1. Guillermo J. Tearney

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    1. Mentioned In 146 Articles

    2. Postdoctoral Research Fellowships in Optical Coherence Tomography at Wellman Center for Photomedicine Massachusetts General Hospital

      Postdoctoral Research Fellowships in Optical Coherence Tomography at Wellman Center for Photomedicine Massachusetts General Hospital
      ...ific areas of interest and contact information for three letters of reference.. Address correspondence to Dr. Gary Tearney, note the position you are applying for in the subject line, and send by email to Princess Cruz a...
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    3. Esophageal-guided biopsy with volumetric laser endomicroscopy and laser cautery marking: a pilot clinical study

      Esophageal-guided biopsy with volumetric laser endomicroscopy and laser cautery marking: a pilot clinical study

      Background Biopsy surveillance protocols for the assessment of Barrett's esophagus can be subject to sampling errors, resulting in diagnostic uncertainty. Optical coherence tomography is a cross-sectional imaging technique that can be used to conduct volumetric laser endomicroscopy (VLE) of the entire distal esophagus. We have developed a biopsy guidance platform that places endoscopically visible marks at VLE-determined biopsy sites. Objective The objective of this study was to demonstrate in human participants the safety and feasibility of VLE-guided biopsy in vivo. Design A pilot feasibility study. Setting Massachusetts General Hospital. Patients A total of 22 participants were enrolled from January ...

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    4. Feature Of The Week 1/12/14: MGH Researchers Demonstrate a Dual-Modality Optical Coherence Tomography & Near Infrared Spectroscopy System and Catheter for Intravascular Imaging

      Feature Of The Week 1/12/14: MGH Researchers Demonstrate a Dual-Modality Optical Coherence Tomography & Near Infrared Spectroscopy System and Catheter for Intravascular Imaging
      ...ction of coronary atherosclerotic lesions. For more information see recent Article . Courtesy Ali M. Fard and Guillermo J. Tearney from Massachusetts General Hospital . Intravascular optical coherence tomography (IVOCT) ...
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    5. State of the Industry report on Optical Coherence Tomography

      State of the Industry report on Optical Coherence Tomography

      The first commercial optical coherence tomography (OCT) imagers were introduced to ophthalmology by Advanced Ophthalmic Devices (now owned by Zeiss Meditec) in 1992. Since then, the market for OCT systems has grown at an impressive compounded annual rate of about 45%. This segment of the biophotonics marketplace has flourished because OCT enables sub-surface imaging of translucent or opaque materials, such as human tissue, in real time at micron resolution and without the use of ionizing radiation. As a result, last year’s global sales of all OCT systems exceeded $400 million and the market now supports more than 36 OCT ...

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    6. Massachusetts General Hospital Receives NIH Grant for Studying the Natural History of Vulnerable Coronary Plaques

      Massachusetts General Hospital Receives NIH Grant for Studying the Natural History of Vulnerable Coronary Plaques
      ...t for $720,595 for Studying the Natural History of Vulnerable Coronary Plaques. The principal Investigator is Guillermo Tearney. The program began in 2004 and ends in 2015. Below is summary of the proposed work.

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    7. Optical coherence tomography – near infrared spectroscopy system and catheter for intravascular imaging

      Optical coherence tomography – near infrared spectroscopy system and catheter for intravascular imaging

      Owing to its superior resolution, intravascular optical coherence tomography (IVOCT) is a promising tool for imaging the microstructure of coronary artery walls. However, IVOCT does not identify chemicals and molecules in the tissue, which is required for a more complete understanding and accurate diagnosis of coronary disease. Here we present a dual-modality imaging system and catheter that uniquely combines IVOCT with diffuse near-infrared spectroscopy (NIRS) in a single dual-modality imaging device for simultaneous acquisition of microstructural and compositional information. As a proof-of-concept demonstration, the device has been used to visualize co-incident microstructural and spectroscopic information obtained from a diseased cadaver ...

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    8. System, method and computer-accessible medium for tracking vessel motion during three-dimensional coronary artery microscopy

      System, method and computer-accessible medium for tracking vessel motion during three-dimensional coronary artery microscopy

      Exemplary embodiments of apparatus, method and computer accessible medium can be provided which can facilitate a determination of at least one characteristic of a structure. For example, it is possible to use at least one first arrangement which can be structured to provide at least one first transmitted radiation along a first axis and at least one second transmitted radiation along a second axis. The first and second transmitted radiations can impact the structure and generate respective first and second returned radiation. The first and second axis can be provided at a predetermined angle with respect with one another which ...

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    9. Four-dimensional visualization of subpleural alveolar dynamics in vivo during uninterrupted mechanical ventilation of living swine

      Four-dimensional visualization of subpleural alveolar dynamics in vivo during uninterrupted mechanical ventilation of living swine
      ... C. Warger, II,^1,^6 Carolin I. Unglert,^1,^2 Jocelyn E. Eckert,^1 Jeroen Hostens,^5 Brett E. Bouma,^1,^3 and Guillermo J. Tearney^1,^3,^4,^* ^1Harvard Medical School and Massachusetts General Hospital, Wellman Center ...
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    10. Optical coherence tomography imaging during thyroid and parathyroid surgery: A novel system of tissue identification and differentiation to obviate tissue resection and frozen section

      Optical coherence tomography imaging during thyroid and parathyroid surgery: A novel system of tissue identification and differentiation to obviate tissue resection and frozen section

      Background : Optical coherence tomography(OCT) allows tissue histologic-like evaluation, but without tissue fixation or staining. We investigated OCT images from tissues obtained at thyroid and parathyroid surgeries to provide a preliminary assessment as to whether these images contain sufficient information for recognition and differentiation of normal neck tissues. Methods : Normal tissues were obtained from patients undergoing surgical treatment. Two new-generations OCT systems including optical frequency domain imaging(OFDI) and µOCT were compared to representative H&E histology. Results : Thyroid, fat, muscle, lymph nodes, and parathyroid tissues were evaluated. Histologic-like microscopic characteristics sufficient for tissue type identification was realized using both ...

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    11. Depth resolved detection of lipid using spectroscopic optical coherence tomography

      Depth resolved detection of lipid using spectroscopic optical coherence tomography

      Optical frequency domain imaging (OFDI) can identify key components related to plaque vulnerability but can suffer from artifacts that could prevent accurate identification of lipid rich regions. In this paper, we present a model of depth resolved spectral analysis of OFDI data for improved detection of lipid. A quadratic Discriminant analysis model was developed based on phantom compositions known chemical mixtures and applied to a tissue phantom of a lipid-rich plaque. We demonstrate that a combined spectral and attenuation model can be used to predict the presence of lipid in OFDI images.

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    12. Postdoctoral Research Fellowship in Optical Coherence Tomography at Massachusetts General Hospital, Boston, MA

      Postdoctoral Research Fellowship  in Optical Coherence Tomography at Massachusetts General Hospital, Boston, MA
      ...cific areas of interest and contact information for three letters of reference. Address correspondence to Dr. Guillermo J. Tearney and send by email to Princess Cruz . A Postdoctoral research fellowship  in the area of o...
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    13. 3D imaging for faster diagnosis of esophageal disease

      3D imaging for faster diagnosis of esophageal disease

      A tethered capsule that is swallowed by the patient offers a quick and pain-free method of screening and diagnosing gastrointestinal diseases. Diagnosing gastrointestinal (GI) diseases usually involves endoscopy, combining an invasive probe and video imaging or other optical methods. While effective, this method often causes patient discomfort and typically requires anesthesia, making it costly and time-consuming. Here we describe a new option for screening using a swallowable optomechanically engineered pill that rapidly provides 3D microscopic images of the gastrointestinal tract. The process is pain-free, so there is no need for anesthesia, and enables quick diagnosis of esophageal diseases.

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  2. About Guillermo J. Tearney

    Guillermo J. Tearney

    Guillermo Tearney M.D., Ph.D. is Professor of Pathology at Harvard Medical School, an Affiliated Faculty member of the Harvard-MIT Division of Health Sciences and Technology (HST), and the Associate Director of the Wellman Center for Photomedicine at the Massachusetts Genera lHospital. Dr. Tearney received his MD magna cum laude from Harvard Medical School and received his PhD in Electrical Engineering and Computer Science from the Massachusetts Institute of Technology.

     

    Dr. Tearney’s research interests are focused on the development and clinical validation of non-invasive, high-resolution optical imaging methods for disease diagnosis. Dr. Tearney's lab was the first to perform human imaging in the coronary arteries and gastrointestinal tract in vivo with Optical Coherence Tomography (OCT), which provides cross-sectional images of tissue architectural microstructure at a resolution of 10 μm. He has also conducted many of the seminal studies validating OCT and is considered an expert on OCT image interpretation. Recently, Dr. Tearney's lab has invented a next generation OCT technology, termed μOCT, which has a resolution of 1 μm and is capable of imaging cells and sub cellular structures in the coronary wall. Dr. Tearney has also developed several other technologies, including a confocal endomicroscope capable of imaging the entire esophagus, an ultraminiature three-dimensional endoscope, a highly efficient form of near field scanning optical microscopy (NSOM), and novel fluorescence spectroscopy and multimodality imaging techniques. He has an active program in Raman spectroscopy and has conducted the first intracoronary Raman in vivo. Dr. Tearney is co-editor of The Handbook of Optical Coherence Tomorgraphy and has written over 170 peer-reviewed publications, including papers that have been highlighted on the covers of Science, Nature Medicine, Circulation, Gastroenterology, and Journal of American College of Cardiology.

     

    Dr. Tearney’s work extends beyond his laboratory at MGH, many of his technologies are being produced commercially and he has founded the International Working Group on Intracoronary OCT Standardization and Validation, a group that is dedicated to establishing standards to ensure the widespread adoption of this imaging technology

  3. Quotes

    1. With our procedure, instead you swallow a capsule. And that capsule captures these microscopic images while you are in the living person. Without taking the tissue out. Not only that but it gathers the microscopic images of the entire esophagus, not just one little spot. So we get a much better understanding and a much better picture of the detailed structure of the esophagus and we are able to get a much better diagnoses.
      In Cancer detection as easy as popping a pill (video)
    2. The images produced have been some of the best we have seen of the esophagus...We originally were concerned that we might miss a lot of data because of the small size of the capsule; but we were surprised to find that, once the pill has been swallowed, it is firmly ‘grasped’ by the esophagus, allowing complete microscopic imaging of the entire wall. Other methods we have tried can compress the esophageal lining, making it difficult to obtain accurate, three-dimensional pictures. The capsule device provides additional key diagnostic information by making it possible to see the surface structure in greater detail.
      In Pill-sized device rivals endoscopy: Novel imaging system screens for Barrett’s esophagus in minutes
    3. OFDI imaging with laser marking has the potential to improve the diagnostic paradigm for patients suspected of having Barrett's esophagus, one of the most common precursors to esophageal cancer... There is a large and growing unmet need to improve the gastroenterologist's ability to detect, diagnose and make critical treatment decisions for patients with Barrett's esophagus, and this technological advancement may significantly improve this paradigm. Provided these results can be confirmed in an ongoing, larger study, OFDI-based guided biopsy may soon be able to help clinicians make more precise and rapid diagnoses while taking fewer, but more targeted, biopsies allowing patients to receive more tailored management for diseases like Barrett's esophagus.
      In NinePoint Medical Announces New Data Presented on Innovative Optical Frequency Domain Imaging Technology at 19th UEGW Meeting
    4. MicroOCT has the contrast and resolution required to investigate the cellular and subcellular components underlying coronary atherosclerosis, the disease that precipitates heart attack...This high level of performance opens up the future possibility of observing these microscopic features in human patients, which has implications for improving the understanding, diagnosis, and therapeutic monitoring of coronary artery disease.
      In A closer look at atherosclerosis: High-res imaging reveals cellular details of coronary arteries
    5. High quality images provided by optical frequency domain imaging – or OFDI – may one day enable physicians to implement routine, less invasive screening procedures for high-risk patients...The ability to perform accurate diagnoses for conditions like Barrett’s esophagus could also provide significant improvements over random biopsies that are currently the standard of care for patients at risk for developing esophageal cancer.
      In NinePoint Medical Licenses 188 Patents and Patent Applications from Massachusetts General Hospital
    6. These results are comparable to what is seen with drug eluting stents in terms of thickness--we did not see a significant hyperplastic injury response.
      In vProtect(TM) Luminal Shield Stabilizes Vulnerable Plaque
    7. The wealth of information that we can now obtain will undoubtedly improve our ability to understand coronary artery disease and may allow cardiologists to diagnose and treat plaque before it leads to serious problems.
      In America wakes up to 3-D human coronary artery imaging