the standard of care for patients at risk for developing esophageal cancer.
      In NinePoint Medical Licenses 188 Patents and Patent Applications from Massachusetts General Hospital
    7. These results are comparable to what is seen with drug eluting stents in terms of thickness--we did not see a significant hyperplastic injury response.
      In vProtect(TM) Luminal Shield Stabilizes Vulnerable Plaque
    8. The wealth of information that we can now obtain will undoubtedly improve our ability to understand coronary artery disease and may allow cardiologists to diagnose and treat plaque before it leads to serious problems.
      In America wakes up to 3-D human coronary artery imaging